LOCUS       NM_001286445            5295 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RHO family interacting cell polarization regulator 2
            (RIPOR2), transcript variant 3, mRNA.
ACCESSION   NM_001286445 XM_005249501
VERSION     NM_001286445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5295)
  AUTHORS   Olmedo-Nieva,L., Munoz-Bello,J.O., Martinez-Ramirez,I.,
            Martinez-Gutierrez,A.D., Ortiz-Pedraza,Y., Gonzalez-Espinosa,C.,
            Madrid-Marina,V., Torres-Poveda,K., Bahena-Roman,M. and Lizano,M.
  TITLE     RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An
            Opportunity in the Search for Prognostic Biomarkers in Cervical
            Cancer
  JOURNAL   Cells 11 (23), 3942 (2022)
   PUBMED   36497200
  REMARK    GeneRIF: RIPOR2 Expression Decreased by HPV-16 E6 and E7
            Oncoproteins: An Opportunity in the Search for Prognostic
            Biomarkers in Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5295)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5295)
  AUTHORS   Pan,H., Yang,M., Lu,L., Tao,B., He,X., Chen,H., Yi,H. and Tang,S.
  TITLE     Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with
            susceptibility to antituberculosis drug-induced hepatotoxicity:
            validation study in a Chinese Han population
  JOURNAL   Pharmacogenet Genomics 29 (4), 84-90 (2019)
   PUBMED   30720667
  REMARK    GeneRIF: this is the first study to explore and validate the
            relationships between seven SNPs in the FAM65B, AGBL4, and CUX2
            genes and ATDH in a Chinese population. On the basis of this
            case-control study, SNP rs10946737 in FAM65B may be associated with
            susceptibility to ATDH in Chinese Han anti-TB treatment patients.
REFERENCE   4  (bases 1 to 5295)
  AUTHORS   Diaz-Horta,O., Abad,C., Cengiz,F.B., Bademci,G., Blackwelder,P.,
            Walz,K. and Tekin,M.
  TITLE     Ripor2 is involved in auditory hair cell stereociliary bundle
            structure and orientation
  JOURNAL   J Mol Med (Berl) 96 (11), 1227-1238 (2018)
   PUBMED   30280293
REFERENCE   5  (bases 1 to 5295)
  AUTHORS   Megrelis,L., El Ghoul,E., Moalli,F., Versapuech,M., Cassim,S.,
            Ruef,N., Stein,J.V., Mangeney,M. and Delon,J.
  TITLE     Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell
            Migration
  JOURNAL   Front Immunol 9, 2001 (2018)
   PUBMED   30254631
  REMARK    GeneRIF: results show that Fam65b expression and phosphorylation
            can finely tune the amount of active RhoA in order to favor optimal
            T lymphocyte motility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5295)
  AUTHORS   Morrish,D.W., Dakour,J. and Li,H.
  TITLE     Life and death in the placenta: new peptides and genes regulating
            human syncytiotrophoblast and extravillous cytotrophoblast lineage
            formation and renewal
  JOURNAL   Curr Protein Pept Sci 2 (3), 245-259 (2001)
   PUBMED   12369935
  REMARK    Review article
REFERENCE   7  (bases 1 to 5295)
  AUTHORS   Kunst,H., Marres,H., Huygen,P., van Duijnhoven,G., Krebsova,A., van
            der Velde,S., Reis,A., Cremers,F. and Cremers,C.
  TITLE     Non-syndromic autosomal dominant progressive non-specific
            mid-frequency sensorineural hearing impairment with childhood to
            late adolescence onset (DFNA21)
  JOURNAL   Clin Otolaryngol Allied Sci 25 (1), 45-54 (2000)
   PUBMED   10764236
REFERENCE   8  (bases 1 to 5295)
  AUTHORS   Bom,S.J., Kunst,H.P., Huygen,P.L., Cremers,F.P. and Cremers,C.W.
  TITLE     Non-syndromal autosomal dominant hearing impairment: ongoing
            phenotypical characterization of genotypes
  JOURNAL   Br J Audiol 33 (5), 335-348 (1999)
   PUBMED   10890148
REFERENCE   9  (bases 1 to 5295)
  AUTHORS   Morrish,D.W., Dakour,J. and Li,H.
  TITLE     Functional regulation of human trophoblast differentiation
  JOURNAL   J Reprod Immunol 39 (1-2), 179-195 (1998)
   PUBMED   9786461
  REMARK    Review article
REFERENCE   10 (bases 1 to 5295)
  AUTHORS   Dakour,J., Li,H. and Morrish,D.W.
  TITLE     PL48: a novel gene associated with cytotrophoblast and
            lineage-specific HL-60 cell differentiation
  JOURNAL   Gene 185 (2), 153-157 (1997)
   PUBMED   9055809
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299047.1, AL512428.13 and
            AA760782.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001286445.2.
