LOCUS       NM_138331                634 bp    mRNA    linear   PRI 06-SEP-2020
DEFINITION  Homo sapiens ribonuclease A family member 8 (RNASE8), mRNA.
ACCESSION   NM_138331
VERSION     NM_138331.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 634)
  AUTHORS   Chan CC, Moser JM, Dyer KD, Percopo CM and Rosenberg HF.
  TITLE     Genetic diversity of human RNase 8
  JOURNAL   BMC Genomics 13, 40 (2012)
   PUBMED   22272736
  REMARK    GeneRIF: Only two single-nucleotide polymorphisms and four unique
            alleles were identified within the RNase 8 coding sequence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 634)
  AUTHORS   Zhang J.
  TITLE     Disulfide-bond reshuffling in the evolution of an ape placental
            ribonuclease
  JOURNAL   Mol. Biol. Evol. 24 (2), 505-512 (2007)
   PUBMED   17116644
  REMARK    GeneRIF: Study shows that both the loss and gain of the cysteines
            in human RNase 8 occurred in the common ancestor of African great
            apes (humans, chimps, and gorillas) 7-13 MYA.
REFERENCE   3  (bases 1 to 634)
  AUTHORS   Rudolph B, Podschun R, Sahly H, Schubert S, Schroder JM and Harder
            J.
  TITLE     Identification of RNase 8 as a novel human antimicrobial protein
  JOURNAL   Antimicrob. Agents Chemother. 50 (9), 3194-3196 (2006)
   PUBMED   16940129
  REMARK    GeneRIF: RNase 8 was identified as a human antimicrobial protein
            with a broad spectrum activity against pathogenic organisms.
REFERENCE   4  (bases 1 to 634)
  AUTHORS   Zhang J, Dyer KD and Rosenberg HF.
  TITLE     RNase 8, a novel RNase A superfamily ribonuclease expressed
            uniquely in placenta
  JOURNAL   Nucleic Acids Res. 30 (5), 1169-1175 (2002)
   PUBMED   11861908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161668.6.
            
            On Oct 30, 2014 this sequence version replaced NM_138331.1.
            
            Summary: The protein encoded by this gene belongs to the pancreatic
            ribonuclease family, a subset of the ribonuclease A superfamily.
            The protein is expressed prominently in the placenta and exhibits
            antimicrobial activity against pathogenic bacteria and fungi.
            [provided by RefSeq, Oct 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC137537.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000308227.2/
                                                  ENSP00000311398.2
            Protein has antimicrobial activity :: PMID: 16940129
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               AL161668.6         111158-111791
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..634
                     /gene="RNASE8"
                     /gene_synonym="RAE2"
                     /note="ribonuclease A family member 8"
                     /db_xref="GeneID:122665"
                     /db_xref="HGNC:HGNC:19277"
                     /db_xref="MIM:612485"
     exon            1..634
                     /gene="RNASE8"
                     /gene_synonym="RAE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..536
                     /gene="RNASE8"
                     /gene_synonym="RAE2"
                     /note="RNase 8, placental; ribonuclease, RNase A family,
                     8; ribonuclease 8"
                     /codon_start=1
                     /product="ribonuclease 8 precursor"
                     /protein_id="NP_612204.1"
                     /db_xref="CCDS:CCDS9567.1"
                     /db_xref="GeneID:122665"
                     /db_xref="HGNC:HGNC:19277"
                     /db_xref="MIM:612485"
                     /translation="MAPARAGCCPLLLLLLGLWVAEVLVRAKPKDMTSSQWFKTQHVQ
                     PSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGP
                     MSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV"
ORIGIN      
        1 caagactccc ccatgatgac ctattcatcc acctacctcc tcactctgtt ccactgtctc
       61 ccttaagaga gatggcaccg gccagagcag gatgctgccc cctgctgctg ctgcttctgg
      121 ggctgtgggt ggcagaggtc ctagtcagag ccaagcccaa ggacatgaca tcatctcagt
      181 ggtttaaaac tcagcatgtg cagcccagcc ctcaagcatg caactcagcc atgagcatca
      241 tcaataagta cacagaacgg tgcaaagacc tcaacacctt cctgcacgag cccttctcca
      301 gtgtggccat cacctgccag acccccaaca tagcctgcaa gaatagctgt aaaaactgcc
      361 accagagcca cgggcccatg tccctgacca tgggtgagct cacctcaggg aagtacccaa
      421 actgcaggta caaagagaag cacctgaaca caccttacat agtggcctgt gaccctccac
      481 aacagggtga cccagggtac ccacttgttc ctgtgcactt ggataaagtt gtctaagccc
      541 tggtgcccac gttccacctc acactctgca gactgtatgc tgctgctttt cctccctcca
      601 gttcgttatt aatccttgct ccccactgca aatg
//
