LOCUS       NM_016120              10565 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein, LIM domain interacting (RLIM),
            transcript variant 1, mRNA.
ACCESSION   NM_016120
VERSION     NM_016120.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10565)
  AUTHORS   Wang,F., Mehta,P. and Bach,I.
  TITLE     How does the Xist activator Rlim/Rnf12 regulate Xist expression?
  JOURNAL   Biochem Soc Trans 52 (3), 1099-1107 (2024)
   PUBMED   38747697
  REMARK    GeneRIF: How does the Xist activator Rlim/Rnf12 regulate Xist
            expression?
            Review article
REFERENCE   2  (bases 1 to 10565)
  AUTHORS   Yu,C., Rao,D., Wang,T., Sheng,J., Lv,E., Zhang,L., Lu,X., Yu,J.,
            Liang,H., Song,J. and Huang,W.
  TITLE     Ring finger protein 12 activates AKT signalling to promote the
            progression of liver cancer by interacting with EGFR
  JOURNAL   J Cell Mol Med 27 (11), 1523-1538 (2023)
   PUBMED   37132043
  REMARK    GeneRIF: Ring finger protein 12 activates AKT signalling to promote
            the progression of liver cancer by interacting with EGFR.
REFERENCE   3  (bases 1 to 10565)
  AUTHORS   Segarra-Fas,A., Espejo-Serrano,C., Bustos,F., Zhou,H., Wang,F.,
            Toth,R., Macartney,T., Bach,I., Nardocci,G. and Findlay,G.M.
  TITLE     An RNF12-USP26 amplification loop drives germ cell specification
            and is disrupted by disease-associated mutations
  JOURNAL   Sci Signal 15 (742), eabm5995 (2022)
   PUBMED   35857630
  REMARK    GeneRIF: An RNF12-USP26 amplification loop drives germ cell
            specification and is disrupted by disease-associated mutations.
REFERENCE   4  (bases 1 to 10565)
  AUTHORS   Li,Y., Yang,C., Wang,H., Zhao,L., Kong,Q., Cang,Y., Zhao,S., Lv,L.,
            Li,Y., Mao,B. and Ma,P.
  TITLE     Sequential stabilization of RNF220 by RLIM and ZC4H2 during
            cerebellum development and Shh-group medulloblastoma progression
  JOURNAL   J Mol Cell Biol 14 (1) (2022)
   PUBMED   35040952
  REMARK    GeneRIF: Sequential stabilization of RNF220 by RLIM and ZC4H2
            during cerebellum development and Shh-group medulloblastoma
            progression.
            Erratum:[J Mol Cell Biol. 2022 May 25;14(2):mjac030. doi:
            10.1093/jmcb/mjac030.. PMID: 35639540]
REFERENCE   5  (bases 1 to 10565)
  AUTHORS   Huang,Y., Liu,S., Shan,M., Hagenaars,S.C., Mesker,W.E., Cohen,D.,
            Wang,L., Zheng,Z., Devilee,P., Tollenaar,R.A.E.M., Li,Z., Song,Y.,
            Zhang,L., Li,D. and Ten Dijke,P.
  TITLE     RNF12 is regulated by AKT phosphorylation and promotes TGF-beta
            driven breast cancer metastasis
  JOURNAL   Cell Death Dis 13 (1), 44 (2022)
   PUBMED   35013159
  REMARK    GeneRIF: RNF12 is regulated by AKT phosphorylation and promotes
            TGF-beta driven breast cancer metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10565)
  AUTHORS   Ostendorff,H.P., Peirano,R.I., Peters,M.A., Schluter,A.,
            Bossenz,M., Scheffner,M. and Bach,I.
  TITLE     Ubiquitination-dependent cofactor exchange on LIM homeodomain
            transcription factors
  JOURNAL   Nature 416 (6876), 99-103 (2002)
   PUBMED   11882901
REFERENCE   7  (bases 1 to 10565)
  AUTHORS   Ostendorff,H.P., Bossenz,M., Mincheva,A., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Lichter,P. and Bach,I.