            
            Summary: This gene encodes an atypical inhibitor of the small G
            protein RhoA. Inhibition of RhoA activity by the encoded protein
            mediates myoblast fusion and polarization of T cells and
            neutrophils. The encoded protein is a component of hair cell
            stereocilia that is essential for hearing. A splice site mutation
            in this gene results in hearing loss in human patients. [provided
            by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) has an alternate 5' exon and
            it thus differs in the 5' UTR and initiates translation at an
            alternate start codon, and it lacks an alternate in-frame exon in
            the central coding region, compared to variant 1. The encoded
            isoform (3) has a distinct N-terminus and is shorter than isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299047.1, SRR14038193.2262007.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643898.2/ ENSP00000494268.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               AK299047.1         1-761
            762-762             AL512428.13        63339-63339         c
            763-2568            AK299047.1         763-2568
            2569-2569           AL512428.13        30646-30646         c
            2570-2872           AK299047.1         2570-2872
            2873-2873           AL512428.13        27634-27634         c
            2874-3212           AK299047.1         2874-3212
            3213-4999           AL512428.13        6931-8717           c
            5000-5295           AA760782.1         36-331              c
FEATURES             Location/Qualifiers
     source          1..5295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..5295
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /note="RHO family interacting cell polarization regulator
                     2"
                     /db_xref="GeneID:9750"
                     /db_xref="HGNC:HGNC:13872"
                     /db_xref="MIM:611410"
     exon            1..123
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..3206
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein FAM65B; myogenesis-related and NCAM-associated
                     protein homolog; family with sequence similarity 65 member
                     B"
                     /codon_start=1
                     /product="rho family-interacting cell polarization
                     regulator 2 isoform 3"
                     /protein_id="NP_001273374.1"
                     /db_xref="CCDS:CCDS69058.1"
                     /db_xref="GeneID:9750"
                     /db_xref="HGNC:HGNC:13872"
                     /db_xref="MIM:611410"
                     /translation="MQFFDAEELLVDEEDDVFGEGLPTRLPEIMLVGSQSFSPGGPNG
                     IIRSQSFAGFSGLQERRSRCNSFIENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKR
                     VEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRR
                     LEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLTEINRSFKEYTEN
                     MCTIEVELENLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQS
                     WDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLG
                     TIKLNLEITWYPFDVEDMTASSGAGNKAAALQRRMSMYSQGTPETPTFKDHSFFSNLP
                     DDIFENGKAAEEKMPLSLSFSDLPNGDCALTSHSTGSPSNSTNPEITITPAEFNLSSL
                     ASQNEGMDDTSSASSRNSLGEGQEPKSHLKEEDPEEPRKPASAPSEACRRQSSGAGAE
                     HLFLENDVAEALLQESEEASELKPVELDTSEGNITKQLVKRLTSAEVPMATDRLLSEG
                     SVGGESEGCRSFLDGSLEDAFNGLLLALEPHKEQYKEFQDLNQEVMNLDDILKCKPAV
                     SRSRSSSLSLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKHSYR
                     SVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVRHLQYCTQLVQQIVF
                     SSKTPFVARSLLEKLSRQIQVMEKLAAVSDENIGNISSVVEAIPEFHKKLSLLSFWTK
                     CCSPVGVYHSPADRVMKQLEASFARTVNKEYPGLADPVFRTLVSQILDRAEPLLSSSL
                     SSEVVTVFQYYSYFTSHGVSDLESYLSQLARQVSMVQTLQSLRDEKLLQTMSDLAPSN
                     LLAQQEVLRTLALLLTREDNEVSEAVTLYLAAASKNQHFREKALLYYCEALTKTNLQL
                     QKAACLALKILEATESIKMLVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPR
