LOCUS       NM_134441                928 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.
ACCESSION   NM_134441
VERSION     NM_134441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   Doneray,H., Tavlas,G., Ozden,A. and Ozturk,N.
  TITLE     The role of breast milk beta-endorphin and relaxin-2 on infant
            colic
  JOURNAL   Pediatr Res 94 (4), 1416-1421 (2023)
   PUBMED   37142649
  REMARK    GeneRIF: The role of breast milk beta-endorphin and relaxin-2 on
            infant colic.
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Kwantwi,L.B.
  TITLE     The dual and multifaceted role of relaxin-2 in cancer
  JOURNAL   Clin Transl Oncol 25 (10), 2763-2771 (2023)
   PUBMED   36947362
  REMARK    GeneRIF: The dual and multifaceted role of relaxin-2 in cancer.
            Review article
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Prudencio,C.B., Nunes,S.K., Pinheiro,F.A., Filho,C.I.S.,
            Antonio,F.I., de Aquino Nava,G.T., Rudge,M.V.C. and Barbosa,A.M.P.
  CONSRTM   Diamater Study Group
  TITLE     Relaxin-2 during pregnancy according to glycemia, continence
            status, and pelvic floor muscle function
  JOURNAL   Int Urogynecol J 33 (11), 3203-3211 (2022)
   PUBMED   35657397
  REMARK    GeneRIF: Relaxin-2 during pregnancy according to glycemia,
            continence status, and pelvic floor muscle function.
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Ng,T.M., Goland,S. and Elkayam,U.
  TITLE     Relaxin for the Treatment of Acute Decompensated Heart Failure:
            Pharmacology, Mechanisms of Action, and Clinical Evidence
  JOURNAL   Cardiol Rev 24 (4), 194-204 (2016)
   PUBMED   26331289
  REMARK    Review article
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Gunnersen,J.M., Fu,P., Roche,P.J. and Tregear,G.W.
  TITLE     Expression of human relaxin genes: characterization of a novel
            alternatively-spliced human relaxin mRNA species
  JOURNAL   Mol Cell Endocrinol 118 (1-2), 85-94 (1996)
   PUBMED   8735594
REFERENCE   6  (bases 1 to 928)
  AUTHORS   Winslow,J.W., Shih,A., Bourell,J.H., Weiss,G., Reed,B., Stults,J.T.
            and Goldsmith,L.T.
  TITLE     Human seminal relaxin is a product of the same gene as human luteal
            relaxin
  JOURNAL   Endocrinology 130 (5), 2660-2668 (1992)
   PUBMED   1572287
REFERENCE   7  (bases 1 to 928)
  AUTHORS   Eigenbrot,C., Randal,M., Quan,C., Burnier,J., O'Connell,L.,
            Rinderknecht,E. and Kossiakoff,A.A.
  TITLE     X-ray structure of human relaxin at 1.5 A. Comparison to insulin
            and implications for receptor binding determinants
  JOURNAL   J Mol Biol 221 (1), 15-21 (1991)
   PUBMED   1656049
REFERENCE   8  (bases 1 to 928)
  AUTHORS   Hansell,D.J., Bryant-Greenwood,G.D. and Greenwood,F.C.
  TITLE     Expression of the human relaxin H1 gene in the decidua,
            trophoblast, and prostate
  JOURNAL   J Clin Endocrinol Metab 72 (4), 899-904 (1991)
   PUBMED   2005217
REFERENCE   9  (bases 1 to 928)
  AUTHORS   Stults,J.T., Bourell,J.H., Canova-Davis,E., Ling,V.T.,
            Laramee,G.R., Winslow,J.W., Griffin,P.R., Rinderknecht,E. and
            Vandlen,R.L.
  TITLE     Structural characterization by mass spectrometry of native and
            recombinant human relaxin
  JOURNAL   Biomed Environ Mass Spectrom 19 (11), 655-664 (1990)
   PUBMED   2076464
REFERENCE   10 (bases 1 to 928)
  AUTHORS   Crawford,R.J., Hudson,P., Shine,J., Niall,H.D., Eddy,R.L. and
            Shows,T.B.
