LOCUS       NP_002925                161 aa            linear   PRI 10-MAR-2024
DEFINITION  non-secretory ribonuclease precursor [Homo sapiens].
ACCESSION   NP_002925
VERSION     NP_002925.1
DBSOURCE    REFSEQ: accession NM_002934.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 161)
  AUTHORS   Thomas,J., Hopson,P., Deb,C., Bornstein,J., Mehta,D., Bittar,K. and
            Smadi,Y.
  TITLE     Addressing diagnostic dilemmas in eosinophilic esophagitis using
            esophageal epithelial eosinophil-derived neurotoxin
  JOURNAL   J Pediatr Gastroenterol Nutr 78 (2), 304-312 (2024)
   PUBMED   38374551
  REMARK    GeneRIF: Addressing diagnostic dilemmas in eosinophilic esophagitis
            using esophageal epithelial eosinophil-derived neurotoxin.
            Review article
REFERENCE   2  (residues 1 to 161)
  AUTHORS   Fardig,M., Lie,A., Borres,M.P., Ekenkrantz,T., Granum,B.,
            Haugen,G., Jonassen,C.M., Moverare,R., Rehbinder,E.M.,
            Skjerven,H.O., Cathrine,A., Vettukattil,R., Lodrup Carlsen,K.C.,
            Soderhall,C. and Nordlund,B.
  TITLE     Eosinophil-derived neurotoxin levels in early childhood and
            association with preschool asthma - A prospective observational
            study
  JOURNAL   Clin Exp Allergy 53 (11), 1198-1211 (2023)
   PUBMED   37795650
  REMARK    GeneRIF: Eosinophil-derived neurotoxin levels in early childhood
            and association with preschool asthma - A prospective observational
            study.
            Erratum:[Clin Exp Allergy. 2024 Mar 8;:. PMID: 38456230]
REFERENCE   3  (residues 1 to 161)
  AUTHORS   Ong,E.Z., Koh,C.W.T., Tng,D.J.H., Ooi,J.S.G., Yee,J.X.,
            Chew,V.S.Y., Leong,Y.S., Gunasegaran,K., Yeo,C.P., Oon,L.L.E.,
            Sim,J.X.Y., Chan,K.R., Low,J.G. and Ooi,E.E.
  TITLE     RNase2 is a possible trigger of acute-on-chronic inflammation
            leading to mRNA vaccine-associated cardiac complication
  JOURNAL   Med 4 (6), 353-360 (2023)
   PUBMED   37105176
  REMARK    GeneRIF: RNase2 is a possible trigger of acute-on-chronic
            inflammation leading to mRNA vaccine-associated cardiac
            complication.
REFERENCE   4  (residues 1 to 161)
  AUTHORS   Tota,M., Lacwik,J., Laska,J., Sedek,L. and Gomulka,K.
  TITLE     The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial
            Growth Factor in the Pathogenesis of Eosinophilic Asthma
  JOURNAL   Cells 12 (9), 1326 (2023)
   PUBMED   37174726
  REMARK    GeneRIF: The Role of Eosinophil-Derived Neurotoxin and Vascular
            Endothelial Growth Factor in the Pathogenesis of Eosinophilic
            Asthma.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 161)
  AUTHORS   Zhu,Y., Tang,X., Xu,Y., Wu,S., Liu,W., Geng,L., Ma,X., Tsao,B.P.,
            Feng,X. and Sun,L.
  TITLE     RNASE2 Mediates Age-Associated B Cell Expansion Through Monocyte
            Derived IL-10 in Patients With Systemic Lupus Erythematosus
  JOURNAL   Front Immunol 13, 752189 (2022)
   PUBMED   35265065
  REMARK    GeneRIF: RNASE2 Mediates Age-Associated B Cell Expansion Through
            Monocyte Derived IL-10 in Patients With Systemic Lupus
            Erythematosus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 161)
  AUTHORS   Domachowske,J.B., Bonville,C.A., Dyer,K.D. and Rosenberg,H.F.
  TITLE     Evolution of antiviral activity in the ribonuclease A gene
            superfamily: evidence for a specific interaction between
            eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory
            syncytial virus
  JOURNAL   Nucleic Acids Res 26 (23), 5327-5332 (1998)
   PUBMED   9826755
  REMARK    GeneRIF: The antimicrobial protein, RNase 2 exhibits antiviral
            against respiratory syncytial virus.