  TITLE     Functional characterization of the gene encoding RLIM, the
            corepressor of LIM homeodomain factors
  JOURNAL   Genomics 69 (1), 120-130 (2000)
   PUBMED   11013082
REFERENCE   8  (bases 1 to 10565)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   9  (bases 1 to 10565)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   10 (bases 1 to 10565)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF686000.1, BC013357.2,
            AL513007.5 and AK127880.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016120.3.
            
            Summary: The protein encoded by this gene is a RING-H2 zinc finger
            protein. It has been shown to be an E3 ubiquitin protein ligase
            that targets LIM domain binding 1 (LDB1/CLIM), and causes
            proteasome-dependent degradation of LDB1. This protein and LDB1 are
            co-repressors of LHX1/LIM-1, a homeodomain transcription factor.
            Multiple alternatively spliced variants, encoding the same protein,
            have been identified. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            5' UTR, compared to variant 2, and may represent the more abundant
            form. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.89394.1,
                                           SRR11853560.30154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332687.11/ ENSP00000328059.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BF686000.1         3-36
            35-2292             BC013357.2         1-2258
            2293-10536          AL513007.5         3662-11905          c
            10537-10565         AK127880.1         2388-2416
FEATURES             Location/Qualifiers
     source          1..10565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.2"
     gene            1..10565
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /note="ring finger protein, LIM domain interacting"
                     /db_xref="GeneID:51132"
                     /db_xref="HGNC:HGNC:13429"
                     /db_xref="MIM:300379"
     exon            1..203
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /inference="alignment:Splign:2.1.0"
     exon            204..395
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..2101
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 12; ring zinc finger protein
                     NY-REN-43antigen; ring zinc finger LIM domain binding
                     protein; E3 ubiquitin-protein ligase RNF12; R-LIM; renal
                     carcinoma antigen NY-REN-43; RING finger LIM
                     domain-binding protein; LIM domain-interacting RING finger
                     protein; RING-type E3 ubiquitin transferase RLIM"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RLIM"
                     /protein_id="NP_057204.2"
                     /db_xref="CCDS:CCDS14427.1"
                     /db_xref="GeneID:51132"
                     /db_xref="HGNC:HGNC:13429"
                     /db_xref="MIM:300379"
