LOCUS       NM_005667               3482 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ring finger protein 103 (RNF103), transcript variant
            1, mRNA.
ACCESSION   NM_005667
VERSION     NM_005667.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Scheper,J., Oliva,B., Villa-Freixa,J. and Thomson,T.M.
  TITLE     Analysis of electrostatic contributions to the selectivity of
            interactions between RING-finger domains and ubiquitin-conjugating
            enzymes
  JOURNAL   Proteins 74 (1), 92-103 (2009)
   PUBMED   18615712
  REMARK    GeneRIF: Analysis reveals that the main determinants of selectivity
            between ubiquitin ligases RNF103 and E2 ubiquitin-conjugating
            enzymes resides on ring domains, rather than on the E2s.
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Maruyama,Y., Yamada,M., Takahashi,K. and Yamada,M.
  TITLE     Ubiquitin ligase Kf-1 is involved in the endoplasmic
            reticulum-associated degradation pathway
  JOURNAL   Biochem Biophys Res Commun 374 (4), 737-741 (2008)
   PUBMED   18675248
  REMARK    GeneRIF: Kf-1 is an ER ubiquitin ligase involved in the endoplasmic
            reticulum-associated degradation pathway.
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Yang,Y., Lorick,K.L., Jensen,J.P. and Weissman,A.M.
  TITLE     Expression and evaluation of RING finger proteins
  JOURNAL   Methods Enzymol 398, 103-112 (2005)
   PUBMED   16275323
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Nishioka,G., Yamada,M., Kudo,K., Takahashi,K., Kiuchi,Y.,
            Higuchi,T., Momose,K., Kamijima,K. and Yamada,M.
  TITLE     Induction of kf-1 after repeated electroconvulsive treatment and
            chronic antidepressant treatment in rat frontal cortex and
            hippocampus
  JOURNAL   J Neural Transm (Vienna) 110 (3), 277-285 (2003)
   PUBMED   12658376
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Yamada,M., Yamada,M., Yamazaki,S., Takahashi,K., Nishioka,G.,
            Kudo,K., Ozawa,H., Yamada,S., Kiuchi,Y., Kamijima,K., Higuchi,T.
            and Momose,K.
  TITLE     Identification of a novel gene with RING-H2 finger motif induced
            after chronic antidepressant treatment in rat brain
  JOURNAL   Biochem Biophys Res Commun 278 (1), 150-157 (2000)
   PUBMED   11071867
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Yasojima,K., Tsujimura,A., Mizuno,T., Shigeyoshi,Y., Inazawa,J.,
            Kikuno,R., Kuma,K., Ohkubo,K., Hosokawa,Y., Ibata,Y., Abe,T.,
            Miyata,T., Matsubara,K., Nakajima,K. and Hashimoto-Gotoh,T.
  TITLE     Cloning of human and mouse cDNAs encoding novel zinc finger
            proteins expressed in cerebellum and hippocampus
  JOURNAL   Biochem Biophys Res Commun 231 (2), 481-487 (1997)
   PUBMED   9070305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA816879.1, BC035053.2,
            AW964704.1 and BC110333.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005667.3.
