LOCUS       NM_014470               1653 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Rho family GTPase 1 (RND1), mRNA.
ACCESSION   NM_014470
VERSION     NM_014470.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Zhou,Y., Yan,J., Chen,H., Zhou,W., Xiao,G., Zou,H. and Yang,J.
  TITLE     MiR-4652-5p Targets RND1 to Regulate Cell Adhesion and Promote Lung
            Squamous Cell Carcinoma Progression
  JOURNAL   Appl Biochem Biotechnol 194 (7), 3031-3043 (2022)
   PUBMED   35334070
  REMARK    GeneRIF: MiR-4652-5p Targets RND1 to Regulate Cell Adhesion and
            Promote Lung Squamous Cell Carcinoma Progression.
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Kumar,A., Mishra,S., Kumar,A., Raut,A.A., Sato,S., Takaoka,A. and
            Kumar,H.
  TITLE     Essential role of Rnd1 in innate immunity during viral and
            bacterial infections
  JOURNAL   Cell Death Dis 13 (6), 520 (2022)
   PUBMED   35654795
  REMARK    GeneRIF: Essential role of Rnd1 in innate immunity during viral and
            bacterial infections.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Swaminathan,B., Youn,S.W., Naiche,L.A., Du,J., Villa,S.R.,
            Metz,J.B., Feng,H., Zhang,C., Kopan,R., Sims,P.A. and
            Kitajewski,J.K.
  TITLE     Endothelial Notch signaling directly regulates the small GTPase
            RND1 to facilitate Notch suppression of endothelial migration
  JOURNAL   Sci Rep 12 (1), 1655 (2022)
   PUBMED   35102202
  REMARK    GeneRIF: Endothelial Notch signaling directly regulates the small
            GTPase RND1 to facilitate Notch suppression of endothelial
            migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Mouly,L., Gilhodes,J., Lemarie,A., Cohen-Jonathan Moyal,E.,
            Toulas,C., Favre,G., Sordet,O. and Monferran,S.
  TITLE     The RND1 Small GTPase: Main Functions and Emerging Role in
            Oncogenesis
  JOURNAL   Int J Mol Sci 20 (15), 3612 (2019)
   PUBMED   31344837
  REMARK    GeneRIF: we highlight that RND1 expression is induced by anticancer
            agents and modulates their response. Of note, RND1 mRNA levels in
            tumors could be used as a predictive marker of both patient
            prognosis and response to anticancer agents.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Nancy,V., Callebaut,I., El Marjou,A. and de Gunzburg,J.
  TITLE     The delta subunit of retinal rod cGMP phosphodiesterase regulates
            the membrane association of Ras and Rap GTPases
  JOURNAL   J Biol Chem 277 (17), 15076-15084 (2002)
   PUBMED   11786539
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Rohm,B., Rahim,B., Kleiber,B., Hovatta,I. and Puschel,A.W.
  TITLE     The semaphorin 3A receptor may directly regulate the activity of
            small GTPases
  JOURNAL   FEBS Lett 486 (1), 68-72 (2000)
   PUBMED   11108845
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Aoki,J., Katoh,H., Mori,K. and Negishi,M.
  TITLE     Rnd1, a novel rho family GTPase, induces the formation of neuritic
            processes in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 278 (3), 604-608 (2000)
   PUBMED   11095956
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Vayssiere,B., Zalcman,G., Mahe,Y., Mirey,G., Ligensa,T.,
            Weidner,K.M., Chardin,P. and Camonis,J.
  TITLE     Interaction of the Grb7 adapter protein with Rnd1, a new member of
            the Rho family
  JOURNAL   FEBS Lett 467 (1), 91-96 (2000)
   PUBMED   10664463
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Nobes,C.D., Lauritzen,I., Mattei,M.G., Paris,S., Hall,A. and
            Chardin,P.
  TITLE     A new member of the Rho family, Rnd1, promotes disassembly of actin
            filament structures and loss of cell adhesion
  JOURNAL   J Cell Biol 141 (1), 187-197 (1998)
   PUBMED   9531558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC026356.1, AL359573.1 and
            N79562.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014470.3.
