LOCUS       NM_005615                844 bp    mRNA    linear   PRI 10-JUL-2024
DEFINITION  Homo sapiens ribonuclease A family member 6 (RNASE6), mRNA.
ACCESSION   NM_005615
VERSION     NM_005615.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 844)
  AUTHORS   Ruiz-Rosado,J.D., Cortado,H., Kercsmar,M., Li,B., Ballash,G.,
            Cotzomi-Ortega,I., Sanchez-Zamora,Y.I., Gupta,S., Ching,C.,
            Boix,E., Jackson,A.R., Spencer,J.D. and Becknell,B.
  TITLE     Human Ribonuclease 6 Has a Protective Role during Experimental
            Urinary Tract Infection
  JOURNAL   J Innate Immun 15 (1), 865-875 (2023)
   PUBMED   37980892
  REMARK    GeneRIF: Human Ribonuclease 6 Has a Protective Role during
            Experimental Urinary Tract Infection.
REFERENCE   2  (bases 1 to 844)
  AUTHORS   Seto,M., Weiner,R.L., Dumitrescu,L., Mahoney,E.R., Hansen,S.L.,
            Janve,V., Khan,O.A., Liu,D., Wang,Y., Menon,V., De Jager,P.L.,
            Schneider,J.A., Bennett,D.A., Gifford,K.A., Jefferson,A.L. and
            Hohman,T.J.
  TITLE     RNASE6 is a novel modifier of APOE-epsilon4 effects on cognition
  JOURNAL   Neurobiol Aging 118, 66-76 (2022)
   PUBMED   35896049
  REMARK    GeneRIF: RNASE6 is a novel modifier of APOE-epsilon4 effects on
            cognition.
REFERENCE   3  (bases 1 to 844)
  AUTHORS   Prats-Ejarque,G., Blanco,J.A., Salazar,V.A., Nogues,V.M.,
            Moussaoui,M. and Boix,E.
  TITLE     Characterization of an RNase with two catalytic centers. Human
            RNase6 catalytic and phosphate-binding site arrangement favors the
            endonuclease cleavage of polymeric substrates
  JOURNAL   Biochim Biophys Acta Gen Subj 1863 (1), 105-117 (2019)
   PUBMED   30287244
  REMARK    GeneRIF: An RNase6 dual catalytic and extended binding site
            arrangement facilitates the cleavage of polymeric substrates
REFERENCE   4  (bases 1 to 844)
  AUTHORS   Pulido,D., Arranz-Trullen,J., Prats-Ejarque,G., Velazquez,D.,
            Torrent,M., Moussaoui,M. and Boix,E.
  TITLE     Insights into the Antimicrobial Mechanism of Action of Human
            RNase6: Structural Determinants for Bacterial Cell Agglutination
            and Membrane Permeation
  JOURNAL   Int J Mol Sci 17 (4), 552 (2016)
   PUBMED   27089320
  REMARK    GeneRIF: These results indicate that RNase6, as previously reported
            for RNase3, is able to specifically agglutinate Gram-negative
            bacteria as a main trait of its antimicrobial activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 844)
  AUTHORS   Becknell,B., Eichler,T.E., Beceiro,S., Li,B., Easterling,R.S.,
            Carpenter,A.R., James,C.L., McHugh,K.M., Hains,D.S.,
            Partida-Sanchez,S. and Spencer,J.D.
  TITLE     Ribonucleases 6 and 7 have antimicrobial function in the human and
            murine urinary tract
  JOURNAL   Kidney Int 87 (1), 151-161 (2015)
   PUBMED   25075772
  REMARK    GeneRIF: Ribonucleases 6 is an antimicrobial peptide with activity
            against uropathogens and participates in the maintenance of urinary
            tract sterility.
REFERENCE   6  (bases 1 to 844)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   7  (bases 1 to 844)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   8  (bases 1 to 844)
  AUTHORS   Domachowske,J.B., Bonville,C.A., Dyer,K.D. and Rosenberg,H.F.
