LOCUS       NM_022780               6183 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens required for meiotic nuclear division 5 homolog A
            (RMND5A), mRNA.
ACCESSION   NM_022780
VERSION     NM_022780.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6183)
  AUTHORS   Gottemukkala,K.V., Chrustowicz,J., Sherpa,D., Sepic,S., Vu,D.T.,
            Karayel,O., Papadopoulou,E.C., Gross,A., Schorpp,K., von Gronau,S.,
            Hadian,K., Murray,P.J., Mann,M., Schulman,B.A. and Alpi,A.F.
  TITLE     Non-canonical substrate recognition by the human WDR26-CTLH E3
            ligase regulates prodrug metabolism
  JOURNAL   Mol Cell 84 (10), 1948-1963 (2024)
   PUBMED   38759627
  REMARK    GeneRIF: Non-canonical substrate recognition by the human
            WDR26-CTLH E3 ligase regulates prodrug metabolism.
REFERENCE   2  (bases 1 to 6183)
  AUTHORS   Deng,X., Ma,J., Zhou,W., Yuan,Y., Wang,B. and Meng,X.
  TITLE     GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer Growth
            and Apoptosis
  JOURNAL   Lab Invest 103 (6), 100122 (2023)
   PUBMED   36828188
  REMARK    GeneRIF: GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer
            Growth and Apoptosis.
REFERENCE   3  (bases 1 to 6183)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6183)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6183)
  AUTHORS   Li,J., Chen,Y., Qin,X., Wen,J., Ding,H., Xia,W., Li,S., Su,X.,
            Wang,W., Li,H., Zhao,Q., Fang,T., Qu,L. and Shao,N.
  TITLE     MiR-138 downregulates miRNA processing in HeLa cells by targeting
            RMND5A and decreasing Exportin-5 stability
  JOURNAL   Nucleic Acids Res 42 (1), 458-474 (2014)
   PUBMED   24057215
  REMARK    GeneRIF: The study identifies a miR-138-RMND5A-Exportin-5 as a
            previously unknown miRNA processing regulatory pathway in HeLa
            cells.
REFERENCE   7  (bases 1 to 6183)
  AUTHORS   Vogel,T.W., Manjila,S. and Cohen,A.R.
  TITLE     Novel neurodevelopmental disorder in the case of a giant
            occipitoparietal meningoencephalocele
  JOURNAL   J Neurosurg Pediatr 10 (1), 25-29 (2012)
   PUBMED   22681319
  REMARK    GeneRIF: Duplications of this region involving RMND5A, whose
            product contains a C-terminal to lis homology (LisH) domain, have
            not previously been associated with a defined phenotype but may
            present insight into encephalocele formation.
REFERENCE   8  (bases 1 to 6183)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
  REMARK    GeneRIF: RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and
            p44CTLH form complexes in cells.
REFERENCE   9  (bases 1 to 6183)
  AUTHORS   Bowzard,J.B., Cheng,D., Peng,J. and Kahn,R.A.
  TITLE     ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs
  JOURNAL   J Biol Chem 282 (24), 17568-17580 (2007)
   PUBMED   17452337
REFERENCE   10 (bases 1 to 6183)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK023972.1, BC047668.1, BC012165.1, AC064848.5 and BU620245.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022780.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.90910.1,
                                           SRR1660805.158266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283632.5/ ENSP00000283632.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AK023972.1         1-369
            370-797             BC047668.1         300-727
            798-3247            BC012165.1         519-2968
            3248-5546           AC064848.5         30938-33236         c
            5547-6183           BU620245.1         19-655              c
