LOCUS       NM_012421               6232 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RLF zinc finger (RLF), mRNA.
ACCESSION   NM_012421
VERSION     NM_012421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6232)
  AUTHORS   Dolan,P.T., Zhang,C., Khadka,S., Arumugaswami,V., Vangeloff,A.D.,
            Heaton,N.S., Sahasrabudhe,S., Randall,G., Sun,R. and LaCount,D.J.
  TITLE     Identification and comparative analysis of hepatitis C virus-host
            cell protein interactions
  JOURNAL   Mol Biosyst 9 (12), 3199-3209 (2013)
   PUBMED   24136289
REFERENCE   2  (bases 1 to 6232)
  AUTHORS   Swick,L. and Kapatos,G.
  TITLE     A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein
            interactions
  JOURNAL   J Neurochem 97 (5), 1447-1455 (2006)
   PUBMED   16696853
REFERENCE   3  (bases 1 to 6232)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   4  (bases 1 to 6232)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
REFERENCE   5  (bases 1 to 6232)
  AUTHORS   Makela,T.P., Hellsten,E., Vesa,J., Hirvonen,H., Palotie,A.,
            Peltonen,L. and Alitalo,K.
  TITLE     The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc
            finger protein
  JOURNAL   Oncogene 11 (12), 2699-2704 (1995)
   PUBMED   8545128
REFERENCE   6  (bases 1 to 6232)
  AUTHORS   Makela,T.P., Kere,J., Winqvist,R. and Alitalo,K.
  TITLE     Intrachromosomal rearrangements fusing L-myc and rlf in small-cell
            lung cancer
  JOURNAL   Mol Cell Biol 11 (8), 4015-4021 (1991)
   PUBMED   1649386
REFERENCE   7  (bases 1 to 6232)
  AUTHORS   Makela,T.P., Saksela,K., Evan,G. and Alitalo,K.
  TITLE     A fusion protein formed by L-myc and a novel gene in SCLC
  JOURNAL   EMBO J 10 (6), 1331-1335 (1991)
   PUBMED   1851085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC113666.1 and BM542854.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012421.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.91576.1, U22377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372771.5/ ENSP00000361857.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5847              BC113666.1         19-5865
            5848-6232           BM542854.1         185-569
FEATURES             Location/Qualifiers
     source          1..6232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..6232
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /note="RLF zinc finger"
                     /db_xref="GeneID:6018"
                     /db_xref="HGNC:HGNC:10025"
                     /db_xref="MIM:180610"
     exon            1..250
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..5758
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /note="rearranged L-myc fusion sequence; Zn-15 related;
                     zn-15-related protein; rearranged L-myc fusion gene
                     protein"
                     /codon_start=1
                     /product="zinc finger protein Rlf"
                     /protein_id="NP_036553.2"
                     /db_xref="CCDS:CCDS448.1"
                     /db_xref="GeneID:6018"
                     /db_xref="HGNC:HGNC:10025"
                     /db_xref="MIM:180610"
                     /translation="MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAP
                     GASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYR
                     LAIQSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWLPFLQSLQES
                     HDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMR
                     IKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSMLPNEDAIKEIAKVDC
                     KEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLD
