LOCUS       NM_006912               3390 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 2,
            mRNA.
ACCESSION   NM_006912
VERSION     NM_006912.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Su,Y., Lin,H., Yu,J., Mao,L., Jin,W., Liu,T., Jiang,S., Wu,Y.,
            Zhang,S., Geng,Q., Ge,C., Zhao,F., Chen,T., Cui,Y., Li,J., Hou,H.,
            Zhou,X. and Li,H.
  TITLE     RIT1 regulates mitosis and promotes proliferation by interacting
            with SMC3 and PDS5 in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 326 (2023)
   PUBMED   38017479
  REMARK    GeneRIF: RIT1 regulates mitosis and promotes proliferation by
            interacting with SMC3 and PDS5 in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Ichikawa,Y., Kuroda,H., Ikegawa,T., Kawai,S., Ono,S., Kim,K.S.,
            Yanagi,S., Kurosawa,K., Aoki,Y. and Ueda,H.
  TITLE     Cardiac features of Noonan syndrome in Japanese patients
  JOURNAL   Cardiol Young 33 (4), 564-569 (2023)
   PUBMED   35475426
  REMARK    GeneRIF: Cardiac features of Noonan syndrome in Japanese patients.
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Che,M. and Lan,Q.
  TITLE     RIT1 Promotes Glioma Proliferation and Invasion via the
            AKT/ERK/NF-kB Signaling Pathway
  JOURNAL   J Mol Neurosci 72 (8), 1547-1556 (2022)
   PUBMED   35290620
  REMARK    GeneRIF: RIT1 Promotes Glioma Proliferation and Invasion via the
            AKT/ERK/NF-kB Signaling Pathway.
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Lo,A., Holmes,K., Kamlapurkar,S., Mundt,F., Moorthi,S., Fung,I.,
            Fereshetian,S., Watson,J., Carr,S.A., Mertins,P. and Berger,A.H.
  TITLE     Multiomic characterization of oncogenic signaling mediated by
            wild-type and mutant RIT1
  JOURNAL   Sci Signal 14 (711), eabc4520 (2021)
   PUBMED   34846918
  REMARK    GeneRIF: Multiomic characterization of oncogenic signaling mediated
            by wild-type and mutant RIT1.
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Hynds,D.L., Spencer,M.L., Andres,D.A. and Snow,D.M.
  TITLE     Rit promotes MEK-independent neurite branching in human
            neuroblastoma cells
  JOURNAL   J Cell Sci 116 (Pt 10), 1925-1935 (2003)
   PUBMED   12668729
  REMARK    GeneRIF: Rit plays a key role in human neuronal development and
            regeneration through activating both known and as yet undefined
            signaling pathways
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Reuther,G.W. and Der,C.J.
  TITLE     The Ras branch of small GTPases: Ras family members don't fall far
            from the tree
  JOURNAL   Curr Opin Cell Biol 12 (2), 157-165 (2000)
   PUBMED   10712923
  REMARK    Review article
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Wes,P.D., Yu,M. and Montell,C.
  TITLE     RIC, a calmodulin-binding Ras-like GTPase
  JOURNAL   EMBO J 15 (21), 5839-5848 (1996)
   PUBMED   8918462
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Lee,C.H., Della,N.G., Chew,C.E. and Zack,D.J.
  TITLE     Rin, a neuron-specific and calmodulin-binding small G-protein, and
            Rit define a novel subfamily of ras proteins
  JOURNAL   J Neurosci 16 (21), 6784-6794 (1996)
   PUBMED   8824319
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK298768.1, BC104186.2,
            AL355388.30, AL139128.24 and BU674989.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2019 this sequence version replaced NM_006912.5.