FEATURES             Location/Qualifiers
     source          1..6183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..6183
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="required for meiotic nuclear division 5 homolog A"
                     /db_xref="GeneID:64795"
                     /db_xref="HGNC:HGNC:25850"
                     /db_xref="MIM:618964"
     exon            1..519
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1553
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /EC_number="2.3.2.27"
                     /note="C-terminal to LisH motif, 44 kDa; protein RMD5
                     homolog A; GID complex subunit 2 homolog A; 44-kD protein
                     coding for CTLH motif"
                     /codon_start=1
                     /product="E3 ubiquitin-protein transferase RMND5A"
                     /protein_id="NP_073617.1"
                     /db_xref="CCDS:CCDS1991.1"
                     /db_xref="GeneID:64795"
                     /db_xref="HGNC:HGNC:25850"
                     /db_xref="MIM:618964"
                     /translation="MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEIL
                     QSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDIS
                     SVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRI
                     LEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAK
                     NFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGL
                     SVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIF
                     ACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF"
     exon            520..662
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            663..797
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            798..898
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1065
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1231
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1334
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1489
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..6183
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="hexamer: AATAAA"
     polyA_site      2345
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="major polyA site"
     regulatory      5925..5930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="hexamer: AATAAA"
     polyA_site      5946
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="major polyA site"
     regulatory      6067..6072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="hexamer: AATAGA"
     polyA_site      6093
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
     regulatory      6161..6166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
                     /note="hexamer: AAGAAA"
     polyA_site      6183
                     /gene="RMND5A"
                     /gene_synonym="CTLH; GID2; GID2A; p44CTLH; RMD5"
ORIGIN      
        1 ctccccccag tcggcggcgc ttggtgccgc ccgggagaac caggtcatcg gtcggttccc
       61 gtgaaaacaa aaacaatcgg ccgcgccgtc gcaggcaccc gaacgtcgcg agcggggcct
      121 ggggacgcgg agccgagtgc agcgagcgaa cgggagcagc ggcgactcgc cggggggcta
      181 gggcgccatg gggcaggcgg gctccggctg cgcggggctc ccccggcgcc gcggctagtg
      241 cgcccgccgc ctcggccgcc tcagcctccc gcgccgcccg cttggggaac gaggagcagg
      301 acgcggcctc ggtggggccc gggccgaacg gctgcggaca cctgggcgcc gaggagccga
      361 gcgccgccgc ctccggcatg gatcagtgcg tgacggtgga gcgcgagctg gagaaggtgc
      421 tgcacaagtt ctcaggctac gggcagctgt gcgagcgcgg cctggaggag ctcatcgact
