LOCUS       NM_003730               8614 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ribonuclease T2 (RNASET2), mRNA.
ACCESSION   NM_003730
VERSION     NM_003730.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8614)
  AUTHORS   Peak,T., Tian,Y., Patel,A., Shaw,T., Obermayer,A., Laborde,J.,
            Kim,Y., Johnson,J., Stewart,P., Fang,B., Teer,J.K., Koomen,J.,
            Berglund,A., Marchion,D., Francis,N., Echevarria,P.R., Dhillon,J.,
            Clark,N., Chang,A., Sexton,W., Zemp,L., Chahoud,J., Wang,L. and
            Manley,B.
  TITLE     Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma
  JOURNAL   Lab Invest 104 (5), 102041 (2024)
   PUBMED   38431116
  REMARK    GeneRIF: Pathogenic Roles for RNASET2 in Clear Cell Renal Cell
            Carcinoma.
REFERENCE   2  (bases 1 to 8614)
  AUTHORS   Liu,Y., Zhang,Z., Xi,P., Chen,R., Cheng,X., Liu,J., Zhu,Q., Nie,Y.,
            Sun,T., Gong,B. and Wang,S.
  TITLE     Systematic analysis of RNASET2 gene as a potential prognostic and
            immunological biomarker in clear cell renal cell carcinoma
  JOURNAL   BMC Cancer 23 (1), 837 (2023)
   PUBMED   37679715
  REMARK    GeneRIF: Systematic analysis of RNASET2 gene as a potential
            prognostic and immunological biomarker in clear cell renal cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8614)
  AUTHORS   Quan,Y., Dai,J., Zhou,S., Zhao,L., Jin,L., Long,Y., Liu,S., Hu,Y.,
            Liu,Y., Zhao,J. and Ding,Z.
  TITLE     HIF2alpha-induced upregulation of RNASET2 promotes triglyceride
            synthesis and enhances cell migration in clear cell renal cell
            carcinoma
  JOURNAL   FEBS Open Bio 13 (4), 638-654 (2023)
   PUBMED   36728187
  REMARK    GeneRIF: HIF2alpha-induced upregulation of RNASET2 promotes
            triglyceride synthesis and enhances cell migration in clear cell
            renal cell carcinoma.
REFERENCE   4  (bases 1 to 8614)
  AUTHORS   Gallo,D., De Vito,A., Roncoroni,R., Bruno,A., Piantanida,E.,
            Bartalena,L., Tanda,M.L., Mortara,L. and Acquati,F.
  TITLE     A potential role of human RNASET2 overexpression in the
            pathogenesis of Graves' disease
  JOURNAL   Endocrine 79 (1), 55-59 (2023)
   PUBMED   36180758
  REMARK    GeneRIF: A potential role of human RNASET2 overexpression in the
            pathogenesis of Graves' disease.
REFERENCE   5  (bases 1 to 8614)
  AUTHORS   Biener-Ramanujan,E., Rosier,F., Coetzee,S.G., McGovern,D.D.P.,
            Hazelett,D., Targan,S.R. and Gonsky,R.
  TITLE     Diagnostic and therapeutic potential of RNASET2 in Crohn's disease:
            Disease-risk polymorphism modulates allelic-imbalance in expression
            and circulating protein levels and recombinant-RNASET2 attenuates
            pro-inflammatory cytokine secretion
  JOURNAL   Front Immunol 13, 999155 (2022)
   PUBMED   36466822
  REMARK    GeneRIF: Diagnostic and therapeutic potential of RNASET2 in Crohn's
            disease: Disease-risk polymorphism modulates allelic-imbalance in
            expression and circulating protein levels and recombinant-RNASET2
            attenuates pro-inflammatory cytokine secretion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8614)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 8614)
  AUTHORS   Liu,Y., Emilion,G., Mungall,A.J., Dunham,I., Beck,S., Le
            Meuth-Metzinger,V.G., Shelling,A.N., Charnock,F.M. and Ganesan,T.S.
