LOCUS       NM_080864               1089 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens relaxin 3 (RLN3), transcript variant 1, mRNA.
ACCESSION   NM_080864
VERSION     NM_080864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Wong,W.L.E., Arathimos,R., Lewis,C.M., Young,A.H. and Dawe,G.S.
  TITLE     Investigating the role of the relaxin-3/RXFP3 system in
            neuropsychiatric disorders and metabolic phenotypes: A candidate
            gene approach
  JOURNAL   PLoS One 18 (11), e0294045 (2023)
   PUBMED   37967073
  REMARK    GeneRIF: Investigating the role of the relaxin-3/RXFP3 system in
            neuropsychiatric disorders and metabolic phenotypes: A candidate
            gene approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1089)
  AUTHORS   Wong,W.L.E., Dawe,G.S. and Young,A.H.
  TITLE     The putative role of the relaxin-3/RXFP3 system in clinical
            depression and anxiety: A systematic literature review
  JOURNAL   Neurosci Biobehav Rev 131, 429-450 (2021)
   PUBMED   34537263
  REMARK    GeneRIF: The putative role of the relaxin-3/RXFP3 system in
            clinical depression and anxiety: A systematic literature review.
            Review article
REFERENCE   3  (bases 1 to 1089)
  AUTHORS   Hanafy,S., Sabry,J.H., Akl,E.M., Elethy,R.A. and Mostafa,T.
  TITLE     Serum relaxin-3 hormone relationship to male delayed puberty
  JOURNAL   Andrologia 50 (2) (2018)
   PUBMED   28786126
  REMARK    GeneRIF: Serum level of relaxin-3 hormone is an important mediator
            in the pathophysiological process of normal puberty being
            significantly decreased in males with delayed puberty.
REFERENCE   4  (bases 1 to 1089)
  AUTHORS   Ang,S.Y., Hutchinson,D.S., Evans,B.A., Hossain,M.A., Patil,N.,
            Bathgate,R.A., Kocan,M. and Summers,R.J.
  TITLE     The actions of relaxin family peptides on signal transduction
            pathways activated by the relaxin family peptide receptor RXFP4
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (1), 105-111 (2017)
   PUBMED   27888281
  REMARK    GeneRIF: Relaxin-3 is a high-efficacy agonist at RXFP4 with a
            comparable signal transduction profile to INSL5.
REFERENCE   5  (bases 1 to 1089)
  AUTHORS   Jayakody,T., Marwari,S., Lakshminarayanan,R., Tan,F.C.,
            Johannes,C.W., Dymock,B.W., Poulsen,A., Herr,D.R. and Dawe,G.S.
  TITLE     Hydrocarbon stapled B chain analogues of relaxin-3 retain
            biological activity
  JOURNAL   Peptides 84, 44-57 (2016)
   PUBMED   27498038
  REMARK    GeneRIF: Therefore, we conclude that stapling of the relaxin3 B
            chain does not compromise its ability to activate RXFP3 and is a
            promising method for developing stable peptide agonists and
            antagonists of RXFP3 to aid relaxin-3/RXFP3 research.
REFERENCE   6  (bases 1 to 1089)
  AUTHORS   Liu,C., Eriste,E., Sutton,S., Chen,J., Roland,B., Kuei,C.,
            Farmer,N., Jornvall,H., Sillard,R. and Lovenberg,T.W.
  TITLE     Identification of relaxin-3/INSL7 as an endogenous ligand for the
            orphan G-protein-coupled receptor GPCR135
  JOURNAL   J Biol Chem 278 (50), 50754-50764 (2003)
   PUBMED   14522968
  REMARK    GeneRIF: GPCR135 is the receptor for relaxin-3
REFERENCE   7  (bases 1 to 1089)
  AUTHORS   Liu,C., Chen,J., Sutton,S., Roland,B., Kuei,C., Farmer,N.,
            Sillard,R. and Lovenberg,T.W.
  TITLE     Identification of relaxin-3/INSL7 as a ligand for GPCR142
  JOURNAL   J Biol Chem 278 (50), 50765-50770 (2003)
   PUBMED   14522967
  REMARK    GeneRIF: relaxin-3/INSL7 is a ligand for GPCR142
REFERENCE   8  (bases 1 to 1089)
  AUTHORS   Kizawa,H., Nishi,K., Ishibashi,Y., Harada,M., Asano,T., Ito,Y.,
            Suzuki,N., Hinuma,S., Fujisawa,Y., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Production of recombinant human relaxin 3 in AtT20 cells
  JOURNAL   Regul Pept 113 (1-3), 79-84 (2003)
   PUBMED   12686464
REFERENCE   9  (bases 1 to 1089)
  AUTHORS   Sudo,S., Kumagai,J., Nishi,S., Layfield,S., Ferraro,T.,
            Bathgate,R.A. and Hsueh,A.J.
