LOCUS       NM_001004333             603 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ribonuclease K (RNASEK), transcript variant 1, mRNA.
ACCESSION   NM_001004333 XM_496180
VERSION     NM_001004333.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Wang,L., Wu,D., Robinson,C.V., Wu,H. and Fu,T.M.
  TITLE     Structures of a Complete Human V-ATPase Reveal Mechanisms of Its
            Assembly
  JOURNAL   Mol Cell 80 (3), 501-511 (2020)
   PUBMED   33065002
REFERENCE   2  (bases 1 to 603)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 603)
  AUTHORS   Vasanthakumar,T. and Rubinstein,J.L.
  TITLE     Structure and Roles of V-type ATPases
  JOURNAL   Trends Biochem Sci 45 (4), 295-307 (2020)
   PUBMED   32001091
  REMARK    Review article
REFERENCE   4  (bases 1 to 603)
  AUTHORS   Adamopoulos,P.G., Kontos,C.K., Scorilas,A. and Sideris,D.C.
  TITLE     Identification of novel alternative transcripts of the human
            Ribonuclease kappa (RNASEK) gene using 3' RACE and high-throughput
            sequencing approaches
  JOURNAL   Genomics 112 (1), 943-951 (2020)
   PUBMED   31200028
  REMARK    GeneRIF: Identification of novel alternative transcripts of the
            human Ribonuclease kappa (RNASEK) gene using 3' RACE and
            high-throughput sequencing approaches.
REFERENCE   5  (bases 1 to 603)
  AUTHORS   Kladi-Skandali,A., Mavridis,K., Scorilas,A. and Sideris,D.C.
  TITLE     Expressional profiling and clinical relevance of RNase kappa in
            prostate cancer: a novel indicator of favorable progression-free
            survival
  JOURNAL   J Cancer Res Clin Oncol 144 (10), 2049-2057 (2018)
   PUBMED   30054827
  REMARK    GeneRIF: Low Rnase K expression is associated with prostate cancer.
REFERENCE   6  (bases 1 to 603)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   7  (bases 1 to 603)
  AUTHORS   Karousis,E.D. and Sideris,D.C.
  TITLE     A subtle alternative splicing event gives rise to a widely
            expressed human RNase k isoform
  JOURNAL   PLoS One 9 (5), e96557 (2014)
   PUBMED   24797913
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 603)
  AUTHORS   Kiritsi,M.N., Fragoulis,E.G. and Sideris,D.C.
  TITLE     Essential cysteine residues for human RNase kappa catalytic
            activity
  JOURNAL   FEBS J 279 (7), 1318-1326 (2012)
   PUBMED   22324914
  REMARK    GeneRIF: Data suggest that the Cys6-Cys69 disulfide bond is likely
            to exist in all RNase kappa family members, including human.
REFERENCE   9  (bases 1 to 603)
  AUTHORS   Economopoulou,M.A., Fragoulis,E.G. and Sideris,D.C.
  TITLE     Molecular cloning and characterization of the human RNase kappa, an
            ortholog of Cc RNase
  JOURNAL   Nucleic Acids Res 35 (19), 6389-6398 (2007)
   PUBMED   17881363
  REMARK    GeneRIF: Based on sequence alignment and substrate specificity
            data, as well as the resistance of the protein to the placental
            ribonuclease inhibitor, the human RNase kappa may be a novel
            endoribonuclease distinct from other known ribonucleases.
REFERENCE   10 (bases 1 to 603)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040977.10.
            
            On May 21, 2020 this sequence version replaced NM_001004333.4.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB125076.1, CD176959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593646.6/ ENSP00000468923.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC040977.10        137468-137605
            139-215             AC040977.10        138510-138586
            216-603             AC040977.10        138989-139376
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..603
                     /gene="RNASEK"
                     /note="ribonuclease K"
                     /db_xref="GeneID:440400"
                     /db_xref="HGNC:HGNC:33911"
                     /db_xref="MIM:617098"
     exon            1..138
                     /gene="RNASEK"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..357
                     /gene="RNASEK"
                     /EC_number="3.1.-.-"
                     /note="RNase kappa; ribonuclease, RNase K; V-ATPase
                     subunit f; V-type proton ATPase subunit f"
                     /codon_start=1
                     /product="ribonuclease kappa"
                     /protein_id="NP_001004333.3"
                     /db_xref="CCDS:CCDS45594.3"
                     /db_xref="GeneID:440400"
                     /db_xref="HGNC:HGNC:33911"
                     /db_xref="MIM:617098"
                     /translation="MASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDV
                     PFTEKDFENGPQNIYNLYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR"
     exon            139..215
                     /gene="RNASEK"
                     /inference="alignment:Splign:2.1.0"
     exon            216..603
                     /gene="RNASEK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASEK"
                     /note="hexamer: AATAAA"
     polyA_site      603
                     /gene="RNASEK"
                     /note="major polyA site"
ORIGIN      
        1 gctttctccc accgctttcc gagcccgctt gcacctcggc gatccccgac tcccttcttt
       61 atggcgtcgc tcctgtgctg tgggccgaag ctggccgcct gcggcatcgt cctcagcgcc
      121 tggggagtga tcatgttgat aatgctcgga atatttttca atgtccattc cgctgtgttg
      181 attgaggacg ttcccttcac ggagaaagat tttgagaatg gcccccagaa catatacaac
      241 ctttacgagc aagtcagcta caactgtttc atcgctgcag gcctttacct cctcctcgga
      301 ggcttctctt tctgccaagt tcggctcaat aagcgcaagg aatacatggt gcgctagggc
      361 cccggcgcgt ttccccgctc cagcccctcc tctatttaaa gactccctgc accgtgtcac
      421 ccaggtcgcg tcccaccctt gccggcgccc tctgcgggac tgggtttccc gggcgagaga
      481 ctgaatccct tctcccatct ctggcatccg gcccccgtgg agagggctga ggctgggggg
      541 ctgttccgtt tctccaccct tcgctgtgtc ccgtatctca ataaagagaa tctgctctct
      601 tca
//
