LOCUS       NM_020639               3831 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 4
            (RIPK4), mRNA.
ACCESSION   NM_020639
VERSION     NM_020639.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3831)
  AUTHORS   Shan,W., Peng,W., Chen,Y., Wang,Y., Yu,Q., Tian,Y., Dou,Y., Tu,J.,
            Huang,X., Li,X., Wang,Z., Zhu,Q., Chen,J. and Xia,B.
  TITLE     GSK3beta and UCHL3 govern RIPK4 homeostasis via deubiquitination to
            enhance tumor metastasis in ovarian cancer
  JOURNAL   Oncogene 43 (25), 1885-1899 (2024)
   PUBMED   38664501
  REMARK    GeneRIF: GSK3beta and UCHL3 govern RIPK4 homeostasis via
            deubiquitination to enhance tumor metastasis in ovarian cancer.
REFERENCE   2  (bases 1 to 3831)
  AUTHORS   Madej,E., Lisek,A., Brozyna,A.A., Cierniak,A., Wronski,N.,
            Deptula,M., Wardowska,A. and Wolnicka-Glubisz,A.
  TITLE     The involvement of RIPK4 in TNF-alpha-stimulated IL-6 and IL-8
            production by melanoma cells
  JOURNAL   J Cancer Res Clin Oncol 150 (4), 209 (2024)
   PUBMED   38656555
  REMARK    GeneRIF: The involvement of RIPK4 in TNF-alpha-stimulated IL-6 and
            IL-8 production by melanoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3831)
  AUTHORS   Yin,X., Zhao,S., Zhang,M., Xing,J., Zhou,J., Gao,W., Chen,L.,
            Zhang,Y., Lin,L., Lu,M., Li,W., Shang,J. and Zhu,X.
  TITLE     m6A-modified RIPK4 facilitates proliferation and cisplatin
            resistance in epithelial ovarian cancer
  JOURNAL   Gynecol Oncol 180, 99-110 (2024)
   PUBMED   38086167
  REMARK    GeneRIF: m6A-modified RIPK4 facilitates proliferation and cisplatin
            resistance in epithelial ovarian cancer.
REFERENCE   4  (bases 1 to 3831)
  AUTHORS   Hua,L., Wu,J.H., Xu,J.Y., Wu,S.G. and Zhou,J.
  TITLE     RIPK4 Promotes Cell Invasion and the Epithelial-Mesenchymal
            Transition in Ovarian Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (12), 368 (2023)
   PUBMED   38179758
  REMARK    GeneRIF: RIPK4 Promotes Cell Invasion and the
            Epithelial-Mesenchymal Transition in Ovarian Cancer.
REFERENCE   5  (bases 1 to 3831)
  AUTHORS   Tang,J., Zhang,X., Chen,C., Wang,B., Chen,Y., Zhang,H., Qiao,M.,
            Liu,X., Guo,W. and Jin,G.
  TITLE     LncRNA MIR31HG promotes cell proliferation and invasive properties
            of the MCF-7 cell line by regulation of receptor-interacting
            serine-threonine kinase 4
  JOURNAL   Acta Biochim Pol 70 (4), 935-941 (2023)
   PUBMED   38064252
  REMARK    GeneRIF: LncRNA MIR31HG promotes cell proliferation and invasive
            properties of the MCF-7 cell line by regulation of
            receptor-interacting serine-threonine kinase 4.
REFERENCE   6  (bases 1 to 3831)
  AUTHORS   Moran,S.T., Haider,K., Ow,Y., Milton,P., Chen,L. and Pillai,S.
  TITLE     Protein kinase C-associated kinase can activate NFkappaB in both a
            kinase-dependent and a kinase-independent manner
  JOURNAL   J Biol Chem 278 (24), 21526-21533 (2003)
   PUBMED   12676934
  REMARK    GeneRIF: PKK may function in both a kinase-dependent as well as a
            kinase-independent manner to activate NFkappaB
REFERENCE   7  (bases 1 to 3831)
  AUTHORS   Meylan,E., Martinon,F., Thome,M., Gschwendt,M. and Tschopp,J.
  TITLE     RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates
            NF-kappa B and is processed during apoptosis
  JOURNAL   EMBO Rep 3 (12), 1201-1208 (2002)
   PUBMED   12446564
REFERENCE   8  (bases 1 to 3831)
  AUTHORS   Chen,L., Haider,K., Ponda,M., Cariappa,A., Rowitch,D. and Pillai,S.
  TITLE     Protein kinase C-associated kinase (PKK), a novel
            membrane-associated, ankyrin repeat-containing protein kinase
  JOURNAL   J Biol Chem 276 (24), 21737-21744 (2001)
   PUBMED   11278382
REFERENCE   9  (bases 1 to 3831)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3831)
  AUTHORS   Bahr,C., Rohwer,A., Stempka,L., Rincke,G., Marks,F. and
            Gschwendt,M.
