LOCUS       NM_138382               1196 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ripply transcriptional repressor 1 (RIPPLY1),
            transcript variant 1, mRNA.
ACCESSION   NM_138382 XM_372239 XM_936957
VERSION     NM_138382.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1196)
  AUTHORS   Whitcomb,D.C., LaRusch,J., Krasinskas,A.M., Klei,L., Smith,J.P.,
            Brand,R.E., Neoptolemos,J.P., Lerch,M.M., Tector,M., Sandhu,B.S.,
            Guda,N.M., Orlichenko,L., Alkaade,S., Amann,S.T., Anderson,M.A.,
            Baillie,J., Banks,P.A., Conwell,D., Cote,G.A., Cotton,P.B.,
            DiSario,J., Farrer,L.A., Forsmark,C.E., Johnstone,M., Gardner,T.B.,
            Gelrud,A., Greenhalf,W., Haines,J.L., Hartman,D.J., Hawes,R.A.,
            Lawrence,C., Lewis,M., Mayerle,J., Mayeux,R., Melhem,N.M.,
            Money,M.E., Muniraj,T., Papachristou,G.I., Pericak-Vance,M.A.,
            Romagnuolo,J., Schellenberg,G.D., Sherman,S., Simon,P., Singh,V.P.,
            Slivka,A., Stolz,D., Sutton,R., Weiss,F.U., Wilcox,C.M.,
            Zarnescu,N.O., Wisniewski,S.R., O'Connell,M.R., Kienholz,M.L.,
            Roeder,K., Barmada,M.M., Yadav,D. and Devlin,B.
  CONSRTM   Alzheimer's Disease Genetics Consortium
  TITLE     Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter
            risk for alcohol-related and sporadic pancreatitis
  JOURNAL   Nat Genet 44 (12), 1349-1354 (2012)
   PUBMED   23143602
REFERENCE   3  (bases 1 to 1196)
  AUTHORS   Takahashi,J., Ohbayashi,A., Oginuma,M., Saito,D., Mochizuki,A.,
            Saga,Y. and Takada,S.
  TITLE     Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism
            underlying the rostro-caudal patterning within a somite
  JOURNAL   Dev Biol 342 (2), 134-145 (2010)
   PUBMED   20346937
REFERENCE   4  (bases 1 to 1196)
  AUTHORS   Kawamura,A., Koshida,S., Hijikata,H., Ohbayashi,A., Kondoh,H. and
            Takada,S.
  TITLE     Groucho-associated transcriptional repressor ripply1 is required
            for proper transition from the presomitic mesoderm to somites
  JOURNAL   Dev Cell 9 (6), 735-744 (2005)
   PUBMED   16326386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591849.7, BC105691.1 and BC007652.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138382.2.
            
            Summary: This gene encodes a protein similar to a zebrafish protein
            which acts as a transcriptional repressor in and is required for
            somite segmentation in zebrafish embryos (PMID: 16326386). Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007652.1, BC101998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276173.5/ ENSP00000276173.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL591849.7         32704-32713         c
            11-1041             BC105691.1         1-1031
            1042-1196           BC007652.1         1018-1172
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..1196
                     /gene="RIPPLY1"
                     /note="ripply transcriptional repressor 1"
                     /db_xref="GeneID:92129"
                     /db_xref="HGNC:HGNC:25117"
                     /db_xref="MIM:300575"
     exon            1..209
                     /gene="RIPPLY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..510
                     /gene="RIPPLY1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein ripply1; ripply1 homolog"
                     /codon_start=1
                     /product="protein ripply1 isoform 1"
                     /protein_id="NP_612391.1"
                     /db_xref="CCDS:CCDS48145.1"
                     /db_xref="GeneID:92129"
                     /db_xref="HGNC:HGNC:25117"
                     /db_xref="MIM:300575"
                     /translation="MDSAACAAAATPVPALALALAPDLAQAPLALPGLLSPSCLLSSG
                     QEVNGSERGTCLWRPWLSSTNDSPRQMRKLVDLAAGGATAAEVTKAESKFHHPVRLFW
                     PKSRSFDYLYSAGEILLQNFPVQATINLYEDSDSEEEEEDEEQEDEEEK"
     exon            210..285
                     /gene="RIPPLY1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..350
                     /gene="RIPPLY1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..1196
                     /gene="RIPPLY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPPLY1"
                     /note="hexamer: AATAAA"
     polyA_site      1196
                     /gene="RIPPLY1"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcagaa ggttctggga agtaggagac cccactggct ttggtcccct aagaatggac
       61 tctgctgcct gtgctgctgc tgccacccct gttccagccc tggctttggc cctagctcca
      121 gacctagcac aagccccact ggcactccct ggcctgttaa gcccatcttg ccttctctcc
      181 tctggacaag aagtaaatgg gagtgaaaga ggaacttgtc tctggaggcc ctggctgtct
      241 tccacaaatg actccccaag gcagatgagg aagctggtgg atttggctgc tggtggggca
      301 acggctgctg aggtcaccaa ggctgaatcc aagttccatc accctgtcag gctcttctgg
      361 cctaaatccc gctccttcga ctatctgtac agtgctgggg agattttact gcagaacttt
      421 cctgtccagg caaccatcaa cctatacgag gactcagaca gcgaagaaga agaggaagat
      481 gaagagcagg aggatgaaga agagaagtag gaggccaatg aaaaggggcc agaagggtgt
      541 gtgagggtac cagggtccat accctacagc gccacagctc atcccccttc ctcaccccta
      601 acctatccaa atggaggcag ccagagtctg attggggttc agtttgtctg gcaagttttc
      661 acagacatca gttagccgga agtattagtc cagcagatag agctttctgg actgaaaatt
      721 gggtcatcta gctgcccagc tcaccctggc ttacctgaat ggcctgtgag ctcaggcctc
      781 ttgcatctca ttgtctgggc tgctgttgtg ttgaccatgg gagggttcta ggagctctag
      841 aaggaaggct tgctgaagcc cccaggaagc agagcagggc agggaatgcc cttgtggagg
      901 gaagtagtca ttcctcaggc cctttgactc cctagccttc ccaggtggcc atgtagtccc
      961 gtctctctgt ggaaagcctg acttctggct tcaccccaag gaataccaac agcagatcca
     1021 tgcaaggttg gggtgccttt ttgatgagtc ttacaggaag ggaaggcagt gtgtagagaa
     1081 tcggcttgct ctggggatgc ctccccattt tgcctgctgt ccattgaagt ctgtgtgttg
     1141 gcatgagatg aatcaggaga aaaataaact ggatggtgtt ttcctttttc ttggaa
//