  TITLE     Physical and transcript map of the region between D6S264 and D6S149
            on chromosome 6q27, the minimal region of allele loss in sporadic
            epithelial ovarian cancer
  JOURNAL   Oncogene 21 (3), 387-399 (2002)
   PUBMED   11821951
REFERENCE   8  (bases 1 to 8614)
  AUTHORS   Acquati,F., Morelli,C., Cinquetti,R., Bianchi,M.G., Porrini,D.,
            Varesco,L., Gismondi,V., Rocchetti,R., Talevi,S., Possati,L.,
            Magnanini,C., Tibiletti,M.G., Bernasconi,B., Daidone,M.G.,
            Shridhar,V., Smith,D.I., Negrini,M., Barbanti-Brodano,G. and
            Taramelli,R.
  TITLE     Cloning and characterization of a senescence inducing and class II
            tumor suppressor gene in ovarian carcinoma at chromosome region
            6q27
  JOURNAL   Oncogene 20 (8), 980-988 (2001)
   PUBMED   11314033
REFERENCE   9  (bases 1 to 8614)
  AUTHORS   Trubia,M., Sessa,L. and Taramelli,R.
  TITLE     Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning
            of a human member located in a region of chromosome 6 (6q27)
            frequently deleted in human malignancies
  JOURNAL   Genomics 42 (2), 342-344 (1997)
   PUBMED   9192857
REFERENCE   10 (bases 1 to 8614)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133458.19 and AL159163.40.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003730.5.
            
            Summary: This ribonuclease gene is a novel member of the
            Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a
            single copy gene that maps to 6q27, a region associated with human
            malignancies and chromosomal rearrangement. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315467.1, SRR1803613.144637.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508775.6/ ENSP00000426455.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AL133458.19        21090-21543         c
            455-515             AL133458.19        17481-17541         c
            516-571             AL133458.19        13563-13618         c
            572-629             AL133458.19        11675-11732         c
            630-700             AL133458.19        8012-8082           c
            701-814             AL133458.19        3888-4001           c
            815-860             AL159163.40        154022-154067       c
            861-935             AL159163.40        150975-151049       c
            936-8614            AL159163.40        142044-149722       c
FEATURES             Location/Qualifiers
     source          1..8614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..8614
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="ribonuclease T2"
                     /db_xref="GeneID:8635"
                     /db_xref="HGNC:HGNC:21686"
                     /db_xref="MIM:612944"
     exon            1..454
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1139
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /EC_number="4.6.1.19"
                     /note="ribonuclease 6"
                     /codon_start=1
                     /product="ribonuclease T2 precursor"
                     /protein_id="NP_003721.2"
                     /db_xref="CCDS:CCDS5295.1"