                     /translation="MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDY
                     RLMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWL
                     NSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSA
                     RRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDH
                     RRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQIS
                     GPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYR
                     QRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNT
                     GLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSG
                     GGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGA
                     RREGRHRAPVTFDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRSFGENDA
                     LKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRESVV
                     "
     exon            396..479
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /inference="alignment:Splign:2.1.0"
     exon            480..10565
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8288..8293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /note="hexamer: AATAAA"
     regulatory      8296..8301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /note="hexamer: ATTATA"
     polyA_site      8307
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /note="major polyA site"
     polyA_site      8315
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
     regulatory      8522..8527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
                     /note="hexamer: AGTAAA"
     polyA_site      8543
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
     polyA_site      10469
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
     polyA_site      10545
                     /gene="RLIM"
                     /gene_synonym="MRX61; NY-REN-43; RNF12; TOKAS"
ORIGIN      
        1 gcagtcgttt cctgtcgctg cttggtaaca atggggaaga taatggctgc ctgagcaacg
       61 tctccgagca ggcgctgggc tagaggcggg tctcaaccag ctactcattg gaggcgggct
      121 tgagagcggc ggccagggag gtgcggagca gcctcggcgg cggcggccga accaaccgag
      181 tcggatcctg accctaaaac ctagtatttt ccacttgttc atcaatatgg aaaactcaga
      241 ttccaatgac aaaggaagtg gtgatcagtc tgcagcacag cgcagaagtc agatggaccg
      301 attggatcga gaagaagctt tctatcaatt tgtaaataac ctgagtgaag aagattatag
      361 gcttatgaga gataacaatt tgctaggcac cccaggtgaa agtactgagg aagagttgct
      421 gagacgacta cagcaaatta aagaaggccc accaccgcaa aactcagatg aaaatagagg
      481 aggagactct tcagatgatg tgtctaatgg tgactctata atagactggc ttaactctgt
      541 cagacaaact ggaaatacaa caagaagtgg gcaaagagga aaccaatctt ggagagcagt
      601 gagtcggact aatccaaaca gtggtgattt cagattcagt ttagagataa atgttaaccg
      661 taataatggg agccaaaatt cagagaatga aaatgagcca tctgcaagac gttctagtgg
      721 agaaaatgtg gaaaacaaca gccaaaggca agtggaaaac ccacgatctg aatcaacatc
      781 tgcaaggcca tctagatcag aacgaaattc aactgaagcg ttaacagagg tcccacctac
      841 cagaggtcag aggagggcaa gaagcaggag cccagaccat cggagaacca gagcaagagc
