LOCUS       NM_001170791            1893 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens regulator of microtubule dynamics 2 (RMDN2),
            transcript variant 2, mRNA.
ACCESSION   NM_001170791
VERSION     NM_001170791.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Nho,K., Risacher,S.L., Apostolova,L.G., Bice,P.J., Brosch,J.R.,
            Deardorff,R., Faber,K., Farlow,M.R., Foroud,T., Gao,S.,
            Rosewood,T., Kim,J.P., Nudelman,K., Yu,M., Aisen,P., Sperling,R.,
            Hooli,B., Shcherbinin,S., Svaldi,D., Jack,C.R. Jr., Jagust,W.J.,
            Landau,S., Vasanthakumar,A., Waring,J.F., Dore,V., Laws,S.M.,
            Masters,C.L., Porter,T., Rowe,C.C., Villemagne,V.L., Dumitrescu,L.,
            Hohman,T.J., Libby,J.B., Mormino,E., Buckley,R.F., Johnson,K.,
            Yang,H.S., Petersen,R.C., Ramanan,V.K., Ertekin-Taner,N.,
            Vemuri,P., Cohen,A.D., Fan,K.H., Kamboh,M.I., Lopez,O.L.,
            Bennett,D.A., Ali,M., Benzinger,T., Cruchaga,C., Hobbs,D., De
            Jager,P.L., Fujita,M., Jadhav,V., Lamb,B.T., Tsai,A.P.,
            Castanho,I., Mill,J., Weiner,M.W. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative (ADNI); Department of
            Defense Alzheimer's Disease Neuroimaging Initiative (DoD-ADNI);
            Anti-Amyloid Treatment in Asymptomatic Alzheimer's Study (A4 Study)
            and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration
            (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL)
  TITLE     CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for
            cerebral tau PET
  JOURNAL   Nat Commun 15 (1), 8251 (2024)
   PUBMED   39304655
  REMARK    GeneRIF: CYP1B1-RMDN2 Alzheimer's disease endophenotype locus
            identified for cerebral tau PET.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Di Mattia,T., Martinet,A., Ikhlef,S., McEwen,A.G., Nomine,Y.,
            Wendling,C., Poussin-Courmontagne,P., Voilquin,L., Eberling,P.,
            Ruffenach,F., Cavarelli,J., Slee,J., Levine,T.P., Drin,G.,
            Tomasetto,C. and Alpy,F.
  TITLE     FFAT motif phosphorylation controls formation and lipid transfer
            function of inter-organelle contacts
  JOURNAL   EMBO J 39 (23), e104369 (2020)
   PUBMED   33124732
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Oishi,K., Okano,H. and Sawa,H.
  TITLE     RMD-1, a novel microtubule-associated protein, functions in
            chromosome segregation in Caenorhabditis elegans
  JOURNAL   J Cell Biol 179 (6), 1149-1162 (2007)
   PUBMED   18070910
  REMARK    Erratum:[J Cell Biol. 2009 Aug 24;186(4):629]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016689.4, AY358269.1, BC024243.2 and BQ017142.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001170791.2.
            
            Transcript Variant: This variant (2) differs in both UTRs and in
            the 5' and 3' coding regions, compared to variant 1. The encoded
            isoform (2) has distinct N- and C-termini and is shorter than
            isoform 1.  Both variants 2 and 3 encode the same isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.181969.1,
                                           SRR3476690.225567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354545.8/ ENSP00000346549.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC016689.4         127028-127059       c
            33-1048             AY358269.1         1-1016
            1049-1049           AC016689.4         61100-61100         c
            1050-1413           AY358269.1         1018-1381
            1414-1890           BC024243.2         1455-1931
            1891-1893           BQ017142.1         21-23               c
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..1893
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="regulator of microtubule dynamics 2"
                     /db_xref="GeneID:151393"
                     /db_xref="HGNC:HGNC:26567"
                     /db_xref="MIM:611872"
     exon            1..139
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            140..607
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1388
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     family with sequence similarity 82, member A; regulator of
                     microtubule dynamics protein 2; microtubule-associated
