LOCUS       NM_002935                734 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ribonuclease A family member 3 (RNASE3), mRNA.
ACCESSION   NM_002935
VERSION     NM_002935.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 734)
  AUTHORS   Obeagu,E.I.
  TITLE     Exploring the role of eosinophil cationic protein (ECP) in
            schizophrenia: Insights and implications
  JOURNAL   Medicine (Baltimore) 103 (22), e38380 (2024)
   PUBMED   39259079
  REMARK    GeneRIF: Exploring the role of eosinophil cationic protein (ECP) in
            schizophrenia: Insights and implications.
            Review article
REFERENCE   2  (bases 1 to 734)
  AUTHORS   Zou,Z., Deng,Y., Zhang,Q., Long,Z., Zhu,W., Gao,P., Xu,Y., Zhou,Y.,
            Tao,Z. and Chen,J.
  TITLE     [The auxiliary diagnostic value of ECP and MPO expression in nasal
            secretions in different types of rhinitis]
  JOURNAL   Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 38 (4), 292-297
            (2024)
   PUBMED   38563171
  REMARK    GeneRIF: [The auxiliary diagnostic value of ECP and MPO expression
            in nasal secretions in different types of rhinitis].
REFERENCE   3  (bases 1 to 734)
  AUTHORS   Nyangiri,O.A., Mulindwa,J., Namulondo,J., Kitibwa,A., Nassuuna,J.,
            Elliott,A., Kimuda,M.P., Boobo,A., Nerima,B., Adriko,M.,
            Dunton,N.J., Madhan,G.K., Kristiansen,M., Casacuberta-Partal,M.,
            Noyes,H. and Matovu,E.
  CONSRTM   TrypanoGEN+ Research group of the H3Africa consortium
  TITLE     Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are
            associated with Schistosoma mansoni worm burden in the Albert Nile
            region of Uganda
  JOURNAL   PLoS Negl Trop Dis 17 (11), e0011796 (2023)
   PUBMED   38033168
  REMARK    GeneRIF: Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci
            are associated with Schistosoma mansoni worm burden in the Albert
            Nile region of Uganda.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 734)
  AUTHORS   DE Amici,M., Piloni,D., Tirelli,C., Mariani,F., Accordino,G.,
            Sacchi,L., Testa,G., Licari,A. and Corsico,A.G.
  TITLE     Eosinophilic cationic protein (ECP) in the clinical work-up of
            chronic cough
  JOURNAL   Minerva Med 114 (2), 148-151 (2023)
   PUBMED   34515456
  REMARK    GeneRIF: Eosinophilic cationic protein (ECP) in the clinical
            work-up of chronic cough.
REFERENCE   5  (bases 1 to 734)
  AUTHORS   Granger,V., Zerimech,F., Arab,J., Siroux,V., de Nadai,P.,
            Tsicopoulos,A., Matran,R., Akiki,Z. and Nadif,R.
  TITLE     Blood eosinophil cationic protein and eosinophil-derived neurotoxin
            are associated with different asthma expression and evolution in
            adults
  JOURNAL   Thorax 77 (6), 552-562 (2022)
   PUBMED   34615736
  REMARK    GeneRIF: Blood eosinophil cationic protein and eosinophil-derived
            neurotoxin are associated with different asthma expression and
            evolution in adults.
REFERENCE   6  (bases 1 to 734)
  AUTHORS   Pulido,D., Torrent,M., Andreu,D., Nogues,M.V. and Boix,E.
  TITLE     Two human host defense ribonucleases against mycobacteria, the
            eosinophil cationic protein (RNase 3) and RNase 7
  JOURNAL   Antimicrob Agents Chemother 57 (8), 3797-3805 (2013)
   PUBMED   23716047
  REMARK    GeneRIF: The antimicrobial protein, Rnase 3, contributes to the
            host immune response against mycobacteria.
REFERENCE   7  (bases 1 to 734)
  AUTHORS   Abu-Ghazaleh,R.I., Dunnette,S.L., Loegering,D.A., Checkel,J.L.,
            Kita,H., Thomas,L.L. and Gleich,G.J.
  TITLE     Eosinophil granule proteins in peripheral blood granulocytes
  JOURNAL   J Leukoc Biol 52 (6), 611-618 (1992)
   PUBMED   1464733
REFERENCE   8  (bases 1 to 734)
  AUTHORS   Mastrianni,D.M., Eddy,R.L., Rosenberg,H.F., Corrette,S.E.,
            Shows,T.B., Tenen,D.G. and Ackerman,S.J.