      901 tgaaagaagt aggtcacctc tgcatccaat gagtgaaatt ccacgaagat ctcatcatag
      961 tatctcatct cagacttttg aacatccttt ggtaaatgag acggagggaa gttctagaac
     1021 ccggcaccat gtgacattga ggcagcaaat atctgggcct gagttgctaa gtagaggtct
     1081 ttttgcagct tctggaacaa gaaatgcttc tcaaggagca ggttcttcag acacagctgc
     1141 cagtggtgaa tctacaggat caggacagag acctccaacc atagtccttg atcttcaagt
     1201 aagaagagtt cgtcctggag aatatcggca gagagatagc atagccagca gaactcggtc
     1261 taggtctcag acaccaaaca acactgtcac ctatgaaagt gaacgaggag gttttaggcg
     1321 tacattttca cgttctgagc gggcaggtgt gagaacctat gtcagtacca tcagaattcc
     1381 cattcgtaga atcttaaata ctggtttaag tgagactaca tctgttgcaa ttcagaccat
     1441 gttaaggcag ataatgacag gttttggtga gttaagctat tttatgtaca gtgatagcga
     1501 ctcagagcct actggctcag tctcaaatcg aaatatggaa agggcagagt cacggagtgg
     1561 aagaggaggt tctggtggtg gtagtagttc tggttccagt tcgagttcca gttccagttc
     1621 gagttccagt tccagttcaa gttccagttc cagtcctagt tccagttccg gtggtgaaag
     1681 ttcagaaact agctcagatt tatttgaagg cagtaatgaa ggaagctcat catcaggctc
     1741 atcaggtgcc aggcgagagg gtcgacatag ggccccagtc acatttgatg aaagtggctc
     1801 tttgcccttc cttagcctgg ctcagttttt cctcttaaat gaggatgatg atgaccaacc
     1861 tagaggactc accaaagaac agattgacaa cttggcaatg agaagttttg gtgaaaatga
     1921 tgcattaaaa acctgtagtg tttgcattac agaatataca gaaggcaaca aacttcgtaa
     1981 actaccttgt tcccatgagt accatgtcca ctgcatcgat cgctggttat ctgagaattc
     2041 tacctgtcct atttgtcgca gagcagtctt agcttctggt aacagagaaa gtgttgtgta
     2101 attaagatct gaactctcag ctatgtagct gatatagtga tgggcaaaca ggaatcactt
     2161 gcttttatgt ccactttttg agtggtactt aaatgtaaag taacaacctg aattgagtca
     2221 ttgctttctg aaggaatcat tgtcctttct ccagtttttg ttccagaata aaaggaaata
     2281 ttttaaaagc cacgttatag gacctaaaaa tctgatttcc gtaccagtta aattggtagc
     2341 atcactgtta ctgataattt atcatataca cttgtcaatt tttcctttgt tatcttaaaa
     2401 gatctgcctt agcaatggct cctttttcat gttgatcttt aaattttccc acaccataag
     2461 agaggagcaa aggaaattac cagtttagac taagttacag tatgtgtttc ataagtgatt
     2521 aaagctatat cattcccagt tattagttaa cacaaattca gccacattct gagtattgtt
     2581 tgttcacctt tcagacttgg tgatactgga catgtcagtg taaataacac taaggttagg
     2641 atcttctaag tgtataactg tctcctaagc ccatcactgt ggcacactgt agagtgagct
     2701 tatagtttaa ttgagatatt tatcttgtgg aaatattaaa aagcctatgc ttgtgtaagt
     2761 gaaaaaaaat cacattcatt tgtttaaaaa tgtaaagcta ttttgtagag gctcagtact
     2821 tttccaatgc actgttgtat gaatgcatta aaaattgtaa agtaccatgc ttagaactga
     2881 gaaaactgct ttttgtgagc caacatagta acaaacacac caaacaaagt acaaagctgc
     2941 ttttgtaagt gtgtagatgt caagagcaga acatatctat aatatttaat gtgtgaacag
     3001 ctactgtgac atgcaaagga aaggacagtg cagaattaaa ccgtgttgaa gaccagtgga
     3061 aattgtataa tttaacttgg atttaggcag gaagtgaaat atgggaggag taaagaaaac
     3121 tgaagaattt aaagttttcc tgaagacagt aataatgcag acacaaactg gtttcatatg
     3181 gtgagagcag ccacagcagc agcttgacct ggtattctac ctgagtagat gaagcagaag
     3241 atcagcaagt ttggcagagt tttggtttaa gaaaaacaaa ccactactac ctagcacaag