      481 acaccggcgg cctcaagcac gagatcctgc agagccacgg ccaagatgct gaattatcag
      541 ggacactttc acttgttttg acacagtgct gtaaaagaat aaaggatact gttcaaaaat
      601 tggcctccga ccacaaagac atccacagca gtgtttctcg ggttggaaaa gccattgata
      661 agaattttga ttctgacatt agcagtgtgg gaatagatgg ctgctggcag gcagacagcc
      721 aaaggcttct caatgaggtg atggtggagc acttctttcg acaaggaatg ctggatgtgg
      781 ctgaggagct ctgtcaggaa tctggtcttt ctgtagaccc aagtcagaag gaaccatttg
      841 tggagttaaa tagaatatta gaggcattaa aggtcagagt tctgagacct gctctggagt
      901 gggcagtgtc aaaccgggaa atgcttatag ctcaaaacag ctccttggaa tttaagctac
      961 acagactgta ttttattagc ttgttaatgg gtggaaccac aaatcagcga gaggcattac
     1021 aatatgctaa aaattttcag ccatttgccc taaatcatca aaaagacatt caggttttga
     1081 tgggaagcct tgtgtacctg agacaaggga ttgagaactc accatatgtt cacctacttg
     1141 atgcaaacca gtgggctgat atctgtgaca tctttacacg ggatgcttgt gccctcctgg
     1201 ggctctccgt ggagtcccct ctcagtgtca gtttctcagc aggttgtgtg gcgctgccag
     1261 ctttaattaa catcaaagcc gtgattgaac agaggcagtg tactggagtt tggaaccaga
     1321 aagatgaatt acctattgaa gtggaccttg gtaaaaagtg ctggtatcac tctatatttg
     1381 cctgccccat tcttcgtcag caaacaacag ataacaatcc acccatgaaa ttggtctgtg
     1441 gtcatattat atcaagagat gccctgaata aaatgtttaa tggtagcaaa ttaaaatgtc
     1501 cctactgtcc aatggaacaa agtccaggag atgccaaaca gatatttttc tgaagagata
     1561 actttagttt gcaatttgta agtgaaactg aatcgtgggt gcatttcaga agagaacgtt
     1621 ccatataatg cagctaacca aggactcctg tgtttctata agctaatgct ccagaaactt
     1681 tgccaacctg ttagtgtaca cacactgagg ggagtgctcc cggtgaatat tatcataggg
     1741 ctttattata ttcttggtct tcatttctga tcaagtaaat acaccagcag ttgtcattca
     1801 atgcaggttt ttgtacttaa ttatatggtg atttttttac tttttaagag cagaaacgga
     1861 aattgacctc cccgccatgt gtttaatatt cctcctgctt ttacttttgt cattttcttg
     1921 ataatcgtaa gccttgagag tgtttgtgaa aaagttttat ttcctgttat gtatacataa
     1981 ttaaatgaaa attcttcaga aaaagtttga taaattgaat tgtggttatg aaactaattt
     2041 gcatttttat ttgcttaaga aagaaagctg tgatagattc cagatatgct ttttgatgtt
     2101 ttcctctgct ccagctccaa gaagtcagca cacctgcatt ttagctctgc atgcagcccc
     2161 agcaggctgc gtgtttaaga atttcattgt ttaactggct ggtgtgagaa gtcttccgtt
     2221 agcatagagt ggaaggagta ctattgtttg gttgggtttt tgtttgtttg ttttttgttt
     2281 ttgcttttat tgccaagagg tgcttgtttt aaaagtatgt ttaataaaat gaaattctaa
     2341 agttagaagt gttcttaagt tgatatttac tctcttggtc ttggtagccc tattatatca
     2401 ttgcagacac agtgttgtgc atgtgtgtat tgtatatgtg caccagcatc aaacattgtg
     2461 tatctggaag gaaagcagca tgttccagtt ctaaaatgca gttaccagac ccatcacttt
     2521 aaatccttaa agttagaagc tagcaaattt tctgtagtgc agaacgttta ttgctgtttt
     2581 tgtgtttgaa tagtataatg tttgatgcct ctcttctgca aagcgtatca tctcattgac
     2641 tgtgaatctg tatattattc tgatggatac agataatgat cttttctctt gtgaggtatc
     2701 ttcatttatg cactgtccaa aaatagccat gtgtaagagt ctttctgtat gacgaactac
     2761 atggaaaaga cttctgtgga cataattctg accgaaaccc atgaagttac ttcagtataa
     2821 gaagaacgtt acacggaaat caccaaatat tttgcaactt tatttcttct gacatggagt
     2881 gaacatcaat aggaatactt tcaaagaaaa tgaaaacaca gaagcaaaga gaaatgtggc
     2941 acttcacatt ttaaactaca gatggacttg gtttgaggga gggggaatca cagatttggt
     3001 gctaagttaa ttagaaactg gcagcgtttt acagtagtac accagcctgg atgttttttc
     3061 taaaatgttt acctgggaga gctggggttt gtttgtgagg agaaagagta ctgtggaaaa
     3121 cctctgcttg agtaccatgt ggccaggcct atgtggatgg ctactccgtg ctgtgcggct
     3181 tcaccagcgg ttgggattgg cccagcttgg agtgcttgtg tggtccaacc tcagtctggc
     3241 cccatagcga cttttgcccc atgattctgc ttcactgttg gaatcctctt tgaagttccc
     3301 cctctctttg ctaaagcagt gaaggaagag aacagagaca aactctttgg actgtgaaag