            
            Summary: This gene encodes a member of a subfamily of Ras-related
            GTPases. The encoded protein is involved in regulating p38
            MAPK-dependent signaling cascades related to cellular stress. This
            protein also cooperates with nerve growth factor to promote
            neuronal development and regeneration. Alternate splicing results
            in multiple transcript variants. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences. These difference cause
            translation at a downstream start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus, compared to isoform
            2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.276594.1,
                                           SRR1803612.3340.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368323.8/ ENSP00000357306.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK298768.1         54-129
            77-129              BC104186.2         1-53
            130-130             AL355388.30        4462-4462           c
            131-1064            BC104186.2         55-988
            1065-2809           AL139128.24        134902-136646       c
            2810-3390           BU674989.1         13-593              c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3390
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /note="Ras like without CAAX 1"
                     /db_xref="GeneID:6016"
                     /db_xref="HGNC:HGNC:10023"
                     /db_xref="MIM:609591"
     exon            1..107
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..256
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..810
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /EC_number="3.6.5.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     GTP-binding protein Roc1; GTP-binding protein Rit1;
                     ras-like without CAAX protein 1; ras-like protein
                     expressed in many tissues; Ric-like, expressed in many
                     tissues"
                     /codon_start=1
                     /product="GTP-binding protein Rit1 isoform 2"
                     /protein_id="NP_008843.1"
                     /db_xref="CCDS:CCDS1123.1"
                     /db_xref="GeneID:6016"
                     /db_xref="HGNC:HGNC:10023"
                     /db_xref="MIM:609591"
                     /translation="MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISH
                     RFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSI
                     TDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPF
                     FETSAAYRYYIDDVFHALVREIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSV
                     T"
     exon            257..313
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..387
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..579
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..3390
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1044
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /note="hexamer: AATACA"
     polyA_site      3390
                     /gene="RIT1"
                     /gene_synonym="NS8; RIBB; RIT; ROC1"
                     /note="major polyA site"
ORIGIN      
        1 agtgccggag cctccgcgag tgaaggaaga cgaagtgcgt gacccgaccg gctgtggtgt
       61 tccagtcccc actgaccagt aggagcagca gggcgtcggc ttgtgaggtg gcttttcctc
      121 ggggcaaccg aggaaggccc caagaggaca atggattctg gaactcgccc agttggtagc
      181 tgctgtagca gccccgctgg gctctcacgg gagtacaaac tagtgatgct gggtgctggt
      241 ggtgtaggga agagtgccat gaccatgcag ttcatcagcc accgattccc agaagatcat
      301 gatcccacca ttgaagatgc ttataagatc aggatccgta ttgatgatga gcctgccaat
      361 ctggacattt tggatacagc tggacaggca gagtttacag ccatgcggga ccagtatatg