                     TFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRSSEDEEMKA
                     SVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNS
                     LRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLE
                     SFLSDYDEGKEDKQYRRRDLTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIE
                     ARILHHSKMHMEDGIYTCPVCIKKFKRKEMFVPHVMEHVKMPPSRRDRSKKKLLLKGS
                     QKGICPKSPSAIPEQNHSLNDQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVF
                     KQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQ
                     PYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRD
                     ASYTCNFLGCKKFYYSKIEYQNHLSMHNVENSNGDIKKSVKLEESATGEKQDCINQPH
                     LLNQTDKSHLPEDLFCAESANSQIDTETAENLKENSDSNSSDQLSHSSSASMNEELID
                     TLDHSETMQDVLLSNEKVFGPSSLKEKCSSMAVCFDGTKFTCGFDGCGSTYKNARGMQ
                     KHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNSDSPDEGLDHN
                     IHIKCKREHQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGY
                     PSSGAKSLQSVSSISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLM
                     HYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRATH
                     KLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDLESSCE
                     ETESKTSDISSPIGSHREEQEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSS
                     FTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKA
                     LAKHCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQCPAVFYTFNKLKHHLMEQHNIEG
                     EIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVC
                     QTADTQGHEHQTTRRSFNAKSKKCGLIKEKKAPISFKTRAEALHMCVEHSEHTQYPCM
                     VQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVVCVKYGTKIKEEPPSEADPCI
                     KKEENRSCESERTEHSHSPGDSSAPIQNTDCCHSSERDGGQKGCIESSSVFDADTLLY
                     RGTLKCNHSSKTTSLEQCNIVQPPPPCKIENSIPNPNGTESGTYFTSFQLPLPRIKES
                     ETRQHSSGQENTVKNPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKE
                     DDFDDWEPSEHLTLSNSSQSSNDLTGNVVANNMVNDSEPEVDIPHSSSDSTIHENLTA
                     IPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDL
                     FPTKKTDELCVGSS"
     exon            251..405
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            406..487
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            488..620
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            621..823
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            824..960
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1102
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..6232
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6210..6215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /note="hexamer: AATAAA"
     polyA_site      6232
                     /gene="RLF"
                     /gene_synonym="ZN-15L; ZNF292L"
                     /note="major polyA site"
ORIGIN      
        1 gggccgtggg aagatggcgg acggaaaggg agacgccgcc gctgtcgccg gggctggggc
       61 tgaggctccg gcggtagcgg gagccggaga tggagtcgag actgagtcca tggttcgggg
      121 tcatcgcccc gtatctccag cgccgggagc ctcgggactg cggccgtgtc tgtggcagct
      181 ggagacagag ctgagggagc aagaggtgtc ggaggtctca tctttgaact actgccggag
      241 cttctgccag accttattgc aatatgcaag caacaagaat gcatcagaac atattgtgta
      301 tcttctggag gtatatcgac ttgccatcca aagctttgcc agtgcacgtc catacttaac
      361 tactgaatgt gaagatgtcc tcttagtgct tggcagatta gtactgagtt gtttcgaatt
