LOCUS       XM_047427096            2329 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ribonuclease L (RNASEL), transcript variant
            X1, mRNA.
ACCESSION   XM_047427096
VERSION     XM_047427096.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..2329
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="ribonuclease L; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 EST, 91 long SRA reads,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 6 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:6041"
                     /db_xref="HGNC:HGNC:10050"
                     /db_xref="MIM:180435"
     CDS             255..2228
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /codon_start=1
                     /product="2-5A-dependent ribonuclease isoform X1"
                     /protein_id="XP_047283052.1"
                     /db_xref="GeneID:6041"
                     /db_xref="HGNC:HGNC:10050"
                     /db_xref="MIM:180435"
                     /translation="MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQL
                     LEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA
                     GSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKED
                     QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV
                     EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTA
                     LLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAE
                     DWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVK
                     TFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG
                     EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI
                     KWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRL
                     FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSE
                     HSKSFDKWTTKMSKLRHRQIIFPTTQNQLMNVL"
ORIGIN      
        1 gacgcagcag gaggaaactg ctcgggctgc aagcagtctt ccaggctttg cggctgccaa
       61 aggaataatt gagacgtctg agttgagcag gtggaatgtc agaagactga gaacattgtt
      121 ccttcttcat actgctgctc tgttgccaga gaatcccaat ttacactcaa agcttctttg
      181 attaagtgct aggagataaa tttgcatttt ctcaaggaaa aggctaaaag tggtagcagg
      241 tggcatttac cgtcatggag agcagggatc ataacaaccc ccaggaggga cccacgtcct
      301 ccagcggtag aagggctgca gtggaagaca atcacttgct gattaaagct gttcaaaacg
      361 aagatgttga cctggtccag caattgctgg aaggtggagc caatgttaat ttccaggaag
      421 aggaaggggg ctggacacct ctgcataacg cagtacaaat gagcagggag gacattgtgg
      481 aacttctgct tcgtcatggt gctgaccctg ttctgaggaa gaagaatggg gccacgcctt
      541 ttatcctcgc agcgattgcg gggagcgtga agctgctgaa acttttcctt tctaaaggag
      601 cagatgtcaa tgagtgtgat ttttatggct tcacagcctt catggaagcc gctgtgtatg
      661 gtaaggtcaa agccctaaaa ttcctttata agagaggagc aaatgtgaat ttgaggcgaa
      721 agacaaagga ggatcaagag cggctgagga aaggaggggc cacagctctc atggacgctg
      781 ctgaaaaagg acacgtagag gtcttgaaga ttctccttga tgagatgggg gcagatgtaa
      841 acgcctgtga caatatgggc agaaatgcct tgatccatgc tctcctgagc tctgacgata
      901 gtgatgtgga ggctattacg catctgctgc tggaccatgg ggctgatgtc aatgtgaggg
      961 gagaaagagg gaagactccc ctgatcctgg cagtggagaa gaagcacttg ggtttggtgc
     1021 agaggcttct ggagcaagag cacatagaga ttaatgacac agacagtgat ggcaaaacag
     1081 cactgctgct tgctgttgaa ctcaaactga agaaaatcgc cgagttgctg tgcaaacgtg
     1141 gagccagtac agattgtggg gatcttgtta tgacagcgag gcggaattat gaccattccc
     1201 ttgtgaaggt tcttctctct catggagcca aagaagattt tcaccctcct gctgaagact
     1261 ggaagcctca gagctcacac tggggggcag ccctgaagga tctccacaga atataccgcc
     1321 ctatgattgg caaactcaag ttctttattg atgaaaaata caaaattgct gatacttcag
     1381 aaggaggcat ctacctgggg ttctatgaga agcaagaagt agctgtgaag acgttctgtg
     1441 agggcagccc acgtgcacag cgggaagtct cttgtctgca aagcagccga gagaacagtc
     1501 acttggtgac attctatggg agtgagagcc acaggggcca cttgtttgtg tgtgtcaccc
     1561 tctgtgagca gactctggaa gcgtgtttgg atgtgcacag aggggaagat gtggaaaatg
     1621 aggaagatga atttgcccga aatgtcctgt catctatatt taaggctgtt caagaactac
     1681 acttgtcctg tggatacacc caccaggatc tgcaaccaca aaacatctta atagattcta
     1741 agaaagctgc tcacctggca gattttgata agagcatcaa gtgggctgga gatccacagg
     1801 aagtcaagag agatctagag gaccttggac ggctggtcct ctatgtggta aagaagggaa
     1861 gcatctcatt tgaggatctg aaagctcaaa gtaatgaaga ggtggttcaa ctttctccag
     1921 atgaggaaac taaggacctc attcatcgtc tcttccatcc tggggaacat gtgagggact
     1981 gtctgagtga cctgctgggt catcccttct tttggacttg ggagagccgc tataggacgc
     2041 ttcggaatgt gggaaatgaa tccgacatca aaacacgaaa atctgaaagt gagatcctca
     2101 gactactgca acctgggcct tctgaacatt ccaaaagttt tgacaagtgg acgactaaga
     2161 tgagcaagct gaggcacaga caaataattt ttccaactac acagaaccaa ttaatgaatg
     2221 tgttatgaaa aaaatgaata agttttatga aaaaagaggc aatttctacc agaacactgt
     2281 gggtgatctg ctaaagttca tccggaattt gggagaacac attgatgaa
//
