LOCUS       NM_001386206            3901 bp    mRNA    linear   PRI 18-DEC-2024
DEFINITION  Homo sapiens ribonuclease A family member 10 (inactive) (RNASE10),
            transcript variant 1, mRNA.
ACCESSION   NM_001386206
VERSION     NM_001386206.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3901)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Haralambieva,I.H., Lambert,N.D.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide SNP associations with rubella-specific cytokine
            responses in measles-mumps-rubella vaccine recipients
  JOURNAL   Immunogenetics 66 (7-8), 493-499 (2014)
   PUBMED   24811271
REFERENCE   3  (bases 1 to 3901)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   4  (bases 1 to 3901)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   5  (bases 1 to 3901)
  AUTHORS   Penttinen,J., Pujianto,D.A., Sipila,P., Huhtaniemi,I. and
            Poutanen,M.
  TITLE     Discovery in silico and characterization in vitro of novel genes
            exclusively expressed in the mouse epididymis
  JOURNAL   Mol Endocrinol 17 (11), 2138-2151 (2003)
   PUBMED   12920233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355075.6.
            
            On Feb 23, 2023 this sequence version replaced NM_001386206.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296766.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000430083.2/
                                                ENSP00000392996.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               AL355075.6         13946-14428         c
            484-3901            AL355075.6         6081-9498           c
FEATURES             Location/Qualifiers
     source          1..3901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3901
                     /gene="RNASE10"
                     /gene_synonym="RAH1; RNASE9"
                     /note="ribonuclease A family member 10 (inactive)"
                     /db_xref="GeneID:338879"
                     /db_xref="HGNC:HGNC:19275"
                     /db_xref="MIM:621046"
     exon            1..483
                     /gene="RNASE10"
                     /gene_synonym="RAH1; RNASE9"
                     /inference="alignment:Splign:2.1.0"
     exon            484..3901
                     /gene="RNASE10"
                     /gene_synonym="RAH1; RNASE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..1139
                     /gene="RNASE10"
                     /gene_synonym="RAH1; RNASE9"
                     /note="inactive ribonuclease-like protein 10; ribonuclease
                     A H1; ribonuclease, RNase A family, 10 (non-active)"
                     /codon_start=1
                     /product="inactive ribonuclease-like protein 10 precursor"
                     /protein_id="NP_001373135.2"
                     /db_xref="CCDS:CCDS32035.1"
                     /db_xref="GeneID:338879"
                     /db_xref="HGNC:HGNC:19275"
                     /db_xref="MIM:621046"
                     /translation="MKLNLVQIFFMLLMLLLGLGMGLGLGLHMATAVLEESDQPLNEF
                     WSSDSQDKAEATEEGDGTQTTETLVLSNKEVVQPGWPEDPILGEDEVGGNKMLRASAL
                     FQSNKDYLRLDQTDRECNDMMAHKMKEPSQSCIAQYAFIHEDLNTVKAVCNSPVIACE
                     LKGGKCHKSSRPFDLTLCELSQPDQVTPNCNYLTSVIKKHIIITCNDMKRQLPTGQ"
ORIGIN      
        1 agctcctaac cgcgagtgat ccgccagcct tggcctccca aggtgccggg attgcagacg
       61 gagtctggtt cactcagtgc tcaatggtgc ccaggctgga gtgcagtggc gtgatctcag
      121 ctcgctacaa cctccatctc ccagccgcct gccttggcct cccaaagtgc cgagattgca
      181 gcctctgcct ggccgccacc ccgtctggga agtgaggagc gtctctgcct ggccgcccat
      241 cgtctgggat acgaggagcc tctctgcctg gctgcccagt ctggaaagtg aggagcgtct
      301 ctgcccggcc gccatcccat ctaggaagcg aggagcgcct cttccccgcc gccatcccat
      361 ctaggaagtg aggagcgtct ctgcccggcc gcccatcgtc tgagatgtgg ggagcacctc
      421 tgccccgccg ccctgtctgg gatgtgagga gcgcctctgc tgggccgcaa ccctgtctgg
      481 gaggcaaaat gaagctgaat ctggtgcaga tctttttcat gttgctgatg ctgctgctgg
      541 gcctggggat gggcctgggg ttgggacttc atatggctac agcagtcttg gaggagagtg
      601 atcaaccgct caatgaattt tggtccagtg actcacagga caaagctgag gccactgagg