     3301 ttaaatttac aagtctgctc ctcaaaaatg aaaaaatgga ggaaagagac tataaaacca
     3361 cttttagcat atgaattgca gttggtacac atgtgtgtgt taataggaaa gtctcgaatt
     3421 tgtgttgttt ttgagatttg tcatttaagg taccagtgca cacttgatca tatttcatta
     3481 ctatctctaa cacagtccta acatctcaaa tttaaagacc agttgaagat taagggattt
     3541 ttatcctttg ttgaaagtca tgttgggtta tttgaaattc aaattttaat tgtgctgccc
     3601 atatatgaaa atgagactgc tgactcgcta tctatggaca tgcactttat gttggtttct
     3661 tagtagtaag agtaacttca tgataacccc agtcttcttg cctaatttct tttttgagac
     3721 tagctggggt taggattaga atgactatgg agcagatatt tgttcttctg ggaaaagctt
     3781 taacaggcca aaatagggat tgaacttgtc cttggccttt atcaaagcaa gctagctacc
     3841 cagacgtagt caaatactct acaaaataaa caagtctgct ttaggaattg tctgggtacc
     3901 ttcactgtta ccaacttagc tgtaaagatt atttcaaagc tcactcttcc atgatttctt
     3961 ctggctttca atcctatcta agtatcaagg aaattaactt gtaaatatgg tagttgttta
     4021 ctaaggatat gtactgctct tgcaaggaaa taatgtccaa acaaagcttc acttattttt
     4081 tttaatataa gcagatttca ctgtttatgg cgcttatgta atacatttta tctttttaaa
     4141 aatttgtccg tgtaaaagtc aggattcctt tatatttgtg agcctccttt tctcctttcc
     4201 taaggatgta atctacagtt ttcagatctg cagggtagtc ttgattggct aaaaacaaat
     4261 caattttctt cttggcataa agtgtttcat tattataggg gtgttcattt taaatagttt
     4321 aaaaacaatt gcagcacatt ctaagcataa gagaaagtta ttgacaacag gtaccttcct
     4381 aatctcccaa gacgtactta ctcatttgtg aagtattaaa gtaagaggta actcaagcag
     4441 aatgctggct atgaatgtag atattgaagc tattcataaa cactggaaat agaattttaa
     4501 gcttttagcc ttcagtggaa tgcacatatt ggacatgtgc atgtgaacac ctttttcagt
     4561 agcactcacg gatttccatt cgattgtata gaatgaatac aagtgtttta gtggaatttg
     4621 ctacttaatt tttaatcttg cgatgtccgt gattattaca tgcttactag tgttgtggac
     4681 attgaagaca aggtcattcg taggtgtcag attacaatgg agaacaaaaa tcgttttccc
     4741 cccacccaca tccaaacacc attctcgagg gagcatttct tgcaaaacac cttacatttc
     4801 attttctatc tttgcacttt ttcttaagta cagaaaagtt gtctttaaga cctagtttga
     4861 acttcatgca gtaagaggaa caaggataaa caatgttggg agttcacatt gttcagagca
     4921 taaggaaaag taccaaaacc caaattttct tgaatatttc agatgttttt aaaaactcac
     4981 ttctagtctg aaacatttga attgttttaa ctctgagcag ctgacaaagt tgaggttttt
     5041 ttgttttgtt ttgttttgtt ttgttttttt gagacagagt cttacttggt tgcccaggat
     5101 gaagtgcaat ggagcgatct cggctcactg caacctctgc ctcctgggtt caagcaattc
     5161 tcctgtctca gcctctcgag tagctgggat tacaggcgca tgccaccaca cctggctagt
     5221 ttttatattt ttagtagaga tggggacttc accgtgttgg ccaggctggt cttgaactcc
     5281 tgacctcaag tgatgtgcct gcctcggcct ccgaaaatgc tgggattaca ggcgtgagcc
     5341 accatgtcca gccaaagttg aggtttatta gtactattag aaacaaaatt gagcaagtta
     5401 agttaaaagt ttgctgactt tgtatcaaca ctatagaaga tgagccacct tgttaatttg
     5461 gaatatttgc tctgaaaaga acatgttagt tacaccttaa tggtgttaat ggaggtgggg
     5521 attgagaaaa gtgttcacat tagtgttgga atgtaggtaa ttgtacagtt tataagacct
     5581 ttagcaccag gaaataaaat atgtgtgtgt acacacacag tttttaaaaa cgattggaat
     5641 tcatccaaac cttaagatta ggaaactgat tggctgtaag tgttgcctca agtaatgtgt
     5701 cccccgcccc ataacatgtc ttttctgtgc caagtatcct ctcctagtgt cagtgtctca
