LOCUS       NM_001394190            1810 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens ribonuclease A family member 11 (inactive) (RNASE11),
            transcript variant 3, mRNA.
ACCESSION   NM_001394190
VERSION     NM_001394190.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   3  (bases 1 to 1810)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL163195.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX102349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557105.7/ ENSP00000452412.2
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL163195.5         46933-47074
            143-205             AL163195.5         47309-47371
            206-1810            AL163195.5         50438-52042
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1810
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="ribonuclease A family member 11 (inactive)"
                     /db_xref="GeneID:122651"
                     /db_xref="HGNC:HGNC:19269"
     exon            1..142
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..205
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..1810
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..827
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="probable ribonuclease 11; epididymis secretory
                     sperm binding protein Li 84p; ribonuclease A J1;
                     ribonuclease, RNase A family, 11 (non-active)"
                     /codon_start=1
                     /product="probable ribonuclease 11 precursor"
                     /protein_id="NP_001381119.1"
                     /db_xref="CCDS:CCDS9553.1"
                     /db_xref="GeneID:122651"
                     /db_xref="HGNC:HGNC:19269"
                     /translation="METFPLLLLSLGLVLAEASESTMKIIKEEFTDEEMQYDMAKSGQ
                     EKQTIEILMNPILLVKNTSLSMSKDDMSSTLLTFRSLHYNDPKGNSSGNDKECCNDMT
                     VWRKVSEANGSCKWSNNFIRSSTEVMRRVHRAPSCKFVQNPGISCCESLELENTVCQF
                     TTGKQFPRCQYHSVTSLEKILTVLTGHSLMSWLVCGSKL"
     regulatory      989..994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="hexamer: ATTAAA"
     polyA_site      1008
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="major polyA site"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="hexamer: ACTAAA"
     polyA_site      1810
                     /gene="RNASE11"
                     /gene_synonym="C14orf6; HEL-S-84p; RAJ1"
                     /note="major polyA site"
ORIGIN      
        1 agagactcat acagtgacct agagcaggca tgggtgggtc acaggctttg gagagcactc
       61 tctgtcctga tcttttcagt tgagagactt cagctgttca ttgctcattt ggacttagtt
      121 caaggtcatg tcaaagaaga agaattttgg gtgtcaccag gtaaacagag ccctcagcat
      181 ctgaatagaa actgaacagg aacagaagag attacactac atctgagatg gagacctttc
      241 ctctgctgct gctcagcctg ggcctggttc ttgcagaagc atcagaaagc acaatgaaga
      301 taattaaaga agaatttaca gacgaagaga tgcaatatga catggcaaaa agtggccaag
      361 aaaaacagac cattgagata ttaatgaacc cgatcctgtt agttaaaaat accagcctca
      421 gcatgtccaa ggatgatatg tcttccacat tactgacatt cagaagttta cattataatg
      481 accccaaggg aaacagttcg ggtaatgaca aagagtgttg caatgacatg acagtctgga
      541 gaaaagtttc agaagcaaac ggatcgtgca agtggagcaa taacttcatc cgcagctcca
      601 cagaagtgat gcgcagggtc cacagggccc ccagctgcaa gtttgtacag aatcctggca
      661 taagctgctg tgagagccta gaactggaaa atacagtgtg ccagttcact acaggcaaac
      721 aattccccag gtgccaatac catagtgtta cctcattaga gaagatattg acagtgctga
      781 caggtcattc tctgatgagc tggttagttt gtggctctaa gttgtaaatc ccacagagct
      841 ttaggactag ggtcttacta aagaaggacc tcttcttgtt cattcttgtt taaacctttc
      901 cttaatatct actctttagc actatagtga actcctgatt atttattcta actggaggag
      961 tgaaaaatcc aaaattgtgg ataattcaat taaaagttat gactgatact ggcgtgcaga
     1021 ttcttctctc tctatctctc tctctgtgtg gggggagggt ggggagggtg taaaacaaac
     1081 tgaatttcat cctagctcag ctataaagcc aagaaacaga atccacctaa ctaggcagaa
     1141 ttaaggaaac aaggactaaa gccaatatgg acaatgaaaa gctaattgta ctgccaatga
     1201 tactattcag aaaaatagtg aatgagtgtg acatatatta ttatcactac tctcttcaaa
     1261 gggtatgtgc tcacacttgt gtgaattgat gtatgcacat aacaaagagt ctgcctgtcc
     1321 ttcaggaaat gccagaggaa aaagattctt tggctgagct gatgctctca gtgtcaatag
     1381 ctccagccct atgcaatctc cattcttcca cccccatctc tatttcacag gttgctgtaa
     1441 agagaagaaa attcttattg taatctttat tcaagccaag tcttgatacc ctggggctgt
     1501 gggagaggaa tggcaagcca tggaagaata gaggagccag aaagatggga atagaaagtc
     1561 tgtgctaagt accaggcagg actggtcttc aaccttgatg tcttatgata ctgtagttaa
     1621 ttttgttcac taccagctat ttatttgcaa acgttcgtgg ttcaacattc tgcttaaagt
     1681 atggacagtt atcttcttca tcgatgtgtg gccatatgtt tctattcctc tccttaaatc
     1741 ctccctccat cctgagacca ctctttctta atgttctaat tttaactaaa tgcatgtaaa
     1801 tgtatgtaaa
//