      661 agggagacgg cacccaaacc acagaaacgc tggtgcttag caacaaagaa gtggtgcaac
      721 ctggctggcc agaagatccc atcctcggtg aagatgaggt tgggggtaac aagatgctca
      781 gagcctcagc tctctttcag agcaacaaag actatcttag gcttgaccag acagatagag
      841 aatgcaatga tatgatggca cacaagatga aggagcccag tcagagttgc atagcccagt
      901 atgcattcat ccatgaggat ctaaacacag tcaaagctgt ctgtaacagt cctgtcattg
      961 cctgtgagct caagggggga aaatgtcaca aaagctcccg accttttgat ttgacattgt
     1021 gcgagctgtc ccaaccagac caggtcactc ctaactgcaa ttacctaact tctgttataa
     1081 aaaagcacat tattataacc tgtaatgaca tgaagcgcca gttaccaact ggacaatgaa
     1141 gcaactcatc atcttttttc tcttcacctt ctcctgttcc tcttcctttt ttacttcttc
     1201 tttctcatat agttctcctg atcttaggta tcatgcagat ggaattcttc cttgccctat
     1261 gggtcaccca acttgcattt tgttcctagg attagagatg gtaggataag gtgatgatgc
     1321 ctagtttctc taagctctct gcctctcctt tcccttaccc tggaaaggag taagtgaaga
     1381 gctgctgtag tccgtactgt agtcctggcc atccatttgt ttcctgctct gctctgagtt
     1441 tgtctctgga tgtggactgg aagagtttag tgtatccttt acccatgttc ttccctgctg
     1501 cccaccctga gcctctacaa caatcacata agactcttgg gttttgcaca actgcacttc
     1561 tctattgcgg atgaagttaa agtgattcta tctgtaatgg cttctggagg accatgtgga
     1621 acaggcttcc ttttccgagc ttggaaaaat ttagggccta ggtatggggg tctgctgggg
     1681 aggtggtgtg gtgctgtaga gcaagataga agatgggctg gagcaagaat agaactcttt
     1741 tttcttgacc cttcactgcc cttttctctt tcttcccacc ttttactagc agcctccttg
     1801 cttggcttct tgttttcatc tcttaccttt gcttttgtcc tttgcttctt tttctcctta
     1861 ctttctctgt tctccttttc ctcttctttt tctttttggg cccgctcttc tctttatctg
     1921 gatcctttta gagattcagt cagccgatac tgatcactta tgctatgttg gtcctatagt
     1981 cagtcatgca agcagatgtt cgtcctatag tcagagtctg gcacagggag ttagaggggg
     2041 gtgggtcaag agaatgagaa aaagagagag gaaaagagag aaagagaaag agagagtgag
     2101 aaatcttttt tgaattatgt ccagaagcag aatagtgctc atatgaggtg cccagtagat
     2161 gtgggatgaa tgggatggga gacagtcttt ttctcattta gcatcgtttc cgctttattg
     2221 ctctaaagaa caagaaagtt agtgaaagaa taatttcagc agagaaggta tcaaacttaa
     2281 tcaaggagaa gagaagctgt gtggctggat acacagaaga tgcaagtggc tgccctcagc
     2341 ctatttcctc taaattcaaa tgagaaatag tgtagttagt catgcatagg gagaagagga
     2401 atctgagaac atagctgtaa ggattcaccg tgtgactgaa ttttgagatt tccttcccct
     2461 agagtttttc tctgcttcac attcctagac tattatagac ccaagtcagg gacatacata
     2521 aatgggagac tgaagggaag aacggtttgc tttactctga cctggcttgc attttcctgt
     2581 tctttctgtc tttattctct ttatccttcc tgttttcaca gacaggcaac cactttagta
     2641 tcctcctaga cgtccctgat tcaatatatc ccttatacct ctgactcact tccagcaata
     2701 acctcttagg aacagtgttg tctcccaggg aattctaata atagtggaca ggaggtatgt
     2761 ctccatctgt gggctggcct gatgttttag aggtggtaat gaagtggtga aaggtgatga
     2821 cccagccaag gcagattcct atgcttcctg agggcgaatc cctctccggg gaaagagaca
     2881 aaagattatc taaggtaagg gggaaaaaat gagaaatagg atgggaagag gggaaagaag
     2941 aataggtgtc agagaaaatc ggccacgtta gcaatctgtc tggtaggtaa accaaggatt
     3001 taggaatgaa atgtgaaaga tctccattgt atggagtgaa ttattaagag aatggaatta
     3061 gccagggatt aaagcctata ttctctagta ttcagatgtg gctccatcct cttcagcttc
     3121 cgtccagctt ctctccctaa gcgttccggc actgtttgat gggcatactc atctcctccg
     3181 ggtcttcact ttgggcaaat ctcagtgggt catgtttttc ttttgttttg ttttgttttg
     3241 tttttgtttt ttttgtttaa tctgaccacg tagactatcg caggaaagca atttacaaaa
     3301 tactccacag gcgcctagtg gctcaagcag gaaaatatag cttccatggc tgataacagg
     3361 gtgacaaggc attgtgggga cctcacctcc caggggcaga aaattaactc actgtagctc
     3421 aaattctgcc tcattcacaa gactttcacc gagtcttcta attccaatgt agcttcctct
     3481 ctacacttcc aggatctgtg ttgagcccat atgacagatc ccagtccctt atctacagta
     3541 cccaaatctc tgaagctctg aaaatggaaa gtttttttca aagtggcccc aaaactcatt
     3601 tagatatgac acctgactag attgacaatg tgaggctatt tatcttgttt atttatgcta
     3661 tgtgaccatt acatatttca ctgtggaaat atcactgtgt tttgttatga gtaggtcctt
     3721 ctaagagtgt gttagtcata tatgatataa acatacacac attaacatac aatagtgctt
     3781 tttaaaatct gaaaatgttg gccaaaatgc attggcccca aaagtttcaa gtaagaaatt
     3841 gtgggatcta tatatactat ttaattagcc ttaattaatt tgagtatact ggatatgatc
     3901 c
//
