LOCUS       NM_016033               2970 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of microtubule dynamics 1 (RMDN1),
            transcript variant 1, mRNA.
ACCESSION   NM_016033 XM_936333
VERSION     NM_016033.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Oishi,K., Okano,H. and Sawa,H.
  TITLE     RMD-1, a novel microtubule-associated protein, functions in
            chromosome segregation in Caenorhabditis elegans
  JOURNAL   J Cell Biol 179 (6), 1149-1162 (2007)
   PUBMED   18070910
  REMARK    Erratum:[J Cell Biol. 2009 Aug 24;186(4):629]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP234465.1, BP199284.1, AF151848.1 and AC103817.6.
            
            On Nov 23, 2018 this sequence version replaced NM_016033.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000672.1, SRR1660809.183142.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406452.8/ ENSP00000385927.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BP234465.1         95-289
            196-313             BP199284.1         274-391
            314-1210            AF151848.1         320-1216
            1211-2970           AC103817.6         84319-86078
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2970
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /note="regulator of microtubule dynamics 1"
                     /db_xref="GeneID:51115"
                     /db_xref="HGNC:HGNC:24285"
                     /db_xref="MIM:611871"
     exon            1..195
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1011
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule-associated protein; regulator of microtubule
                     dynamics protein 1; family with sequence similarity 82,
                     member B"
                     /codon_start=1
                     /product="regulator of microtubule dynamics protein 1
                     isoform 1"
                     /protein_id="NP_057117.2"
                     /db_xref="CCDS:CCDS34918.1"
                     /db_xref="GeneID:51115"
                     /db_xref="HGNC:HGNC:24285"
                     /db_xref="MIM:611871"
                     /translation="MALAARLWRLLPFRRGAAPGSRLPAGTSGSRGHCGPCRFRGFEV
                     MGNPGTFKRGLLLSALSYLGFETYQVISQAAVVHATAKVEEILEQADYLYESGETEKL
                     YQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVYEALEYAKRALEKNESS
                     FASHKWYAICLSDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTF
                     AEMPWYQRRIAKMLFATPPSSTYEKALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNK
                     KLAAFWLMKAKDYPAHTEEDKQIQTEAAQLLTSFSEKN"
     exon            196..313
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..401
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..561
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..651
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..707
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..795
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..826
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..960
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..2970
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /note="hexamer: AATAAT"
     polyA_site      1210
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /note="hexamer: AATAAA"
     polyA_site      2970
                     /gene="RMDN1"
                     /gene_synonym="CGI-90; FAM82B; RMD-1; RMD1"
                     /note="major polyA site"
ORIGIN      
        1 cctttagccc cgcccgcctc cgtagctgcc tgaagtagtg cagggtcagc ccgcaagttg
       61 caggtcatgg cgctggctgc tcgactgtgg cgccttctgc ctttccgacg tggagccgcc