                     /db_xref="GeneID:8635"
                     /db_xref="HGNC:HGNC:21686"
                     /db_xref="MIM:612944"
                     /translation="MRPAALRGALLGCLCLALLCLGGADKRLRDNHEWKKLIMVQHWP
                     ETVCEKIQNDCRDPPDYWTIHGLWPDKSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIH
                     SFPNRSRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSI
                     NYYQVADFKDALARVYGVIPKIQCLPPSQDEEVQTIGQIELCLTKQDQQLQNCTEPGE
                     QPSPKQEVWLANGAAESRGLRVCEDGPVFYPPPKKTKH"
     exon            455..515
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            516..571
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            572..629
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            630..700
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            701..814
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            815..860
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            861..935
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     exon            936..8614
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1211
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="major polyA site"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="hexamer: ATTAAA"
     polyA_site      1409
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="hexamer: AATATA"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="hexamer: AATAGA"
     polyA_site      2190
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
     polyA_site      2208
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
     polyA_site      2893
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
     regulatory      8583..8588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
                     /note="hexamer: AATAAA"
     polyA_site      8614
                     /gene="RNASET2"
                     /gene_synonym="bA514O12.3; RNASE6PL"
ORIGIN      
        1 gagcaacgcg actgaccgtg gtcgtgggcg gacggcggct gcagcgtgga ggagctgggg
       61 tcgctgtggg tcgcgaagca gagcccggga cgtgcgcgct tggtgcacga tcctgaaggg
      121 gagctccgag gggcccgggt cgccagggct gctgcggcca ttcccggagc ccggcgcggg
      181 gcccgcgaga tactggttta ggccgtccca gggctccggg cgcacccggt ggccgctgct
      241 gcagcggagg gagcgcggcg gcgcgggggc tcggagacag cgtttctccc ggaagtcttc
      301 ctcgggcagc aggtgggaag tgggagccgg agcggcagct ggcagcgttc tctccgcagg
      361 tcggcaccat gcgccctgca gccctgcgcg gggccctgct gggctgcctc tgcctggcgt
      421 tgctttgcct gggcggtgcg gacaagcgcc tgcgtgacaa ccatgagtgg aaaaaactaa
      481 ttatggttca gcactggcct gagacagtat gcgagaaaat tcaaaacgac tgtagagacc
      541 ctccggatta ctggacaata catggactat ggcccgataa aagtgaagga tgtaatagat
      601 cgtggccctt caatttagaa gagattaagg atcttttgcc agaaatgagg gcatactggc
      661 ctgacgtaat tcactcgttt cccaatcgca gccgcttctg gaagcatgag tgggaaaagc
      721 atgggacctg cgccgcccag gtggatgcgc tcaactccca gaagaagtac tttggcagaa
      781 gcctggaact ctacagggag ctggacctca acagtgtgct tctaaaattg gggataaaac
      841 catccatcaa ttactaccaa gttgcagatt ttaaagatgc ccttgccaga gtatatggag
      901 tgatacccaa aatccagtgc cttccaccaa gccaggatga ggaagtacag acaattggtc