      421 actgctttca gtgtctgaaa gtgaactgcc atgtgaagtc tggctaccat tccttcagtc
      481 tctacaggag tcacatgatg cattattgga atttgggaat aataacctac aaatattggt
      541 tcatgttacc aaggaagggg tgtggaaaaa cccagttctt cttaaaattc tgtctcaaca
      601 gccagtagaa acggaggaag tcaataaatt gattgcacaa gaaggacctt cctttctgca
      661 aatgcgaata aaacatttgt tgaaatctaa ctgcatcccc caggctactg ctttatcaaa
      721 actatgtgca gaatctaaag aaatttcaaa tgtgtcatct tttcagcaag cctatatcac
      781 atgtttatgt tctatgctcc ctaatgaaga tgctattaag gagattgcaa aggtcgactg
      841 caaggaagta ctagacatca tttgtaatct ggaatctgag gggcaggata acacagcatt
      901 tgttctttgt acgacttacc ttacccagca gctccaaact gcaagtgtat attgttcttg
      961 ggaactgact cttttttgga gtaaactgca aagaagaatt gacccttctt tagatacttt
     1021 tttggagcgc tgtcgtcagt ttggtgtcat agctaaaacg cagcagcatt tattttgcct
     1081 cattagagtt atacaaactg aagcacaaga tgctggtctt ggggtgtcaa ttttactgtg
     1141 tgtcagagct cttcaactca gatcaagtga agatgaggaa atgaaggcat cagtttgtaa
     1201 aacaattgcc tgtcttttac cagaagattt agaagttaga cgagcctgtc agcttacaga
     1261 attcttaatt gaacccagtt tggatggatt taatatgtta gaagaactat atttgcaacc
     1321 agatcaaaaa tttgatgaag aaaatgcacc ggttccaaat tctcttcgat gtgagctctt
     1381 actagcttta aaagcccact ggccttttga tcctgagttt tgggactgga aaactttaaa
     1441 acgacactgc caccaacttt taggacaaga agcctcagat tctgatgatg atttaagtgg
     1501 ctatgaaatg tccattaatg acacagatgt tttagagtca tttctcagtg actatgatga
     1561 gggtaaagaa gataaacaat atagaagaag agatttgaca gatcagcata aggagaaaag
     1621 agacaaaaaa cctattggct cttctgaaag atatcagagg tggcttcagt acaagttttt
     1681 ctgtttgtta tgtaagcggg aatgtataga ggctagaatt cttcatcatt ctaagatgca
     1741 tatggaagat ggaatttaca cctgtccagt ttgtattaaa aaatttaaga gaaaagaaat
     1801 gtttgttcct catgtgatgg agcatgttaa aatgccacca agcagaaggg accgctctaa
     1861 aaagaaatta ctgttaaaag gctctcaaaa gggtatttgt cctaagagcc cctctgcaat
     1921 cccagagcaa aaccattcat tgaatgacca agccaaagga gagtctcatg aatatgtcac
     1981 attcagcaaa ttagaagatt gccacctgca agacagagat ttgtatccat gtcccggtac
     2041 agactgttcc cgtgtgttta agcaatttaa atacttaagt gtgcatctta aagctgaaca
     2101 ccaaaataat gatgaaaatg ccaagcacta cttggatatg aaaaatagaa gagagaagtg
     2161 tacttactgt cgacgacatt ttatgtctgc ttttcacctt cgagagcacg aacaagtgca
     2221 ttgtgggcct cagccttata tgtgtgtatc tatagattgc tatgctaggt ttggatcagt
     2281 aaatgaacta cttaaccata aacaaaagca tgacgatctg cgttacaaat gtgaattaaa
     2341 tggctgtaat attgttttca gtgacttggg acagctttac caccatgaag cacaacactt
     2401 tagggatgca tcttacacat gcaacttcct tggctgtaaa aagttctatt actccaaaat
     2461 tgaataccag aatcacctct caatgcataa tgttgaaaat tcaaatggag acataaagaa
     2521 atcagtgaaa cttgaggagt ctgcaacagg tgaaaagcaa gattgtatta atcagcccca
     2581 tctacttaac caaactgata aatcacattt acctgaagat cttttctgtg cagaatcagc
     2641 taattctcaa atagatacag aaactgcaga aaacctgaaa gaaaacagtg acagtaattc
     2701 tagtgatcag ttaagtcata gctcttcagc ttcaatgaat gaagagctaa ttgacacact
     2761 agatcactct gaaactatgc aggatgtatt gttatctaat gagaaagtct ttgggccctc
     2821 cagtttaaaa gaaaaatgtt ccagtatggc agtttgtttt gacgggacta agtttacctg
     2881 tggttttgat ggctgtggtt ccacatacaa aaatgcaaga ggaatgcaga aacatttacg
     2941 gaaggttcat ccataccatt tcaagcccaa aaagataaag acgaaagatc tgtttccctc
     3001 tttgggtaat gaacataatc agacaactga aaagttggat gcagaaccta aaccctgctc
     3061 agatacaaac agtgactccc cagatgaagg tctagatcac aatattcaca ttaaatgtaa
     3121 acgagaacat caaggttatt cctcagaatc ctccatttgt gcttctaaaa ggccctgtac
     3181 agaggatacc atgttggaac ttctgttacg cttgaaacat ttaagcttga aaaactcaat
     3241 aacacatgga tctttctcag ggtcattgca ggggtaccca tccagtggtg ctaagtctct
     3301 tcagtcagtt tcatctatct cagaccttaa ttttcagaat caagatgaaa acatgccaag