                     DCVKVGGRHGTEVATAF"
     exon            124..250
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            251..406
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            407..485
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            486..509
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            510..563
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            564..713
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            714..777
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            778..821
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            822..947
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1096
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1226
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1919
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2101
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2270
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2406
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2568
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2727
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2930
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3014
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3105
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..5295
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5268..5273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /note="hexamer: AATAAA"
     polyA_site      5295
                     /gene="RIPOR2"
                     /gene_synonym="C6orf32; DFNA21; DFNB104; DIFF40; DIFF48;
                     FAM65B; MYONAP; PL48"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgactg ctgagactgc cggggctgct gcctgctgct tctcgcgcct gtcctctcca
       61 agatgcagtt ttttgatgct gaggagctcc tggtcgatga agaggatgat gtttttggtg
      121 aaggactacc gaccagactc ccggaaatca tgttggtagg atcccagtct ttttcgcctg
      181 gagggcccaa tgggatcatt agaagccagt cctttgcggg tttcagcggc ctccaggaaa
      241 ggcgatccag gtgtaactcc ttcattgaaa attcctccgc tctcaagaag cctcaggcca
      301 aactgaagaa aatgcacaat ttaggccaca aaaacaacaa tccccccaaa gagcctcagc
      361 ctaaaagggt ggaagaagtc tacagggcct tgaaaaatgg acttgatgaa tatctggagg
      421 ttcaccagac ggagctggac aagttgacag ctcagttaaa agatatgaaa agaaactctc
      481 gcctgggtgt actgtatgac ctagacaagc aaattaaaac aattgaaaga tacatgagac
      541 gcctggagtt tcatataagt aaggtagatg aactctatga agcttattgt atccagcgac
      601 gcctccagga tggtgccagc aaaatgaagc aagccttcgc aacatcccct gccagcaaag
      661 ctgcccggga gagtctgaca gagatcaatc ggagcttcaa ggagtacaca gagaatatgt
      721 gcaccattga agtggagcta gagaatctgc tgggagaatt ctccatcaag atgaaaggtc
      781 tggctggctt tgcacgcctc tgtcctggag atcaatatga aattttcatg aagtatggcc
      841 ggcagcggtg gaaactgaaa ggcaaaatag aagtaaatgg caagcagagc tgggatggag
      901 aagaaacagt ttttctgccc ctgatagttg ggttcatctc catcaaggtc acggagctca
      961 aagggctagc aactcacatc ctggtaggta gcgtgacctg tgagaccaaa gagctgtttg
     1021 cagcccgacc tcaggtagtg gctgtcgaca tcaatgacct tggtaccatc aaactgaacc
     1081 tggaaatcac ctggtatcca tttgacgtgg aggacatgac cgcatcctca ggcgctggga
     1141 acaaggcagc agcccttcag aggagaatgt ccatgtacag ccagggtacc ccggaaacgc
     1201 ccaccttcaa agaccactcc ttcttttcaa atctacctga tgacatcttt gaaaatggaa
     1261 aggcagccga ggagaaaatg ccactgtcgc tcagcttcag tgacctgccc aacggggact
     1321 gcgccctcac ctcccactca acaggctccc cttccaactc aacaaatcca gaaattacca
     1381 tcacccctgc ggagtttaac ctcagcagct tggcctccca gaatgagggt atggatgaca
     1441 ccagctcagc atcttccagg aactccctgg gagaaggcca agagccaaag tcacacctga
     1501 aggaggaaga cccagaggag cccagaaaac ctgcctcggc cccatctgag gcttgccgcc
     1561 gacagtcctc aggtgctggg gctgagcacc tgttccttga gaatgatgtt gcagaagcac
     1621 ttctgcaaga gtctgaggag gcctctgagc tcaagcctgt ggaactggac acttcggaag
     1681 gaaacatcac aaagcagctg gtcaagaggc tcacatctgc agaggtgcca atggccacag
     1741 acaggctgct ctctgagggt tctgttggtg gagaatctga aggctgcaga tcctttctag
     1801 atggaagctt agaggatgct tttaatgggc ttttacttgc attagaacca cataaagagc
     1861 agtataaaga gtttcaggat ctgaaccaag aagtcatgaa tttggatgat attctaaaat
     1921 gcaagccagc agtaagccgc agcaggtctt ccagtttaag tctcacagtt gaaagtgctt