  TITLE     Two human relaxin genes are on chromosome 9
  JOURNAL   EMBO J 3 (10), 2341-2345 (1984)
   PUBMED   6548703
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135786.17, BC126415.1,
            BX094853.1, BG206251.1 and AI033912.1.
            
            On Nov 23, 2018 this sequence version replaced NM_134441.2.
            
            Summary: This gene encodes a member of the relaxin subfamily and
            insulin superfamily of peptide hormones. In humans there are three
            non-allelic relaxin genes. This gene encodes multiple protein
            isoforms, at least one of which undergoes proteolytic processing.
            This processing generates relaxin A and B chains that are linked by
            disulfide bonds to form the mature peptide hormone. This hormone
            plays a role in the male and female reproductive systems and was
            initially noted for its role in pregnancy. This protein also plays
            broader roles in the cardiovascular system, including in the
            regulation of blood pressure and control of heart rate, and data
            from animal models shows that this protein may have anti-fibrotic
            and cardioprotective effects. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126419.1, X00948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381627.4/ ENSP00000371040.3
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AL135786.17        6692-6796           c
            106-777             BC126415.1         1-672
            778-916             BX094853.1         502-640
            917-919             BG206251.1         551-553
            920-928             AI033912.1         7-15                c
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..928
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /note="relaxin 2"
                     /db_xref="GeneID:6019"
                     /db_xref="HGNC:HGNC:10027"
                     /db_xref="MIM:179740"
     exon            1..347
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..694
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; relaxin, ovarian, of pregnancy; prorelaxin H2;
                     H2-preprorelaxin; relaxin H2"
                     /codon_start=1
                     /product="prorelaxin H2 isoform 1 preproprotein"
                     /protein_id="NP_604390.1"
                     /db_xref="CCDS:CCDS6460.1"
                     /db_xref="GeneID:6019"
                     /db_xref="HGNC:HGNC:10027"
                     /db_xref="MIM:179740"
                     /translation="MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQI
                     AICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTL
                     SEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKK
                     RQLYSALANKCCHVGCTKRSLARFC"
     exon            348..928
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      901..906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /note="hexamer: ATTAAA"
     polyA_site      928
                     /gene="RLN2"
                     /gene_synonym="bA12D24.1.1; bA12D24.1.2; H2; H2-RLX;
                     RLXH2"
                     /note="major polyA site"
ORIGIN      
        1 caaaagaccg cttgagccgg gtagggaaag cagcctaaag cccgggacag gcacacaggc
       61 ccaggtgtgt aggccacagc agctgcagtc ctgaaaggct gcaacgtccc gacctccagg
      121 agagaccagg cccaggatgc ctcgcctgtt ttttttccac ctgctaggag tctgtttact
      181 actgaaccaa ttttccagag cagtcgcgga ctcatggatg gaggaagtta ttaaattatg
      241 cggccgcgaa ttagttcgcg cgcagattgc catttgcggc atgagcacct ggagcaaaag
      301 gtctctgagc caggaagatg ctcctcagac acctagacca gtggcagaaa ttgtgccatc
      361 cttcatcaac aaagatacag aaaccataaa tatgatgtca gaatttgttg ctaatttgcc
      421 acaggagctg aagttaaccc tgtctgagat gcagccagca ttaccacagc tacaacaaca
      481 tgtacctgta ttaaaagatt ccagtcttct ctttgaagaa tttaagaaac ttattcgcaa
      541 tagacaaagt gaagccgcag acagcagtcc ttcagaatta aaatacttag gcttggatac
      601 tcattctcga aaaaagagac aactctacag tgcattggct aataaatgtt gccatgttgg
      661 ttgtaccaaa agatctcttg ctagattttg ctgagatgaa gctaattgtg cacatctcgt
      721 ataatattca cacatattct taatgacatt tcactgatgc ttctatcagg tcccatcaat
      781 tcttagaata tctaagaatc tttgttagat attaggtccc atcaattctt agaatatcta
      841 aacatctttg ttgatgttta gattttttta tttgatgtgt aagaaaatgt tctttgtgtg
      901 attaaatgac acattttttt gctgaaaa
//
