LOCUS       NM_001410885            4474 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RHO family interacting cell polarization regulator 1
            (RIPOR1), transcript variant 5, mRNA.
ACCESSION   NM_001410885 XM_047434623
VERSION     NM_001410885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4474)
  AUTHORS   Mardakheh,F.K., Self,A. and Marshall,C.J.
  TITLE     RHO binding to FAM65A regulates Golgi reorientation during cell
            migration
  JOURNAL   J Cell Sci 129 (24), 4466-4479 (2016)
   PUBMED   27807006
  REMARK    GeneRIF: These results reveal a previously unidentified pathway
            downstream of RHO that regulates the polarity of migrating cells
            through Golgi reorientation in a FAM65A-, CCM3- and MST3- and
            MST4-dependent manner.
REFERENCE   2  (bases 1 to 4474)
  AUTHORS   Gao,K., Tang,W., Li,Y., Zhang,P., Wang,D., Yu,L., Wang,C. and Wu,D.
  TITLE     Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at
            leading edges polarizes neutrophils
  JOURNAL   J Cell Sci 128 (5), 992-1000 (2015)
   PUBMED   25588844
REFERENCE   3  (bases 1 to 4474)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 4474)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4474)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027682.10.
            
            On Aug 17, 2022 this sequence version replaced XM_047434623.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2541285.1,
                                           SRR14038196.1655271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               AC027682.10        120818-121288
            472-598             AC027682.10        129853-129979
            599-751             AC027682.10        130101-130253
            752-830             AC027682.10        130419-130497
            831-854             AC027682.10        131157-131180
            855-908             AC027682.10        131275-131328
            909-1061            AC027682.10        131482-131634
            1062-1125           AC027682.10        131729-131792
            1126-1169           AC027682.10        131887-131930
            1170-1295           AC027682.10        132008-132133
            1296-1444           AC027682.10        132859-133007
            1445-1574           AC027682.10        133082-133211
            1575-2972           AC027682.10        133296-134693
            2973-3091           AC027682.10        134780-134898
            3092-3224           AC027682.10        135728-135860
            3225-3360           AC027682.10        136124-136259
            3361-3522           AC027682.10        136385-136546
            3523-3681           AC027682.10        136805-136963
            3682-3878           AC027682.10        137093-137289
            3879-3962           AC027682.10        137378-137461
            3963-4053           AC027682.10        137570-137660
            4054-4474           AC027682.10        137795-138215
FEATURES             Location/Qualifiers
     source          1..4474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4474
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="RHO family interacting cell polarization regulator
                     1"
                     /db_xref="GeneID:79567"
                     /db_xref="HGNC:HGNC:25836"
                     /db_xref="MIM:619842"
     exon            1..471
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..4151
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="isoform 5 is encoded by transcript variant 5;
                     protein FAM65A; family with sequence similarity 65 member
                     A"
                     /codon_start=1
                     /product="rho family-interacting cell polarization
                     regulator 1 isoform 5"
                     /protein_id="NP_001397814.1"
                     /db_xref="CCDS:CCDS92176.1"
                     /db_xref="GeneID:79567"
                     /db_xref="HGNC:HGNC:25836"
                     /db_xref="MIM:619842"
                     /translation="MTIWQMQKQAQRGSPARTHSMMSLSVRPQRRLLSARVNRSQSFA
                     GVLGSHERGPRSFPVFSPPGPPRKPPALSRVSRMFSVAHPAAKVPQPERLDLVYTALK
                     RGLTAYLEVHQQEQEKLQGQIRESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKID
                     ELYEAYCVQRRLRDGAYNMVRAYTTGSPGSREARDSLAEATRGHREYTESMCLLESEL
