LOCUS       NM_018145               2246 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens regulator of microtubule dynamics 3 (RMDN3),
            transcript variant 1, mRNA.
ACCESSION   NM_018145
VERSION     NM_018145.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Markovinovic,A., Martin-Guerrero,S.M., Morotz,G.M., Salam,S.,
            Gomez-Suaga,P., Paillusson,S., Greig,J., Lee,Y., Mitchell,J.C.,
            Noble,W. and Miller,C.C.J.
  TITLE     Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS
            mutant TDP43 linked Ca2+ and synaptic defects
  JOURNAL   Acta Neuropathol Commun 12 (1), 32 (2024)
   PUBMED   38395965
  REMARK    GeneRIF: Stimulating VAPB-PTPIP51 ER-mitochondria tethering
            corrects FTD/ALS mutant TDP43 linked Ca[2+] and synaptic defects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   He,M., Wang,X., Chen,W., Zhang,J., Xiong,Y., Cao,L., Zhang,L.,
            Zhao,N., Yang,Y. and Wang,L.
  TITLE     PTPIP51 inhibits non-small-cell lung cancer by promoting
            PTEN-mediated EGFR degradation
  JOURNAL   Life Sci 297, 120293 (2022)
   PUBMED   35240162
  REMARK    GeneRIF: PTPIP51 inhibits non-small-cell lung cancer by promoting
            PTEN-mediated EGFR degradation.
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Oishi,K., Okano,H. and Sawa,H.
  TITLE     RMD-1, a novel microtubule-associated protein, functions in
            chromosome segregation in Caenorhabditis elegans
  JOURNAL   J Cell Biol 179 (6), 1149-1162 (2007)
   PUBMED   18070910
  REMARK    Erratum:[J Cell Biol. 2009 Aug 24;186(4):629]
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Lv,B.F., Yu,C.F., Chen,Y.Y., Lu,Y., Guo,J.H., Song,Q.S., Ma,D.L.,
            Shi,T.P. and Wang,L.
  TITLE     Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a
            novel mitochondria protein with an N-terminal mitochondrial
            targeting sequence and induces apoptosis
  JOURNAL   Apoptosis 11 (9), 1489-1501 (2006)
   PUBMED   16820967
  REMARK    GeneRIF: PTPIP51 is a mitochondrial protein with apoptosis-inducing
            function and that the N-terminal TM domain is required for both the
            correct targeting of the protein to mitochondria and its apoptotic
            functions.
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Stenzinger,A., Kajosch,T., Tag,C., Porsche,A., Welte,I.,
            Hofer,H.W., Steger,K. and Wimmer,M.
  TITLE     The novel protein PTPIP51 exhibits tissue- and cell-specific
            expression
  JOURNAL   Histochem Cell Biol 123 (1), 19-28 (2005)
   PUBMED   15609043
  REMARK    GeneRIF: PTPIP51 might be involved in the regulation of cellular
            processes associated with differentiation, movement, or
            cytoskeletal organization
REFERENCE   9  (bases 1 to 2246)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   10 (bases 1 to 2246)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA280017.1 and BC063844.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018145.2.
            
            Transcript Variant: This variant (1) represents transcript variant
            1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.507336.1, AK001441.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338376.8/ ENSP00000342493.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA280017.1         55-84
            31-2246             BC063844.1         1-2216
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2246
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /note="regulator of microtubule dynamics 3"
                     /db_xref="GeneID:55177"
                     /db_xref="HGNC:HGNC:25550"
                     /db_xref="MIM:611873"
     exon            1..172
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            173..366
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1592
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     family with sequence similarity 82, member C;
                     microtubule-associated protein; family with sequence
                     similarity 82, member A2; regulator of microtubule
                     dynamics protein 3; cerebral protein 10; TCPTP-interacting
                     protein 51; protein tyrosine phosphatase-interacting
                     protein 51"
                     /codon_start=1
                     /product="regulator of microtubule dynamics protein 3
                     isoform 1"
                     /protein_id="NP_060615.1"