            
            Summary: The protein encoded by this gene contains a RING-H2
            finger, a motif known to be involved in protein-protein and
            protein-DNA interactions. This gene is highly expressed in normal
            cerebellum, but not in the cerebral cortex. The expression of the
            rat counterpart in the frontal cortex and hippocampus was shown to
            be induced by elctroconvulsive treatment (ECT) as well as chronic
            antidepressant treatment, suggesting that this gene may be a
            molecular target for ECT and antidepressants. The protein is a
            ubiquitin ligase that functions in the endoplasmic
            reticulum-associated degradation pathway. Alternative splicing of
            this gene results in multiple transcript variants. Read-through
            transcription also exists between this gene and the downstream
            CHMP3 (charged multivesicular body protein 3) gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035053.2, D76444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237455.5/ ENSP00000237455.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA816879.1         13-41
            30-500              BC035053.2         1-471
            501-966             BC035053.2         473-938
            967-1159            AW964704.1         110-302
            1160-3482           BC110333.1         322-2644
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..3482
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /note="ring finger protein 103"
                     /db_xref="GeneID:7844"
                     /db_xref="HGNC:HGNC:12859"
                     /db_xref="MIM:602507"
     exon            1..1205
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /inference="alignment:Splign:2.1.0"
     CDS             980..3037
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF103; zinc finger protein
                     expressed in cerebellum; zinc finger protein 103 homolog;
                     RING-type E3 ubiquitin transferase RNF103"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF103 isoform 1"
                     /protein_id="NP_005658.1"
                     /db_xref="CCDS:CCDS33237.1"
                     /db_xref="GeneID:7844"
                     /db_xref="HGNC:HGNC:12859"
                     /db_xref="MIM:602507"
                     /translation="MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALS
                     FKKLKTILECRGLGYSGLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFS
                     GEMHFYELVEDTKDGIWLVQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDP
                     RYCRRRGWVRSTLIMSVPQTSTSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIY
                     NAEHLKEEWNKSDQYWLKIYLFANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSY
                     MTDIGIYNMPSYILRTPEGIYRYGNHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLV
                     NLMAWMDLFITQGATIKRFVVLISTLGTYNSLLIISWLPVLGFLQLPYLDSFYEYSLK
                     LLRYSNTTTLASWVRADWMFYSSHPALFLSTYLGHGLLIDYFEKKRRRNNNNDEVNAN
                     NLEWLSSLWDWYTSYLFHPIASFQNFPVESDWDEDPDLFLERLAFPDLWLHPLIPTDY
                     IKNLPMWRFKCLGVQSEEEMSEGSQDTENDSESENTDTLSSEKEVFEDKQSVLHNSPG
                     TASHCDAEACSCANKYCQTSPCERKGRSYGSYNTNEDMEPDWLTWPADMLHCTECVVC
                     LENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSND
                     VPS"
     exon            1206..1345
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1461
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..3482
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="RNF103"
                     /gene_synonym="HKF-1; KF-1; KF1; ZFP-103; ZFP103"
                     /note="major polyA site"
ORIGIN      
        1 gttatgtctc ggctccggcc gcggccgccg ctgatacacg gttgtggagg gtacggccgc
       61 ggtctccgga ggtggcgggg gtgttgggga cgggtgctgc gaccggcact gcccatccga
      121 gcgggacggg cgctgagtgg ccgggaggca gccgggtagc cgcctggagg agcagtctcg
      181 gggcctatta ttggtttttt ccctccgaga ccgattccat ctgcagagac cgcgacgccc