  TITLE     Evolution of antiviral activity in the ribonuclease A gene
            superfamily: evidence for a specific interaction between
            eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory
            syncytial virus
  JOURNAL   Nucleic Acids Res 26 (23), 5327-5332 (1998)
   PUBMED   9826755
REFERENCE   9  (bases 1 to 844)
  AUTHORS   Deming,M.S., Dyer,K.D., Bankier,A.T., Piper,M.B., Dear,P.H. and
            Rosenberg,H.F.
  TITLE     Ribonuclease k6: chromosomal mapping and divergent rates of
            evolution within the RNase A gene superfamily
  JOURNAL   Genome Res 8 (6), 599-607 (1998)
   PUBMED   9647635
REFERENCE   10 (bases 1 to 844)
  AUTHORS   Rosenberg,H.F. and Dyer,K.D.
  TITLE     Molecular cloning and characterization of a novel human
            ribonuclease (RNase k6): increasing diversity in the enlarging
            ribonuclease gene family
  JOURNAL   Nucleic Acids Res 24 (18), 3507-3513 (1996)
   PUBMED   8836175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020848.1 and AI151384.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005615.4.
            
            Summary: The protein encoded by this gene is a member of the
            ribonuclease A superfamily and functions in the urinary tract. The
            protein has broad-spectrum antimicrobial activity against
            pathogenic bacteria. [provided by RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005479.1, SRR1163657.551577.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000304677.3/
                                                  ENSP00000302046.2
            Protein has antimicrobial activity :: PMID: 25075772
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               BC020848.1         218-800
            584-844             AI151384.1         5-265               c
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..844
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /note="ribonuclease A family member 6"
                     /db_xref="GeneID:6039"
                     /db_xref="HGNC:HGNC:10048"
                     /db_xref="MIM:601981"
     exon            1..71
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /inference="alignment:Splign:2.1.0"
     exon            72..844
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..529
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /note="ribonuclease K6; ribonuclease A D1; ribonuclease,
                     RNase A family, k6; testicular tissue protein Li 166;
                     ribonuclease A family member k6"
                     /codon_start=1
                     /product="ribonuclease K6 precursor"
                     /protein_id="NP_005606.1"
                     /db_xref="CCDS:CCDS9558.1"
                     /db_xref="GeneID:6039"
                     /db_xref="HGNC:HGNC:10048"
                     /db_xref="MIM:601981"
                     /translation="MVLCFPLLLLLLVLWGPVCPLHAWPKRLTKAHWFEIQHIQPSPL
                     QCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMT
                     DCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL"
     regulatory      817..822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /note="hexamer: AATAAA"
     polyA_site      844
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /note="major polyA site"
ORIGIN      
        1 agacaacagc ttctgagctt tggactaatc acagcctctg ttctcagcag gagccccaac
       61 actgagacca gaaaagatgg tgctatgctt tcctcttctt ttactgctgc tggttctatg
      121 gggaccagtg tgtccacttc atgcttggcc taagcgtctc accaaggctc actggtttga
      181 aattcagcat atacagccaa gtcctctcca atgcaacagg gcaatgagtg gcatcaacaa
      241 ttatacccag cactgtaagc atcaaaatac ctttctgcat gactctttcc agaatgtggc
      301 tgctgtctgt gatttgctca gcattgtctg caaaaatcgt cggcacaact gccaccagag
      361 ctcaaagcct gtcaacatga ctgactgcag actcacttca ggaaagtatc cccagtgccg
      421 ctatagtgct gctgcccagt acaaattctt cattgttgcc tgtgaccccc ctcagaagag
      481 cgatcccccc tacaagttgg ttcctgtaca cttagatagt attctctaag gcatccactg
      541 catttccttt catttgacat agcttctgtt acaattgcat ccatgttttc ttttcttttg
      601 ttgattttct tgttcccgta gaagaaagaa gaaaggtgtt tggagaattc gagtgcctag
      661 gatgccagac cagagttgag acaaaaagaa ataagattat tttctgcttt gtagttctgt
      721 acttttcgag agaagggaat agggaagaca gcaaagaaag attcagattt ctaaccctgc
      781 aacttttgcc aagctttatt gccctgtgtt cacagcaata aaaccacttc ctgctgcatt
      841 ctaa
//