     3361 agaaggtaga gaattccagg caacagtctg accaagggtg taaaccagtt tattatatat
     3421 atatttttcc tttgaattaa aacctagagt gttgtatttt tctttctttc tttttttttt
     3481 tttttttttt tacccttttt ctccttaggc caagtttagc ttattcttat ctttccaccc
     3541 aaacacctac acaacgttta ggcttcctgt aaggtttgaa tgagacagat gtactctgaa
     3601 ggctggtggt aaatgtgttt gatgaccaga ctcttcatac agtcggcttg ggccacttta
     3661 aaggacaaaa gccagagctc agctttatcc ctctcccagt gctgggagcc aaaaaactgt
     3721 tgacggtttt ttgtgcagct caagaaaact ttgaaaagaa catgctttaa ctgaagcatt
     3781 ggactctgca gctttctgtg taaggcccgt gtactcccac tgggcagggt gaggaccaaa
     3841 aatctgaaac tcttatgaat ctgacatatt atatggaaat tatatcttgt gaccgtcttc
     3901 aagtgcatgg acttaaaatt catgagagac taaatgtgag ggagaggtgg atttaaagag
     3961 gccagacctt aaccaaagat gctgagatac agcattctgt cccccctgcc ctagaaactc
     4021 cataaatgct gtcacaaccc tatcatcgct gatgctttct gcatgtcagc agtccaggag
     4081 gatgcttttt gtctctcttt gcctccactt tacaaaagat aatatgatag aggcaacgtt
     4141 tataacagtc acatttaatt ataatgtaca tcaaaggcag aatttcagaa tggtttctta
     4201 aatttccttg ggaaccgttt ccacatatca gttatagaca aaggccatgg gactatgcta
     4261 aaccaataaa accttattag caaatcttta gattctgact tagccagagc atctgagtgt
     4321 tcaagtacag ttttacagtg gctaaggttg tctcttgatc ttttttctcc gttgtgtgat
     4381 cacagatgct atttctgttt tattggtgat tatacgagac ttctaataca taaatgaacg
     4441 ggtattggtg cctctttatt ttaaaaaatt tgaagaaaag agccacctca tattcatagg
     4501 gtgtgtattt tttgagtgtg agcatttaat tgaaaataag aaagctatga agtaaatgtt
     4561 aacttctctg tagcagctaa tgcatagaga cactaaaacc cacaccacat tttgtgggaa
     4621 atgaggatcc tgatcctctt ttgtcctctc caggtagtct cgcaggttat gcagcttaag
     4681 ttcagtcttc tttatgctgc gattgatttc cacctcagtg gcttagcctt tgggacagtg
     4741 gatactgcaa cagccaagaa ctcttggtta tccgcacaag ctgctggtag actacattag
     4801 ccctctggtt ttccagctca acctctgata aagtggactg agagccacgc tgctcagtct
     4861 gtttcgtcag ccgactcagg ttattttcag ggaaggcatg gaggcatagt ttggttagtt
     4921 tcatcactag gatgtataag gtgacgacac aaaccaaata cctttctttc atcacttaac
     4981 tatacgtact ttatctctgg taacactaga atgctgtggt cttgagggaa tgttagcaag
     5041 gaacacatag aagatttggt gtttcataag cctgtctagg tgtggcaggt tttgtgtggt
     5101 acactgatgt ttaccataag caggtacaag cttcatgaac cgttcttaat gaactataat
     5161 tgaatagata ccaaaaatag aatgacaaat gtattttaat agcagatgag gcagttttag
     5221 gatgaatttt ccactgttga ttttacttca agacatagca agagaaacaa aattttgttt
     5281 tcaagacatt tccactgcag tttcaagctg tagtgggcat atgcttcatt tacttccaaa
     5341 gaggcaaaag cagctggaat tggcttacag cacatgcttt gtttcatgtt atgggtgagg
     5401 acctacatac actcttactt tagcagtcac ttaaccttct ccagcaaggc agttgtgggg
     5461 ttcactagga tttagtgcct gatctttttt ttgggaaggg gcgggaatga atgtgttggg
     5521 gctgggaggg aagcagaaga aaatgggagt gtgagtgagt gtgcatgtgt ctgaagttca
     5581 ccattgcccc cacctgcacc tagcaaggaa caggtgtttg atgtattttg ctcatgactg
     5641 cagtatgcat gtattttttt ccttctctgt gttttctaaa cttacactaa aggattcatc
     5701 aaatcatctt gttcagatgg ctcaggattg tatttatttt gcttaccccg tgctcttggg
     5761 ttctatagta tttctataat tatgtaacga gaatagtgtt gcactgtaat ctatcatata
     5821 gagctatatg tatggaaaat tttgatcaat tttttaagaa atgtatcctg tttgcaaagg
     5881 cacagtaaag ttgcatctta tagactatag gcaataaagc taacaataaa ccttatttaa
     5941 cacaaaccac atccatatcc tctgttcatt tgattttgga aaaagtagca tatccagtag
     6001 tttcagggaa ttcattttaa ctttaagaat tctgatatat ttaatttata aatttcggac
     6061 tgatataata gagttttgga aaactataag aaatgctttg ttaatgtgtg tattcctatg
     6121 taaaacacat ggcttttcct gtgtatattt ttaaaaatta aagaaatgca catttaaaaa
     6181 gtg
//
