LOCUS       NM_032848               1858 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RBPJ interacting and tubulin associated 1 (RITA1),
            transcript variant 1, mRNA.
ACCESSION   NM_032848
VERSION     NM_032848.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Tang,H., Li,X., Jiang,L., Liu,Z., Chen,L., Chen,J., Deng,M.,
            Zhou,F., Zheng,X. and Liu,Z.
  TITLE     RITA1 drives the growth of bladder cancer cells by recruiting
            TRIM25 to facilitate the proteasomal degradation of RBPJ
  JOURNAL   Cancer Sci 113 (9), 3071-3084 (2022)
   PUBMED   35701858
  REMARK    GeneRIF: RITA1 drives the growth of bladder cancer cells by
            recruiting TRIM25 to facilitate the proteasomal degradation of
            RBPJ.
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Wildner,J.M., Friemel,A., Jennewein,L., Roth,S., Ritter,A.,
            Schuttler,C., Chen,Q., Louwen,F., Yuan,J. and Kreis,N.N.
  TITLE     RITA Is Expressed in Trophoblastic Cells and Is Involved in
            Differentiation Processes of the Placenta
  JOURNAL   Cells 8 (12), 1484 (2019)
   PUBMED   31766533
  REMARK    GeneRIF: RITA Is Expressed in Trophoblastic Cells and Is Involved
            in Differentiation Processes of the Placenta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Hoock,S.C., Ritter,A., Steinhauser,K., Roth,S., Behrends,C.,
            Oswald,F., Solbach,C., Louwen,F., Kreis,N.N. and Yuan,J.
  TITLE     RITA modulates cell migration and invasion by affecting focal
            adhesion dynamics
  JOURNAL   Mol Oncol 13 (10), 2121-2141 (2019)
   PUBMED   31353815
  REMARK    GeneRIF: This study identifies RITA as a novel crucial player in
            cell migration and invasion by affecting the turnover of focal
            adhesions through its interference with the dynamics of actin
            filaments and microtubules. Its deregulation may contribute to
            malignant progression.
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Brockmann,B., Mastel,H., Oswald,F. and Maier,D.
  TITLE     Analysis of the interaction between human RITA and Drosophila
            Suppressor of Hairless
  JOURNAL   Hereditas 151 (6), 209-219 (2014)
   PUBMED   25588307
  REMARK    GeneRIF: human RITA, binding to Drosophila Su(H) and tubulin,
            cannot influence the Notch signalling pathway in the fly
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Wang,H., Yang,Z., Liu,C., Huang,S., Wang,H., Chen,Y. and Chen,G.
  TITLE     RBP-J-interacting and tubulin-associated protein induces apoptosis
            and cell cycle arrest in human hepatocellular carcinoma by
            activating the p53-Fbxw7 pathway
  JOURNAL   Biochem Biophys Res Commun 454 (1), 71-77 (2014)
   PUBMED   25445601
  REMARK    GeneRIF: RITA overexpression increased expression of p53 and Fbxw7
            and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1
            and NF-kappaB p65. These changes led to growth inhibition and
            induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2
            cells.
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Wang,H., Chen,G., Wang,H. and Liu,C.
  TITLE     RITA inhibits growth of human hepatocellular carcinoma through
            induction of apoptosis
  JOURNAL   Oncol Res 20 (10), 437-445 (2013)
   PUBMED   24308154
  REMARK    GeneRIF: RITA might suppress tumor growth and induce apoptosis in
            hepatocellular carcinoma.
REFERENCE   9  (bases 1 to 1858)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 1858)
  AUTHORS   Wacker,S.A., Alvarado,C., von Wichert,G., Knippschild,U.,
            Wiedenmann,J., Clauss,K., Nienhaus,G.U., Hameister,H., Baumann,B.,
            Borggrefe,T., Knochel,W. and Oswald,F.
