LOCUS       NM_014868               3814 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ring finger protein 10 (RNF10), transcript variant 1,
            mRNA.
ACCESSION   NM_014868
VERSION     NM_014868.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3814)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3814)
  AUTHORS   Kan,B., Yan,G., Shao,Y., Zhang,Z. and Xue,H.
  TITLE     CircRNA RNF10 inhibits tumorigenicity by targeting
            miR-942-5p/GOLIM4 axis in breast cancer
  JOURNAL   Environ Mol Mutagen 63 (7), 362-372 (2022)
   PUBMED   36054164
  REMARK    GeneRIF: CircRNA RNF10 inhibits tumorigenicity by targeting
            miR-942-5p/GOLIM4 axis in breast cancer.
REFERENCE   3  (bases 1 to 3814)
  AUTHORS   Garshott,D.M., An,H., Sundaramoorthy,E., Leonard,M., Vicary,A.,
            Harper,J.W. and Bennett,E.J.
  TITLE     iRQC, a surveillance pathway for 40S ribosomal quality control
            during mRNA translation initiation
  JOURNAL   Cell Rep 36 (9), 109642 (2021)
   PUBMED   34469731
REFERENCE   4  (bases 1 to 3814)
  AUTHORS   Garzia,A., Meyer,C. and Tuschl,T.
  TITLE     The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of
            ribosomes compromised in translation
  JOURNAL   Cell Rep 36 (5), 109468 (2021)
   PUBMED   34348161
  REMARK    GeneRIF: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal
            subunits of ribosomes compromised in translation.
REFERENCE   5  (bases 1 to 3814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3814)
  AUTHORS   Hoshikawa,S., Ogata,T., Fujiwara,S., Nakamura,K. and Tanaka,S.
  TITLE     A novel function of RING finger protein 10 in transcriptional
            regulation of the myelin-associated glycoprotein gene and myelin
            formation in Schwann cells
  JOURNAL   PLoS One 3 (10), e3464 (2008)
   PUBMED   18941509
  REMARK    GeneRIF: RNF10 is a trans-acting protein regulating MAG expression
            and is required for myelin formation.
REFERENCE   7  (bases 1 to 3814)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 3814)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 3814)
  AUTHORS   Lin,J., Friesen,M.T., Bocangel,P., Cheung,D., Rawszer,K. and
            Wigle,J.T.
  TITLE     Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription
            factor binding to RING finger protein 10
  JOURNAL   Mol Cell Biochem 275 (1-2), 75-84 (2005)
   PUBMED   16335786
  REMARK    GeneRIF: MEOX2 and Meox2 binding to RNF10 protein was
            characterized.
REFERENCE   10 (bases 1 to 3814)
  AUTHORS   Seki,N., Hattori,A., Sugano,S., Muramatsu,M. and Saito,T.
  TITLE     cDNA cloning, expression profile, and genomic structure of human
            and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein
  JOURNAL   J Hum Genet 45 (1), 38-42 (2000)
   PUBMED   10697961
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA103961.1, BC016622.1,
            DB526099.1 and BQ015862.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014868.4.
