LOCUS       NM_021133               4238 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ribonuclease L (RNASEL), mRNA.
ACCESSION   NM_021133
VERSION     NM_021133.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Kadanga,E., Zoure,A.A., Zohoncon,T.M., Traore,L., Ky,B.D.,
            Yonli,A.T., Traore,D.D.A., Bazie,B.V.J.T.E., Sombie,H.K.,
            Sorgho,P.A., Tovo,S.F.A., Traore,K., Ouedraogo,T.C., Djigma,F.W.
            and Simpore,J.
  TITLE     Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of
            the RNASEL gene and risk factors in patients with prostate cancer
            in Burkina Faso
  JOURNAL   BMC Med Genomics 15 (1), 123 (2022)
   PUBMED   35655265
  REMARK    GeneRIF: Carriage of mutations R462Q (rs 486907) and D541E (rs
            627928) of the RNASEL gene and risk factors in patients with
            prostate cancer in Burkina Faso.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Boehmer,D.F.R., Formisano,S., de Oliveira Mann,C.C., Mueller,S.A.,
            Kluge,M., Metzger,P., Rohlfs,M., Horth,C., Kocheise,L.,
            Lichtenthaler,S.F., Hopfner,K.P., Endres,S., Rothenfusser,S.,
            Friedel,C.C., Duewell,P., Schnurr,M. and Koenig,L.M.
  TITLE     OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis
  JOURNAL   Sci Immunol 6 (61) (2021)
   PUBMED   34272227
  REMARK    GeneRIF: OAS1/RNase L executes RIG-I ligand-dependent tumor cell
            apoptosis.
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Whelan,J.N., Parenti,N.A., Hatterschide,J., Renner,D.M., Li,Y.,
            Reyes,H.M., Dong,B., Perez,E.R., Silverman,R.H. and Weiss,S.R.
  TITLE     Zika virus employs the host antiviral RNase L protein to support
            replication factory assembly
  JOURNAL   Proc Natl Acad Sci U S A 118 (22) (2021)
   PUBMED   34031250
  REMARK    GeneRIF: Zika virus employs the host antiviral RNase L protein to
            support replication factory assembly.
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Li,Y., Renner,D.M., Comar,C.E., Whelan,J.N., Reyes,H.M.,
            Cardenas-Diaz,F.L., Truitt,R., Tan,L.H., Dong,B.,
            Alysandratos,K.D., Huang,J., Palmer,J.N., Adappa,N.D.,
            Kohanski,M.A., Kotton,D.N., Silverman,R.H., Yang,W., Morrisey,E.E.,
            Cohen,N.A. and Weiss,S.R.
  TITLE     SARS-CoV-2 induces double-stranded RNA-mediated innate immune
            responses in respiratory epithelial-derived cells and
            cardiomyocytes
  JOURNAL   Proc Natl Acad Sci U S A 118 (16) (2021)
   PUBMED   33811184
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2310153120.
            doi: 10.1073/pnas.2310153120.. PMID: 37428938]
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Ramnani,B., Manivannan,P., Jaggernauth,S. and Malathi,K.
  TITLE     ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections
  JOURNAL   Viruses 13 (2), 315 (2021)
   PUBMED   33670646
  REMARK    GeneRIF: ABCE1 Regulates RNase L-Induced Autophagy during Viral
            Infections.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Bisbal,C., Martinand,C., Silhol,M., Lebleu,B. and Salehzada,T.
  TITLE     Cloning and characterization of a RNAse L inhibitor. A new
            component of the interferon-regulated 2-5A pathway
  JOURNAL   J Biol Chem 270 (22), 13308-13317 (1995)
   PUBMED   7539425
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Dong,B., Xu,L., Zhou,A., Hassel,B.A., Lee,X., Torrence,P.F. and
            Silverman,R.H.
  TITLE     Intrinsic molecular activities of the interferon-induced
            2-5A-dependent RNase
  JOURNAL   J Biol Chem 269 (19), 14153-14158 (1994)
   PUBMED   7514601
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Squire,J., Zhou,A., Hassel,B.A., Nie,H. and Silverman,R.H.
  TITLE     Localization of the interferon-induced, 2-5A-dependent RNase gene
            (RNS4) to human chromosome 1q25
  JOURNAL   Genomics 19 (1), 174-175 (1994)
   PUBMED   7514564
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Zhou,A., Hassel,B.A. and Silverman,R.H.
  TITLE     Expression cloning of 2-5A-dependent RNAase: a uniquely regulated
            mediator of interferon action
  JOURNAL   Cell 72 (5), 753-765 (1993)
   PUBMED   7680958
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Carter,B.S., Beaty,T.H., Steinberg,G.D., Childs,B. and Walsh,P.C.
  TITLE     Mendelian inheritance of familial prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3367-3371 (1992)
   PUBMED   1565627
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138776.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021133.3.