REFERENCE   7  (residues 1 to 161)
  AUTHORS   Abu-Ghazaleh,R.I., Dunnette,S.L., Loegering,D.A., Checkel,J.L.,
            Kita,H., Thomas,L.L. and Gleich,G.J.
  TITLE     Eosinophil granule proteins in peripheral blood granulocytes
  JOURNAL   J Leukoc Biol 52 (6), 611-618 (1992)
   PUBMED   1464733
REFERENCE   8  (residues 1 to 161)
  AUTHORS   Mastrianni,D.M., Eddy,R.L., Rosenberg,H.F., Corrette,S.E.,
            Shows,T.B., Tenen,D.G. and Ackerman,S.J.
  TITLE     Localization of the human eosinophil Charcot-Leyden crystal protein
            (lysophospholipase) gene (CLC) to chromosome 19 and the human
            ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3
            (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome
            14
  JOURNAL   Genomics 13 (1), 240-242 (1992)
   PUBMED   1577491
REFERENCE   9  (residues 1 to 161)
  AUTHORS   Sakakibara,R., Hashida,K., Kitahara,T. and Ishiguro,M.
  TITLE     Characterization of a unique nonsecretory ribonuclease from urine
            of pregnant women
  JOURNAL   J Biochem 111 (3), 325-330 (1992)
   PUBMED   1587793
REFERENCE   10 (residues 1 to 161)
  AUTHORS   Hamann,K.J., Ten,R.M., Loegering,D.A., Jenkins,R.B., Heise,M.T.,
            Schad,C.R., Pease,L.R., Gleich,G.J. and Barker,R.L.
  TITLE     Structure and chromosome localization of the human
            eosinophil-derived neurotoxin and eosinophil cationic protein
            genes: evidence for intronless coding sequences in the ribonuclease
            gene superfamily
  JOURNAL   Genomics 7 (4), 535-546 (1990)
   PUBMED   2387583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X55988.1, M28129.1 and
            AL355922.4.
            
            Summary: The protein encoded by this gene is a non-secretory
            ribonuclease that belongs to the pancreatic ribonuclease family, a
            subset of the ribonuclease A superfamily. The protein antimicrobial
            activity against viruses. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.80020.1, X55988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000304625.3/
                                                  ENSP00000303276.2
            Protein has antimicrobial activity :: PMID: 9826755
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     Protein         1..161
                     /product="non-secretory ribonuclease precursor"
                     /EC_number="4.6.1.18"
                     /note="non-secretory ribonuclease; RNase 2; RNase UpI-2;
                     ribonuclease 2; ribonuclease US; eosinophil-derived
                     neurotoxin; ribonuclease A F3; ribonuclease, RNase A
                     family, 2 (liver, eosinophil-derived neurotoxin)"
                     /calculated_mol_wt=15464
     sig_peptide     1..27
                     /calculated_mol_wt=2909
     mat_peptide     28..161
                     /product="ribonuclease 2"
                     /experiment="DESCRIPTION:antimicrobial peptide[PMID:
                     9826755]"
                     /calculated_mol_wt=15464
     Region          31..161
                     /region_name="RNAse_Pc"
                     /note="Pancreatic ribonuclease; smart00092"
                     /db_xref="CDD:128403"
     Site            order(38..46,49,53,55..57,65,68..73,108,129,154)
                     /site_type="active"
                     /note="dimerization with domain swap [active]"
                     /db_xref="CDD:119387"
     Site            order(42,65,69,97,109,156..157)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:119387"
     Site            order(66,100,111,128,130,132..133,135)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119387"
     CDS             1..161
                     /gene="RNASE2"
                     /gene_synonym="EDN; RAF3; RNS2"
                     /coded_by="NM_002934.3:56..541"
                     /db_xref="CCDS:CCDS9561.1"
                     /db_xref="GeneID:6036"
                     /db_xref="HGNC:HGNC:10045"
                     /db_xref="MIM:131410"
ORIGIN      
        1 mvpklftsqi clllllglla vegslhvkpp qftwaqwfet qhinmtsqqc tnamqvinny
       61 qrrcknqntf llttfanvvn vcgnpnmtcp snktrknchh sgsqvplihc nlttpspqni
      121 sncryaqtpa nmfyivacdn rdqrrdppqy pvvpvhldri i
//
