LOCUS       NM_152308               1427 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RecQ mediated genome instability 2 (RMI2), transcript
            variant 1, mRNA.
ACCESSION   NM_152308
VERSION     NM_152308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Tsai,H.W., Cheng,S.W., Chen,C.C., Chen,I.W. and Ho,C.L.
  TITLE     A combined bioinformatics and experimental approach identifies RMI2
            as a Wnt/beta-catenin signaling target gene related to
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 23 (1), 1025 (2023)
   PUBMED   37875822
  REMARK    GeneRIF: A combined bioinformatics and experimental approach
            identifies RMI2 as a Wnt/beta-catenin signaling target gene related
            to hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Soniat,M.M., Nguyen,G., Kuo,H.C. and Finkelstein,I.J.
  TITLE     The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA
            resection motor proteins
  JOURNAL   J Biol Chem 299 (2), 102802 (2023)
   PUBMED   36529288
  REMARK    GeneRIF: The MRN complex and topoisomerase IIIa-RMI1/2 synchronize
            DNA resection motor proteins.
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Wei,W., Ying,X., Chen,L., Sun,Q., Lu,X., Xia,Y., Xu,R., Zhu,Z.,
            Zhang,D., Tang,Q., Li,L., Xie,J. and Yu,H.
  TITLE     RecQ mediated genome instability 2 (RMI2): a potential prognostic
            and immunological biomarker for pan-cancers
  JOURNAL   Aging (Albany NY) 14 (9), 4107-4136 (2022)
   PUBMED   35552266
  REMARK    GeneRIF: RecQ mediated genome instability 2 (RMI2): a potential
            prognostic and immunological biomarker for pan-cancers.
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Harami,G.M., Palinkas,J., Seol,Y., Kovacs,Z.J., Gyimesi,M.,
            Harami-Papp,H., Neuman,K.C. and Kovacs,M.
  TITLE     The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's
            syndrome helicase for efficient disruption of D-loops
  JOURNAL   Nat Commun 13 (1), 654 (2022)
   PUBMED   35115525
  REMARK    GeneRIF: The toposiomerase IIIalpha-RMI1-RMI2 complex orients human
            Bloom's syndrome helicase for efficient disruption of D-loops.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Bakx,J.A.M., Biebricher,A.S., King,G.A., Christodoulis,P.,
            Sarlos,K., Bizard,A.H., Hickson,I.D., Wuite,G.J.L. and
            Peterman,E.J.G.
  TITLE     Duplex DNA and BLM regulate gate opening by the human
            TopoIIIalpha-RMI1-RMI2 complex
  JOURNAL   Nat Commun 13 (1), 584 (2022)
   PUBMED   35102151
  REMARK    GeneRIF: Duplex DNA and BLM regulate gate opening by the human
            TopoIIIalpha-RMI1-RMI2 complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Xu,D., Muniandy,P., Leo,E., Yin,J., Thangavel,S., Shen,X., Ii,M.,
            Agama,K., Guo,R., Fox,D. 3rd, Meetei,A.R., Wilson,L., Nguyen,H.,
            Weng,N.P., Brill,S.J., Li,L., Vindigni,A., Pommier,Y., Seidman,M.
            and Wang,W.
  TITLE     Rif1 provides a new DNA-binding interface for the Bloom syndrome
            complex to maintain normal replication
  JOURNAL   EMBO J 29 (18), 3140-3155 (2010)
   PUBMED   20711169
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Wang,F., Yang,Y., Singh,T.R., Busygina,V., Guo,R., Wan,K., Wang,W.,
            Sung,P., Meetei,A.R. and Lei,M.
  TITLE     Crystal structures of RMI1 and RMI2, two OB-fold regulatory
            subunits of the BLM complex
  JOURNAL   Structure 18 (9), 1159-1170 (2010)
   PUBMED   20826342
  REMARK    GeneRIF: Crystal structures of RMI1 and RMI2, two OB-fold
            regulatory subunits of the BLM complex
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Hoadley,K.A., Xu,D., Xue,Y., Satyshur,K.A., Wang,W. and Keck,J.L.
  TITLE     Structure and cellular roles of the RMI core complex from the bloom
            syndrome dissolvasome
  JOURNAL   Structure 18 (9), 1149-1158 (2010)
   PUBMED   20826341
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Singh,T.R., Ali,A.M., Busygina,V., Raynard,S., Fan,Q., Du,C.H.,
            Andreassen,P.R., Sung,P. and Meetei,A.R.