  TITLE     DIK, a novel protein kinase that interacts with protein kinase
            Cdelta. Cloning, characterization, and gene analysis
  JOURNAL   J Biol Chem 275 (46), 36350-36357 (2000)
   PUBMED   10948194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ278016.1, BC035755.1,
            AK027424.1 and BM979316.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020639.2.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase that interacts with protein kinase C-delta. The
            encoded protein can also activate NFkappaB and is required for
            keratinocyte differentiation. This kinase undergoes
            autophosphorylation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278016.1, AB047783.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332512.8/ ENSP00000332454.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1015              AJ278016.1         38-1052
            1016-2430           BC035755.1         1007-2421
            2431-2455           AK027424.1         2485-2509
            2456-3810           BC035755.1         2446-3800
            3811-3831           BM979316.1         23-43               c
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..3831
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /note="receptor interacting serine/threonine kinase 4"
                     /db_xref="GeneID:54101"
                     /db_xref="HGNC:HGNC:496"
                     /db_xref="MIM:605706"
     exon            1..193
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2366
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /EC_number="2.7.11.1"
                     /note="PKC-delta-interacting protein kinase;
                     serine/threonine-protein kinase ANKRD3; ankyrin repeat
                     domain-containing protein 3; protein kinase C-associated
                     kinase"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 4"
                     /protein_id="NP_065690.2"
                     /db_xref="CCDS:CCDS13675.1"
                     /db_xref="GeneID:54101"
                     /db_xref="HGNC:HGNC:496"
                     /db_xref="MIM:605706"
                     /translation="MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHW
                     KTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETG
                     SLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKIS
                     DFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLT
                     QKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTF
                     QEITSETEDLCEKPDDEVKETAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSE
                     LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFE
                     REPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQ
                     EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL
                     HFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ
                     GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI
                     DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH
                     LATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALH
                     LAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAATLLRRSKT"
     exon            194..485
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..634
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            635..684
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            685..843
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            844..947
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1206
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..3831
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /note="hexamer: AATAAA"
     polyA_site      3831
                     /gene="RIPK4"
                     /gene_synonym="ANKK2; ANKRD3; CHANDS; DIK; NKRD3; PKK;
                     PPS2; RIP4"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgcgc gatggagggc gacggcggga ccccatgggc cctggcgctg ctgcgcacct
       61 tcgacgcggg cgagttcacg ggctgggaga aggtgggctc gggcggcttc gggcaggtgt
      121 acaaggtgcg ccatgtccac tggaagacct ggctggccat caagtgctcg cccagcctgc
      181 acgtcgacga cagggagcgc atggagcttt tggaagaagc caagaagatg gagatggcca
      241 agtttcgcta catcctgcct gtgtatggca tctgccgcga acctgtcggc ctggtcatgg
      301 agtacatgga gacgggctcc ctggaaaagc tgctggcttc ggagccattg ccatgggatc
