LOCUS       NM_032572               1362 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.
ACCESSION   NM_032572
VERSION     NM_032572.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Ho,C.H., Liao,P.W., Fan,C.K., Liu,S.P. and Cheng,P.C.
  TITLE     RNase 7 Inhibits Uropathogenic Escherichia coli-Induced
            Inflammation in Bladder Cells under a High-Glucose Environment by
            Regulating the JAK/STAT Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (9), 5156 (2022)
   PUBMED   35563546
  REMARK    GeneRIF: RNase 7 Inhibits Uropathogenic Escherichia coli-Induced
            Inflammation in Bladder Cells under a High-Glucose Environment by
            Regulating the JAK/STAT Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Pierce,K.R., Eichler,T., Mosquera Vasquez,C., Schwaderer,A.L.,
            Simoni,A., Creacy,S., Hains,D.S. and Spencer,J.D.
  TITLE     Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial
            activity and associates with pediatric urinary tract infections
  JOURNAL   J Clin Invest 131 (22) (2021)
   PUBMED   34779412
  REMARK    GeneRIF: Ribonuclease 7 polymorphism rs1263872 reduces
            antimicrobial activity and associates with pediatric urinary tract
            infections.
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Neopane,P., Kurashige,Y., Yoshida,K., Uehara,O., Paudel,D.,
            Morikawa,T., Sato,J., Saitoh,M. and Abiko,Y.
  TITLE     Involvement of RNase 7 in the malignant potential of oral squamous
            cell carcinoma cells
  JOURNAL   Oncol Rep 44 (3), 1216-1223 (2020)
   PUBMED   32705284
  REMARK    GeneRIF: Involvement of RNase 7 in the malignant potential of oral
            squamous cell carcinoma cells.
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Kopfnagel,V., Dreyer,S., Baumert,K., Stark,M., Harder,J.,
            Hofmann,K., Kleine,M., Buch,A., Sodeik,B. and Werfel,T.
  TITLE     RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and
            Activates an Antiviral Immune Response
  JOURNAL   J Invest Dermatol 140 (8), 1589-1598 (2020)
   PUBMED   31978413
  REMARK    GeneRIF: RNase 7 Promotes Sensing of Self-DNA by Human
            Keratinocytes and Activates an Antiviral Immune Response.
REFERENCE   6  (bases 1 to 1362)
  AUTHORS   Abtin,A., Eckhart,L., Mildner,M., Ghannadan,M., Harder,J.,
            Schroder,J.M. and Tschachler,E.
  TITLE     Degradation by stratum corneum proteases prevents endogenous RNase
            inhibitor from blocking antimicrobial activities of RNase 5 and
            RNase 7
  JOURNAL   J Invest Dermatol 129 (9), 2193-2201 (2009)
   PUBMED   19262607
  REMARK    GeneRIF: proteases contribute indirectly to the defense function of
            the stratum corneum by releasing the RNase inhibitor mediated
            inhibition of RNase 5 and RNase 7.
REFERENCE   7  (bases 1 to 1362)
  AUTHORS   Rudolph,B., Podschun,R., Sahly,H., Schubert,S., Schroder,J.M. and
            Harder,J.
  TITLE     Identification of RNase 8 as a novel human antimicrobial protein
  JOURNAL   Antimicrob Agents Chemother 50 (9), 3194-3196 (2006)
   PUBMED   16940129
REFERENCE   8  (bases 1 to 1362)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   9  (bases 1 to 1362)
  AUTHORS   Zhang,J., Dyer,K.D. and Rosenberg,H.F.
  TITLE     Human RNase 7: a new cationic ribonuclease of the RNase A
            superfamily
  JOURNAL   Nucleic Acids Res 31 (2), 602-607 (2003)
   PUBMED   12527768
REFERENCE   10 (bases 1 to 1362)
  AUTHORS   Harder,J. and Schroder,J.M.
  TITLE     RNase 7, a novel innate immune defense antimicrobial protein of
            healthy human skin
  JOURNAL   J Biol Chem 277 (48), 46779-46784 (2002)
   PUBMED   12244054
  REMARK    GeneRIF: RNase 7 is an antimicrobial protein that plays an
            important role in the innate immune defense system of human
            epithelia.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161668.6.