  TITLE     BLAP18/RMI2, a novel OB-fold-containing protein, is an essential
            component of the Bloom helicase-double Holliday junction
            dissolvasome
  JOURNAL   Genes Dev 22 (20), 2856-2868 (2008)
   PUBMED   18923083
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   Xu,D., Guo,R., Sobeck,A., Bachrati,C.Z., Yang,J., Enomoto,T.,
            Brown,G.W., Hoatlin,M.E., Hickson,I.D. and Wang,W.
  TITLE     RMI, a new OB-fold complex essential for Bloom syndrome protein to
            maintain genome stability
  JOURNAL   Genes Dev 22 (20), 2843-2855 (2008)
   PUBMED   18923082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022427.1, BC039361.1 and AK123764.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152308.2.
            
            Summary: RMI2 is a component of the BLM (RECQL3; MIM 604610)
            complex, which plays a role in homologous recombination-dependent
            DNA repair and is essential for genome stability (Xu et al., 2008
            [PubMed 18923082]).[supplied by OMIM, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.135542.1, AK123764.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312499.6/ ENSP00000310356.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-849               BC022427.1         6-854
            850-1422            BC039361.1         1293-1865
            1423-1427           AK123764.1         1433-1437
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..1427
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /note="RecQ mediated genome instability 2"
                     /db_xref="GeneID:116028"
                     /db_xref="HGNC:HGNC:28349"
                     /db_xref="MIM:612426"
     exon            1..308
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..457
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /note="BLM-associated protein of 18 kDa; RMI2, RecQ
                     mediated genome instability 2, homolog"
                     /codon_start=1
                     /product="recQ-mediated genome instability protein 2"
                     /protein_id="NP_689521.1"
                     /db_xref="CCDS:CCDS10548.1"
                     /db_xref="GeneID:116028"
                     /db_xref="HGNC:HGNC:28349"
                     /db_xref="MIM:612426"
                     /translation="MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLS
                     RAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYV
                     MVMGVVQACSPEPCLQAVKMTDLSDNPIHESMWELEVEDLHRNIP"
     exon            309..1427
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /note="hexamer: AATAAA"
     polyA_site      1427
                     /gene="RMI2"
                     /gene_synonym="BLAP18; C16orf75"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgaggc ggaatggcgg cggctgcgga ctcgttctca ggcggccccg cgggggtgcg
       61 gcttccgagg tcgccgccac tcaaggtgct ggcggagcag ctgcggcgcg acgcggaggg
      121 cggcccgggc gcgtggcggc tgtcacgggc ggcggcgggc cgcgggccgc tggacctggc
      181 ggccgtgtgg atgcagggca gggtagtgat ggcggaccgc ggcgaggctc ggctgaggga
      241 cccgagcggg gacttctcgg tccgcggcct ggagcgggtg ccgcgcgggc ggccctgtct
      301 agtcccagga aagtatgtga tggtgatggg agtggttcag gcctgcagcc ctgagccctg
      361 cctgcaggct gtgaagatga cagacctttc tgataatccc atccatgaaa gtatgtggga
      421 actggaggta gaagatttac acaggaatat tccttagagt atgttggaac tgtcgttaaa
      481 aacaaccaaa atcccgaaac tatttagaag cttataatga tgtggatttc atggacactt
      541 ttcaatgcgt atttttcaaa tgcttctcag agagccttgc tttggttgac caaggagtcc
      601 ggatgtagga atgtttaaat cctcggatac ttcagtgaca cagcctctgc tgccccttgc
      661 tttgcctgtg tttgctgatg aaaagcagat gcttgtgttt cattttcctt cctggtttgt
      721 gtgtgttaat tctctctctc tctctcagac acagaagtct catgttgcat tttccaaatt
      781 ttatgagtga tgatactttt tccattactg ctgcgtccct gttttacaat gcaaaattta
      841 agtacggtcg ttgcccatgg tgattaaagt gtggttatgg gcaggaagac agactgtgta
      901 aaaaaggaat gacatcctgg ctcctcatct tcttcatcag caactaccat aaccagtttg
      961 cgagtcaaat ggcatttcct aacggcaggc atggcggccc ctgaaagaca acagctccct
     1021 ttctgcttcg gacaccactc aaacatttag acgcagctct atcccttttc ctagctagag
     1081 aaggtgatgc cttcttccat tactcagaga tgttgagacg ttttcagaat ttcttgttga
     1141 aatgaaaaac atcaagataa aggacgcctt tcaggcatta gctaaacttc cacttcataa
     1201 ctttcggcga gacatggtga gcctcctggt gtagagttct tttgtctttg tatggaatga
     1261 ctttttgctg tgatggtttt gaatgttggg tttctgctgt ctgcttagta cccatgcctg
     1321 aattttttga gattgtaaat atcaaaggag ttagattgtg ttctgacatg gttgtagact
     1381 ttcacctgga ttattgatat tctacctcta ataaattttt aataggc
//