            
            Summary: This gene encodes a component of the interferon-regulated
            2-5A system that functions in the antiviral and antiproliferative
            roles of interferons. The protein is involved in innate immunity
            and is active against multiple RNA viruses, including the influenza
            and SARS-CoV-2 viruses. Mutations in this gene have been associated
            with predisposition to prostate cancer and this gene is a candidate
            for the hereditary prostate cancer 1 (HPC1) allele. [provided by
            RefSeq, Nov 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.2432.1,
                                           SRR11853565.2404.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000367559.7/ ENSP00000356530.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL138776.10        95752-95841         c
            91-1734             AL138776.10        91912-93555         c
            1735-1820           AL138776.10        90666-90751         c
            1821-2026           AL138776.10        88638-88843         c
            2027-2159           AL138776.10        87810-87942         c
            2160-2293           AL138776.10        82841-82974         c
            2294-4238           AL138776.10        80219-82163         c
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4238
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="ribonuclease L"
                     /db_xref="GeneID:6041"
                     /db_xref="HGNC:HGNC:10050"
                     /db_xref="MIM:180435"
     exon            1..90
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     exon            91..1734
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..2480
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /EC_number="3.1.26.-"
                     /EC_number="3.1.27.-"
                     /note="interferon-induced 2-5A-dependent RNase;
                     2',5'-oligoisoadenylate synthetase-dependent; ribonuclease
                     4; RNase L"
                     /codon_start=1
                     /product="2-5A-dependent ribonuclease"
                     /protein_id="NP_066956.1"
                     /db_xref="CCDS:CCDS1347.1"
                     /db_xref="GeneID:6041"
                     /db_xref="HGNC:HGNC:10050"
                     /db_xref="MIM:180435"
                     /translation="MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQL
                     LEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIA
                     GSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKED
                     QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV
                     EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTA
                     LLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAE
                     DWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVK
                     TFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRG
                     EDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI
                     KWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRL
                     FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSE
                     HSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMK
                     LKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPG
                     C"
     exon            1735..1820
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2026
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2159
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2293
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..4238
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3677..3682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="hexamer: AATAAA"
     polyA_site      3700
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="major polyA site"
     regulatory      4217..4222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="hexamer: AATAAA"
     polyA_site      4238
                     /gene="RNASEL"
                     /gene_synonym="PRCA1; RNS4"
                     /note="major polyA site"
ORIGIN      
        1 gacgcagcag gaggaaactg ctcgggctgc aagcagtctt ccaggctttg cggctgccaa
       61 aggaataatt gagacgtctg agttgagcag gtggaatgtc agaagactga gaacattgtt
      121 ccttcttcat actgctgctc tgttgccaga gaatcccaat ttacactcaa agcttctttg
      181 attaagtgct aggagataaa tttgcatttt ctcaaggaaa aggctaaaag tggtagcagg
      241 tggcatttac cgtcatggag agcagggatc ataacaaccc ccaggaggga cccacgtcct
      301 ccagcggtag aagggctgca gtggaagaca atcacttgct gattaaagct gttcaaaacg
      361 aagatgttga cctggtccag caattgctgg aaggtggagc caatgttaat ttccaggaag
      421 aggaaggggg ctggacacct ctgcataacg cagtacaaat gagcagggag gacattgtgg
