LOCUS       NM_002934                720 bp    mRNA    linear   PRI 10-MAR-2024
DEFINITION  Homo sapiens ribonuclease A family member 2 (RNASE2), mRNA.
ACCESSION   NM_002934
VERSION     NM_002934.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 720)
  AUTHORS   Thomas,J., Hopson,P., Deb,C., Bornstein,J., Mehta,D., Bittar,K. and
            Smadi,Y.
  TITLE     Addressing diagnostic dilemmas in eosinophilic esophagitis using
            esophageal epithelial eosinophil-derived neurotoxin
  JOURNAL   J Pediatr Gastroenterol Nutr 78 (2), 304-312 (2024)
   PUBMED   38374551
  REMARK    GeneRIF: Addressing diagnostic dilemmas in eosinophilic esophagitis
            using esophageal epithelial eosinophil-derived neurotoxin.
            Review article
REFERENCE   2  (bases 1 to 720)
  AUTHORS   Fardig,M., Lie,A., Borres,M.P., Ekenkrantz,T., Granum,B.,
            Haugen,G., Jonassen,C.M., Moverare,R., Rehbinder,E.M.,
            Skjerven,H.O., Cathrine,A., Vettukattil,R., Lodrup Carlsen,K.C.,
            Soderhall,C. and Nordlund,B.
  TITLE     Eosinophil-derived neurotoxin levels in early childhood and
            association with preschool asthma - A prospective observational
            study
  JOURNAL   Clin Exp Allergy 53 (11), 1198-1211 (2023)
   PUBMED   37795650
  REMARK    GeneRIF: Eosinophil-derived neurotoxin levels in early childhood
            and association with preschool asthma - A prospective observational
            study.
            Erratum:[Clin Exp Allergy. 2024 Mar 8;:. PMID: 38456230]
REFERENCE   3  (bases 1 to 720)
  AUTHORS   Ong,E.Z., Koh,C.W.T., Tng,D.J.H., Ooi,J.S.G., Yee,J.X.,
            Chew,V.S.Y., Leong,Y.S., Gunasegaran,K., Yeo,C.P., Oon,L.L.E.,
            Sim,J.X.Y., Chan,K.R., Low,J.G. and Ooi,E.E.
  TITLE     RNase2 is a possible trigger of acute-on-chronic inflammation
            leading to mRNA vaccine-associated cardiac complication
  JOURNAL   Med 4 (6), 353-360 (2023)
   PUBMED   37105176
  REMARK    GeneRIF: RNase2 is a possible trigger of acute-on-chronic
            inflammation leading to mRNA vaccine-associated cardiac
            complication.
REFERENCE   4  (bases 1 to 720)
  AUTHORS   Tota,M., Lacwik,J., Laska,J., Sedek,L. and Gomulka,K.
  TITLE     The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial
            Growth Factor in the Pathogenesis of Eosinophilic Asthma
  JOURNAL   Cells 12 (9), 1326 (2023)
   PUBMED   37174726
  REMARK    GeneRIF: The Role of Eosinophil-Derived Neurotoxin and Vascular
            Endothelial Growth Factor in the Pathogenesis of Eosinophilic
            Asthma.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 720)
  AUTHORS   Zhu,Y., Tang,X., Xu,Y., Wu,S., Liu,W., Geng,L., Ma,X., Tsao,B.P.,
            Feng,X. and Sun,L.
  TITLE     RNASE2 Mediates Age-Associated B Cell Expansion Through Monocyte
            Derived IL-10 in Patients With Systemic Lupus Erythematosus
  JOURNAL   Front Immunol 13, 752189 (2022)
   PUBMED   35265065
  REMARK    GeneRIF: RNASE2 Mediates Age-Associated B Cell Expansion Through
            Monocyte Derived IL-10 in Patients With Systemic Lupus
            Erythematosus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 720)
  AUTHORS   Domachowske,J.B., Bonville,C.A., Dyer,K.D. and Rosenberg,H.F.
  TITLE     Evolution of antiviral activity in the ribonuclease A gene
            superfamily: evidence for a specific interaction between
            eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory
            syncytial virus
  JOURNAL   Nucleic Acids Res 26 (23), 5327-5332 (1998)
   PUBMED   9826755
  REMARK    GeneRIF: The antimicrobial protein, RNase 2 exhibits antiviral
            against respiratory syncytial virus.
REFERENCE   7  (bases 1 to 720)
  AUTHORS   Abu-Ghazaleh,R.I., Dunnette,S.L., Loegering,D.A., Checkel,J.L.,
            Kita,H., Thomas,L.L. and Gleich,G.J.
