LOCUS       NM_024519               4092 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RHO family interacting cell polarization regulator 1
            (RIPOR1), transcript variant 1, mRNA.
ACCESSION   NM_024519
VERSION     NM_024519.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4092)
  AUTHORS   Mardakheh,F.K., Self,A. and Marshall,C.J.
  TITLE     RHO binding to FAM65A regulates Golgi reorientation during cell
            migration
  JOURNAL   J Cell Sci 129 (24), 4466-4479 (2016)
   PUBMED   27807006
  REMARK    GeneRIF: These results reveal a previously unidentified pathway
            downstream of RHO that regulates the polarity of migrating cells
            through Golgi reorientation in a FAM65A-, CCM3- and MST3- and
            MST4-dependent manner.
REFERENCE   2  (bases 1 to 4092)
  AUTHORS   Gao,K., Tang,W., Li,Y., Zhang,P., Wang,D., Yu,L., Wang,C. and Wu,D.
  TITLE     Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at
            leading edges polarizes neutrophils
  JOURNAL   J Cell Sci 128 (5), 992-1000 (2015)
   PUBMED   25588844
REFERENCE   3  (bases 1 to 4092)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 4092)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4092)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN401995.1 and BC098587.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024519.3.
            
            Transcript Variant: This variant (1) encodes the shortest but
            dominant isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000042381.9/ ENSP00000042381.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               CN401995.1         16-565
            551-4092            BC098587.1         3-3544
FEATURES             Location/Qualifiers
     source          1..4092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4092
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="RHO family interacting cell polarization regulator
                     1"
                     /db_xref="GeneID:79567"
                     /db_xref="HGNC:HGNC:25836"
                     /db_xref="MIM:619842"
     exon            1..86
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            87..213
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3769
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM65A; family with sequence similarity 65 member
                     A"
                     /codon_start=1
                     /product="rho family-interacting cell polarization
                     regulator 1 isoform 1"
                     /protein_id="NP_078795.2"
                     /db_xref="CCDS:CCDS10840.1"
                     /db_xref="GeneID:79567"
                     /db_xref="HGNC:HGNC:25836"
                     /db_xref="MIM:619842"
                     /translation="MMSLSVRPQRRLLSARVNRSQSFAGVLGSHERGPRSFPVFSPPG
                     PPRKPPALSRVSRMFSVAHPAAKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQGQ
                     IRESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMV
                     RAYTTGSPGSREARDSLAEATRGHREYTESMCLLESELEAQLGEFHLRMKGLAGFARL
                     CVGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEETIFLPLLTEFLSIKVTELKGLAN
                     HVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVTWSPFDKDDQPSAASSVNKA
                     STVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSG
                     TARHSPAPRPLVQQPEPLPIQVAFRRPETPSSGPLDEEGAVAPVLANGHAPYSRTLSH
                     ISEASVDAALAEASVEAVGPESLAWGPSPPTHPAPTHGEHPSPVPPALDPGHSATSST
                     LGTTGSVPTSTDPAPSAHLDSVHKSTDSGPSELPGPTHTTTGSTYSAITTTHSAPSPL
                     THTTTGSTHKPIISTLTTTGPTLNIIGPVQTTTSPTHTMPSPTHTTASPTHTSTSPTH
                     TPTSPTHKTSMSPPTTTSPTPSGMGLVQTATSPTHPTTSPTHPTTSPILINVSPSTSL
