LOCUS       NM_005440               4162 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho family GTPase 2 (RND2), mRNA.
ACCESSION   NM_005440
VERSION     NM_005440.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4162)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4162)
  AUTHORS   Xu,Y., Sun,Q., Yuan,F., Dong,H., Zhang,H., Geng,R., Qi,Y.,
            Xiong,X., Chen,Q. and Liu,B.
  TITLE     RND2 attenuates apoptosis and autophagy in glioblastoma cells by
            targeting the p38 MAPK signalling pathway
  JOURNAL   J Exp Clin Cancer Res 39 (1), 174 (2020)
   PUBMED   32867814
  REMARK    GeneRIF: RND2 attenuates apoptosis and autophagy in glioblastoma
            cells by targeting the p38 MAPK signalling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4162)
  AUTHORS   Yang,X., Yang,B., Li,H. and Ren,H.
  TITLE     Upregulation of Rho7 in the temporal lobe tissue of humans with
            intractable epilepsy
  JOURNAL   Mol Med Rep 16 (6), 9613-9619 (2017)
   PUBMED   29039551
  REMARK    GeneRIF: Rho7 expression was increased in the neurons of patients
            with IE compared with control samples, which indicated that Rho7
            may be associated with the progression of IE or act as a potential
            target for IE treatment.
REFERENCE   4  (bases 1 to 4162)
  AUTHORS   Wylie,T., Garg,R., Ridley,A.J. and Conte,M.R.
  TITLE     Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd
            family proteins
  JOURNAL   PLoS One 12 (10), e0185899 (2017)
   PUBMED   29040270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4162)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4162)
  AUTHORS   Tanaka,H., Fujita,H., Katoh,H., Mori,K. and Negishi,M.
  TITLE     Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a
            novel Rho family GTPase, Rnd2
  JOURNAL   Biochem J 365 (Pt 2), 349-353 (2002)
   PUBMED   11931639
REFERENCE   7  (bases 1 to 4162)
  AUTHORS   Katoh,H., Harada,A., Mori,K. and Negishi,M.
  TITLE     Socius is a novel Rnd GTPase-interacting protein involved in
            disassembly of actin stress fibers
  JOURNAL   Mol Cell Biol 22 (9), 2952-2964 (2002)
   PUBMED   11940653
  REMARK    GeneRIF: Socius is a novel Rnd GTPase-interacting protein involved
            in disassembly of actin stress fibers
REFERENCE   8  (bases 1 to 4162)
  AUTHORS   Nobes,C.D., Lauritzen,I., Mattei,M.G., Paris,S., Hall,A. and
            Chardin,P.
  TITLE     A new member of the Rho family, Rnd1, promotes disassembly of actin
            filament structures and loss of cell adhesion
  JOURNAL   J Cell Biol 141 (1), 187-197 (1998)
   PUBMED   9531558
REFERENCE   9  (bases 1 to 4162)
  AUTHORS   Smith,T.M., Lee,M.K., Szabo,C.I., Jerome,N., McEuen,M., Taylor,M.,
            Hood,L. and King,M.C.
  TITLE     Complete genomic sequence and analysis of 117 kb of human DNA
            containing the gene BRCA1
  JOURNAL   Genome Res 6 (11), 1029-1049 (1996)
   PUBMED   8938427
REFERENCE   10 (bases 1 to 4162)
  AUTHORS   Chardin,P.
  TITLE     Small GTP-binding proteins of the ras family: a conserved
            functional mechanism?
  JOURNAL   Cancer Cells 3 (4), 117-126 (1991)
   PUBMED   1909153
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135721.4, DB502558.1,
            BC094842.1 and BU687800.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005440.4.
