LOCUS       NM_001110356            1217 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ribonuclease A family member 9 (inactive) (RNASE9),
            transcript variant 5, mRNA.
ACCESSION   NM_001110356
VERSION     NM_001110356.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Haralambieva,I.H., Lambert,N.D.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide SNP associations with rubella-specific cytokine
            responses in measles-mumps-rubella vaccine recipients
  JOURNAL   Immunogenetics 66 (7-8), 493-499 (2014)
   PUBMED   24811271
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Liu,J., Li,J., Wang,H., Zhang,C., Li,N., Lin,Y., Liu,J. and Wang,W.
  TITLE     Cloning, expression and location of RNase9 in human epididymis
  JOURNAL   BMC Res Notes 1, 111 (2008)
   PUBMED   18992174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Devor,E.J., Moffat-Wilson,K.A. and Galbraith,J.J.
  TITLE     LOC 390443 (RNase 9) on chromosome 14q11.2 is related to the RNase
            A superfamily and contains a unique amino-terminal preproteinlike
            sequence
  JOURNAL   Hum Biol 76 (6), 921-935 (2004)
   PUBMED   15974301
  REMARK    GeneRIF: may be involved in host defense
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Penttinen,J., Pujianto,D.A., Sipila,P., Huhtaniemi,I. and
            Poutanen,M.
  TITLE     Discovery in silico and characterization in vitro of novel genes
            exclusively expressed in the mouse epididymis
  JOURNAL   Mol Endocrinol 17 (11), 2138-2151 (2003)
   PUBMED   12920233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL163195.5.
            
            On Jan 31, 2023 this sequence version replaced NM_001110356.1.
            
            Transcript Variant: This variant (5), also known as alpha2, lacks
            two alternate exons in the 5' region and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (2) has a shorter N-terminus than isoform 1. Variants 5, 6,
            7, and 8 encode the same isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF061297.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000554964.6/
                                                ENSP00000450599.2
            RefSeq Select criteria           :: based on manual assertion,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL163195.5         73887-74060
            175-226             AL163195.5         75301-75352
            227-1217            AL163195.5         77851-78841
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1217
                     /gene="RNASE9"
                     /gene_synonym="h461; HEL128; RAK1"
                     /note="ribonuclease A family member 9 (inactive)"
                     /db_xref="GeneID:390443"
                     /db_xref="HGNC:HGNC:20673"
                     /db_xref="MIM:614014"
     exon            1..174
                     /gene="RNASE9"
                     /gene_synonym="h461; HEL128; RAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..226
                     /gene="RNASE9"
                     /gene_synonym="h461; HEL128; RAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1217
                     /gene="RNASE9"
                     /gene_synonym="h461; HEL128; RAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..858
                     /gene="RNASE9"
                     /gene_synonym="h461; HEL128; RAK1"
                     /note="isoform 2 is encoded by transcript variant 5;
                     ribonuclear enzyme; inactive ribonuclease-like protein 9;
                     ribonuclease A K1; ribonuclease, RNase A family, 9
                     (non-active)"
                     /codon_start=1
                     /product="inactive ribonuclease-like protein 9 isoform 2"
                     /protein_id="NP_001103826.2"
                     /db_xref="CCDS:CCDS32036.1"
                     /db_xref="GeneID:390443"
                     /db_xref="HGNC:HGNC:20673"
                     /db_xref="MIM:614014"
                     /translation="MRTLITTHPLPLLLLPQQLLQLVQFQEVDTDFDFPEEDKKEEFE
                     ECLEKFFSTGPARPPTKEKVKRRVLIEPGMPLNHIEYCNHEIMGKNVYYKHRWVAEHY
                     FLLMQYDELQKICYNRFVPCKNGIRKCNRSKGLVEGVYCNLTEAFEIPACKYESLYRK
                     GYVLITCSWQNEMQKRIPHTINDLVEPPEHRSFLSEDGVFVISP"
ORIGIN      
        1 gactctgtca ttacatggag aggcccctac atgagaataa agttagtgta caaaggagag
       61 tagagtggga gagagtaaaa acaagagtct agtcaagaat ttgatttctt tctcctgctc
      121 tacctcttgg acttccaact tctgtgagtc aacatagtgc ctcttgcatt taagaaattt
      181 caattagtga gaactgagga aaaaccaaga agcctgcatt ccacagtgtc tgcaggaaaa
      241 atgatgagaa ctctcatcac cacacaccca ctgcccctgc ttctattgcc gcagcagctg
      301 ctgcagctgg tgcagtttca agaggtggat acagattttg atttcccaga agaagataaa
      361 aaagaagaat ttgaagagtg tttggaaaaa ttttttagta cagggcccgc cagaccacct
      421 accaaagaaa aagtcaaaag acgtgtcctt attgaacctg gaatgccact aaatcatata
      481 gagtactgta accatgaaat catgggaaaa aatgtttact acaaacaccg ttgggtggca
      541 gaacattact tccttcttat gcaatatgac gagctccaaa aaatctgtta caacagattt
      601 gtgccatgta agaatggaat taggaaatgt aacaggagca aaggtcttgt agaaggagtg
      661 tattgtaatt taacagaagc atttgaaata ccagcgtgta aatacgaatc actttatagg
      721 aagggctacg tccttatcac ttgttcatgg caaaatgaaa tgcaaaaacg tattcctcat
      781 actataaatg atctcgtgga gccacctgaa cacagaagtt tcctcagtga ggatggtgtc
      841 tttgtcatat cgccctagca gagcgttctc tgagagctta gggtgggagg aatatttctc
      901 tccatactga tccttataga tcaaagttga gaatggtaat tttgcttcca ttcactttaa
      961 tcacccacct tcctttcttc ctttcccaac acctcacaaa agcaccttag gctaggttca
     1021 cagacggtgc tctgagatgt ggtctcatgc aggtccccta agttagcatg ccttgaatgt
     1081 gttacggata cagatgcctg cagtggaagg atgaccagca ccaagaggaa aaggaaatgg
     1141 ttgcctgaag tgtgctccaa agacacatcc atgtgattct ctagttcagc agaaagaata
     1201 aaaattgctt caatcta
//