            
            Summary: The protein encoded by this gene contains a ring finger
            motif, which is known to be involved in protein-protein
            interactions. The specific function of this protein has not yet
            been determined. EST data suggests the existence of multiple
            alternatively spliced transcript variants, however, their full
            length nature is not known. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.177399.1,
                                           SRR1660807.18609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325954.9/ ENSP00000322242.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA103961.1         35-43
            10-3114             BC016622.1         1-3105
            3115-3392           DB526099.1         152-429
            3393-3814           BQ015862.1         24-445              c
FEATURES             Location/Qualifiers
     source          1..3814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3814
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /note="ring finger protein 10"
                     /db_xref="GeneID:9921"
                     /db_xref="HGNC:HGNC:10055"
                     /db_xref="MIM:615998"
     exon            1..613
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2892
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein; E3
                     ubiquitin-protein ligase RNF10"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF10 isoform 1"
                     /protein_id="NP_055683.3"
                     /db_xref="CCDS:CCDS9201.1"
                     /db_xref="GeneID:9921"
                     /db_xref="HGNC:HGNC:10055"
                     /db_xref="MIM:615998"
                     /translation="MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGP
                     AGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSKTFNKMPPQRGGG
                     SSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQTGHFEGS
                     GHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRIC
                     SHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLK
                     SVVATESHQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLL
                     ASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAAIQELKTREEALSGLAGSRREV
                     TGVVAALEQLVLMAPLAKESVFQPRKGVLEYLSAFDEETTEVCSLDTPSRPLALPLVE
                     EEEAVSEPEPEGLPEACDDLELADDNLKEGTICTESSQQEPITKSGFTRLSSSPCYYF
                     YQAEDGQHMFLHPVNVRCLVREYGSLERSPEKISATVVEIAGYSMSEDVRQRHRYLSH
                     LPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEIEENK
                     KQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSISPLSRSPGSHADF
                     LLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENSLVP
                     PAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEEKGGKKRKKQK
                     QKLLFSTSVVHTK"
     exon            614..810
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1010
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1101
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1286
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1423
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1584
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1710
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1987
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2121
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2239
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2341
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2497
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2598
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2656
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2815
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3814
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3093..3098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /note="hexamer: AATAAA"
     polyA_site      3114
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /note="major polyA site"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="RNF10"
                     /gene_synonym="RIE2"
     regulatory      3794..3799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF10"
                     /gene_synonym="RIE2"
                     /note="hexamer: AATAAA"
     polyA_site      3814
                     /gene="RNF10"
                     /gene_synonym="RIE2"
ORIGIN      
        1 gctgtttggc gactcgtcgc cattcccgga gcaggtcggc ctcggcccag gggcgagtat
       61 ccgttgctgt gtcggagaca ctagtccccg acaccgagac agccagccct ctcccctgcc