  TITLE     RITA, a novel modulator of Notch signalling, acts via nuclear
            export of RBP-J
  JOURNAL   EMBO J 30 (1), 43-56 (2011)
   PUBMED   21102556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA207985.1, AK027733.1 and AA594422.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032848.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.684349.1,
                                           SRR3476690.1160026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000548278.2/ ENSP00000449841.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA207985.1         194-222
            30-1804             AK027733.1         1-1775
            1805-1858           AA594422.1         4-57                c
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1858
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /note="RBPJ interacting and tubulin associated 1"
                     /db_xref="GeneID:84934"
                     /db_xref="HGNC:HGNC:25925"
                     /db_xref="MIM:620696"
     exon            1..301
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /inference="alignment:Splign:2.1.0"
     exon            302..433
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /inference="alignment:Splign:2.1.0"
     exon            434..799
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1307
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RBPJ-interacting and tubulin-associated protein 1"
                     /codon_start=1
                     /product="RBPJ-interacting and tubulin-associated protein
                     1 isoform 1"
                     /protein_id="NP_116237.1"
                     /db_xref="CCDS:CCDS9166.1"
                     /db_xref="GeneID:84934"
                     /db_xref="HGNC:HGNC:25925"
                     /db_xref="MIM:620696"
                     /translation="MKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAG
                     TRPTPPDFDPPWVEKANRTRGVGKEASKALGAKGSCETTPSRGSTPTLTPRKKNKYRP
                     ISHTPSYCDESLFGSRSEGASFGAPRMAKGDAAKLRALLWTPPPTPRGSHSPRPREAP
                     LRAIHPAGPSKTEPGPAADSQKLSMGGLHSSRPLKRGLSHSLTHLNVPSTGHPATSAP
                     HTNGPQDLRPSTSGVTFRSPLVTSRARSVSISVPSTPRRGGATQKPKPPWK"
     exon            800..1858
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /note="major polyA site"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
                     /note="hexamer: AATAGA"
     polyA_site      1858
                     /gene="RITA1"
                     /gene_synonym="C12orf52; RITA"
ORIGIN      
        1 agtgctgctg gctgctccct ggttgctggg tgcaaagtgc tgggttctgg gtttctggat
       61 tcgcgggccg ttcacacgta gcctgtgccg gctcctcggg tgagtccgtc cgcgcgcggt
      121 gccccgggac ggcctaggct gccgggggtc cggggcccca ggcattccgg gctgcagatt
      181 gacggggatc ccggatgcac cgcgcgcccc cgcgccctca ccgacgggtc cagacctggt
      241 gggaagaagg tgcggggacg ggtccctgag gatcccgatg cctacgagcc aagatgctca
      301 gctttatagg tgtgacctac acatgtgact tcacctcagt tttgtgatcc gtaaaatgga
      361 caaattcgaa gctacttcac agtgctgttg agaggattaa atgaaacaat gcttgtaaag
      421 ctctttgcag gagggagcct cggaagcagg gcctggccgg cagagcacac ctgctgtcac
      481 cagggaccac aggcagcatg aagacccccg tggagctggc cgtcagtggg atgcagaccc
      541 tcggccttca gcaccgctgc cgaggtggct accgggtcaa ggccaggacg tcatatgtgg
      601 atgagactct gtttggcagc ccagcaggca cccggcctac cccaccggac ttcgatccgc
      661 cctgggtgga gaaggctaac agaaccagag gcgtgggcaa ggaggcatcg aaggccttgg
      721 gggcaaaggg gagctgtgag accaccccct caaggggcag cacccccacc ctcacaccaa
      781 ggaagaagaa caaatacaga cccatcagcc acaccccgtc ttactgtgat gagtcgctgt
      841 ttggctcccg atctgaaggc gccagcttcg gggccccgcg gatggcgaag ggggatgccg
      901 caaagctccg tgctctcttg tggacgccac cacctacccc caggggtagc cactcgcccc
      961 gccccaggga ggcaccactg cgagccattc acccagctgg tccctccaag acagagccgg
     1021 ggccagcggc agactcccag aagttatcta tgggtgggtt acactcttca cgccccctga
     1081 agcggggact ttcccattcc ctcacccacc tgaatgtccc cagcactggt catccagcca
     1141 ccagtgcccc ccacacaaat gggcctcagg atctcaggcc ttccacgtca ggggtgacct
     1201 tccggagccc cctggtgact tccagggctc gctcagttag catttcagtg ccatctaccc
     1261 cacgacgagg tggggccacc cagaaaccaa agcccccttg gaaatgatac tctttcatca
     1321 gggttgccta tggggccacg gcgacaggta tggccccttg ccagggtagg aggacattca
     1381 tcacccaggg aaccccaggt attaaagaag cccctgtggg ggcagacaga catagcaggg
     1441 gtgggcagtg cctcccttta tcctgacaat ctctagtcga ttcttgcctt tttctcccga
     1501 ttgcggattt gggggccacc tctaagatgc ctctctccag ccctgtctca accatactcc
     1561 aaattagtgc caacccaggg gcctggcacc tcccacatca tccattgtct tgctgccaag
     1621 tgcgaataaa cggcgtgatt gccaacctgg agggtcccct cttatccctt caagccaagc
     1681 ttcctgctca ggattagttt ccagctaagt ctgcaagccc tagaggagtt tttccaggct
     1741 gtctgtgaag cctggggaac acaacggcaa ctgggagatt tgtgagtgaa cactgtttca
     1801 tcttaatatg cttctgaatt tattttcatg tactaaatag atcagctcat caaagcca
//