      421 agggcaggag aagggtttat catctgttac tctatcacgg atcgtcgaag tttccatgaa
      481 gttcgtgagt ttaaacagct tatttatcga gtccgacgta ctgacgatac acctgtggtt
      541 cttgtgggaa acaagtcaga cctcaaacag ctaagacagg tcaccaagga agaaggattg
      601 gccttggccc gagaattcag ctgtcccttt tttgagacat ctgctgcata ccgctactat
      661 attgatgatg ttttccatgc ccttgtacgg gagatacgta ggaaagaaaa ggaggcagta
      721 ctggccatgg agaaaaaatc taagcccaaa aacagtgtat ggaagaggct aaaatcacca
      781 ttccggaaga agaaagattc agtaacttga agagaagatg tgaagtgttt atctgtgaac
      841 tgcagtgctg tatcaaagca gtccagtaac ctgcagtact gagtatggtg cttgctcttt
      901 cacttaactg ataagaggga catgcctact aggagttttt aatgatgtgg tatttaaagt
      961 attgtctctt agttaagtat gatttattaa cccagtggag cactgtctgc ttttaaattg
     1021 tcacattaga atttgttcta ccaatgtttt gggttctgtt gcgctattaa ttaatgtaaa
     1081 tttgtttata cccaggagaa tatgtatacc atgtgtgttt gactaagttc acaagggaag
     1141 tttttggctc tgcactccac attatccttt aatttcaatt tcctgggact atcccagaga
     1201 aagacctcag tctcttctat tcacactatg cttcctagag acagaacaaa aatcatgtag
     1261 ggaaattggg gctaatgaga tcagtgccaa atttcagcag atacctgtga ggctgacacc
     1321 tgttgcagac tatggagtgg tgagatttgg gaaagttggg ctatatgttt gcagggactt
     1381 aaaaaggtag gttcagaaca gtattctcag tacaagcttc gcttttctaa gaagtacaca
     1441 tttggcccaa attcaccggg ataagtgaga acagccagaa gcataaaatg tgatgaaggt
     1501 ttctcctggg aaccttattt tactcttcat ttcagggttt tctttttttt tttaccttca
     1561 aaggtagaca ttttgggaat cataactgta ttactaaacg tgtttaatca aaattcatag
     1621 ttggatcagc cattgccttg tacaggttta ttttttcccc acagacgcac acaccaacac
     1681 atttatattc attgcttcct cccactttgt gctctgtaaa agagctacag ctggcaagat
     1741 gttttttcgg cccttcatca ctgattgcat tttccataca gaagagacat caggggtgtg
     1801 ggtaaaattg tgtgtgtgcc tccttgacgt ggacaatcac tagactcagt gctctgagaa
     1861 aatctgctat ttctgttgaa tgggtcagtc ttaaagcttt aaaattcaca taggtggagt
     1921 ttcccatctg aagatttctt tacaaggact ttgctaagtt catctcaggg ttatctgagc
     1981 cttgaccaag tttatcctaa gggaatacca ctttgctccc tgtgcatagt ttaggaactg
     2041 tagtcctagg aggaaacagc tttaaatatt ggtagtgagt tgtctaagat caggactgtt
     2101 ttgatatctg accttgttat atgcggagag taaatgcaaa aatgctaaga gtaatgcatc
     2161 atgtattgaa tattaagtgt cactgaagca atgtttgtgt tgactagaaa cgtaagatga
     2221 cttgtgtagc acctctttat aagcacacag ctcatcttaa tattttccat ttttattaga
     2281 ggaagtagga cagagttgtg tttttcttta taaacaaatg ataaactagc ttttttaaaa
     2341 agtgactgtt agaacttttt tagctctgag tagtggtccc tttttaaact cctggaaaca
     2401 tttttgttac caaataaatc atgttttatg gtactcagcc atccaaaagt gaaagaccta
     2461 gcatttgatt ctgtgcagga cacaaatctc acaggaacta tagcactttg gaaaagcatc
     2521 aaagtagaaa agaaatacag tgcaattcta ttatgagaat gttttacatt taaactggtt
     2581 tagcaccttt taagtttaaa gcccatagct tcttattact agtgacctag ggaattgtta
     2641 ttaacattaa gagatatata tatatatata tatatatatt tttttttttt tttttttttt
     2701 tttttaaata gagatgaggt ttcactatgt tgcccaggct gatctcgaac tcctaggctc
     2761 aagcaatcct cccaatatgc tgggattaca ggcatgagcc accacctggc ccaagcaaga
     2821 aattgacact atatagttat ttaaggtagt caggcagtag aaacattgcc agaaggatag
     2881 aaaggaattt ggattatata taaggaaaat aacaaatcgg tgtttttaag actatcactg
     2941 tcatatatta gatccttgta ttagtccatc cattaatatt agttctattc gtggtgctag
     3001 gtagcttgac aggtatgata tgcataagtc atagctctat tcttagtgtc ataaagtgta
     3061 gctaatttat aagctctaag taatcagctt tatctaattt gagggcatta aaattactgc
     3121 ctagaacttt gagaagagaa aaattcaggg ataagttgaa aggcactgga actgttcatg
     3181 tccataccag accggtaaat tataagatcc agatgttagt gtctagaatt agctgtttag
     3241 aattcagagg ggacatatgt tttaactttg tcatatatta gcaagaattg gtctactgtg
     3301 atgtttgggg aggaggaggg ggggataatt tttttaatgc acttgtatgt gaagacagtt
     3361 tgtatgacat aatacaaaac ttttaaacaa
//
