LOCUS       NM_022762               3911 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens required for meiotic nuclear division 5 homolog B
            (RMND5B), transcript variant 2, mRNA.
ACCESSION   NM_022762
VERSION     NM_022762.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3911)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3911)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3911)
  AUTHORS   Pfirrmann,T., Villavicencio-Lorini,P., Subudhi,A.K., Menssen,R.,
            Wolf,D.H. and Hollemann,T.
  TITLE     RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions
            in early embryonic forebrain development
  JOURNAL   PLoS One 10 (3), e0120342 (2015)
   PUBMED   25793641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3911)
  AUTHORS   Pope,S.N. and Lee,I.R.
  TITLE     Yeast two-hybrid identification of prostatic proteins interacting
            with human sex hormone-binding globulin
  JOURNAL   J Steroid Biochem Mol Biol 94 (1-3), 203-208 (2005)
   PUBMED   15862967
REFERENCE   5  (bases 1 to 3911)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   6  (bases 1 to 3911)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB053605.1, BC009911.2, CA440193.1 and AC136632.3.
            
            On Nov 23, 2018 this sequence version replaced NM_022762.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.175081.1,
                                           SRR1803612.231224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313386.9/ ENSP00000320623.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB053605.1         54-66
            14-1821             BC009911.2         1-1808
            1822-1913           CA440193.1         19-110              c
            1914-3911           AC136632.3         139835-141832
FEATURES             Location/Qualifiers
     source          1..3911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3911
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /note="required for meiotic nuclear division 5 homolog B"
                     /db_xref="GeneID:64777"
                     /db_xref="HGNC:HGNC:26181"
     exon            1..41
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            42..181
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            182..332
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1375
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 2;
                     protein RMD5 homolog B; GID complex subunit 2 homolog B;
                     E3 ubiquitin-protein transferase RMND5B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein transferase RMND5B isoform
                     a"
                     /protein_id="NP_073599.2"
                     /db_xref="CCDS:CCDS4431.1"
                     /db_xref="GeneID:64777"
                     /db_xref="HGNC:HGNC:26181"
                     /translation="MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELA
                     SAALQGTPLSATLSLVMSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEIC
                     GVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELN
                     RILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSY
                     ARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLL
                     GLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHS
                     VFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRII
                     F"
     exon            333..478
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            479..619
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            620..720
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            721..887
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1053
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1156
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1311
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..3911
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1862
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /note="hexamer: AACAAA"
     polyA_site      1909
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /note="major polyA site"
     polyA_site      3335
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
     regulatory      3889..3894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
                     /note="hexamer: ATTAAA"
     polyA_site      3911
                     /gene="RMND5B"
                     /gene_synonym="GID2; GID2B"
ORIGIN      
        1 gacagtggcg ccggaagccg gggccggggc tgcggggcga gttgtcggcc ctgggccggg
       61 agctggagtc ccagactcat aggtcccggc ccagcccccg aagagccgcc tcagccgggg
      121 ggagttgctc ggactcaaac gtccagtcct cgtgcgaccg cgctgggtcg gaagtgagca