                     EAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEETIF
                     LPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEV
                     TWSPFDKDDQPSAASSVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENG
                     TAWSLSSESSDDSSSPQLSGTARHSPAPRPLVQQPEPLPIQVAFRRPETPSSGPLDEE
                     GAVAPVLANGHAPYSRTLSHISEASVDAALAEASVEAVGPESLAWGPSPPTHPAPTHG
                     EHPSPVPPALDPGHSATSSTLGTTGSVPTSTDPAPSAHLDSVHKSTDSGPSELPGPTH
                     TTTGSTYSAITTTHSAPSPLTHTTTGSTHKPIISTLTTTGPTLNIIGPVQTTTSPTHT
                     MPSPTHTTASPTHTSTSPTHTPTSPTHKTSMSPPTTTSPTPSGMGLVQTATSPTHPTT
                     SPTHPTTSPILINVSPSTSLELATLSSPSKHSDPTLPGTDSLPCSPPVSNSYTQADPM
                     APRTPHPSPAHSSRKPLTSPAPDPSESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPV
                     PTAAGGSGDRSLEEALGALMAALDDYRGQFPELQGLEQEVTRLESLLMRQGLTRSRAS
                     SLSITVEHALESFSFLNEDEDEDNDVPGDRPPSSPEAGAEDSIDSPSARPLSTGCPAL
                     DAALVRHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVLEAVCEFSRRWEIPASS
                     AQEVVQFSASRPGFLTFWDQCTERLSCFLCPVERVLLTFCNQYGARLSLRQPGLAEAV
                     CVKFLEDALGQKLPRRPQPGPGEQLTVFQFWSFVETLDSPTMEAYVTETAEEVLLVRN
                     LNSDDQAVVLKALRLAPEGRLRRDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPTFR
                     ERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQ
                     QCGEEGQSAHRRLEESLDALPRIFGPGSMASTAF"
     exon            472..598
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            599..751
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            752..830
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            831..854
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            855..908
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1061
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1125
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1169
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1295
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1444
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1574
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..2972
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3091
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3224
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3360
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3522
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3681
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3878
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3879..3962
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4053
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4474
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4449..4454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="hexamer: AATAAA"
     polyA_site      4474
                     /gene="RIPOR1"
                     /gene_synonym="FAM65A"
                     /note="major polyA site"
ORIGIN      
        1 gtggccggcc ccgaggtgac cgagcctggg ctggagccgg gctctccgcc caaacctggc
       61 gtagccgaag ccggagagga tcgtccttgt cggggaacgg agcttttccc tggaaatgga
      121 ggttggcgca aggttcctgc aacagccggg cctgggctct ctgcagaact ggtttgggca
      181 aggggctgct caccagggct agaggtcgga ttcagtccag attcagcacc ctttgtcctc
      241 ctctccaggg tgagccctga gtccggcctc ccctacagac cctccccagc cagttctaac
      301 gtgtgtccag gctggccgcc ccagcaccta ctgtgcgcag cctcgtgtaa caatacttgt
      361 gccctggctg cagtctgcgg ggccgcgccc tgggcctgcc gcattcggcc aacgcacagc
      421 atctgaggag ggttatgacc atctggcaga tgcagaaaca ggcccagaga gggagccccg
      481 cgcggactca ctctatgatg tccctgtcgg tgcggccgca gcgccgtctg ctcagcgccc
      541 gggtcaatag gagccagtcc ttcgcaggcg tcctcggcag ccacgagcgg gggcccagga
      601 gtttcccggt cttcagcccg ccggggcccc cacggaagcc ccccgcgctc tcccgagtgt
      661 ccaggatgtt ttccgtggct cacccagccg ccaaggtgcc gcagcccgag cggctggacc
      721 tggtgtacac ggcgctgaag cggggcctga cggcctactt ggaagtgcac cagcaggagc
      781 aagagaaact ccaggggcag ataagggagt ccaagaggaa ttcccgcttg ggcttcctgt
      841 atgatctgga caagcaagtc aagtccattg aacgcttcct gcgacgactg gagttccatg
      901 ccagcaagat cgatgagctg tatgaggcat actgtgtcca gcggcgtctc cgggatggtg
      961 cctacaacat ggtccgtgcc tacaccactg ggtccccggg aagccgagag gcccgggaca