  TITLE     Eosinophil granule proteins in peripheral blood granulocytes
  JOURNAL   J Leukoc Biol 52 (6), 611-618 (1992)
   PUBMED   1464733
REFERENCE   8  (bases 1 to 720)
  AUTHORS   Mastrianni,D.M., Eddy,R.L., Rosenberg,H.F., Corrette,S.E.,
            Shows,T.B., Tenen,D.G. and Ackerman,S.J.
  TITLE     Localization of the human eosinophil Charcot-Leyden crystal protein
            (lysophospholipase) gene (CLC) to chromosome 19 and the human
            ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3
            (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome
            14
  JOURNAL   Genomics 13 (1), 240-242 (1992)
   PUBMED   1577491
REFERENCE   9  (bases 1 to 720)
  AUTHORS   Sakakibara,R., Hashida,K., Kitahara,T. and Ishiguro,M.
  TITLE     Characterization of a unique nonsecretory ribonuclease from urine
            of pregnant women
  JOURNAL   J Biochem 111 (3), 325-330 (1992)
   PUBMED   1587793
REFERENCE   10 (bases 1 to 720)
  AUTHORS   Hamann,K.J., Ten,R.M., Loegering,D.A., Jenkins,R.B., Heise,M.T.,
            Schad,C.R., Pease,L.R., Gleich,G.J. and Barker,R.L.
  TITLE     Structure and chromosome localization of the human
            eosinophil-derived neurotoxin and eosinophil cationic protein
            genes: evidence for intronless coding sequences in the ribonuclease
            gene superfamily
  JOURNAL   Genomics 7 (4), 535-546 (1990)
   PUBMED   2387583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X55988.1, M28129.1 and
            AL355922.4.
            
            On Nov 23, 2018 this sequence version replaced NM_002934.2.
            
            Summary: The protein encoded by this gene is a non-secretory
            ribonuclease that belongs to the pancreatic ribonuclease family, a
            subset of the ribonuclease A superfamily. The protein antimicrobial
            activity against viruses. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.80020.1, X55988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000304625.3/
                                                  ENSP00000303276.2
            Protein has antimicrobial activity :: PMID: 9826755
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                X55988.1           17-54
            39-719              M28129.1           33-713
            720-720             AL355922.4         47020-47020         c
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..720
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /note="ribonuclease A family member 2"
                     /db_xref="GeneID:6036"
                     /db_xref="HGNC:HGNC:10045"
                     /db_xref="MIM:131410"
     exon            1..50
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /inference="alignment:Splign:2.1.0"
     exon            51..720
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..541
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /EC_number="4.6.1.18"
                     /note="non-secretory ribonuclease; RNase 2; RNase UpI-2;
                     ribonuclease 2; ribonuclease US; eosinophil-derived
                     neurotoxin; ribonuclease A F3; ribonuclease, RNase A
                     family, 2 (liver, eosinophil-derived neurotoxin)"
                     /codon_start=1
                     /product="non-secretory ribonuclease precursor"
                     /protein_id="NP_002925.1"
                     /db_xref="CCDS:CCDS9561.1"
                     /db_xref="GeneID:6036"
                     /db_xref="HGNC:HGNC:10045"
                     /db_xref="MIM:131410"
                     /translation="MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHIN
                     MTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSG
                     SQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRI
                     I"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /note="hexamer: AATAAA"
     polyA_site      720
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /note="major polyA site"
ORIGIN      
        1 agaacaacca gctggatcag ttctcacagg agctacagcg cggagactgg gaaacatggt
       61 tccaaaactg ttcacttccc aaatttgtct gcttcttctg ttggggcttc tggctgtgga
      121 gggctcactc catgtcaaac ctccacagtt tacctgggct caatggtttg aaacccagca
      181 catcaatatg acctcccagc aatgcaccaa tgcaatgcag gtcattaaca attatcaacg
      241 gcgatgcaaa aaccaaaata ctttccttct tacaactttt gctaacgtag ttaatgtttg
      301 tggtaaccca aatatgacct gtcctagtaa caaaactcgc aaaaattgtc accacagtgg
      361 aagccaggtg cctttaatcc actgtaacct cacaactcca agtccacaga atatttcaaa
      421 ctgcaggtat gcgcagacac cagcaaacat gttctatata gttgcatgtg acaacagaga
      481 tcaacgacga gaccctccac agtatccggt ggttccagtt cacctggata gaatcatcta
      541 agctcctgta tcagcactcc tcatcatcac tcatctgcca agctcctcaa tcatagccaa
      601 gatcccatct ctccatatac tttgggtatc agcatctgtc ctcatcagtc tccatacccc
      661 ttcagctttc ctgagctgaa gtgccttgtg aaccctgcaa taaactgctt tgcaaattca
//