      121 ccggggtctc gtctccctgc ggggacttcg ggcagccgcg ggcattgcgg cccctgtcga
      181 ttccgcggct tcgaggtaat gggaaaccca ggaactttca aaagaggcct tttactctca
      241 gctttgtcgt atttgggttt tgaaacttac caggttatct ctcaggctgc tgtggttcat
      301 gccacagcca aagttgaaga aatacttgaa caagcagact acctgtatga aagcggagaa
      361 acagaaaaac tttatcagtt gctaacccaa tacaaggaaa gtgaagatgc agagttactg
      421 tggcgtttgg cacgggcatc acgtgatgta gctcagctta gcagaacctc agaagaggag
      481 aaaaagctat tggtgtatga agccctagag tatgcaaaaa gagcactaga aaaaaatgaa
      541 tcaagttttg catctcataa gtggtatgca atctgcctta gtgatgttgg agattatgaa
      601 ggcatcaagg ctaaaattgc aaatgcatat atcatcaagg agcattttga gaaagcaatt
      661 gaactgaacc ctaaagatgc tacttcaatt caccttatgg gtatttggtg ctatacattt
      721 gccgaaatgc cttggtatca aagaagaatt gctaaaatgc tgtttgcaac tcctcctagt
      781 tccacctatg agaaggcctt aggctacttt cacagggcag aacaagtgga tccaaacttc
      841 tacagcaaaa acttacttct tttaggaaag acatacttga aactacacaa caaaaagctt
      901 gctgctttct ggctaatgaa agccaaggac tatccagcac acacagagga ggataaacag
      961 atacagacag aagctgctca gttgcttaca agtttcagtg agaagaattg agaacttttc
     1021 agagaagatt tatgaaatag ctaataaaca ttgccttttc ttttaattct aaacttaata
     1081 tatgaactat aactgttcta cggcttttta aatgttgtga ccatttaacc gtgtaaatat
     1141 aaaatattct aggcttcttc acaaataata gggtaaaata aataatcgcc ataagagtgg
     1201 tagaaataaa tctccatggc tcaggcaaag agattatttt gcatcctgga taccagcaat
     1261 gcaaaatggt atgagatttc taaggattga tcacattggg atgggagatc aagcaaagaa
     1321 atatttgtag aggaggggaa atggatctat aggggatata cagggggatg gattttcaaa
     1381 ttggattgat tctaagttga aatcttgaag agaaggtgtg gtgacagtgg ttaggatgtt
     1441 gtgggttcct gacataaagt agttaaatga tatatcttgg agctaacctg tgtaagtaaa
     1501 gaactaagta aggagatgac taaaaatgga gtagtttcct tttttatttt tttgagacag
     1561 agtctcactt tgtttcccag gctggtgtgc agtggcacaa tctcggccca ctgcagcctc
     1621 cgcctcccgg gttcaagtga ttctcctgcc ttagcctcct gagtggctgg gattacaggg
     1681 ttgtaccacc acactcggct aacttttgta tttttggtag agatggggtt ttgccatgtt
     1741 ggctaggctg gtctcaaact cctggcctca agtgatctgc ccgccttggc ctcccaaatt
     1801 gctgggatta caggcgtgag ccaccgcacc tggccagttt actttaaatg tggtgtagtc
     1861 tcatggtaaa ctgaatttgt catcagatgc aaagttctat tccctaatgg aatggaagga
     1921 acacaaaact taagagtgaa atggaatact aagatgtttt taaataggca ggactatgct
     1981 actcacttga ggctggagtg ccaccactgc aaaatctttt taagttttgt aaaaaggagc
     2041 atcttgaatc cacttagata aagacagact gtgtgtgtag gtggattttt cccaaaggat
     2101 ttgggaattg taatgttaca atgaactgta tggatatgtt tgtcatgtac attttcaaac
     2161 aaaaaggaaa actgaaagta gtgatctttg tatacccatc tcttagattc agtgattttg
     2221 ctatataggt tgtgtatccc ttatctgaaa tacttgggac tagtagaagc atcttggatt
     2281 tgggatgttt ttccaaattt tggaatacct gcatacacac aataagatat cttggagatg
     2341 ggacccaagt ttaaacacaa attcacttgt ttcatatata ccttatgcac atagcttgaa
     2401 ggtaacttta tataacatta tttttaataa ttttgtgcat tgagaccaag tttgcatacc
     2461 ttgaaccatc agaaagcaaa ggtgtcatta tctcagccac tcatgtgggt aatttgtggt
     2521 tggttgatgt caccatcatt cctgactgaa tgtatatgct accaataagc agttattttc
     2581 ttatacttat tcatgcataa gtacttaaca gtaaaaaata tgacataact cgcacaggaa
     2641 caaggatggc aaaaaaaaaa atatgacaca ccactgatac agtgaaaaaa taatgtggtc
     2701 agggtagcta ggcaacagta gcatcaccag aaacctgtat cagctgttaa acggcaacaa
     2761 caatggcagg ctttcagttt cccacttaat gatgctgtat tttaaaaggt tattgtatac
     2821 tgtaatttta tttttgtagg tgaagagaaa cagaagcagc tgaagggcca ggaagtgggt
     2881 ctttctaggg atgtggcatt ctgctggatg gctttttaaa atgggttttt tcctttaggg
     2941 agaccgaata aactgtgttg tgcacctgca
//