      121 tcgcggcggg agagcgtgtc cggccggccg gccggcgggg ctcgcgcaac ctccctcgcc
      181 tccccttccc ccgcagcctc cgccccgcca ggcccggccc ggactcccga gccccggcct
      241 cctcgtcctc ggtcgccgct gccgccgggc ttaacagccc cgtccgccgc ttctcttcct
      301 agtttgagaa gccaaggaag gaaacaggga aaaatgtcgc catgaaggcc gagaaccgct
      361 gccgccgccg acccccgccg gccctgaacg ccatgagcct gggtccccgc cgcgcccgct
      421 ccgctccgac tgccgtcgcc gccgaggccc ccgttgatgc cgctgagctc ccccaacgcc
      481 gccgccaccg cctccgacat ggacaagaac agcggctcca acagctcctc cgcctcttcg
      541 ggcagcagca aagggcaaca gccgccccgc tccgcctcgg cggggccagc cggcgagtct
      601 aaacccaaga gcgatggaaa gaactccagt ggatccaagc gttataatcg caaacgtgaa
      661 ctttcctacc ccaaaaatga aagttttaac aaccagtccc gtcgctccag ttcacagaaa
      721 agcaagactt ttaacaagat gcctcctcaa aggggcggcg gcagcagcaa actctttagc
      781 tcttctttta atggtggaag acgagatgag gtagcagagg ctcaacgggc agagtttagc
      841 cctgcccagt tctctggtcc taagaagatc aacctgaacc acttgttgaa tttcactttt
      901 gaaccccgtg gccagacggg tcactttgaa ggcagtggac atggtagctg gggaaagagg
      961 aacaagtggg gacataagcc ttttaacaag gaactctttt tacaggccaa ctgccaattt
     1021 gtggtgtctg aagaccaaga ctacacagct cattttgctg atcctgatac attagttaac
     1081 tgggactttg tggaacaagt gcgcatttgt agccatgaag tgccatcttg cccaatatgc
     1141 ctctatccac ctactgcagc caagataacc cgttgtggac acatcttctg ctgggcatgc
     1201 atcctgcact atctttcact gagtgagaag acgtggagta aatgtcccat ctgttacagt
     1261 tctgtgcata agaaggatct caagagtgtt gttgccacag agtcacatca gtatgttgtt
     1321 ggtgatacca ttacgatgca gctgatgaag agggagaaag gggtgttggt ggctttgccc
     1381 aaatccaaat ggatgaatgt agaccatccc attcatctag gagatgaaca gcacagccag
     1441 tactccaagt tgctgctggc ctctaaggag caggtgctgc accgggtagt tctggaggag
     1501 aaagtagcac tagagcagca gctggcagag gagaagcaca ctcccgagtc ctgctttatt
     1561 gaggcagcta tccaggagct caagactcgg gaagaggctc tgtcgggatt ggccggaagc
     1621 agaagggagg tcactggtgt tgtggctgct ctggaacaac tggtgctgat ggctcccttg
     1681 gcgaaggagt ctgtttttca acccaggaag ggtgtgctgg agtatctgtc tgccttcgat
     1741 gaagaaacca cggaagtttg ttctctggac actccttcta gacctcttgc tctccctctg
     1801 gtagaagagg aggaagcagt gtctgaacca gagcctgagg ggttgccaga ggcctgtgat
     1861 gacttggagt tagcagatga caatcttaaa gaggggacca tttgcactga gtccagccag
     1921 caggaaccca tcaccaagtc aggcttcaca cgcctcagca gctctccttg ttactacttt
     1981 taccaagcgg aagatggaca gcatatgttc ctgcaccctg tgaatgtgcg ctgcctcgtg
     2041 cgggagtacg gcagcctgga gaggagcccc gagaagatct cagcaactgt ggtggagatt
     2101 gctggctact ccatgtctga ggatgttcga cagcgtcaca gatatctctc tcacttgcca
     2161 ctcacctgtg agttcagcat ctgtgaactg gctttgcaac ctcctgtggt ctctaaggaa
     2221 accctagaga tgttctcaga tgacattgag aagaggaaac gtcagcgcca aaagaaggct
     2281 cgggaggaac gccgccgaga gcgcaggatt gagatagagg agaacaagaa acagggcaag
     2341 tacccagaag tccacattcc cctcgagaat ctacagcagt ttcctgcctt caattcttat
     2401 acctgctcct ctgattctgc tttgggtccc accagcaccg agggccatgg ggccctctcc
     2461 atttctcctc tcagcagaag tccaggttcc catgcagact ttctgctgac ccctctgtca
     2521 cccactgcca gtcagggcag tccctcattc tgcgttggga gtctggaaga agactctccc
     2581 ttcccttcct ttgcccagat gctgagggtt ggaaaagcaa aagcagatgt gtggcccaaa
     2641 actgctccaa agaaagatga gaacagctta gttcctcctg cccctgtgga cagcgacggg
     2701 gagagtgata attcagaccg tgttcctgtg cccagttttc aaaattcctt cagccaagct
     2761 attgaagcag ccttcatgaa actggacaca ccagctactt cagatcccct ctctgaagag
     2821 aaaggaggaa agaaaagaaa aaaacagaaa cagaagctcc tgttcagcac ctcagtcgtc
     2881 cacaccaagt gacactactg gcccaggcta ccttctccat ctggtttttg tttttgtttt
     2941 tttttccccc atgcttttgt ttggctgctg taatttttaa gtatttgagt ttgaacagat
     3001 tagctctggg gggagggggt ttccacaatg tgagggggaa ccaagaaaat tttaaataca
     3061 gtgtattttc cagcttcctg tctttacacc aaaataaagt attgacacaa gagatctctt
     3121 cctgccaagg tttttagttc attgccagtt tagtcttttt gacccatgtg taattaattt
     3181 ttctcaaccc aaagtaagat tgagtcccct ttgagatgca ttagagcagt ccaacccaga
     3241 atggcacaca ctgctctgct gtagcatcat gtcagggctt cctggactca gtacacctct
     3301 cagtttgtct tttaaaaaac agctgaatct ttactaccta tttagttctc cttgttaaag
     3361 aaacaggggt gggaataaaa tggatttagg acacccagtt tgaattgcag tttttttttt
     3421 tctgacacat ggccaggctg tggtgccagc ttaatggagt aggctgtcct tggcacttgc
     3481 atgtgtgaaa ggagggtttt gcctcttctt gagcatggct tgagttggta aggaaagctg
     3541 taactcacga agccctgaga cctgctaccc ctaagatcga gcttgttttc agtgactggc
     3601 ttgagtcata ggaggaggag tctggtacag ctgcaggaga gcagggccat ctgaagcggt
     3661 agcattgcca ccatctccct ctcatctaga gcagttttct tatgccttgg tttgagctga
     3721 atttgatgtg aattcttttg ctgcttaata aagtgacctc taggtgcatt agaatgcgaa
     3781 ggcaaatagt tgcaataaat cacctgcaca agca
//
