LOCUS       NM_001198954            3373 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens RNF103-CHMP3 readthrough (RNF103-CHMP3), mRNA.
ACCESSION   NM_001198954
VERSION     NM_001198954.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK294389.1, AC015971.4 and AC068288.6.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring RNF103 (ring finger protein
            103) and CHMP3 (charged multivesicular body protein 3) genes. The
            read-through transcript encodes a fusion protein that shares
            sequence identity with each individual gene product. [provided by
            RefSeq, Oct 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294389.1, SRR1803615.163642.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 7844, 51652
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AK294389.1         1-347
            348-348             AC015971.4         54176-54176
            349-1135            AK294389.1         349-1135
            1136-3373           AC068288.6         115291-117528       c
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..3373
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="RNF103-CHMP3 readthrough"
                     /db_xref="GeneID:100526767"
                     /db_xref="HGNC:HGNC:38847"
     exon            1..141
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            142..235
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            236..375
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..999
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="RNF103-CHMP3 read-through; RNF103-VPS24
                     readthrough; Charged multivesicular body protein 3;
                     Chromatin-modifying protein 3; Neuroendocrine
                     differentiation factor; Vacuolar protein
                     sorting-associated protein 24"
                     /codon_start=1
                     /product="RNF103-CHMP3 protein"
                     /protein_id="NP_001185883.1"
                     /db_xref="GeneID:100526767"
                     /db_xref="HGNC:HGNC:38847"
                     /translation="MEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWLVQ
                     VNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKA
                     VSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELS
                     KEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALP
                     EPEPPGAMAASEDEEEEEEALEAMQSRLATLRS"
     exon            376..436
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            437..616
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            617..738
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            739..853
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     exon            854..3373
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="hexamer: AATAAA"
     polyA_site      1202
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="major polyA site"
     regulatory      3279..3284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="hexamer: AATAAA"
     polyA_site      3299
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="major polyA site"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="hexamer: AATAAA"
     polyA_site      3373
                     /gene="RNF103-CHMP3"
                     /gene_synonym="CGI149; CHMP3; hVps24; NEDF; RNF103-VPS24;
                     VPS24"
                     /note="major polyA site"
ORIGIN      
        1 actcgggggt cggcagtttg caggtgcgat gggcggcccc ctcacccacg tttatccgga
       61 ctggagcccg ccgctcccgg ctgggtttcc gggtggttcg cgctccttct gaattggcag
      121 cgaggtcgcg gcaggttcga ggctttgaca ccagcacctc tctatgaaga aaagagtgtg
      181 ttgtgaacga agtcagaatt tcctgtgttc cctttgccgc tcctggagtt cactggtgac
      241 ttgatggagg gtgagctcta ttctgctctc aaggaagaag aagcatccga atcggtttct