                     protein; family with sequence similarity 82, member A1"
                     /codon_start=1
                     /product="regulator of microtubule dynamics protein 2
                     isoform 2"
                     /protein_id="NP_001164262.1"
                     /db_xref="CCDS:CCDS54351.1"
                     /db_xref="GeneID:151393"
                     /db_xref="HGNC:HGNC:26567"
                     /db_xref="MIM:611872"
                     /translation="MPYSTNKELILGIMVGTAGISLLLLWYHKVRKPGIAMKLPEFLS
                     LGNTFNSITLQDEIHDDQGTTVIFQERQLQILEKLNELLTNMEELKEEIRFLKEAIPK
                     LEEYIQDELGGKITVHKISPQHRARKRRLPTIQSSATSNSSEEAESEGGYITANTDTE
                     EQSFPVPKAFNTRVEELNLDVLLQKVDHLRMSESGKSESFELLRDHKEKFRDEIEFMW
                     RFARAYGDMYELSTNTQEKKHYANIGKTLSERAINRAPMNGHCHLWYAVLCGYVSEFE
                     GLQNKINYGHLFKEHLDIAIKLLPEEPFLYYLKGRYCYTVSKLSWIEKKMAATLFGKI
                     PSSTVQEALHNFLKAEELCPGYSNPNYMYLAKCYTDLEENQNALKFCNLALLLPTVTK
                     EDKEAQKEMQKIMTSLKR"
     exon            608..782
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..885
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            886..946
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1022
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1100
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1199
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1253
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1334
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1893
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="major polyA site"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="hexamer: AATAAA"
     polyA_site      1893
                     /gene="RMDN2"
                     /gene_synonym="BLOCK18; FAM82A; FAM82A1; PRO34163;
                     PYST9371; RMD-2; RMD2; RMD4"
                     /note="major polyA site"
ORIGIN      
        1 atctgggtca ggacgcgacg gccgcggcgc gggaccttag gacccgcggg ctccagggct
       61 actgtccgtc cgccactgcg cgccagcagg tcctggtctc cgctctccaa cagctgaaag
      121 gccggcgcag tgaacacaga aacgaaaacc aagaaatgcc ttattccaca aacaaagagt
      181 tgatacttgg catcatggtg ggcactgctg gaatcagctt gctgctcttg tggtaccaca
      241 aggtccgtaa accagggata gcaatgaagt tacctgaatt tctttctctg ggtaatacat
      301 ttaattcaat aactttgcaa gatgaaatac atgatgacca aggaacaaca gtaatctttc
      361 aagaaaggca acttcagata ctggagaagt taaacgaatt actgacaaat atggaagaac
      421 tcaaagagga aatcagattt cttaaagaag ctattccaaa gctggaggaa tatatacaag
      481 atgaacttgg agggaaaata actgttcata agataagccc tcagcacaga gcgagaaaaa
      541 gaagactccc cacaattcaa agttcagcaa caagtaatag ttcagaggaa gcagaaagtg
      601 aaggagggta tattacagct aatactgaca cagaagaaca gagttttcca gtccctaagg
      661 catttaacac acgtgtagag gaattaaatt tagatgtcct tcttcagaag gtagatcatt
      721 tacgtatgag tgagtctggc aagtcggaga gttttgaact acttcgtgac cacaaagaaa
      781 agtttagaga tgaaatagag tttatgtggc gatttgctcg tgcttatgga gacatgtatg
      841 aactatctac aaacacacaa gaaaagaaac attatgctaa tattggaaaa actttaagtg
      901 aaagagctat taatagagca cccatgaatg gacattgtca tctgtggtat gcagttttgt
      961 gtggctatgt atctgagttt gagggtttac aaaacaaaat caactatggg cacctcttca
     1021 aggaacatct agatatagca atcaaacttt taccagagga accctttcta tattacctca
     1081 aagggagata ctgctatact gtctcaaaac tgagctggat tgagaaaaaa atggctgcta
     1141 ctctgtttgg aaaaatacca tcttcaactg tacaagaagc tttacacaat ttccttaagg
     1201 ctgaagaact atgccctggt tattctaatc ccaattacat gtacttagca aagtgttata
     1261 ctgatcttga ggaaaaccag aatgctttga agttctgtaa tttggcttta ttgcttccta
     1321 ctgttaccaa agaggataaa gaggcacaga aagagatgca aaaaataatg acttccttga
     1381 agaggtaaat aaacgaattt actcttcaac aaatcagatg tggtctacca aaatttaaat
     1441 gaatcaaagt tgtgctttta ttatccttca tttttgatgt aagggtattg tgcttagatt
     1501 tgaaggtaaa gccatgtttc tgcagaatgc attccactag tagcactaca aaattaatta
     1561 tgttatttgg agaatctata tactataatg tcaatacata atctataaac atgtatgctt
     1621 tatatttttc ttatcaataa actgcagcct taagaatatt tctttaaata aaatatttaa
     1681 atccaataaa atgaattctc atgaatattt tattgtttca atggagactt cgtaagacaa
     1741 aataatttca ttaatgtgga tgaaaaatgg aaaactcagc aaaggacatg aacaagttgt
     1801 tggcagaaga ggaaaaacaa acaaatgtag tattgtaact ggtaatcaaa agatgtgaat
     1861 aaaattacaa taaaatactg ttttaccatc aaa
//
