LOCUS       NM_005168               2684 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens Rho family GTPase 3 (RND3), transcript variant 2,
            mRNA.
ACCESSION   NM_005168
VERSION     NM_005168.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Abbey,C.A., Duran,C.L., Chen,Z., Chen,Y., Roy,S., Coffell,A.,
            Sveeggen,T.M., Chakraborty,S., Wells,G.B., Chang,J. and
            Bayless,K.J.
  TITLE     Identification of New Markers of Angiogenic Sprouting Using
            Transcriptomics: New Role for RND3
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (5), e145-e167 (2024)
   PUBMED   38482696
  REMARK    GeneRIF: Identification of New Markers of Angiogenic Sprouting
            Using Transcriptomics: New Role for RND3.
REFERENCE   2  (bases 1 to 2684)
  AUTHORS   Shan,M., Liu,D., Sun,L., Yang,M., He,M., Zhang,Y., Xiang,L., Lu,L.,
            He,H., Niu,D., Chen,L., Li,S., Chen,A., He,F., Wang,Y. and Lian,J.
  TITLE     KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3
            down-regulation in hepatocellular carcinoma cells
  JOURNAL   Cancer Lett 584, 216598 (2024)
   PUBMED   38224863
  REMARK    GeneRIF: KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent
            RND3 down-regulation in hepatocellular carcinoma cells.
REFERENCE   3  (bases 1 to 2684)
  AUTHORS   Basbous,S., Dif,L., Dantzer,C., Di-Tommaso,S., Dupuy,J.W.,
            Bioulac-Sage,P., Raymond,A.A., Desdouets,C., Saltel,F. and
            Moreau,V.
  TITLE     Loss of RND3/RHOE controls entosis through LAMP1 expression in
            hepatocellular carcinoma
  JOURNAL   Cell Death Dis 15 (1), 46 (2024)
   PUBMED   38218945
  REMARK    GeneRIF: Loss of RND3/RHOE controls entosis through LAMP1
            expression in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2684)
  AUTHORS   Almaran,B., Ramis,G., Fernandez de Mattos,S. and Villalonga,P.
  TITLE     Rnd3 Is a Crucial Mediator of the Invasive Phenotype of
            Glioblastoma Cells Downstream of Receptor Tyrosine Kinase
            Signalling
  JOURNAL   Cells 11 (23), 3716 (2022)
   PUBMED   36496976
  REMARK    GeneRIF: Rnd3 Is a Crucial Mediator of the Invasive Phenotype of
            Glioblastoma Cells Downstream of Receptor Tyrosine Kinase
            Signalling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2684)
  AUTHORS   Dai,L., Chen,X., Zhang,H., Zeng,H., Yin,Z., Ye,Z. and Wei,Y.
  TITLE     RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration
            and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis
            Through the Rho/ROCK Pathway
  JOURNAL   J Interferon Cytokine Res 42 (6), 279-289 (2022)
   PUBMED   35699481
  REMARK    GeneRIF: RND3 Transcriptionally Regulated by FOXM1 Inhibits the
            Migration and Inflammation of Synovial Fibroblasts in Rheumatoid
            Arthritis Through the Rho/ROCK Pathway.
            Erratum:[J Interferon Cytokine Res. 2022 Nov;42(11):594. doi:
            10.1089/jir.2021.0228.correx.. PMID: 36383127]
REFERENCE   6  (bases 1 to 2684)
  AUTHORS   Riento,K., Guasch,R.M., Garg,R., Jin,B. and Ridley,A.J.
  TITLE     RhoE binds to ROCK I and inhibits downstream signaling
  JOURNAL   Mol Cell Biol 23 (12), 4219-4229 (2003)
   PUBMED   12773565
REFERENCE   7  (bases 1 to 2684)
  AUTHORS   Fiegen,D., Blumenstein,L., Stege,P., Vetter,I.R. and Ahmadian,M.R.
  TITLE     Crystal structure of Rnd3/RhoE: functional implications
  JOURNAL   FEBS Lett 525 (1-3), 100-104 (2002)
   PUBMED   12163169
REFERENCE   8  (bases 1 to 2684)
  AUTHORS   Katoh,H., Harada,A., Mori,K. and Negishi,M.