      301 agtaccaatt tcagtggtga aatgcacttc tatgagcttg tggaagacac aaaagatggc
      361 atctggctgg ttcaggtcaa tgagtggtca ttgaagataa gaaaggaaat gagagttgtt
      421 gacaggcaaa taagggatat ccaaagagaa gaagaaaaag tgaaacgatc tgtgaaagat
      481 gctgccaaga agggccagaa ggatgtctgc atagttctgg ccaaggagat gatcaggtca
      541 aggaaggctg tgagcaagct gtatgcatcc aaagcacaca tgaactcagt gctcatgggg
      601 atgaagaacc agctcgcggt cttgcgagtg gctggttccc tgcagaagag cacagaagtg
      661 atgaaggcca tgcaaagtct tgtgaagatt ccagagattc aggccaccat gagggagttg
      721 tccaaagaaa tgatgaaggc tgggatcata gaggagatgt tagaggacac ttttgaaagc
      781 atggacgatc aggaagaaat ggaggaagaa gcagaaatgg aaattgacag aattctcttt
      841 gaaattacag caggggcctt gggcaaagca cccagtaaag tgactgatgc ccttccagag
      901 ccagaacctc caggagcgat ggctgcctca gaggatgagg aggaggagga agaggctctg
      961 gaggccatgc agtcccggct ggccacactc cgcagctagg ggctgcctac cccgctgggt
     1021 gtgcacacac tcctctcaag agctgccatt ttatgtgtct cttgcactac acctctgttg
     1081 tgaggactac cattttggag aaggttctgt ttgtctcttt tcattctctg cccaggtttt
     1141 gggatcgcaa agggattgtt cttataaaag tggcataaat aaatgcatca tttttaggag
     1201 tatagacaga tatatcttat tgtggggagg ggaaagaaat ccatctgctc atgaagcact
     1261 tctgaaaata taggtgattg cctgaatgtc gaagactcta cttttgtcta taaaacacta
     1321 tataaatgaa ttttaataaa tttttgcttt agcacttggc cccattgtag attgccctgt
     1381 gcagtaaact ttcaaggtgt cggctgcccc agattgcttc atttgctggg tgtggaaaga
     1441 gttgctatgg ccaggcatat gggatttgga agctcagcag aagtgacttc tgctctgtgg
     1501 ttgctgctcc ccggctttca cagacatggt atggcagcca ttcttttatc tatttaacca
     1561 agaggatgct ggggaattgt gctgcttgtc ctgttggctg gtggctgcat tatgtcctgg
     1621 ggtgtgcatg tgggtctatt tagagcttct gtcccttcct tcccattgca agttgcaccc
     1681 agatgagaca gctgtagtac taggtctctt tcacctctca ttgcctgtcc ctgcttcgag
     1741 ctggttgtct tgtgcgtggg acatgggcct tcctatctgt gttttctcaa agtcaggagc
     1801 tgaccaggag cacactaagg tgtggtcatg catcataacc aacattcact catctgggac
     1861 attcttaaga tacatttata aatcatttca gcagtagtac tttgtatgtg ttgagagttt
     1921 acagagctct ttgacatacg cgatcttagt ctttacaaat aaggaaaaca gctcagtttg
     1981 ggaagtatca gagatgggat tcaaacccag atcctctggt ccaagttgta tgtgcactga
     2041 actaatcagg caggaaaaaa gcccagccac tgtctcacag attgtttttt gtatattgta
     2101 gcaaaatcct gaaacaatgg ggtccttcca gtctcatcat acaaaatggc aatcttggct
     2161 gggtgcggtg gttcatgcct ataatcccag tgctttacaa ggctgaggca ggaggctctc
     2221 ttgagaatag gagttcaaga ccagcctggg caacatagca agatcctgtc tctccaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aatttcattt ttgagtccag aggaccctcc tattactctt
     2341 gatttcatct tcagagtgta gttaaaaaat tattttaaat aattattttt ttaaatcagt
     2401 tgtaggttca cagcaaaagt ggacaaaaag aaatttctca tatatcccct gccctcacac
     2461 atgcatagcc tcccaccact atcagtatcc cacaccagag tggtacattt gttacaatca
     2521 ataaacctcc attgacacat cattatcacc caaagtccat agtttacatg aagattcact
     2581 ctggtgttgt acattgtatg ggcttagaca aatgtatgat gatatctaca attatagaat
     2641 catacagaat agtttcactg ccctaaaact tctctatgct tcacctgttc atccctttct
     2701 tccctaatcc cctggcaacc actttaaaaa aaaaattagg ttcagggggt acatgtgcag
     2761 gtaaactcgt gacaaggggg tttgttatac agattattta gtgacccagg tactaagcct
     2821 agtacccaat agttactttt ctggtcctgt cccttttccc accctccacc ctcaggtagg
     2881 ccccagtatg ttattccttt gtgtccatgt tatttcactc ccacttgtga gaacatggaa
     2941 tatttggttt cctgttccta tgttagtttg ttaaggataa tggcctccag ccccatccat
     3001 gttcctgcaa aggacatgat ctttctttgg caaccacttt ttactgtcgc catagttctt
     3061 ccttttctag aatgtcatat tggaatcata tagtatgtag ccttttcaga ctggcttctt
     3121 tcacttaata atatgcaatt aaggttcctc catgtcattt catggcttaa tagtgcattt
     3181 atttttagca ctgaataata ctccattgtc tagatgaata gtttatccat tcacctattg
     3241 aaagacttct tggtggtttc caagttttgg caattatgaa taaagctgtt gtaaacatct
     3301 ttgtgcaggt ttttctatgg gcatgttttt aattcatttg aataaatacc aagagcttca
     3361 gtgctggatc ata
//