      181 ggctgaggcc accatggagc agtgtgcgtg cgtggagaga gagctggaca aggtcctgca
      241 gaagttcctg acctacgggc agcactgtga gcggagcctg gaggagctgc tgcactacgt
      301 gggccagctg cgggctgagc tggccagcgc agccctccag gggacccctc tctcagccac
      361 cctctctctg gtgatgtcac agtgctgccg gaagatcaaa gatacggtgc agaaactggc
      421 ttcggaccat aaggacattc acagcagtgt atcccgagtg ggcaaagcca ttgacaggaa
      481 cttcgactct gagatctgtg gtgttgtgtc agatgcggtg tgggacgcgc gggaacagca
      541 gcagcagatc ctgcagatgg ccatcgtgga acacctgtat cagcagggca tgctcagcgt
      601 ggccgaggag ctgtgccagg aatcaacgct gaatgtggac ttggatttca agcagccttt
      661 cctagagttg aatcgaatcc tggaagccct gcacgaacaa gacctgggtc ctgcgttgga
      721 atgggccgtc tcccacaggc agcgcctgct ggaactcaac agctccctgg agttcaagct
      781 gcaccgactg cacttcatcc gcctcttggc aggaggcccc gcgaagcagc tggaggccct
      841 cagctatgct cggcacttcc agccctttgc tcggctgcac cagcgggaga tccaggtgat
      901 gatgggcagc ctggtgtacc tgcggctggg cttggagaag tcaccctact gccacctgct
      961 ggacagcagc cactgggcag agatctgtga gacctttacc cgggacgcct gttccctgct
     1021 ggggctttct gtggagtccc cccttagcgt cagctttgcc tctggctgtg tggcgctgcc
     1081 tgtgttgatg aacatcaagg ctgtgattga gcagcggcag tgcactgggg tctggaatca
     1141 caaggacgag ttaccgattg agattgaact aggcatgaag tgctggtacc actccgtgtt
     1201 cgcttgcccc atcctccgcc agcagacgtc agattccaac cctcccatca agctcatctg
     1261 tggccatgtt atctcccgag atgcactcaa taagctcatt aatggaggaa agctgaagtg
     1321 tccctactgt cccatggagc agaacccggc agatgggaaa cgcatcatat tctgattcct
     1381 acctggaagg aattttgttg aaaggggttt tcacctgtga gccttggtct gtctcggtag
     1441 ggtggtcaac ttcagtggac tgtggttggt ttcagagcgc ctggctgagg agttccactg
     1501 aggggagcac tggagcagcc ctttggcaga ggctgaggag ggagatggac cagcccacgc
     1561 ctggcacctg gctccatggc ataaggaaag ggagatgctg gcctctgtgc tcctgctgtc
     1621 ttttcctgtt tctgtttgcg tttgacttag tagcaaccga cagagtggca agggatttgg
     1681 tcttcagcag tagacatcct tccacccctg ccctcagcca agtctcttgc tgccatgcca
     1741 atgctatgtc cacccttgcc cctcggccca agagtgtcca gcggtggccc acctcttcct
     1801 cccactacag cctcaacagt atgtaccatc tcccactgta aatagtccca gttagaacgg
     1861 aatgccgttg ttttataact ttgaacaaat gtatttactg cccttctcat ttctcctggc
     1921 caacctttag cctcactgac aaattatgac cacatgtcta ccacacacag ggactgggca
     1981 cggcctggtg gctgccgcaa acaaaaacat ggccagcagg tatccagtgt ccaggcagga
     2041 agaacacaac ttgcatccct gactgcgggg agcttagatg tcagaccccg ggcaaggtgc
     2101 ttttacatat acccatacca gatcttacta actccatagg agaaatccgt gtaatgggat
     2161 tcaggaaaat gaagtaactt gcacaacagg gctcacagct tagaaaggag agagcttgga
     2221 gttttaacca gatctgaccc tcaagcccaa gctatttcca gtttattcca gggtgcctga
     2281 acttggctgt tatgtatact gagtcctgtg cagggcctct gacagcagga aggggcccca
     2341 agtctaaaat acttgaaggg attgggttac tagggccatt atgttaagca agagagctcg
     2401 ggggaatgca ttttagcttc atattcctat ttaaaatgtg ctgtgtgggt gggtaaattg
     2461 cttccataag cttcacagtg gcatttaagg ctcctgggtt aagttaggaa tgggggtgtt
     2521 cctgatgtgg gggctttagg cttccatgaa gtgggtctgg gccccctgcc ttacctcaca
     2581 gcccccatct accctggaag agggagttga aaatgctggg atagcagcag gatcagttct
     2641 cagcttgagc caaagcaccc ggccctgggc agctgagcat cagcacagaa ccctctgagt
     2701 cctttgggct ctctgctgag gaagactgct tcactcttcc cgcccaccaa ctcgctggcc
     2761 caaccagcag ctgctgctta agaaaacacc cacagactca ccacatttta gtcttagcat
     2821 ttactttccc caccccacat tcttggaaca gcctttagtt ctacaggaaa tggcactgat
     2881 ggacagaaga ctagcattac cttcatgaaa gggctgttag agctgcctgg gaagaaggcg
     2941 tgccttgggg aactgggaag atgccgtcag tgtgggtggg caggaggaca gccagtcgtc
     3001 ctgctgccag cccaatagct tccagcggca ggtgcccagg tgctaccgga gcccctcata
     3061 ggggtagggg cagggactgc acctcctcca ggcactcatc gtaagcctcc tggtactcct
     3121 catggggctt gaccattatc acacaggtgg ggcgcttgga gcctgcggct gcacccaggt
     3181 cctacagagg ggaaagaagt gctgtttgga aaaaagctgt acaacctgta tgccaggaag
     3241 tcaccaactg atgacccacc agcctaatct ggcccacaac catgttctgt tcggtccatg
     3301 ttctatttaa aagcatcttg aattggttgc catcatttaa actcaatcag actttgaagg
     3361 catggtccag ccacacaggg cctacattcc cacatggcaa ctatgaaagg gctccagccc
     3421 agcaggggct gtcccggtcc ctgccacccc cacttcctgt gcctcagatc tggcccctgt
     3481 tacgtaagat aaggacagct acaggtccct ctgagcctaa acccacctaa ccggactaac
     3541 atgggtgaag catcttagct tacaaagctc tttcacatac atctatctct ttattctcat
     3601 agtccacaga taactgacta tttggttctt accatcaggc caaacggtaa gttccttcag
     3661 aacagggcct cctgctttat cccaagaagt gatactgtag gtacccaaga tccaccccca
     3721 gcctctattt tttttttttg agacagggcc tcactctgtc atgcagtctg gagtgtggtg
     3781 gtgtatgatc atggctcact gcagccttga actcctgggt tcaagtgatc tcctgcttta
     3841 gcctcccaag tggctgggac tacaggcatg tgccaccaca cccagctaat taaaaaaatt
     3901 ttttttgtag a
//