  TITLE     Socius is a novel Rnd GTPase-interacting protein involved in
            disassembly of actin stress fibers
  JOURNAL   Mol Cell Biol 22 (9), 2952-2964 (2002)
   PUBMED   11940653
  REMARK    GeneRIF: Socius is a novel Rnd GTPase-interacting protein involved
            in disassembly of actin stress fibers
REFERENCE   9  (bases 1 to 2684)
  AUTHORS   Nobes,C.D., Lauritzen,I., Mattei,M.G., Paris,S., Hall,A. and
            Chardin,P.
  TITLE     A new member of the Rho family, Rnd1, promotes disassembly of actin
            filament structures and loss of cell adhesion
  JOURNAL   J Cell Biol 141 (1), 187-197 (1998)
   PUBMED   9531558
REFERENCE   10 (bases 1 to 2684)
  AUTHORS   Foster,R., Hu,K.Q., Lu,Y., Nolan,K.M., Thissen,J. and Settleman,J.
  TITLE     Identification of a novel human Rho protein with unusual
            properties: GTPase deficiency and in vivo farnesylation
  JOURNAL   Mol Cell Biol 16 (6), 2689-2699 (1996)
   PUBMED   8649376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC367501.1, BC012513.1, BX460517.2 and CF127383.1.
            
            On Aug 14, 2020 this sequence version replaced NM_005168.4.
            
            Summary: This gene encodes a protein which is a member of the small
            GTPase protein superfamily. The encoded protein binds only GTP but
            has no GTPase activity, and appears to act as a negative regulator
            of cytoskeletal organization leading to loss of adhesion. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012513.1, SRR11853567.17469.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263895.9/ ENSP00000263895.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DC367501.1         30-46
            18-1235             BC012513.1         1-1218
            1236-2097           BC012513.1         1221-2082
            2098-2098           BX460517.2         860-860
            2099-2649           BC012513.1         2084-2634
            2650-2681           BC012513.1         2636-2667
            2682-2684           CF127383.1         502-504
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..2684
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="Rho family GTPase 3"
                     /db_xref="GeneID:390"
                     /db_xref="HGNC:HGNC:671"
                     /db_xref="MIM:602924"
     exon            1..119
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     exon            120..307
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..892
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="ras homolog gene family, member E; rho-related
                     GTP-binding protein RhoE; small GTP binding protein Rho8;
                     protein MemB; rho-related GTP-binding protein Rho8"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoE precursor"
                     /protein_id="NP_005159.1"
                     /db_xref="CCDS:CCDS2190.1"
                     /db_xref="GeneID:390"
                     /db_xref="HGNC:HGNC:671"
                     /db_xref="MIM:602924"
                     /translation="MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFA
                     KDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICF
                     DISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYD
                     QGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRIS
                     HMPSRPELSAVATDLRKDKAKSCTVM"
     exon            308..395
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     exon            396..505
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     exon            506..640
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2684
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="hexamer: ATTAAA"