            
            Summary: This gene encodes a member of the Rho GTPase family, whose
            members play a key role in the regulation of actin cytoskeleton
            organization in response to extracellular growth factors. This
            particular family member has been implicated in the regulation of
            neuronal morphology and endosomal trafficking. The gene localizes
            to chromosome 17 and is the centromeric neighbor of the
            breast-ovarian cancer susceptibility gene BRCA1. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.193540.1,
                                           SRR3476690.141824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587250.4/ ENSP00000466680.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC135721.4         134180-134189       c
            11-17               DB502558.1         1-7
            18-1349             BC094842.1         1-1332
            1350-3743           AC135721.4         127798-130191       c
            3744-4162           BU687800.1         18-436              c
FEATURES             Location/Qualifiers
     source          1..4162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4162
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /note="Rho family GTPase 2"
                     /db_xref="GeneID:8153"
                     /db_xref="HGNC:HGNC:18315"
                     /db_xref="MIM:601555"
     exon            1..219
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..801
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /note="ras homolog gene family, member N; GTP-binding
                     protein Rho7; rho-related GTP-binding protein Rho7;
                     CTD-3199J23.4"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoN"
                     /protein_id="NP_005431.1"
                     /db_xref="CCDS:CCDS11452.1"
                     /db_xref="GeneID:8153"
                     /db_xref="HGNC:HGNC:18315"
                     /db_xref="MIM:601555"
                     /translation="MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENY
                     TASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQ
                     GETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVE
                     CSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGMQRSAQLSGRPDRGNEGEIHK
                     DRAKSCNLM"
     exon            220..307
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /inference="alignment:Splign:2.1.0"
     exon            308..417
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /inference="alignment:Splign:2.1.0"
     exon            418..552
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /inference="alignment:Splign:2.1.0"
     exon            553..4162
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /note="major polyA site"
     regulatory      4139..4144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
                     /note="hexamer: AATAAA"
     polyA_site      4162
                     /gene="RND2"
                     /gene_synonym="ARHN; RHO7; RhoN"
ORIGIN      
        1 gcgggcccgc gagatgccgg tgttggcggc ccgagcggct gcagttgcag gggcggggga
       61 ggcggcggcg gggcccggga gaggggtggc gtgggggacc ggcgcgtagc cgggaccatg
      121 gaggggcaga gcggccgctg caagatcgtg gtggtgggag acgcagagtg cggcaagacg
      181 gcgctgctgc aggtgttcgc caaggacgcc tatcccggga gttatgtccc caccgtgttt
      241 gagaactaca ctgcgagctt tgagatcgac aagcgccgca ttgagctcaa catgtgggac
      301 acttcaggtt cctcttacta tgataatgtc cggcctctgg cctatcctga ttctgatgct
      361 gtgctcatct gcttcgacat tagccgacca gaaacactgg acagtgttct caagaagtgg
      421 caaggagaga ctcaagagtt ctgccccaat gccaaggttg tgctggttgg ctgtaaactg
      481 gacatgcgga ctgacctggc cacactgagg gagctgtcca agcagaggct tatccctgtt
      541 acacatgagc agggcactgt gctggccaag caggtggggg ctgtgtccta tgttgagtgc
      601 tcctcccggt cctctgagcg cagcgtcagg gatgtcttcc atgtggctac agtggcctcc
      661 cttggccgtg gccataggca gctgcgccga actgactcac gccggggaat gcagcgatcc
      721 gctcagctgt caggacggcc agaccggggg aatgagggcg agatacacaa ggatcgagcc
      781 aaaagctgca acctcatgtg aggggctagg agagggcaga gtgtgaagag gggtggtgag