                     /db_xref="CCDS:CCDS10063.1"
                     /db_xref="GeneID:55177"
                     /db_xref="HGNC:HGNC:25550"
                     /db_xref="MIM:611873"
                     /translation="MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRS
                     QSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLV
                     ALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFT
                     ASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEE
                     AASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDF
                     LWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAE
                     HESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLE
                     SPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDV
                     TKEDLAIQKDLEELEVILRD"
     exon            367..559
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..703
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..986
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1089
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1150
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1226
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1304
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1403
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1457
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1538
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2246
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /note="hexamer: AATAAA"
     polyA_site      2246
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /note="major polyA site"
ORIGIN      
        1 acggtcactg acagcgtgag cccgcggcgg ctgctgccat ggtggctggc ggccgggtaa
       61 gggtctgagt ggatctcctg ccaggccaga gcgccttcgg gggccgcggc ggaaggccag
      121 gagtttgcag ccagggcgcc gggtttgtgg tctgcagtgt cgtgaggctg aggtgcagca
      181 tgtctagact gggagccctg ggtggtgccc gtgccgggct gggactgttg ctgggtaccg
      241 ccgccggcct tggattcctg tgcctccttt acagccagcg atggaaacgg acccagcgtc
      301 atggccgcag ccagagcctg cccaactccc tggactatac gcagacttca gatcccggac
      361 gccacgtgat gctcctgcgg gctgtcccag gtggggctgg agatgcctca gtgctgccca
      421 gccttccacg ggaaggacag gagaaggtgc tggaccgcct ggactttgtg ctgaccagcc
      481 ttgtggcgct gcggcgggag gtggaggagc tgagaagcag cctgcgaggg cttgcggggg
      541 agattgttgg ggaggtccga tgccacatgg aagagaacca gagagtggct cggcggcgaa
      601 ggtttccgtt tgtccgggag aggagtgact ccactggctc cagctctgtc tacttcacgg
      661 cctcctcggg agccacgttc acagatgctg agagtgaagg gggttacaca acagccaatg
      721 cggagtctga caatgagcgg gactctgaca aagaaagtga ggacggggaa gatgaagtga
      781 gctgtgagac tgtgaagatg gggagaaagg attctcttga cttggaggaa gaggcagctt
      841 caggtgcctc cagtgccctg gaggctggag gttcctcagg cttggaggat gtgctgcccc
      901 tcctgcagca ggccgacgag ctgcacaggg gtgatgagca aggcaagcgg gagggcttcc
      961 agctgctgct caacaacaag ctggtgtatg gaagccggca ggactttctc tggcgcctgg
     1021 cccgagccta cagtgacatg tgtgagctca ctgaggaggt gagcgagaag aagtcatatg
     1081 ccctagatgg aaaagaagaa gcagaggctg ctctggagaa gggggatgag agtgctgact
     1141 gtcacctgtg gtatgcggtg ctttgtggtc agctggctga gcatgagagc atccagaggc
     1201 gcatccagag tggctttagc ttcaaggagc atgtggacaa agccattgct ctccagccag
     1261 aaaaccccat ggctcacttt cttcttggca ggtggtgcta tcaggtctct cacctgagct
     1321 ggctagaaaa aaaaactgct acagccttgc ttgaaagccc tctcagtgcc actgtggaag
     1381 atgccctcca gagcttccta aaggctgaag aactacagcc aggattttcc aaagcaggaa
     1441 gggtatatat ttccaagtgc tacagagaac tagggaaaaa ctctgaagct agatggtgga
     1501 tgaagttggc cctggagctg ccagatgtca cgaaggagga tttggctatc cagaaggacc
     1561 tggaagaact ggaagtcatt ttacgagact aaccacgttt cactggcctt catgacttga
     1621 tgccactatt taaggtgggg gggcggggag gcttttttcc ttagaccttg ctgagatcag
     1681 gaaaccacac aaatctgtct cctgggtctg actgctaccc actaccactc cccattagtt
     1741 aatttattct aacctctaac ctaatctaga attggggcag tactcatggc ttccgtttct
     1801 gttgttctct cccttgagta atctcttaaa aaaatcaaga ttcacacctg ccccaggatt
     1861 acacatgggt agagcctgca agacctgaga ccttccaatt gctggtgagg tggatgaact
     1921 tcaaagctat aggaacaaag cacataactt gtcactttaa tctttttcac tgactaatag
     1981 gactcagtac atatagtctt aagatcatac cttacctacc aaggtaaaaa gagggatcag
     2041 agtggcccac agacattgct ttcttatcac ctatcatgtg aattctacct gtattcctgg
     2101 gctggaccac ttgataactt ccagtgtcct ggcagctttt ggaatgacag cagtggtatg
     2161 gggtttatga tgctataaaa caatgtctga aaagttgcct agaatatatt ttgttacaaa
     2221 cttgaaataa accaaatttg atgtta
//