     5761 aattatattt atgaagggtt atcacataat atgctttgta tttaactacc tgcttcccag
     5821 gcgtccatga catgaaatgg gtgaagcatc agccatgact ttcggtcagt tcccaaaata
     5881 cccaaatgat agggaggtaa agattgcaaa attcctctta aaaggccatt tttacagctt
     5941 gctaaaatac agtggcacct tatggttgtt aatatttttt cttttaaaga tggagaatgt
     6001 ttttattctt ccccttttct cctttgttct tttgcgaaca aaaaaaatta taatctgcct
     6061 tatttgattt tttttttaag ttttacctta caggcttccc tgtcacatgt tttaccatat
     6121 taagtacata gaagccatgt ttgcagggca cttttattct cctagtctta taagactatg
     6181 ctaattgtta ctttctgaag tattctgtac cttagtatgc aagattgtta aggcacatgt
     6241 taaagtgtca ggtgtgtttt tttcccttta attcttcagt atgtttatat tcaataacag
     6301 tattgtaatt cattgagtta actagtaaat tgtgtgcttt tgaaaaaaca tgaaaaatgt
     6361 aaattgacag catacttcat ttggaaaaaa gtaaaagatc cgaggaacta gtatgtcact
     6421 tatttatttt tattttattt tattttttac tttttgagac agggtcttgc tctgtcaccc
     6481 aggctggagt gcagtggcat ggtcacagct cactgcagcc ttgacttcct gggctcaggt
     6541 gattctccca cctcagcctt ccaagtagct gggactacag gcatgcacca cattgcctgg
     6601 ctaatttttt gtggagatgg ggtttcgcca tgttgtccag gctgttcttg aactcctggg
     6661 ctcaggcaat ttgcctgcct cattctccca aagtgctggg attataggcg tgagccactg
     6721 cgcccagcct tacttatttt taaatcagat tttttaatca actaaaacag ctatgagtta
     6781 agtacctgcc ctgcaaaaat ttttagaaaa agttttagga ttatgaaatt aagaattatt
     6841 ttccttaact ggaacagttc taaaatttat ctgatacttc tctaacaagt gagtgatctc
     6901 atgtaacccc agtttgtatc ttaaaggctg cagcatagaa ttgagctgta taacagtgtt
     6961 agaactgtca agtgataatc acagaacagt ttgtatcggt tttataattc tcatgtcttg
     7021 atcagatctg aaggaaatag gcataccctc caacattcta aaaattattt atttttatta
     7081 ggatttgttt attaaagttc cacgagctgc tttatggtca gttgggctga gtagtagata
     7141 tcttaaagac atgcagtgaa agtgaaccct gtcatatcat ggtgcctctt tcaaggttcc
     7201 tctgtaagtt cctcatcttg cagaattatt tcaataccaa ggtatggttg aaccagctgt
     7261 ccagccttaa ctctatttag tgccccatta ctaatgttct tttaactggt ttgtatgtgt
     7321 tttaactgtc cagtgtttgg attttacctc ttgatagctc catttgtccc tggtgctgct
     7381 tttaaggatg tagggccatg tgatcaggta tcaagttgag taggtacgca gttggcctgg
     7441 tgatgtatct gtgcctgttt tatcttctcc caggaagagc tgctttggta tagttgttta
     7501 cttggattca tacaaagaac agggcagcaa tcttggaaag ctttctgaag cttataagaa
     7561 cctgaagggg tttggagggg gaacagtaac aaaggctgcc tttatgtctt tggtcacaaa
     7621 gcacatagat gtatgttctg taaagactaa agtgattgtt ataccagggc ttcctgacct
     7681 tcgggagaga ctcaaaaaag cagagaggag cacaaagtga agttaatttg gttggcttgc
     7741 tttatctggt ttctcatttt ctttcaattt aaacctgaac ataacaccct tctccgatac
     7801 ctatccagca gactcctggt tgggaagccc tgtattaaat tttgagaatg tacacagttt
     7861 tcttttgtac agtgctttac aactgctaaa agttaacttg tttaaagcaa aacaagacct
     7921 tgaaaggtca atcatattaa agctggtttg attattaata gttatctttt aggaagaagc
     7981 ttttttccct atgtaagatg tcatactgca gatttaaaat atagactatc aataaaatgc
     8041 atgaagtgat catttgtgct tgatcatctc tccttgggtt tttctttaaa aaggggaatc
     8101 tgctataaag gttctgttgc ttcaaaccaa tgtcaaatag acttgatttt tagagtcatg