      841 ggacacaatt gttcccctgc ctgcgcccag gcttcctgac ctcctgatcc tggctgggaa
      901 gttagggcag gcagagcgag caattctggg caggggagct ggagggcaga agggtatcat
      961 cgtttctcat ctcctcctcc ctcctcttct ccagtggatg ttgagggagc taacagggct
     1021 ggcatctggg gcatgaactg ggatggggca ggtgggcgtt agggaagctg gtatcaaatg
     1081 gtgaccttgg tggagtctcc tatgtgaaga gtaccctccc tctccacccc cagtccccat
     1141 atcctggttc tggcccaagg aaaatgtcca ttctatgacc ttctcttttc ctctcctctc
     1201 acttctgcag ctattctcac acatctaacc tctaggcaac atgcactaaa ttcaaaagca
     1261 aggagaagcc cttgcccccc atcagtccac cagccctaga acctcccttg cctcaacagt
     1321 cacctaataa agcccacctc catggaaaac ggctgtggct ttagttttgt tgctttttaa
     1381 aaaaatcaat ctaccaatct ttagcagtaa gagggaaagt tagacctcag ctggggaact
     1441 ttcctgtcca tgtccacaga tagagcagag gacaaagcca taggttggat cagaagtgtc
     1501 cttttaggag tcagagttgg gagaaggaga catcctggga ctgttcatcc tagttaatga
     1561 agtgggcaat tctcaggcca ttagggggtt ttagagcaga ccgacatata attagtcagc
     1621 atttctcagc ccagccaggc ctgctgctag tgtgggaggg gtcctgctca ccatctgtac
     1681 ccctggcttg gagcctgctg gtaccctggg ggttgtgggg ataaggaggc atcaggccgg
     1741 gcgcgctggc tcacgcctgt aatcccagca ctttgggagg ccgaggtggg cggatcacaa
     1801 gttcaggaga tcgagaccat cctggctaac acggtgaaac cccatctcta ctaaaaatac
     1861 aaaaaattag ccaggcgcgg tggcagtgcc tgtagtccca gctgctcggg aggctgaggc
     1921 aggagaatgg tgtgaacccg ggtgaacctg ggaggcggag cttgcagtga gccgagattg
     1981 cgccactgca ttctagcctg gatgacagag caagactctg tctccaaaaa aaaaaaaaaa
     2041 aaaaaaaaag aaggcatcaa aagcctccac atcacagaag ctacccctgt acagcgtgaa
     2101 gtttcctaag aggtcagtag tttgattctg gggtctcctt agaggctcag gccagggacc
     2161 tttctctcct cccatgctga gtttcatgat ggctttcagg ggagcatcag ctgttagagt
     2221 cacccctacc ctgtccctta aaggaaagac ggtggagagg acggctgagc gcctgttgtc
     2281 aggaaagaca gtactggtct gttttctcgg gagtctggtt tcagattgtc ctgtattccc
     2341 ttcctggctc tggtcccact ggcctctttt cggtgacatt ctcccccagg aaccatccct
     2401 ggcccttccc tcccccagcc ctagccagtt ctcccagaca cactggaaga gaacactgac
     2461 cttacccaac tatctgctgg gatcccaccc aaatttatag cccattcctc cctcattcat
     2521 tcattcagca agtatgtact gaacaccaac tgtgtggcat acactggctt gggagattgc
     2581 aaggaccagt ctctaagctt ttggaggcca gcccagtgtg gaagagaggt acctcaggtg
     2641 tgagggtgcc atggctgagg gatatttgta catgtatggg atgctatggg agctccttgc
     2701 agcctgagaa gccagtcctg tgagccaggt cctgagggtt gaagaggagt tttccgggca
     2761 gggaaggggt aggaaaggca ctctgggcag agggtacagc atgtgtaaac acgtggagat
     2821 gagaatgagc atagcactgt tggggctccc atggcaggga gaatagaaga caaggctagg
     2881 aaggtacact gaggctactg cagggtccac agaggaatca gaatttcatt ctgaggatga
     2941 atgaaatcat cctcagagga tgaagccacc aggaatttca ggcagagagt gaagtgatca
     3001 gagttgtttt ttggatagat ggttatctgg atgtggtgtt ggagctggga gatttggctc
     3061 tgaggtgtgt catttaaaat aatagcttct cggcagtggc tcacacctat aatcccagcc
     3121 aagattcctc ctttgggagg ccaagctggg aggatcgctt gaggccagga gttagagact
     3181 gcagtgagct atgatcatgc cattgtcttc cagcctgagt gtcagagtga gaccctgtct
     3241 ctaaaaaaaa ttaaaaaata aaaaataaaa aatagcttct cctttccctt atgccaggtt
     3301 ccagtcttga gaggaaagga atccctaccc accactccct ggatcatcag atatccctat
     3361 cccaacctct cctatgggac tagttcatct cagccagtct caaagattct aggataactt
     3421 caatggcatt tgaaattatc taagtgtgct tggataacca ccccctcaaa ctgagacctg
     3481 gttagggact gactcaaaga ccctgagtcc tcggctaagg gtacaggaga gggcaggggc
     3541 tccaggccca gctaggtgga tctccatctg tctctgagga ctgacccttt ccccacaagg
     3601 acctgccata aaaatcgact tgcgattttt agctgagtgg cttctctttt ccactttgga
     3661 cttctcagtg tatagcaggt tcaagcctgc aaccaccaaa gtgcagagtg tggagtgttt
     3721 gtgccccctc tttcctccaa cctccatatc ctgccatgtg agctcaggga atgcaaatgc
     3781 atttaaatat ccatctaaag caaacataat tagaaaaatc aatcagctgg aggacccccc
     3841 aaagtttaat acattttcaa taccaccagg aatggatttt tggtcccttt ctgcaggtct
     3901 gggttgccag acgttttatt tctggggagg agggctctgg gctgaggagc tcagtgggtg
     3961 ggaggaggga atgggactgt tgctgatcct caaaggcctc tgtaggatgg agggagggga
     4021 ccttactccc ttccccaccc cagatgcagg agtcacccag cttccttctc tgcgctgttt
     4081 ccttcacaaa ttagacattg gtttgggaaa caatgtagcc tcgttaaaca tttaatgaaa
     4141 taaacaaata atcacactgt ga
//