      481 aacttctgct tcgtcatggt gctgaccctg ttctgaggaa gaagaatggg gccacgcctt
      541 ttatcctcgc agcgattgcg gggagcgtga agctgctgaa acttttcctt tctaaaggag
      601 cagatgtcaa tgagtgtgat ttttatggct tcacagcctt catggaagcc gctgtgtatg
      661 gtaaggtcaa agccctaaaa ttcctttata agagaggagc aaatgtgaat ttgaggcgaa
      721 agacaaagga ggatcaagag cggctgagga aaggaggggc cacagctctc atggacgctg
      781 ctgaaaaagg acacgtagag gtcttgaaga ttctccttga tgagatgggg gcagatgtaa
      841 acgcctgtga caatatgggc agaaatgcct tgatccatgc tctcctgagc tctgacgata
      901 gtgatgtgga ggctattacg catctgctgc tggaccatgg ggctgatgtc aatgtgaggg
      961 gagaaagagg gaagactccc ctgatcctgg cagtggagaa gaagcacttg ggtttggtgc
     1021 agaggcttct ggagcaagag cacatagaga ttaatgacac agacagtgat ggcaaaacag
     1081 cactgctgct tgctgttgaa ctcaaactga agaaaatcgc cgagttgctg tgcaaacgtg
     1141 gagccagtac agattgtggg gatcttgtta tgacagcgag gcggaattat gaccattccc
     1201 ttgtgaaggt tcttctctct catggagcca aagaagattt tcaccctcct gctgaagact
     1261 ggaagcctca gagctcacac tggggggcag ccctgaagga tctccacaga atataccgcc
     1321 ctatgattgg caaactcaag ttctttattg atgaaaaata caaaattgct gatacttcag
     1381 aaggaggcat ctacctgggg ttctatgaga agcaagaagt agctgtgaag acgttctgtg
     1441 agggcagccc acgtgcacag cgggaagtct cttgtctgca aagcagccga gagaacagtc
     1501 acttggtgac attctatggg agtgagagcc acaggggcca cttgtttgtg tgtgtcaccc
     1561 tctgtgagca gactctggaa gcgtgtttgg atgtgcacag aggggaagat gtggaaaatg
     1621 aggaagatga atttgcccga aatgtcctgt catctatatt taaggctgtt caagaactac
     1681 acttgtcctg tggatacacc caccaggatc tgcaaccaca aaacatctta atagattcta
     1741 agaaagctgc tcacctggca gattttgata agagcatcaa gtgggctgga gatccacagg
     1801 aagtcaagag agatctagag gaccttggac ggctggtcct ctatgtggta aagaagggaa
     1861 gcatctcatt tgaggatctg aaagctcaaa gtaatgaaga ggtggttcaa ctttctccag
     1921 atgaggaaac taaggacctc attcatcgtc tcttccatcc tggggaacat gtgagggact
     1981 gtctgagtga cctgctgggt catcccttct tttggacttg ggagagccgc tataggacgc
     2041 ttcggaatgt gggaaatgaa tccgacatca aaacacgaaa atctgaaagt gagatcctca
     2101 gactactgca acctgggcct tctgaacatt ccaaaagttt tgacaagtgg acgactaaga
     2161 ttaatgaatg tgttatgaaa aaaatgaata agttttatga aaaaagaggc aatttctacc
     2221 agaacactgt gggtgatctg ctaaagttca tccggaattt gggagaacac attgatgaag
     2281 aaaagcataa aaagatgaaa ttaaaaattg gagacccttc cctgtatttt cagaagacat
     2341 ttccagatct ggtgatctat gtctacacaa aactacagaa cacagaatat agaaagcatt
     2401 tcccccaaac ccacagtcca aacaagcctc agtgtgatgg agctggtggg gccagtgggt
     2461 tggccagccc tgggtgctga tggactgatt tgctggagtt cagggaacta cttattagct
     2521 gtagagtcct tggcaaatca caacattctg ggccttttaa ctcaccaggt tgcttgtgag
     2581 ggatgagttg catagctgat atgtcagtcc ctggcatcgt gtattccata tgtctataac
     2641 aaaagcaata tatacccaga ctacactagt ccataagctt tacccactaa ctgggaggac
     2701 attctgctaa gattcctttt gtcaattgca ccaaaagaat gagtgccttg acccctaatg
     2761 ctgcatatgt tacaattctc tcacttaatt ttcccaatga tcttgcaaaa cagggattat
     2821 catccccatt taagaactga ggaacctgag actcagagag tgtgagctac tggcccaaga
     2881 ttattcaatt tatacctagc actttataaa tttatgtggt gttattggta cctctcattt
     2941 gggcacctta aaacttaact atccttccag ggctcttcca gatgaggccc aaaacatata
     3001 taggggttcc aggaatctca ttcattcatt cagtatttat tgagcatcta gtataagtct
     3061 gggcactgga tgcatgaatt ccactccttc cagaaccaac tgcattggtt ttccatgacc
     3121 ttaaggcagt agttctcaac tggggggcaa ttttgcactg aagagagcat ttggcagagt
     3181 ctgaagaagt ttttggtgtc acagctttgt ggggagcatg ctatggcatt tagtgggtaa
     3241 agaccaggga tgctgccaaa cctgccttgc acaggacagc ccctgcaaca aagaattatc
     3301 cagacaaaaa tatcaatggt gctgaggttg agaaaacctg acttaagggg ctgggatgct
     3361 tttgaactag cttaaggccc aggactgtgg agtgtgtgga ccaccccaca gaggagggac
     3421 tcagatttat ttactcttgc tggatctgta gtgatggagt tccttctggt gtcagcccca
     3481 caggaggctc ccaggcctcc ctcacttccc atacccagtc taggagctcc ttctggctcc
     3541 caagcaccca gagctttcct ccgcctttta gttttggttc ctccactgga atgtaggctc
     3601 ctcacgggcg atggctgtct tttcttgact ttgtatcttc actgccaagc aaaaagtctg
     3661 ccaagtggga atgtttaata aatattcatt gaataatgaa tgaaccatct tcgtacatga
     3721 ataataatac tgtcttacgt ttttctggtg ctttataatg tatacattac atctgagtat
     3781 tttattttat ttaattttca aaacaatcct ttaaggtcaa cattgttatc cctattttgc
     3841 tgatgaggaa actaaggtta gaaacatttt gatttcctct aggacgtata gctaggaagt
     3901 gttactatct tgatttgaac aaattttctg gtgctaagtc tgatgttctt tccatgaatc
     3961 attgtggtgg ttgagatgga gctttgtaat gggaataaaa cagtacctta ggttctttct
     4021 gaaaaggagg tatctagcaa tggataaata gataccactg aatgaaatta aatgttgatt
     4081 aggaacaaat ttaaggctta aaaaatactt tatgagcagc aagattgctt taacttttaa
     4141 aatgaagctt tggttctctg atttgtaatg agcacctgga catgtcaatt aaaatgccca
     4201 tttgtgaagc ttactcaata aaactttaaa ttgtctta
//