     1981 tagaaagctt tgatttcctg aacacctctg attttgacga ggaggaggat ggtgatgagg
     2041 tttgtaatgt tggcggaggt gctgactcag tattttcaga cactgagact gagaaacaca
     2101 gttacaggtc ggttcaccca gaagccaggg ggcatctcag tgaagcgctc actgaagaca
     2161 caggagttgg gaccagtgtg gcaggaagtc ctctcccact gaccacaggc aacgagagcc
     2221 tggacatcac catcgtcagg cacctccagt actgcaccca actcgtgcag caaattgttt
     2281 tctcaagcaa aaccccattt gtggcaagaa gtctcttaga gaagctttct aggcagatcc
     2341 aagtgatgga gaaactcgca gctgtcagtg atgagaacat aggaaatatc agttctgttg
     2401 tggaagccat accagaattt cacaaaaagc tgtctttgct gtcattctgg accaagtgct
     2461 gcagccctgt tggtgtctac cacagcccag cggacagagt gatgaagcag ctggaggcca
     2521 gctttgccag aactgtcaac aaagaatatc caggacttgc agacccagtg tttcgaaccc
     2581 tggtgtccca aattctggac cgggctgagc ctctgctttc ctccagcctg tcctcggaag
     2641 tcgtcactgt tttccagtat tacagttact tcaccagcca cggcgtcagt gacctggaga
     2701 gttacctgag ccagctggcc aggcaagttt ccatggttca gactctgcaa tcactaagag
     2761 atgaaaaact gctacaaacc atgagtgacc ttgctcccag caacctcctg gcccagcagg
     2821 aagtactcag gactctggct ctgctattaa ccagagagga caacgaagtt agtgaggctg
     2881 tgacgcttta cttggcagca gcctccaaaa atcagcattt cagggaaaag gccttgctct
     2941 attactgtga agcactaaca aagacaaacc tccagctcca gaaagcagct tgcctggctc
     3001 tgaaaatcct tgaggctact gaaagcatta aaatgctggt gacattgtgt caatctgata
     3061 ctgaagaaat cagaaatgtg gcctcagaaa ccctcttgtc tctgggagaa gatgggcggc
     3121 tggcatatga acaattggac aaatttcctc gagactgtgt taaagtcgga ggtcgtcatg
     3181 gaactgaagt tgccacagcc ttttaattac aggttaactg cctaacagct gtcttaatat
     3241 ctggcccttt tcatcaggat ggtgctgtgg tttgggctgg aaattgttta gagcctgaga
     3301 gacacgacaa ctgaaataaa aatgtaggcc aggtgcagtg gctcatgcct gtaatcccag
     3361 tactttggga ggccaacgca ggagaattgc ttaagcccag gaggttcaag accaacctgg
     3421 gcaacatagc aaggccctgt ctctacaaaa aaaatagttt aattagtcag gcgtggtggc
     3481 atgcacctgt agtcccagct acttgggagg ctaaggtggg aggattgctt gagcccagaa
     3541 gattcaggct gcagtgagcc ataattgccc cactgcactc cagactgggt gacagagcaa
     3601 aaccctgtct caaaaaacaa aacaacaaca acaactaaaa aaacatgtta tagaaagaat
     3661 tcagagtctc gtttcacagt acctatctac ttttcctttg gccaatatag aatagggcta
     3721 tggtataatt caaatatatt acatcgtcga ttgtgtctaa taatactcag tgaaagagtc
     3781 catcttatct taatatgtat gaaatttaaa aatagccatc tttgtacttt tttgcaagtt
     3841 tctctataag cttgaaatag tcatgtgata cttcgacaaa catcatatgc cttgcagttt
     3901 ttctcggtcg tgttctcagg gttgagtagt ccccttagct acctaacttt actttcaata
     3961 caaagcacaa aaaagaatat cttcaaataa aagtttgcct gcagaacctg gcaaaatgac
     4021 ccattaggag agtttagatg ttttaatttt atgtgctccc agctactctg gagtctgagg
     4081 tgggaggatc acttgaggca gaggttgcag taagctgaga ttacactact gcactccagc
     4141 ccatgtgaca gaggaatgag agccagtctc aaaaaaaaaa acaaaaaact cccataattt
     4201 attttgtttc ttttccccat cctgaaaatt cccaaatcat gtttccatta tggaaaaatg
     4261 ataagtaaat gactaagaac tacattaaga ttatgcctat acacttaaac aaaaaactca
     4321 aagcttatgc tttttttttt ttaattaatg agagctattt tttatgatat tcttaccata
     4381 ggggtgtttt gctgctaaga caaatcaaaa ccaaaagctg tagattcaca aacctgtgat
     4441 gctctttgag gtggaggaac ctagaagtca gagaaatcct aatggagtag gagtggagga
     4501 acatttaaag tggtccctcc ttctgtaaaa atgaccgtgg gattagaaag aaggacatcc
     4561 tgaggggtgg ttactgcccc cagggaaatc actcactggt aggattccct ggccaaatag
     4621 ttcaaacatc aggtcccatt attgcttcag tatcagagat gcaagttcat taagcaaagt
     4681 acaagaccat tcagtagctc ttattaaaat atcttttctt cctctaaaga gtgtacaagg
     4741 tggggtatgc caaggtatca aaacaatata tgtgagtgta atttaaactg tggaatatca
     4801 actgtactat ggacgtgttt gtatcattta gatgtcattt taaatattta cattttagca
     4861 agacttttaa aaaggactca tttcatttca aagtgcaaat tgtttgccag gcttctggca
     4921 aatggttctt tcaactgtga acttatcgtg tacatatctg tatatttata aatattatat
     4981 atattcatac atccttcact ttaaaggtac attgtacagt ctgtagttag gaggtatagc
     5041 ctatagctta tgttaaatgg ttgaaatggt tctttttata gaaagtcaaa cacagatgtt
     5101 acaggatttt gtgtttggtt tgtcattttt ttatttttta ttttgactat tgcatgagta
     5161 attaattcca gatcttttgt attcacttct gtattttatg tttggttgag gggtgctttt
     5221 agttgtgtgg catttgtatt cattgatctt tcagtcatgt aagttaaaat aaaaattatt
     5281 tttgaattac tagca
//