            
            Summary: This gene encodes a protein that belongs to the Rho GTPase
            family. Members of this family regulate the organization of the
            actin cytoskeleton in response to extracellular growth factors. A
            similar protein in rat interacts with a microtubule regulator to
            control axon extension. [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026356.1, SRR3476690.375607.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155984 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309739.6/ ENSP00000308461.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              BC026356.1         1-1307
            1308-1650           AL359573.1         541-883
            1651-1653           N79562.1           15-17               c
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1653
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /note="Rho family GTPase 1"
                     /db_xref="GeneID:27289"
                     /db_xref="HGNC:HGNC:18314"
                     /db_xref="MIM:609038"
     exon            1..223
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..802
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /note="ras homolog gene family, member S; rho-related
                     GTP-binding protein Rho6"
                     /codon_start=1
                     /product="rho-related GTP-binding protein Rho6 precursor"
                     /protein_id="NP_055285.1"
                     /db_xref="CCDS:CCDS8771.1"
                     /db_xref="GeneID:27289"
                     /db_xref="HGNC:HGNC:18314"
                     /db_xref="MIM:609038"
                     /translation="MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVP
                     TVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDS
                     ALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLG
                     AEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELIS
                     STFKKEKAKSCSIM"
     exon            224..311
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            312..421
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            422..556
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /inference="alignment:Splign:2.1.0"
     exon            557..1653
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /note="hexamer: AATATA"
     polyA_site      1653
                     /gene="RND1"
                     /gene_synonym="ARHS; RHO6; RHOS"
                     /note="major polyA site"
ORIGIN      
        1 agttggaggg aggcagggaa tctggcttga ttggcgtgct gagacgcacc tggcgcaacc
       61 ctcccttctg aatcgaagtt caagtcccgc ggacactgca accatgaagg agagacgggc
      121 cccccagcca gtcgtggcca gatgtaagct cgttctggtc ggggacgtgc agtgtgggaa
      181 gaccgcgatg ttgcaagtgt tagcgaagga ttgctatcca gagacctatg tgcccaccgt
      241 gttcgaaaat tacacagcct gtttggagac agaggaacag agggtggagc ttagtctctg
      301 ggatacctca ggatctccct actacgataa tgtccgtcca ctctgctaca gcgactcgga
      361 tgcagtatta ctatgttttg acatcagccg tccagagaca gtggacagcg cactcaagaa
      421 gtggaggaca gaaatcctag attattgtcc cagcacccgc gttttgctca ttggctgcaa
      481 gacagacctg cgaacagacc tgagtactct gatggagctg tcccaccaga agcaggcgcc
      541 catctcctat gagcagggtt gtgcaatagc aaagcagctg ggtgcagaaa tctacctgga
      601 aggctcagct ttcacctcag aaaagagcat ccacagcatc tttcggacgg catccatgct
      661 gtgtctgaac aagcctagcc cactgcccca gaagagccct gtccgaagcc tctccaaacg
      721 actgctccac ctccccagtc gctctgaact catctcttct accttcaaga aggaaaaggc
      781 caaaagctgt tccattatgt gaagtggaaa ttggaggggg gagacaaccc cctacttcct
      841 cccttggggt gcagaggcac ggggagaggg aggatgagac aatttaggac actggacatg
      901 agtttttcag atggccacgg tgagggcttg gaaggagaca ggaatggggc gaggaaggag
      961 ccaggcccgg catgaggacc tgacgctgag agagaaccat cataccccaa gccaggcact
     1021 agattttgga gggggcgact accccagtgc cccccccgct ccagaggaag gaaagctgtg
     1081 ggggacgggg ggcatgctgg cctcatgggc ttgggggcct acagcagcct caccttcagc
     1141 ttcatgcctc ttccacacag cgtttccatg caggtcaggg gatgggaggg gtccctgagc
     1201 ccttcccttc ccctctaagg aggcagcaac ggagagtggg gaagtggagc ggcagctccc
     1261 ttgggggctt agcccaggtg cttcgtaact gcaatcggaa gtgcaggagc tggtcagagc
     1321 caatgagaag gaaacctcat ctttgcatag cccatgcctc atggagaggt gacatcatac
     1381 attcacatgc ttctcaccta agtccccagg gtccaaggga gaagccccag acccccttct
     1441 cttgcagagt gtgggggtgg tggtgctgca ggggcagggc tgggtggggg tcaccagact
     1501 ttttctgccc ttagggtagt acagctggca tttgttttat agactcttgt ctttggaatt
     1561 ggggggaggg ggggagtgtt tcaatctgtt atatgttctg tgtttaatga agaaaaccta
     1621 tttattaatg aaaaatataa tacatataaa gaa
//