     polyA_site      1655
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="major polyA site"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="hexamer: AATAAA"
     polyA_site      2684
                     /gene="RND3"
                     /gene_synonym="ARHE; memB; Rho8; RhoE"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggct cggaattgga cttgggaggc gcggtgagga gtcaggctta aaacttgttg
       61 gaggggagta accagcctgc tcctctcgct ctcctcctcg tctgcgccgc gtttcagaga
      121 gaaaattcct gttccaagag aaaataaggc aacatcaatg aaggagagaa gagccagcca
      181 gaaattatcc agcaaatcta tcatggatcc taatcagaac gtgaaatgca agatagttgt
      241 ggtgggagac agtcagtgtg gaaaaactgc gctgctccat gtcttcgcca aggactgctt
      301 ccccgagaat tacgttccta cagtgtttga gaattacacg gccagttttg aaatcgacac
      361 acaaagaata gagttgagcc tgtgggacac ttcgggttct ccttactatg acaatgtccg
      421 ccccctctct taccctgatt cggatgctgt gctgatttgc tttgacatca gtagaccaga
      481 gaccctggac agtgtcctca aaaagtggaa aggtgaaatc caggaatttt gtccaaatac
      541 caaaatgctc ttggtcggct gcaagtctga tctgcggaca gatgttagta cattagtaga
      601 gctctccaat cacaggcaga cgccagtgtc ctatgaccag ggggcaaata tggccaaaca
      661 gattggagca gctacttata tcgaatgctc agctttacag tcggaaaata gcgtcagaga
      721 catttttcac gttgccacct tggcatgtgt aaataagaca aataaaaacg ttaagcggaa
      781 caaatcacag agagccacaa agcggatttc acacatgcct agcagaccag aactctcggc
      841 agttgctacg gacttacgaa aggacaaagc gaagagctgc actgtgatgt gaatctttca
      901 ttatctttaa tgaagacaaa ggaatctagt gtaaaaaaca acagcaaaca aaaaggtgaa
      961 gtctaaatga agtgcacagc caaagtcatg tataccagag gcttaggagg cgtttgagag
     1021 gatactcatc tttttggaat cctgacctta ggttcggcat gtagaccaag tgatgagaag
     1081 tgaatacatg gaagagtttt taagtgtgac ttgaaaaata tgccaaaaaa tgagagatac
     1141 aaatgagcta gaggaagatg aggggggatg cgagtacctc caagaagaaa aatcacactc
     1201 tgaatggtgc ttgcattttt gggttttttt tttttgttat aatctattca tggatctcca
     1261 ctttgattta atttttaaat gttttaatct cctttacaaa aagtatacgt taatataccg
     1321 tcctcaaggg ggaactggca ctgtgacctt agcatttagt tttctagagg atgtgatcta
     1381 atttctttct agctcatcat taaaaaggaa attgtatcag gacccatggg atatatccag
     1441 aggcaaactt tatgaggctt tgaaatcttg ccttcctgaa gatagctgag taggatggtt
     1501 ctaaggaaag cctttgcaat cttgcaagat ttgtagacca gcactacaaa gatcgcatag
     1561 atcaaatagg aaaaaaaatg tcgattttta ttcagtctga tggttctgtt cttcattgtg
     1621 attgtcatta aaaagtggta aattgctcaa tgtaatattt ttgtgcgctg tttagaagtt
     1681 gtgtgatttt ttgccatcgt tgataaaaat gcaaagtcaa ataaaaggtg tcttggtttg
     1741 atgtcataga atgatccaag gagagaaaaa aggtagttac tgttttcacc agaaaaggta
     1801 atgagtgaag gaaagaatag tagcagaaag cacagtttgt gagtaaagct gtctggaatt
     1861 aagttaccaa aaatacaaag caaaaggact attattttgg gttgaagctc caaaactgac
     1921 agcatctgat aatctgttgg tttatttcac ttttcattaa atgaacattg atgagagaag
     1981 atgccactta cccaagcttt agagaatccc tagtggaaga ttatatgata aactttcagt
     2041 cctgacataa cactagggca tttctagagt gtcattgcta aaacctcact gaacagatgc
     2101 agccaaggtc tgtgttcagc acttggtctc tgttgttacg taaaataata agcatttaaa
     2161 atagtttaca gatatttttg accagttcct tttagagatt ctttcagaga agaaaccaga
     2221 tctgacctgt ttattgttgg cgcttgttga aaacgagctt tctttcccat gatagtgctt
     2281 cgtttttgaa gtgttgaagc tgtgctcccc ttaaatcgtg gcaggagaga ttaaggtaat
     2341 tacaacactc agttctatgt cttacaagca ctttgtcttg tctctgcaag aaaattcgat
     2401 tccagtcatt tcccataaaa tacagacatt ttaccaacat aatatgcttt gattgatgca
     2461 gcattatgct ttgggcagta ttacaaaata gctggcgagt gctttctgta tttaaatatt
     2521 gtaaaaagaa aataagttat aactgttata aagcagaact tttgttgcat tttttaaact
     2581 gttgaagtca ctgtgtatgt ttgtttggtc aatgtttccg cagtatttat taaaacatac
     2641 tttttttttc ttcaaataaa aaagtaacca tgtctttgtc taaa
//