  TITLE     Localization of the human eosinophil Charcot-Leyden crystal protein
            (lysophospholipase) gene (CLC) to chromosome 19 and the human
            ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3
            (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome
            14
  JOURNAL   Genomics 13 (1), 240-242 (1992)
   PUBMED   1577491
REFERENCE   9  (bases 1 to 734)
  AUTHORS   Hamann,K.J., Ten,R.M., Loegering,D.A., Jenkins,R.B., Heise,M.T.,
            Schad,C.R., Pease,L.R., Gleich,G.J. and Barker,R.L.
  TITLE     Structure and chromosome localization of the human
            eosinophil-derived neurotoxin and eosinophil cationic protein
            genes: evidence for intronless coding sequences in the ribonuclease
            gene superfamily
  JOURNAL   Genomics 7 (4), 535-546 (1990)
   PUBMED   2387583
REFERENCE   10 (bases 1 to 734)
  AUTHORS   Rosenberg,H.F., Ackerman,S.J. and Tenen,D.G.
  TITLE     Human eosinophil cationic protein. Molecular cloning of a cytotoxin
            and helminthotoxin with ribonuclease activity
  JOURNAL   J Exp Med 170 (1), 163-176 (1989)
   PUBMED   2473157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133371.3.
            
            On Oct 9, 2020 this sequence version replaced NM_002935.2.
            
            Summary: The protein encoded by this gene belongs to the pancreatic
            ribonuclease family, a subset of the ribonuclease A superfamily.
            The protein exhibits antimicrobial activity against pathogenic
            bacteria [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28128.1, DN998783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000304639.4/
                                                  ENSP00000302324.3
            Protein has antimicrobial activity :: PMID: 23716047
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AL133371.3         143437-143503
            68-734              AL133371.3         143734-144400
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..734
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /note="ribonuclease A family member 3"
                     /db_xref="GeneID:6037"
                     /db_xref="HGNC:HGNC:10046"
                     /db_xref="MIM:131398"
     exon            1..67
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /inference="alignment:Splign:2.1.0"
     exon            68..734
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..555
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /EC_number="3.1.27.-"
                     /note="cytotoxic ribonuclease; eosinophil cationic
                     protein; RNase 3; ribonuclease 3; ribonuclease, RNase A
                     family, 3"
                     /codon_start=1
                     /product="eosinophil cationic protein precursor"
                     /protein_id="NP_002926.2"
                     /db_xref="CCDS:CCDS9560.1"
                     /db_xref="GeneID:6037"
                     /db_xref="HGNC:HGNC:10046"
                     /db_xref="MIM:131398"
                     /translation="MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHIS
                     LNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSR
                     FRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
                     "
     regulatory      713..718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /note="hexamer: AATAAA"
     polyA_site      734
                     /gene="RNASE3"
                     /gene_synonym="ECP; RAF1; RNS3"
                     /note="major polyA site"
ORIGIN      
        1 agctgcccct gaaccccaga acaaccagct ggatcagttc tcacaggagc cacagctcag
       61 agactgggaa acatggttcc aaaactgttc acttcccaaa tttgtctgct tcttctgttg
      121 gggcttatgg gtgtggaggg ctcactccat gccagacccc cacagtttac gagggctcag
      181 tggtttgcca tccagcacat cagtctgaac ccccctcgat gcaccattgc aatgcgggca
      241 attaacaatt atcgatggcg ttgcaaaaac caaaatactt ttcttcgtac aacttttgct
      301 aatgtagtta atgtttgtgg taaccaaagt atacgctgcc ctcataacag aactctcaac
      361 aattgtcatc ggagtagatt ccgggtgcct ttactccact gtgacctcat aaatccaggt
      421 gcacagaata tttcaaactg cacgtatgca gacagaccag gaaggaggtt ctatgtagtt
      481 gcatgtgaca acagagatcc acgggattct ccacggtatc ctgtggttcc agttcacctg
      541 gataccacca tctaagctcc tgtatcagca gtcctcatca tcactcatct gccaagctcc
      601 tcaatcatag ccaagatccc atccctccat gtactctggg tatcagcaac tgtcctcatc
      661 agtctccata ccccttcagc tttcctgagc tgaagtccct tgtgaaccct gcaataaact
      721 gctttgcaaa ttca
//