                     ELATLSSPSKHSDPTLPGTDSLPCSPPVSNSYTQADPMAPRTPHPSPAHSSRKPLTSP
                     APDPSESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPVPTAAGGSGDRSLEEALGALM
                     AALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNED
                     EDEDNDVPGDRPPSSPEAGAEDSIDSPSARPLSTGCPALDAALVRHLYHCSRLLLKLG
                     TFGPLRCQEAWALERLLREARVLEAVCEFSRRWEIPASSAQEVVQFSASRPGFLTFWD
                     QCTERLSCFLCPVERVLLTFCNQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPQP
                     GPGEQLTVFQFWSFVETLDSPTMEAYVTETAEEVLLVRNLNSDDQAVVLKALRLAPEG
                     RLRRDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPTFRERALLCFLDQLEDEDVQTR
                     VAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRRLEESLDA
                     LPRIFGPGSMASTAF"
     exon            214..366
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            367..445
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            446..469
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            470..523
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            524..676
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            677..740
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            741..784
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            785..910
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1059
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1189
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..2587
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2709
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2842
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2978
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3140
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3299
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3496
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3580
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3671
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..4092
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4067..4072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="hexamer: AATAAA"
     polyA_site      4092
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="major polyA site"
ORIGIN      
        1 ggcgacagcg gcagctgcgg cgcgaccagg ccgggcacct ccgagcgcaa ggacagcgcg
       61 aggtccgcgc agcccagcgc agccatggag ccccgcgcgg actcactcta tgatgtccct
      121 gtcggtgcgg ccgcagcgcc gtctgctcag cgcccgggtc aataggagcc agtccttcgc
      181 aggcgtcctc ggcagccacg agcgggggcc caggagtttc ccggtcttca gcccgccggg
      241 gcccccacgg aagccccccg cgctctcccg agtgtccagg atgttttccg tggctcaccc
      301 agccgccaag gtgccgcagc ccgagcggct ggacctggtg tacacggcgc tgaagcgggg
      361 cctgacggcc tacttggaag tgcaccagca ggagcaagag aaactccagg ggcagataag
      421 ggagtccaag aggaattccc gcttgggctt cctgtatgat ctggacaagc aagtcaagtc
      481 cattgaacgc ttcctgcgac gactggagtt ccatgccagc aagatcgatg agctgtatga
      541 ggcatactgt gtccagcggc gtctccggga tggtgcctac aacatggtcc gtgcctacac
      601 cactgggtcc ccgggaagcc gagaggcccg ggacagcctg gcagaggcca ctcgggggca
      661 tcgcgagtac acggagagca tgtgtctgct ggagagcgag ctggaggcac agctgggcga
      721 gtttcatctc cgaatgaaag ggctggctgg cttcgccagg ctgtgtgtag gcgatcagta
      781 tgagatctgc atgaaatatg ggcgtcagcg ctggaaacta cggggccgaa ttgagggtag
      841 tggaaagcag gtgtgggaca gtgaagaaac catctttctc cctctactca cggaatttct
      901 gtctattaag gtgacagaac tgaagggcct ggccaaccat gtggttgtgg gcagtgtctc
      961 ctgtgagacc aaggacctgt ttgccgccct gccccaggtt gtggctgtgg atatcaatga
     1021 ccttggtacc atcaagctca gcctggaagt cacatggagc cccttcgaca aggatgacca
     1081 gccctcagct gcttcttctg tcaacaaggc ctccacagtc accaagcgct tctccaccta