      961 agatagaact gtgcctcact aagcaagacc agcagctgca aaactgcacc gagccggggg
     1021 agcagccgtc ccccaagcag gaagtctggc tggcaaatgg ggccgccgag agccggggtc
     1081 tgagagtctg tgaagatggc ccagtcttct atcccccacc taaaaagacc aagcattgat
     1141 gcccaagttt tggaaatatt ctgttttaaa aagcaagaga aattcacaaa ctgcagcttt
     1201 ctaaaaaaca actccaaagt gaagtctgtt tattttgctg tttcccctcc atgcctgtga
     1261 attggatgtt gtggtccctg tagagtgagt gcatgtggcg tacacgggga gaaaggagct
     1321 ctcccacgcc tgagtggctg ttttgtgctt gggataaagc tcacagattg tttttttttt
     1381 tctctattaa actcttcagt gccctggtag atcaggcagg catacttgga atttagacag
     1441 atggcaccga ttcaggggac tctcttgctc gagttttccc ctcggagcct gttgccttct
     1501 tggcgcaggg accctgtcaa gacgaagagc tccacgcatg gcaggagccc acgctgatgc
     1561 ctggtgggcc tggggggtgt ctctagctca gactgggtct gttccatgtg accagagccc
     1621 caggacatcg ttccttagcc agctgctccg ttgttggagg cctggtgtgg tcacaggtgt
     1681 gtcctagaac ggtgactttg cccctcctgc cctaggagat ttgggtgtat tcacagagca
     1741 gccatctcct gtctccgtca gagcagtctc ttccaggtta ctggaaggtc agtttctgtc
     1801 aggcctcact tccttcttat cagagggtag ccaggtccct gcactggtat ctatttagaa
     1861 atgtacatgg agcccccagc gaaatgtgcc tacattgtgt gttccagaac cggaggtacc
     1921 cttaccttct agatatgtga tgacatggct ctcacgtcag gcagactgct gcacccacgc
     1981 tctcggcctg ccgtgcaggg atttcactcg tggagtgagg catctggggg ctgtgcagtg
     2041 aggagctttc catgtgttgt taagacaacc tgttagcatt gtcttctccc gcgtctcctg
     2101 gcctcttctc tctttaaatc cttttctctg tttgtcttaa tcacattaac gtcctattta
     2161 tgttttattc aatatacatt taaaatagaa cttactatgt gccaggcatt gtgttcaaca
     2221 cgtgaaatat ttaatcctta gaataaccat attgtcagca taatttacaa aaaaaaaaaa
     2281 aacagctgta tcaatgcctg tgaatattcg gctttactcg cccatttaaa gaagagattt
     2341 tcaaattggc tcaaaccaaa acctcacttc atggtgtcta caagacagtc tgaaatgcag
     2401 aatgttcaga gagagacaaa ggtttaccag gcagatggga cggtgagaaa gtaggtgtcg
     2461 cagtcctgat cctagactca gtggcctctg cgtcccccgc aggcattaaa ggagacacag
     2521 gacggcctct ggccctctgg aaacaagctc tgcagtaaga gcctgagaca ggcagcaccc
     2581 agccaggcct gacagcttct gcagacagac agagtgagat gatgggggat ttgatggaag
     2641 cagtccctgt attttgtctc ttctgtaatg gaggagctga gccctcttct gcaagctgtg
     2701 gggaaggcta gcggagccca agggtccagg gtccccacct tgtcattgtc cctcggccct
     2761 tctctgagct catttctgtc tccagtgttt ttctgttggc ttggcagggc aggatttgtt
     2821 tctgtcggga actgatgatt tgtgttttga tgcctgtgag agggacaaga tctgatttgt
     2881 tttgcacctg gaagggcgtg atttcctgca tttgctctgc gtcctcaggg agtgggtgta
     2941 ctttagagtt ggactcttaa gcctcagagt cctttaaatg atgtcaattc tttttttttt
     3001 tttttttttt tttgagtcat tttgcgaaca cagggatcaa ggcttgggtt ttatcttcat
     3061 tattcccaga ggagctggtg aatttgaaca gacttcctat tcaaattgca tttattttat
     3121 agccttgggg ggtcaaggaa agcagctctt cagaggctgt ctgcagtcgg ctggcctttg
     3181 cggtttttaa agaagccatt ctttttttta agtagcgtgt atttattata tgagtgtgag
     3241 catttgagag cggatgggga cgccaacaag gtagcatcct ggtgggaggc atgggctgcg
     3301 gagtgctggt ttcctgccat tgtcacgtca gctaaatgga agaaggcact ggtgaggggc
     3361 tggatggttc aaaacatgag cacaagcaaa tgcttggctc tcttaatatt cctattttgg
     3421 cctagagctc aggagcaggt agaacatgag cgtttgataa cctgcctcag atcatgtaag
     3481 tataaggcac ttatgagccg caggagacag aaggggaaga ctctgcgttt aaggttcagt