     3361 tcagtacctt gcacagttgg cggctaagcc gtttttctgt gagcttcaag gatgcaaata
     3421 tgaatttgtg accagagagg ctctgttaat gcattatctt aaaaagcata attattcaaa
     3481 agaaaaagtc cttcagttaa ccatgttcca acatcggtat tccccatttc agtgtcatat
     3541 ttgccaaagg tcatttacaa gaaaaacaca ccttaggatt cattataaaa ataaacatca
     3601 aattggcagt gacagagcaa ctcacaaact attagataat gaaaagtgtg atcatgaagg
     3661 cccatgttca gtagataggt tgaaaggtga ttgttctgca gaacttggag gtgatcccag
     3721 tagtaactct gagaaaccac actgtcatcc taaaaaggat gaatgtagtt ctgaaacaga
     3781 tttggaatca tcttgtgaag aaacagaaag taaaacatct gacatttcat caccaatagg
     3841 cagccataga gaagaacaag aaggaagaga gggcagaggt agcaggcgaa ctgttgctaa
     3901 aggaaatctg tgttatattt tgaataaata ccacaaacca ttccattgta ttcataaaac
     3961 ttgcaactcc tcattcacca atctaaaagg cttaattcgc cattacagaa ctgtacatca
     4021 gtacaacaaa gaacagttat gtttggagaa agacaaagca agaaccaaaa gggaacttgt
     4081 caaatgtaaa aagatatttg cttgcaaata taaggaatgt aataaacgct tcctgtgttc
     4141 caaagctctt gctaagcact gtagtgattc tcataaccta gaccatattg aagagcctaa
     4201 agtactttcc gaagctggat ctgcagcaag gttttcttgt aaccagcctc agtgccctgc
     4261 tgttttttat acattcaaca agttgaagca ccacttgatg gaacagcata atattgaagg
     4321 ggaaatacat tcagattatg aaattcattg tgatcttaat ggctgtggcc agattttcac
     4381 ccatcgcagt aattactcac aacatgtata ttaccgacat aaagactatt atgatgattt
     4441 gtttagaagc cagaaagtag caaatgagag actactaagg agtgaaaagg tatgtcaaac
     4501 agctgatact caggggcatg aacatcagac caccaggaga tcatttaatg ctaagtctaa
     4561 aaaatgtggc ttaatcaaag aaaagaaagc cccaataagt tttaaaacca gagctgaggc
     4621 cctccatatg tgtgtggagc actctgagca cacacagtac ccctgcatgg ttcaaggatg
     4681 cttatctgtg gtgaagttgg agagcagcat tgtgaggcat tacaaacgca ctcatcagat
     4741 gagtagtgcc tatttagagc aacagatgga gaatcttgtt gtttgcgtta agtacggtac
     4801 caaaattaag gaggaacccc cttctgaagc agatccctgt ataaagaaag aagaaaatag
     4861 aagctgtgaa tcagagcgca cagaacacag ccattccccg ggtgacagta gtgcacccat
     4921 ccagaacact gattgctgtc attcaagtga aagggatgga ggtcagaaag ggtgcataga
     4981 aagcagctca gtatttgatg cagatactct gctctacagg ggaactttga aatgtaatca
     5041 tagttccaaa accacttccc tagaacagtg taatatagtt cagcctcctc ctccttgtaa
     5101 aatagaaaat tccataccta atcccaatgg gactgaaagt gggacttatt tcacaagttt
     5161 ccagctgcct ttaccaagga tcaaagaatc agaaactagg cagcatagtt cagggcaaga
     5221 aaacactgta aaaaatccaa cccatgtccc aaaagagaat tttaggaaac attcacagcc
     5281 ccggtcattt gatttgaaga cttacaaacc tatgggattt gaatcttcat ttctgaaatt
     5341 tattcaggaa agtgaagaga aagaagatga ttttgatgat tgggagcctt cagagcactt
     5401 aacattaagt aattcttcac agtccagtaa tgatttaaca gggaatgttg tggcaaataa
     5461 tatggtgaat gacagtgaac ctgaagttga catacctcat tcttccagtg actctacaat
     5521 tcatgagaac ctgactgcaa tcccaccttt aatagtagct gaaacaacaa cagttccttc
     5581 cttggaaaac ctgagggttg tattggacaa agcattaaca gactgtggag agcttgcctt
     5641 aaaacagctt cattatcttc ggccagtggt ggttcttgaa agatctaagt tttccacacc
     5701 aattttagac ttatttccaa caaaaaagac agatgagctt tgtgtaggaa gttcataagt
     5761 agcaattttg ttttagtaac agactggctc caacactgca acatggggac atttgccaac
     5821 tcgaacaaag gctgagaagc agccacaccg ttgtttaggg tagaataggc tgtgtattta
     5881 catgaatgta taatatctat gtcagcagta ttggctgagt ccattagctc tccagttggt
     5941 ttaatgattg ggtttatttt tgtttgtttg tttattaaaa aaatggaact gtacacttgt
     6001 ttggtgctaa ttaatacatc aaaatatact ggggcttcct ttttcaaatt aagtgtgcat
     6061 gattgtatat ggaacaaata ctaaggtccc agggtgggag ggctagggaa agggatatgg
     6121 agttcttact tgacttgaat gtgcacctga gggtgctttg tgtaatatat tgtacactac
     6181 agcatcttat attttttgag ttgagtttca ataaattaca atttttcacc ca
//