     1021 gcctggcaga ggccactcgg gggcatcgcg agtacacgga gagcatgtgt ctgctggaga
     1081 gcgagctgga ggcacagctg ggcgagtttc atctccgaat gaaagggctg gctggcttcg
     1141 ccaggctgtg tgtaggcgat cagtatgaga tctgcatgaa atatgggcgt cagcgctgga
     1201 aactacgggg ccgaattgag ggtagtggaa agcaggtgtg ggacagtgaa gaaaccatct
     1261 ttctccctct actcacggaa tttctgtcta ttaaggtgac agaactgaag ggcctggcca
     1321 accatgtggt tgtgggcagt gtctcctgtg agaccaagga cctgtttgcc gccctgcccc
     1381 aggttgtggc tgtggatatc aatgaccttg gtaccatcaa gctcagcctg gaagtcacat
     1441 ggagcccctt cgacaaggat gaccagccct cagctgcttc ttctgtcaac aaggcctcca
     1501 cagtcaccaa gcgcttctcc acctatagcc agagcccacc ggacacaccc tcacttcggg
     1561 aacaggcttt ctataacatg ctgcgacggc aggaggagct ggagaatggg acagcatggt
     1621 ccctgtcatc tgaatcttca gacgactcat ccagcccaca gctctcaggc actgcccgcc
     1681 actcaccagc ccctaggccc ctggtgcagc agcccgagcc ccttcccatc caagttgcct
     1741 tccgcaggcc tgagaccccc agctctgggc ccttggatga ggagggggcc gtggccccag
     1801 tcctggcaaa tgggcatgca ccctacagtc ggactctgag ccacatcagt gaggctagtg
     1861 tagatgctgc cttggctgag gcttcagtgg aggccgttgg cccagaaagc ctagcctggg
     1921 gacctagccc acctacacac ccagctccca cccatggaga gcaccccagt cctgttcctc
     1981 ctgccctgga ccctggccac tctgccacaa gctctaccct cggtacaaca ggctctgtcc
     2041 ccacatctac agaccctgcc ccatctgcac acctagactc agttcataag tccacagact
     2101 ctggcccttc agaactgcca ggccccactc acaccactac aggctctacc tatagtgcca
     2161 ttaccactac ccacagtgct ccaagccccc tcactcacac tactacaggc tccacccaca
     2221 agcccataat ctctaccctt actactacag gccctaccct caatatcata ggcccagtcc
     2281 agactaccac aagccccacc cacactatgc caagccctac ccataccaca gcaagcccca
     2341 ctcatacttc cacaagcccc acccataccc ccacaagtcc cacccacaaa accagtatgt
     2401 cacctcccac cactacaagt cctaccccca gtggtatggg cctagtccag actgccacaa
     2461 gtcccaccca tcctaccaca agccccaccc atcccaccac aagccccatc cttataaatg
     2521 taagcccttc cacttctcta gaacttgcta ccctctccag cccctccaaa cactcagacc
     2581 ccaccctccc aggcactgac tcccttccct gtagtccccc agtctccaat tcctacactc
     2641 aggcagaccc tatggccccc agaactcccc acccaagtcc tgcccattcc agtaggaaac
     2701 ccctcacaag ccctgcccca gatccctcag agtctacggt tcagagtcta agccccactc
     2761 cctcaccccc aacccctgca ccccagcatt cagacctttg cctggccatg gctgtccaga
     2821 ccccagtccc aacggcagcc ggagggtctg gggacaggag cctggaggag gcactggggg
     2881 ccctaatggc tgccctggat gactaccgtg gccagtttcc tgagctgcag ggcctggagc
     2941 aggaggtgac ccgcctagaa agtctgctca tgagacaagg tctgactcgc agccgggcct
     3001 ccagtctcag catcactgtg gagcatgcct tggagagctt cagcttcctc aatgaagacg
     3061 aagatgaaga caatgatgtt cctggggaca ggcctccaag cagcccggag gctggggctg
     3121 aggacagcat agactcaccc agtgcccgcc ccctcagcac ggggtgtcca gctctggatg
     3181 ctgccttggt ccggcacctg taccactgca gtcgcctcct gctgaaactg ggcacatttg
     3241 ggcccctgcg ctgccaggag gcatgggccc tggagcggct gctgcgggaa gcccgagtac
     3301 tggaggcagt atgcgagttc agcaggcggt gggagatccc ggccagctct gcccaggaag
     3361 tggtgcagtt ctcggcctct cggcctggct tcctgacctt ctgggaccag tgcacagaga
     3421 gactcagctg cttcctctgc ccggtggagc gggtgcttct caccttctgc aaccagtatg
     3481 gtgcccgcct ctccctgcgc cagccaggct tggctgaggc tgtgtgtgtg aagttcctgg
     3541 aggatgccct ggggcagaag ctgcccagaa ggccccagcc agggcctgga gagcagctca
     3601 cagtcttcca gttctggagt tttgtggaaa ccttggacag ccccaccatg gaggcctacg
     3661 tgactgagac cgctgaggag gtgctactgg tgcggaatct gaactcggat gatcaggctg
     3721 ttgtgctgaa ggccctgaga ttggcgcccg aggggcgtct gcgaagggac gggctgcggg
     3781 ccctcagctc cctgctcgtc catggcaaca acaaggtcat ggctgctgtc agcacccagc
     3841 tccggagcct gtcactgggc cctaccttcc gggagagggc cctcctgtgc ttcctggacc
     3901 agctggagga tgaggacgtg cagactcgag tggctggctg cctggcccta ggctgcatca
     3961 aggctcccga gggcattgag cccctggtgt acctctgcca aactgacaca gaagctgtga
     4021 gggaagctgc ccggcaaagc ctacagcagt gtggagaaga gggacagtct gcccatcgac
     4081 ggctggagga gtccctggac gccctgcccc gcatctttgg gcctggcagc atggccagca
     4141 cagcattcta aactattcac ccatgggttc ctggtgcccc tttcccccca ctttcagggc
     4201 tcaccaggca ctggcaggga gggtaagggc tggctccaga tacccctccc ccacagattc
     4261 ctagcaatga aaatctaata tattcttctg ttgcccctgg ggttggagag tcagtgcctg
     4321 cagtcaagtg cctcccagcc tcggctcagc acatcccttg ccacaaatca gtgtctgggg
     4381 cttggccacc ctgccgctgc ccagccacat cccttggttt tgtattttat ttacagagtt
     4441 ttacagaaaa taaaaaagca aaatgtcttt ccta
//