     3541 gatggagatc agatccaagc acatgttttt acatcattaa acaagtaggt cgtgcatttt
     3601 ccagattcaa ctcaggaaga tgcaactctg accacacggt tctcgctgta actgggcgga
     3661 ggtgactgag aaatgcctcc catgtgagcg gggtctcagg ctcgtatgtg tggaaggagg
     3721 agcaggccag gctctgggat cagagctggg ggtacaagtg tctcccaggg ggacaaagga
     3781 gcaggcgcat ctcaggatgg agagcagcca ggaggggcag ctggcccggg tctcagccag
     3841 agcaggcgtc tgcctggagc atctctgcgg caccatggaa aagaggaccc gtggactagg
     3901 ccacagggat gagtggaact tatggtggaa aaagacacca taggtaaaag cgagacaaga
     3961 aaaccaggtt cccatgaaac tccttcagac cagccccttc tcagcagggc tattgctgta
     4021 cccaagagca tttctcttgg cctgggaggg gacaatgctt tgtcacctgg aaagcaatcc
     4081 ctctctccaa gctagtagtg ggagatcatt atgcgcttga ataactaaca gtagcaattg
     4141 tatcatattc agaactagat atcttttctt ttcttttctt tttttttttt tttgagactg
     4201 agtctcactc tgtcgcccag gctggagtgc agtggtgcga tctcggctca ctgcaacctc
     4261 tgtctcctgg gttcaagcaa ttcttctgcc tcagcctccc gagtagctgg gactaggcac
     4321 gccaccatgc ccggctattt tttgtatttt tagtagagtt ggggtttcac tgtgttggcc
     4381 aggctggtct ggaactcctg acctcaggtg atctgcctgc ctcagcctcc cagagtgcta
     4441 ggattatagg tgtgagccac cgcgcctggc ccaggtatct tatctttcca ccgaaacttt
     4501 tgcctccatc tcggtgaatg acatcaccat ccgcttattc caggtagaaa cctcaaagtg
     4561 aactggaaac tttttaaaaa aattttgcct aaattgtgaa agtattctga attatattca
     4621 gcttatcctt ctcattactg acttagttca agcctcagtc tcccatctgg gccatgcatt
     4681 gactgccacg ccacctgact gtcagtgctg gacgctggca ccgtgtttgt gccactctcc
     4741 gtaaccaacc atggctctct gctcccagat cacacctccc cagtatggcg gctcagggac
     4801 attccctcaa tccctcctgc cctgttggca gtgcctccac ccactcccca cagcccatga
     4861 gggctctgct tagcacttcc ttgtgcctgg attctccgcg cagtttgggt ggcctggagt
     4921 gctcttctgc tcacctagtt tagcaagttc catgggatat caacacccag ttccatggtt
     4981 ggccgttaag agttcttttg cagtcctggg tggctctgcg cctccacgcc cagggaccag
     5041 ggcctcttct cttccagctc ttgttgtgtt acatagaaga tgccagctgg atggcacagg
     5101 ggagggccgt acagtgtaga tgcggacaat gtggcatagg tgaggactgg acagcagaga
     5161 cagtggctgc atgatggagg tgagggctgg acgggggagg caagggctgg accggggagg
     5221 tgagggctgg acaggggagg tgagggctgg gcagtataga tgaggcctgg gtggcagagg
     5281 tgagggctgt gcagtgtagg tgaggacggg ctggacaggg gaggtgaggg ctaggcagtg
     5341 tagatgaggc ctgggtggca ggaatgatgc ctggatggag gaagtgagag ctgggtggct
     5401 tgagtgaggg ctagatggca tgggtgaggg ctaagtggca tagatgaggc ctgggcagcg
     5461 gagacatgga ctgcgcatcg taggtgtcgg ctggacagca agggtgatgc ctggacagca
     5521 gaggtgaggg ctgggcggca ggagtgaggg ctgggcggca ggagtgaggg ctggatggcg
     5581 tagatgaggc ctgggcagca gaggtgaggg ctgtgctgtt ccggttttgg gctagacggc
     5641 agggagaatg cctagatgac tgggtagagg cctgggtggg agaagtgagg tctggacact
     5701 gtgggtgagg gctggatggc gtagatgagg cctgcgcggt ggaggtgagg cctgtacttc
     5761 tcctgccact aaatcaagag ctgtttattg attcattcca cacttttttc aacccttcct
     5821 atgagccgcc tctcttctag gcactgggac atggccataa gcagggatct tttcctcttg
     5881 ggcccactcc aagagtggtg gcatatgcca ccatgcccgg ctaattttgt atttttagta
     5941 gagatgggtt ttctccatgt tggtcacgct ggtctcaaac tcccgacctc gggtgatcca
     6001 cctgcctcag cctcccaaag tgcagggcaa cagacggcaa gggaaaagag gagcatagct