     1141 tagccagagc ccaccggaca caccctcact tcgggaacag gctttctata acatgctgcg
     1201 acggcaggag gagctggaga atgggacagc atggtccctg tcatctgaat cttcagacga
     1261 ctcatccagc ccacagctct caggcactgc ccgccactca ccagccccta ggcccctggt
     1321 gcagcagccc gagccccttc ccatccaagt tgccttccgc aggcctgaga cccccagctc
     1381 tgggcccttg gatgaggagg gggccgtggc cccagtcctg gcaaatgggc atgcacccta
     1441 cagtcggact ctgagccaca tcagtgaggc tagtgtagat gctgccttgg ctgaggcttc
     1501 agtggaggcc gttggcccag aaagcctagc ctggggacct agcccaccta cacacccagc
     1561 tcccacccat ggagagcacc ccagtcctgt tcctcctgcc ctggaccctg gccactctgc
     1621 cacaagctct accctcggta caacaggctc tgtccccaca tctacagacc ctgccccatc
     1681 tgcacaccta gactcagttc ataagtccac agactctggc ccttcagaac tgccaggccc
     1741 cactcacacc actacaggct ctacctatag tgccattacc actacccaca gtgctccaag
     1801 ccccctcact cacactacta caggctccac ccacaagccc ataatctcta cccttactac
     1861 tacaggccct accctcaata tcataggccc agtccagact accacaagcc ccacccacac
     1921 tatgccaagc cctacccata ccacagcaag ccccactcat acttccacaa gccccaccca
     1981 tacccccaca agtcccaccc acaaaaccag tatgtcacct cccaccacta caagtcctac
     2041 ccccagtggt atgggcctag tccagactgc cacaagtccc acccatccta ccacaagccc
     2101 cacccatccc accacaagcc ccatccttat aaatgtaagc ccttccactt ctctagaact
     2161 tgctaccctc tccagcccct ccaaacactc agaccccacc ctcccaggca ctgactccct
     2221 tccctgtagt cccccagtct ccaattccta cactcaggca gaccctatgg cccccagaac
     2281 tccccaccca agtcctgccc attccagtag gaaacccctc acaagccctg ccccagatcc
     2341 ctcagagtct acggttcaga gtctaagccc cactccctca cccccaaccc ctgcacccca
     2401 gcattcagac ctttgcctgg ccatggctgt ccagacccca gtcccaacgg cagccggagg
     2461 gtctggggac aggagcctgg aggaggcact gggggcccta atggctgccc tggatgacta
     2521 ccgtggccag tttcctgagc tgcagggcct ggagcaggag gtgacccgcc tagaaagtct
     2581 gctcatgcag agacaaggtc tgactcgcag ccgggcctcc agtctcagca tcactgtgga
     2641 gcatgccttg gagagcttca gcttcctcaa tgaagacgaa gatgaagaca atgatgttcc
     2701 tggggacagg cctccaagca gcccggaggc tggggctgag gacagcatag actcacccag
     2761 tgcccgcccc ctcagcacgg ggtgtccagc tctggatgct gccttggtcc ggcacctgta
     2821 ccactgcagt cgcctcctgc tgaaactggg cacatttggg cccctgcgct gccaggaggc
     2881 atgggccctg gagcggctgc tgcgggaagc ccgagtactg gaggcagtat gcgagttcag
     2941 caggcggtgg gagatcccgg ccagctctgc ccaggaagtg gtgcagttct cggcctctcg
     3001 gcctggcttc ctgaccttct gggaccagtg cacagagaga ctcagctgct tcctctgccc
     3061 ggtggagcgg gtgcttctca ccttctgcaa ccagtatggt gcccgcctct ccctgcgcca
     3121 gccaggcttg gctgaggctg tgtgtgtgaa gttcctggag gatgccctgg ggcagaagct
     3181 gcccagaagg ccccagccag ggcctggaga gcagctcaca gtcttccagt tctggagttt
     3241 tgtggaaacc ttggacagcc ccaccatgga ggcctacgtg actgagaccg ctgaggaggt
     3301 gctactggtg cggaatctga actcggatga tcaggctgtt gtgctgaagg ccctgagatt
     3361 ggcgcccgag gggcgtctgc gaagggacgg gctgcgggcc ctcagctccc tgctcgtcca
     3421 tggcaacaac aaggtcatgg ctgctgtcag cacccagctc cggagcctgt cactgggccc
     3481 taccttccgg gagagggccc tcctgtgctt cctggaccag ctggaggatg aggacgtgca
     3541 gactcgagtg gctggctgcc tggccctagg ctgcatcaag gctcccgagg gcattgagcc
     3601 cctggtgtac ctctgccaaa ctgacacaga agctgtgagg gaagctgccc ggcaaagcct
     3661 acagcagtgt ggagaagagg gacagtctgc ccatcgacgg ctggaggagt ccctggacgc
     3721 cctgccccgc atctttgggc ctggcagcat ggccagcaca gcattctaaa ctattcaccc
     3781 atgggttcct ggtgcccctt tccccccact ttcagggctc accaggcact ggcagggagg
     3841 gtaagggctg gctccagata cccctccccc acagattcct agcaatgaaa atctaatata
     3901 ttcttctgtt gcccctgggg ttggagagtc agtgcctgca gtcaagtgcc tcccagcctc
     3961 ggctcagcac atcccttgcc acaaatcagt gtctggggct tggccaccct gccgctgccc
     4021 agccacatcc cttggttttg tattttattt acagagtttt acagaaaata aaaaagcaaa
     4081 atgtctttcc ta
//