      361 tccggttccg aatcatccac gagacggcgg tgggcatgaa cttcctgcac tgcatggccc
      421 cgccactcct gcacctggac ctcaagcccg cgaacatcct gctggatgcc cactaccacg
      481 tcaagatttc tgattttggt ctggccaagt gcaacgggct gtcccactcg catgacctca
      541 gcatggatgg cctgtttggc acaatcgcct acctccctcc agagcgcatc agggagaaga
      601 gccggctctt cgacaccaag cacgatgtat acagctttgc gatcgtcatc tggggcgtgc
      661 tcacacagaa gaagccgttt gcagatgaga agaacatcct gcacatcatg gtgaaggtgg
      721 tgaagggcca ccgccccgag ctgccgcccg tgtgcagagc ccggccgcgc gcctgcagcc
      781 acctgatacg cctcatgcag cggtgctggc agggggatcc gcgagttagg cccaccttcc
      841 aagaaattac ttctgaaacc gaggacctgt gtgaaaagcc tgatgacgaa gtgaaagaaa
      901 ctgctcatga tctggacgtg aaaagccccc cggagcccag gagcgaggtg gtgcctgcga
      961 ggctcaagcg ggcctctgcc cccaccttcg ataacgacta cagcctctcc gagctgctct
     1021 cacagctgga ctctggagtt tcccaggctg tcgagggccc cgaggagctc agccgcagct
     1081 cctctgagtc caagctgcca tcgtccggca gtgggaagag gctctcgggg gtgtcctcgg
     1141 tggactccgc cttctcttcc agaggatcac tgtcgctgtc ctttgagcgg gaaccttcaa
     1201 ccagcgatct gggcaccaca gacgtccaga agaagaagct tgtggatgcc atcgtgtccg
     1261 gggacaccag caaactgatg aagatcctgc agccgcagga cgtggacctg gcactggaca
     1321 gcggtgccag cctgctgcac ctggcggtgg aggccgggca agaggagtgc gccaagtggc
     1381 tgctgctcaa caatgccaac cccaacctga gcaaccgtag gggctccacc ccgttgcaca
     1441 tggccgtgga gaggagggtg cggggtgtcg tggagctcct gctggcgcgg aagatcagtg
     1501 tcaacgccaa ggatgaggac cagtggacag ccctccactt tgcagcccag aacggggacg
     1561 agtctagcac acggctgctg ttggagaaga acgcctcggt caacgaggtg gactttgagg
     1621 gccggacgcc catgcacgtg gcctgccagc acgggcagga gaatatcgtg cgcatcctgc
     1681 tgcgccgagg cgtggacgtg agcctgcagg gcaaggatgc ctggctgcca ctgcactacg
     1741 ctgcctggca gggccacctg cccatcgtca agctgctggc caagcagccg ggggtgagtg
     1801 tgaacgccca gacgctggat gggaggacgc cattgcacct ggccgcacag cgcgggcact
     1861 accgcgtggc ccgcatcctc atcgacctgt gctccgacgt caacgtctgc agcctgctgg
     1921 cacagacacc cctgcacgtg gccgcggaga cggggcacac gagcactgcc aggctgctcc
     1981 tgcatcgggg cgctggcaag gaggccatga cctcagacgg ctacaccgct ctgcacctgg
     2041 ctgcccgcaa cggacacctg gccactgtca agctgcttgt cgaggagaag gccgatgtgc
     2101 tggcccgggg acccctgaac cagacggcgc tgcacctggc tgccgcccac gggcactcgg
     2161 aggtggtgga ggagttggtc agcgccgatg tcattgacct gttcgacgag caggggctca
     2221 gcgcgctgca cctggccgcc cagggccggc acgcacagac ggtggagact ctgctcaggc
     2281 atggggccca catcaacctg cagagcctca agttccaggg cggccatggc cccgccgcca
     2341 cgctcctgcg gcgaagcaag acctagctgg ctgcctgcgg agaccggggg tccacgtggg
     2401 gctcttgtcc tgtcctgtgt tcctcgtggg gatggaacga tcctgcgtgg ggccctgttg
     2461 tggcttacct aaatgttaac caagcagagg tgacatggtg ccatcaggag gcggctgctg
     2521 ctgaccggag tgtcccctcc aggtgaagct ggctcaggtg cacatgcccg ctccatcatc
     2581 gatctaggca cctgctgtct gaagggaccg tgggtcagaa tcatttcgtt gtgctcctaa
     2641 tgggtcgctg aggctggtct ctcagtgatg aagccccagg cgtggaagca tccactctct
     2701 cctgaggcga gccaccttgg gttgctggag ctcaccagtc ttgagggagg tgcaggggaa
     2761 actgtgtttt ttatcttcat acatgacggt gggcagagag gcctgtctta aagtttccat
     2821 ggaattgttt tataaaatat cttaagagat gaatacctta tcagctgttg cttgaaacct
     2881 gttaaaaatg ttcataacat tggatagtct agtctctaaa tgatgactaa gtagtggggt
     2941 tggctttgaa aacaatgttt tatgcaacaa ggaacgaatg gtagcagcca gctttgcggg
     3001 gcgtatgtgt ggccagctct taaccattcc agtctattac ttgggtgagt ccttgtggac
     3061 aaccacacac acgtgcccac atggtactag ctgccgttcg tttctcgttg cctaagatgt
     3121 tttggcaact ctagagccac aggcctaagt cattaaaaaa ttctcccttt gtaacctcag
     3181 tgctggggac tgaggcgagc cccctcaggt cgctggagtg caccagtctt ggggaagagg
     3241 tgcaggagaa gctgtgtttt ttatctccac acgcagtatg aagataaaat tacatagtat
     3301 tacctagaca tagacagtat tacctaggta gatgcactgc tcacctgcgc ccttcccagc
     3361 tctcattttt gttaggtgat ttgggatagg gatagtgttt tggggtatgg ggggagtgtt
     3421 tctgacctgc tttgcagacg tgcctccgca cctcagcagt ttggggtgtg gccccagggc
     3481 ggttcttgga tgtaaaagat gtggccatct agcctcgtaa cttcactgtc acctgtgtcc
     3541 catagggtgc cttctgaata ctgttattag aataagtttg ttgcagaacg tgaccctgcg
     3601 tgcaaacatg taccgtggcc tggtatatga tagagattga tattaatgta ccatgtatgt
     3661 taatgtgaat ctgtgggcag gatacttttc catggcagga aatatccaag ctgttgaaac
     3721 tggctatgtt ttaatatgcc tcattgtgcc tttactgttg tgtggactgc gtgagggaca
     3781 agaagttcca tttgatgtca ataaagcaaa gtacttgcct acttttttga a
//