      241 catcctgggc cgggccgcag tgcccgcccg cctgagaggc gccgcccgcc agccggcccg
      301 agcgaacctg gagccgccgc cgtgcccgcc gctcttctcg cggagcctgg gcggtcggcg
      361 gggcctgggg cctgggcttc gggcgcggcg ttgcggcggc cgctcctccc cgcgcagaac
      421 acgctgggcc ccgggcctgg cccggccgag cgccgcgccc tcctgacccg cggccgcggg
      481 agtccggccc ccacggcccc tcgggccccg gcctgccgcc cggatccccg cctcctgggc
      541 ggatctgagt tattttttgg tctccccctc ccccttgaga tcgcggcacc ggagggccga
      601 ccccgccacc tgggtcagtg cccgccccgg gggaagcgtc cctcgttttg ttcttccccg
      661 cgagctctcc ccgcgcccct ctcctttctg tgcttaatgg atgggggttt tgagtttttc
      721 ccctttattt ttgtcggctc ttgactggga ggcccggcgc gaggctctgc gtctctgcgt
      781 ccctcgtcgc cgcctcgcgc ccgcgcggat cccgtcacct gcttccccgc cggggatggc
      841 cggccagtga cggcgccggg tggcccgcgc gtggacacgg ggccctcgcc caagctgcca
      901 ccgagccgcg gcccccgccc tcgacccttc tctctcccgt attccgagct ctctggaaag
      961 agaggaaact ccagggaaga tgtggctgaa gctttttttc ttgctcctct atttcctggt
     1021 cctgttcgtc ctggccaggt tttttgaggc cattgtgtgg tatgaaactg gcatctttgc
     1081 cacccagctg gtggatccgg tggcgctgag cttcaagaag ctgaagacca ttttggagtg
     1141 ccgggggttg ggctactcag ggttgcccga gaagaaggat gtccgggagc tggtggaaaa
     1201 gtcaggtgac ttgatggagg gtgagctcta ttctgctctc aaggaagaag aagcatccga
     1261 atcggtttct agtaccaatt tcagtggtga aatgcacttc tatgagcttg tggaagacac
     1321 aaaagatggc atctggctgg ttcaggtcat agcaaatgac agaagtccct tggtgggcaa
     1381 aattcactgg gagaaaatgg ttaaaaaggt gtcaagattt ggaatacgta caggcacatt
     1441 taactgttcc agtgatccca gatattgcag gagaagaggc tgggtccgat ccacactcat
     1501 tatgtctgtt ccacaaacaa gtacttcaaa agggaaagtc atgcttaaag aatacagtgg
     1561 acgcaagatt gaagtagagc acatttttaa atggataact gctcatgcag cttctcggat
     1621 caaaaccatt tataatgctg aacacttgaa agaagaatgg aataaaagtg atcagtattg
     1681 gttaaaaata tacctatttg caaaccttga ccagccccca gctttcttct ctgcactaag
     1741 tataaagttt actggaagag ttgagtttat ttttgttaat gtagaaaatt gggacaacaa
     1801 gagttatatg acagatattg gcatatataa tatgccatca tacatactta gaactcctga
     1861 aggaatttac aggtatggaa accacacagg cgaatttata tcccttcagg ccatggattc
     1921 atttttgcgc tcattacaac ccgaggtaaa tgatctgttt gttttgagct tggttctagt
     1981 taatcttatg gcttggatgg acttatttat tacacaagga gctaccataa agcgatttgt
     2041 ggttctcata agcactttag ggacatataa ttctctatta attatttcct ggctacctgt
     2101 gttgggcttt ttacagctac cttacttaga tagcttttat gaatatagct taaaattgtt
     2161 gagatattcc aatacaacca cactggcttc atgggtaagg gcagactgga tgttttactc
     2221 ttcacaccca gccctgtttc tcagtacata ccttggtcat ggtttactaa ttgattactt
     2281 tgagaagaag agaaggcgca acaacaacaa tgatgaagtc aatgccaata acttagaatg
     2341 gttatcaagt ctgtgggact ggtacaccag ctacctcttc cacccgattg cttcttttca
     2401 gaactttcct gtagaatctg attgggacga agaccctgac ttattcttgg agcgcttagc
     2461 tttccctgac ctttggcttc accctctgat accaactgat tatattaaaa acttaccaat
     2521 gtggcgattt aaatgtcttg gagtccagtc tgaagaggaa atgtcggagg ggtctcaaga
     2581 tactgaaaat gactcggaaa gtgagaacac agacactttg agtagtgaga aggaagtatt
     2641 tgaagataag caaagcgtac ttcacaattc tccaggaaca gcaagtcact gtgatgctga
     2701 ggcttgttca tgtgccaata aatattgtca gaccagccca tgtgaaagga aggggaggtc
     2761 atatggatca tataacacta atgaagatat ggaacctgat tggttaactt ggcctgctga
     2821 tatgctgcac tgtactgaat gtgttgtttg cctagagaat tttgaaaatg gatgtttgct
     2881 aatggggttg ccttgtggtc atgtgtttca tcagaattgc attgtgatgt ggttggctgg
     2941 gggccgacat tgttgccctg tttgccggtg gccttcttat aaaaaaaagc agccatatgc
     3001 acaacaccag cccttgtcaa atgatgtccc atcttaacca tgtgcaattt gtcctttata
     3061 agctttgagt atcttacagc ttgccttttt aatgttagtc acaatgtttt tgtggtttga
     3121 agtttagttt aatgttagtg cagtgacggg aaatacacat tatgctaatg ttgatgacag
     3181 aatttatttg gttgccttgt gtgttaattg aatgcatacc taattgtaaa atttttttat
     3241 ttacaacatt ggaaattcag aagttaatgt ttttttgtaa gcacaaaaga agtattatag
     3301 aaatttatcc tagcaagact ttacaagata ggatcaaatt ctaatggaat tgagccggtt
     3361 tcttatccta aatgtttcct ccctttttac aatctctgtc cagcacctct tggttaaata
     3421 atgtatgctg tgagacatga aattaaaaca gacctatgaa ataaattatt ttaaaaccag
     3481 aa
//
