LOCUS       NM_001012264            1631 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens ribonuclease A family member 13 (inactive) (RNASE13),
            mRNA.
ACCESSION   NM_001012264 XM_498573
VERSION     NM_001012264.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Yamada,Y., Sakuma,J., Takeuchi,I., Yasukochi,Y., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H., Muramatsu,M., Sawabe,M., Fujiwara,Y.,
            Taniguchi,Y., Obuchi,S., Kawai,H., Shinkai,S., Mori,S., Arai,T. and
            Tanaka,M.
  TITLE     Identification of EGFLAM, SPATC1L and RNASE13 as novel
            susceptibility loci for aortic aneurysm in Japanese individuals by
            exome-wide association studies
  JOURNAL   Int J Mol Med 39 (5), 1091-1100 (2017)
   PUBMED   28339009
  REMARK    GeneRIF: rs1465567 of EGFLAM and rs113710653 of SPATC1L may be
            susceptibility loci for true aortic aneurysm and rs143881017 of
            RNASE13 may be such a locus for dissecting aortic aneurysm in
            Japanese individuals.
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161668.6, BC044831.1 and AY665808.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001012264.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044831.1, FJ237363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMN02400288
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382951.4/ ENSP00000372410.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL161668.6         88122-88143         c
            23-160              BC044831.1         1-138
            161-631             AY665808.1         1-471
            632-1629            AL161668.6         86156-87153         c
            1630-1631           AL161668.6         86154-86155         c
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1631
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /note="ribonuclease A family member 13 (inactive)"
                     /db_xref="GeneID:440163"
                     /db_xref="HGNC:HGNC:25285"
     exon            1..152
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..1631
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..631
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /note="ribonuclease 13; ribonuclease-like protein 13;
                     probable inactive ribonuclease-like protein 13; epididymis
                     secretory sperm binding protein Li 86p; ribonuclease A L1;
                     ribonuclease, RNase A family, 13 (non-active)"
                     /codon_start=1
                     /product="probable inactive ribonuclease-like protein 13
                     precursor"
                     /protein_id="NP_001012264.1"
                     /db_xref="CCDS:CCDS32039.1"
                     /db_xref="GeneID:440163"
                     /db_xref="HGNC:HGNC:25285"
                     /translation="MAPAVTRLLFLQLVLGPTLVMDIKMQIGSRNFYTLSIDYPRVNY
                     PKGFRGYCNGLMSYMRGKMQNSDCPKIHYVIHAPWKAIQKFCKYSDSFCENYNEYCTL
                     TQDSLPITVCSLSHQQPPTSCYYNSTLTNQKLYLLCSRKYEADPIGIAGLYSGI"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /note="hexamer: AATAAA"
     polyA_site      1631
                     /gene="RNASE13"
                     /gene_synonym="HEL-S-86p; RAL1"
                     /note="major polyA site"
ORIGIN      
        1 gacattccct cctcccagac tgatttttac ctagaaacct ttctagcctc tcctcatctc
       61 ttgactgtct tggccttggc aagaagaata cacgtcccta cccagctatc ttcagctcct
      121 gtccttcctc ccagctgcca gagaattgtc agcaggagga atggcaccag ctgtgacccg
      181 gctccttttc ctccagcttg ttctggggcc aactctggtc atggacatca agatgcagat
      241 tggcagcagg aacttctata ccttaagcat tgactatccc agggttaact acccaaaggg
      301 tttccggggc tattgtaatg gtctgatgtc ctatatgcga ggcaagatgc aaaattcaga
      361 ttgcccaaag atccattatg tgatacatgc cccttggaag gccatccaga agttctgcaa
      421 gtatagtgac agcttctgtg agaattacaa tgaatactgc acactcaccc aggattccct
      481 ccccatcacg gtctgctccc tgagccacca acagccaccc actagctgct actacaatag
      541 caccctaacc aaccagaagc tctacctact ctgctcccgc aagtatgaag ctgatccaat
      601 aggtatcgct ggtctctatt cgggaattta attcctgagc cactccccaa cctctaccac
      661 cacaggccag ctgtctccat ttccaacact ctgatccctg taacaagact tccttcctga
      721 cttacgaggc aggcagggtc ccctcccaag agaccaggtg ggtgcgaaaa tgtccagggc
      781 tttgatcacc atgcaaagtg gtgctatctt ctaggttctt tccagcttgt ttaccccctc
      841 ttcgccccca cctcctcatc atccttcctc tcccagagac agtaaaaccc acccaagaag
      901 ttgactgtgt ccagttggca gtgactgtcc acccactggg ccagatccta agtcctggat
      961 ggaggcccag ggcctcagct cacaccatgg caacaggcac cagctccgag tctcacctcc
     1021 ccatccccac cagccttctc atgtcagcct cccccagttc ccttataatt ccctccactc
     1081 acccacctac tcaggggata tggctagcta taggaacctc cctgaggccc tcagactcat
     1141 gttagcctca cttccccaca acccccagtt tccagcctgc ttctctctgt gaaatcatgg
     1201 tttctccctt catataactg tcctctcctg cttcctctta ccatggagcc taggactgtc
     1261 tcccccacac tcccaacaac cgtagtcacc ctgccttcct ttttccaacc tctttttctt
     1321 ccagtcttct taccttggct cactggcatt tcaaggtatc ttctctcacc cattccccag
     1381 aggttcctgc ttcccttctc ttccagaagc tcctcccaaa tcccccagac tccagagtct
     1441 gcccctgacc aggcagcgaa tgaggcaggc ccggctctaa tcgaacataa atttctaaaa
     1501 ccacatctga gtatgtaaga tgtaaccatt gggggaaact gggtgaaggg cacacgagcc
     1561 ccctctgtac cattttttgt aacttcctgt caacccataa tcaattcaaa ataaaaagtt
     1621 aataacacac a
//