            
            On Nov 23, 2018 this sequence version replaced NM_032572.3.
            
            Summary: The protein encoded by this gene belongs to the pancreatic
            ribonuclease family, a subset of the ribonuclease A superfamily.
            The protein has broad-spectrum antimicrobial activity against
            bacteria and fungi. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ306610.1, AY170392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000298690.5/
                                                  ENSP00000298690.3
            Protein has antimicrobial activity :: PMID: 12244054
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL161668.6         95698-95778
            82-1362             AL161668.6         96289-97569
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1362
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /note="ribonuclease A family member 7"
                     /db_xref="GeneID:84659"
                     /db_xref="HGNC:HGNC:19278"
                     /db_xref="MIM:612484"
     exon            1..81
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..1362
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..592
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /note="ribonuclease 7; SAP-2; RNase 7; ribonuclease, RNase
                     A family, 7; skin-derived antimicrobial protein 2"
                     /codon_start=1
                     /product="ribonuclease 7 precursor"
                     /protein_id="NP_115961.3"
                     /db_xref="CCDS:CCDS41914.1"
                     /db_xref="GeneID:84659"
                     /db_xref="HGNC:HGNC:19278"
                     /db_xref="MIM:612484"
                     /translation="MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHM
                     QPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHG
                     AVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /note="hexamer: AATAAA"
     polyA_site      1044
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="RNASE7"
                     /gene_synonym="RAE1"
                     /note="major polyA site"
ORIGIN      
        1 agagatctga cagcctagga gtgcgtggac accacctcag cccactgagc aggagtcaca
       61 gcacgaagac caagcgcaaa gcgacccctg ccctccatcc tgactgctcc tcctaagaga
      121 gatggcaccg gccagagcag gattctgccc ccttctgctg cttctgctgc tggggctgtg
      181 ggtggcagag atcccagtca gtgccaagcc caagggcatg acctcatcac agtggtttaa
      241 aattcagcac atgcagccca gccctcaagc atgcaactca gccatgaaaa acattaacaa
      301 gcacacaaaa cggtgcaaag acctcaacac cttcctgcac gagcctttct ccagtgtggc
      361 cgccacctgc cagaccccca aaatagcctg caagaatggc gataaaaact gccaccagag
      421 ccacggggcc gtgtccctga ccatgtgtaa gctcacctca gggaagcatc cgaactgcag
      481 gtacaaagag aagcgacaga acaagtctta cgtagtggcc tgtaagcctc cccagaaaaa
      541 ggactctcag caattccacc tggttcctgt acacttggac agagtccttt aggtttccag
      601 actggcttgc tctttggctg accttcaatt ccctctccag gactccgcac cactccccta
      661 cacccagagc attctcttcc cctcatctct tggggctgtt cctggttcag cctctgctgg
      721 gaggctgaag ctgacactct ggtgagctga gctctagagg gatggctttt catctttttg
      781 ttgctgtttt cccagatgct tatccccaag aaacagcaag ctcaggtctg tgggttccct
      841 ggtctatgcc attgcacatg tctcccctgc cccctggcat tagggcagca tgacaaggag
      901 aggaaataaa tggaaagggg gcatatggga tttgtggaca cagctgtttc tgttcctgaa
      961 ctagaagtct tccccagctc tgacgtggca gtgaggtgac ctgaaggaaa gaaaaatata
     1021 aataaatacc acttcatatt tgtatagaat cctctaatcc cttgtgacat agacttgaca
     1081 gggattgtat gccttcttta tggatgagga aattaaggtt ttagaaagct taatgaatta
     1141 aagagcttgt ctaattagtt agtagcagaa cctggacttg aacctaggtc tccttgctct
     1201 aaatacagtg taccttctac tctaccagtt gcgcaagaaa gaagtcactg ttacagaggc
     1261 aagcggtgaa ctaggtaaga gttcactcat gaagaaacga gtgctctgaa gagccagtta
     1321 ccctgtgttg gctgcaataa aggtcattac ctctctagcc aa
//