     8161 gaattacagt gcaaccttga tttttattcc cctcactgct atgagtgtgg gcaggtactg
     8221 gtttatatgt tataacttcc gttttatctg tgttgtgtag ttgaatggct taatcgttga
     8281 gtggtaaaat aaaagattat attccaatac aagaatcctg gaaagattta tgtgaatgac
     8341 attttaagta ggcgcatctt tgctgtttct tgtattctcg ccattgctct gaccactccc
     8401 ttgcttgccc tgtatatata caaaaacttg taggtgtgca cgtgtgcttg tacttctgtc
     8461 ttccatttct atcttaatct cttaaacata ttgcttaagc cactaagatg tccttgtttc
     8521 aagtaaatcg tcacattgtg acacctggtg tattgtatta tagtttcatt tcctctggtg
     8581 cctgcagagc tatctgtcat tggcatcata actcggtttc tcaggatagt tttgatgtag
     8641 tcagctcttc aactcatgac cttcccaagg ttttaagttt agtgtcattc atgattttat
     8701 tatttgaaac tcaataccac catcaaaaag ttagtgctct agacaatgaa gccaaagcac
     8761 aggcatctta ggtcagtgaa aaggatccag acataaatta gccaggtgtg gtggtacaca
     8821 gctgtggtcc cagctacttg ggaggctgag gtggtagaat cacttgagcc cgggaggtca
     8881 aggctgcagt gagccatgat catgctgatg cactccagcc tgggttacag agcaaaacct
     8941 tgtctcaaaa aaacccccag atacctagaa gaaaggattc gataaatctg ggtggattat
     9001 aaactgaact cttaatggtc attttaaaaa ataagaaagc aagggtccag tttctttgag
     9061 gtctttgaat ttagacaaga tttaactata aggccttgca tggattacta actataatta
     9121 aattagctaa acttttctgg ttgctgtcag gcattgtatt aagtattcta tataaattat
     9181 ttaatcatca cagtgactgt gaggtgaaag tataccaccc attttatagg taatgcagct
     9241 gagatacaga tgtttggtaa tttgcccagg tcacatagta agtagcagat tatttgcaat
     9301 catctttgat gcagtcatct tccttgtgct cttaatccca ctactatatg acttctaatt
     9361 tgtttcttag tatttatccc aagccctaga ctagattgct tatgaggtgt gatttcttag
     9421 gaaaaacatc agttttggct ggtttgccaa gaaaaaaaaa ggccaaattg gtttttgttt
     9481 atttttttgt ttgtttgaga tggattctcg ccctgtcgcc caggctggag tgcaatggtg
     9541 cgatcttggc tcactgcaac ctctgcctct gggttcaaac gattctcctg cctcagcctc
     9601 ccgagtagct gggattacag gcgcccgcca ccacgcccag ctaatttttc tatttttagt
     9661 agagacaggg tttcaccatg ttggccaggc tggtcttgaa cccctgatcc catgatctgc
     9721 ccgtctcggc ctcccacagt ggtggtatta caggcgtgag ccaccacgcc cggccgcaaa
     9781 ttgttttttg tttttttgtt ttttggagga ttaatggtaa tatactgtaa attcagtaaa
     9841 gcactgggca ttaccagata caccttagca ctatgaataa catgaactat cattttagca
     9901 gtttaagtgt accttgtaat cagccctagg gcaaacggta tcaaggtgtt ttatttccag
     9961 aagtctcaaa atagactgga ataaaaattt ggtgaattca tcaacacaga caatgggtcc
    10021 acgtcttgca gctacagctg ctgcagctac tcctgctgtc cgcaccgttc cacagtataa
    10081 atatgctgcg ggagtttgca atcctcagca acatcttaat gcacagccac aagttacagt
    10141 gcaacagcct gctattcatg tacaaggtca ggaacctttg actgtttcca tgttggcatc
    10201 tgcccctcaa gagcaaaagc aaatgttggg tgaatggctg tttcctctta ttcaagccat
    10261 gcaccctact cttgccggta aaatcactgg cgtgttgttg gagattgata attcagaact
    10321 tcttcatatg ctcaagtctc cagagtcact ccattctaag gttgatgaag ctgtagctgt
    10381 actacaagcc caccaagcta aagagactgc ccagaaagca gttaacagtg ccaccggtgt
    10441 tccaactgtt taaaattgat cagggaccac gaaaagaaac ttgtgcttca ccaaagaaaa
    10501 atatctaaac atcgaaaaac ttaaatatgg aaaaaaatat caaaatataa aagaaggaaa
    10561 ctgaa
//