     6061 ggtgcatttg atgctggtag gttggaggga gggaggaggt cagagttatg aaggcggcca
     6121 gggaaggctt cctcggaacc tgaagaaagg gagacagcaa ctgcagggaa ggatctgtgg
     6181 gccctaatgg ccacgtcaca ctacaaaggc ccggactttg tccaactcgc ttctgtgctc
     6241 catgagtgca cctgtgtctg aggcacatca gctctaagcc agtgttctct agtgatggag
     6301 tgaataaatg aataaaatag aaaagagagg ccgggcgtgg tggctcatgc ctgtaatacc
     6361 agcactttgg gaggccaagg caggcggatc ccaaggtcag gagttcgaga ccagcctgga
     6421 cagtatggtg aaactccatc tctactaaaa atacaaaaat tggccgggca tggtggcggg
     6481 cacctgtagt cccagctact cgggaggctg aggcaggaga atgaatcact tgaagccagg
     6541 aggcagaggt tgcagtgagc cgaaatcaca ccattgcact ccagtctgga tgacagagca
     6601 agactccgtt tcaaaaaaag aaaaaaagag aatgcagcac tggtcccagt ggaaggtgcc
     6661 tgctgttggc ttctcaccac gcccagatga ggaaacatgc agatcgcctg ttttcacttt
     6721 ttgtttctgc gaactttgga tcaggaataa aaataattta atgcaggtcc taaggcagct
     6781 gagaattgta atgtaaaata ttttcagaat tcaactatat tggctagatc tatcactgca
     6841 gaaggctgga aaagactcag aagttaaaat actacttttc ctcacaagct ctagctcctg
     6901 aaatgaaatt accaggatac aatcacagat atgaagtcag tatttgggcg tctatagaaa
     6961 agaagtccat tgcattgctt atgggatgag ctacgtttcc catagaaggg gcagtagtga
     7021 gggttttctt atctgaagca aaatctctga cagatgatga gaaatgcagt tttatgtcat
     7081 tttttttctg ataagaattc tatttttttt ttctgagtga ctgtaatggg ccttccattt
     7141 attttagaca aaaaagacag aattagcatt ttaggctcag atgatagtta ttagaaagtt
     7201 tgagatgggc caggcgcagt ggcttatacc tgtaatccta gcaccttggg aggccgaggt
     7261 gggcggatca cttgaggtca agcgttcaag accaccctgg ccaacaggac gaaaccctat
     7321 ctctactaaa aatacattag ctgggtgtgg tggcgggtgt ctgcaatccc agctactcag
     7381 gaggctgagg tgagaggatg gcttgaaccc aggaggtgga ggctgcagtg agccgagact
     7441 gtactcaagc ttgggcaaca gagtaagact ctgtctcaaa aaaaaaaaaa aaaaaaaagg
     7501 ccgggcctgg tggctcacgc ctgtaatccc agccctctgg gaggctggag gttgcagtga
     7561 gtggagattg cgccactgcg ctccaccctc cagcctgggc aacagagtga gactccatct
     7621 ccaaaagaaa gtttgagatg gataaagtta agatccatta aatgctgtat ggactttatg
     7681 ctgacgtgct tttcacattt cagacctgtg cattcttatg catttacatt ccctttattt
     7741 gagggagcaa gaattacaca atcacctttt cctacccgct tttaacactg agaaaagtct
     7801 gcagagtgac agtggcccat ttttaccagc aaagacattg aacctggcgt gtacagcttt
     7861 ggtggttggt acctgtcacc atctgctctt ctgtcttgat gaccatatgt cttggactgc
     7921 accctgagat gtgggctgct cgtgctgccc cagtactgaa cacagctact tgagcatagt
     7981 aggtgttttg aaaatattta acctgaattg agaaaagata gtcagcagtg gcccaaagat
     8041 aacaacatac atcaaaagtc atgtacaaga ttcagccagt caccaagatg ctcccaatat
     8101 tcaggggctt ggtacctcac taatcaaaac tgaaatgtca cccgattggt ttttctctga
     8161 atgttttaga gcagaataga ctcagccatg ggaagagaca tttgagtgga ctctattcag
     8221 gttgattgga gtctcctcca ggttaatcat tccacttaag tcaatgagtg aaattttata
     8281 cacctgagac tctagcctat ggcaattcct ggaaatcaag tggttttttt gatggggagc
     8341 cgggggatgg tcagtgggat gcaacttgct gatgatgaga gatgaggtgt aagatattat
     8401 caggcaaaca ccaacgaaac aggctttact ataactcaga tcaccgcgct ttttgagtgt
     8461 gtcagtgagt aatccataat cacatttata gatacttctt tcacatttat aataatgtcc
     8521 ccaacataaa catgtaaaca tgatcaacat atatgcttag cagttaggat cctatagtta
     8581 tcaataaaaa gtggaagctg tctttaaaaa caga
//