  TITLE     H3 relaxin is a specific ligand for LGR7 and activates the receptor
            by interacting with both the ectodomain and the exoloop 2
  JOURNAL   J Biol Chem 278 (10), 7855-7862 (2003)
   PUBMED   12506116
REFERENCE   10 (bases 1 to 1089)
  AUTHORS   Bathgate,R.A., Samuel,C.S., Burazin,T.C., Layfield,S., Claasz,A.A.,
            Reytomas,I.G., Dawson,N.F., Zhao,C., Bond,C., Summers,R.J.,
            Parry,L.J., Wade,J.D. and Tregear,G.W.
  TITLE     Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3)
            gene. Novel members of the relaxin peptide family
  JOURNAL   J Biol Chem 277 (2), 1148-1157 (2002)
   PUBMED   11689565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC140935.1, AC022098.9 and
            AY358181.1.
            
            On May 17, 2019 this sequence version replaced NM_080864.3.
            
            Summary: This gene encodes a member of the relaxin family of
            insulin-like hormones that is expressed predominantly in the brain
            and plays a role in physiological processes such as stress, memory
            and appetite regulation. The encoded protein is a precursor that is
            proteolytically processed to generate a heterodimeric mature form
            consisting A and B chains interlinked by disulfide bonds.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140935.1, AB076563.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431365.3/ ENSP00000397415.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BC140935.1         1-44
            45-45               AC022098.9         65569-65569
            46-391              BC140935.1         46-391
            392-1089            AY358181.1         1175-1872
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1089
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /note="relaxin 3"
                     /db_xref="GeneID:117579"
                     /db_xref="HGNC:HGNC:17135"
                     /db_xref="MIM:606855"
     exon            1..247
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..486
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /note="prorelaxin H3; insulin-like peptide 7; insulin-like
                     peptide INSL7"
                     /codon_start=1
                     /product="relaxin-3 preproprotein"
                     /protein_id="NP_543140.1"
                     /db_xref="CCDS:CCDS12302.1"
                     /db_xref="GeneID:117579"
                     /db_xref="HGNC:HGNC:17135"
                     /db_xref="MIM:606855"
                     /translation="MARYMLLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVI
                     FTCGGSRWRRSDILAHEAMGDTFPDADADEDSLAGELDEAMGSSEWLALTKSPQAFYR
                     GRPSWQGTPGVLRGSRDVLAGLSSSCCKWGCSKSEISSLC"
     exon            248..1089
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /note="hexamer: AATAAA"
     polyA_site      1089
                     /gene="RLN3"
                     /gene_synonym="H3; insl7; RXN3; ZINS4"
                     /note="major polyA site"
ORIGIN      
        1 gccaagaggc agcagagaca ctggcccact ctcacgttca aagcatctcc gtccagcatg
       61 gccaggtaca tgctgctgct gctcctggcg gtatgggtgc tgaccgggga gctgtggccg
      121 ggagctgagg cccgggcagc gccttacggg gtcaggcttt gcggccgaga attcatccga
      181 gcagtcatct tcacctgcgg gggctcccgg tggagacgat cagacatcct ggcccacgag
      241 gctatgggag ataccttccc ggatgcagat gctgatgaag acagtctggc aggcgagctg
      301 gatgaggcca tggggtccag cgagtggctg gccctgacca agtcacccca ggccttttac
      361 agggggcgac ccagctggca aggaacccct ggggttcttc ggggcagccg agatgtcctg
      421 gctggccttt ccagcagctg ctgcaagtgg gggtgtagca aaagtgaaat cagtagcctt
      481 tgctagtttg agggctgggc agccgtgggc accaggacca atgccccagt cctgccatcc
      541 actcaactag tgtctggctg ggcacctgtc tttcgagcct cacacattca ttcattcatc
      601 tacaagtcac agaggcactg tgggctcagg cacagtctcc cgacaccacc tatccaaccc
      661 tgccctttga ccagcctatc atgaccctgg cccctaagga agctgtgccc ctgcctggtc
      721 aagtggggac ccccccatcc tgacccctga cctctcccca gccctaacca tgcgtttgcc
      781 tggcctacac actccactgc cacaactggg tccctactct acctaggctg gccacacaga
      841 gacccctgcc cccttcccag tccaaactgt ggccattgtc ccctgaccag ctaaaatcaa
      901 gcctctgtct cagtccagcc tttgcacgca cgcttccttt gccctgcttt ccatcccctc
      961 tccctccaac tcccctgcca gagttccaag gctgtggacc ccagagaagg tggcaggtgg
     1021 cccccctagg agagctctgg gcacattcga atcttcccaa actccaataa taaaaattcg
     1081 aagactttg
//
