LOCUS       NM_006871               1872 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 3
            (RIPK3), mRNA.
ACCESSION   NM_006871
VERSION     NM_006871.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Kang,J.S., Cho,N.J., Lee,S.W., Lee,J.G., Lee,J.H., Yi,J.,
            Choi,M.S., Park,S., Gil,H.W., Oh,J.C., Son,S.S., Park,M.J.,
            Moon,J.S., Lee,D., Kim,S.Y., Yang,S.H., Kim,S.S., Lee,E.S.,
            Chung,C.H., Park,J. and Lee,E.Y.
  TITLE     RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic
            podocytopathy through PGAM5-Drp1 signaling
  JOURNAL   Metabolism 159, 155982 (2024)
   PUBMED   39089491
  REMARK    GeneRIF: RIPK3 causes mitochondrial dysfunction and albuminuria in
            diabetic podocytopathy through PGAM5-Drp1 signaling.
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Shen,L., Yang,Z., Gao,C., Li,L., Wang,Y., Cai,Y. and Feng,Z.
  TITLE     Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for
            necrotising enterocolitis in preterm infants
  JOURNAL   Pediatr Surg Int 40 (1), 115 (2024)
   PUBMED   38696138
  REMARK    GeneRIF: Receptor-interacting protein kinase-3 (RIPK3): a new
            biomarker for necrotising enterocolitis in preterm infants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Wang,T., Wang,D., Kuang,G., Gong,X., Zhang,L., Wan,J. and Li,K.
  TITLE     Derlin-1 promotes diet-induced non-alcoholic fatty liver disease
            via increasing RIPK3-mediated necroptosis
  JOURNAL   Free Radic Biol Med 217, 29-47 (2024)
   PUBMED   38522486
  REMARK    GeneRIF: Derlin-1 promotes diet-induced non-alcoholic fatty liver
            disease via increasing RIPK3-mediated necroptosis.
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Lai,K., Wang,J., Lin,S., Chen,Z., Lin,G., Ye,K., Yuan,Y., Lin,Y.,
            Zhong,C.Q., Wu,J., Ma,H. and Xu,Y.
  TITLE     Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated
            necroptosis and ferroptosis in response to diquat poisoning
  JOURNAL   Cell Death Differ 31 (5), 635-650 (2024)
   PUBMED   38493248
  REMARK    GeneRIF: Sensing of mitochondrial DNA by ZBP1 promotes
            RIPK3-mediated necroptosis and ferroptosis in response to diquat
            poisoning.
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Divandari,M., Javadifar,A., Moghadam,A.B. and Janatabadi,A.A.
  TITLE     RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular
            insights into pathogenesis
  JOURNAL   Mol Biol Rep 51 (1), 524 (2024)
   PUBMED   38630344
  REMARK    GeneRIF: RIPK3 and RIPK1 gene expression in pterygium: unveiling
            molecular insights into pathogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Sun,X., Yin,J., Starovasnik,M.A., Fairbrother,W.J. and Dixit,V.M.
  TITLE     Identification of a novel homotypic interaction motif required for
            the phosphorylation of receptor-interacting protein (RIP) by RIP3
  JOURNAL   J Biol Chem 277 (11), 9505-9511 (2002)
   PUBMED   11734559
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Kasof,G.M., Prosser,J.C., Liu,D., Lorenzi,M.V. and Gomes,B.C.
  TITLE     The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear
            translocation and localizes to mitochondria
  JOURNAL   FEBS Lett 473 (3), 285-291 (2000)
   PUBMED   10818227
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Sun,X., Lee,J., Navas,T., Baldwin,D.T., Stewart,T.A. and Dixit,V.M.
  TITLE     RIP3, a novel apoptosis-inducing kinase
  JOURNAL   J Biol Chem 274 (24), 16871-16875 (1999)
   PUBMED   10358032
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Yu,P.W., Huang,B.C., Shen,M., Quast,J., Chan,E., Xu,X., Nolan,G.P.,
            Payan,D.G. and Luo,Y.
  TITLE     Identification of RIP3, a RIP-like kinase that activates apoptosis
            and NFkappaB
  JOURNAL   Curr Biol 9 (10), 539-542 (1999)
   PUBMED   10339433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB274842.1, BC062584.1 and
            BE676675.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006871.3.
            
            Summary: The product of this gene is a member of the
            receptor-interacting protein (RIP) family of serine/threonine
            protein kinases, and contains a C-terminal domain unique from other
            RIP family members. The encoded protein is predominantly localized
            to the cytoplasm, and can undergo nucleocytoplasmic shuttling
            dependent on novel nuclear localization and export signals. It is a
            component of the tumor necrosis factor (TNF) receptor-I signaling
            complex, and can induce apoptosis and weakly activate the NF-kappaB
            transcription factor. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062584.1, AK075275.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216274.10/ ENSP00000216274.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB274842.1         46-69
            25-1807             BC062584.1         1-1783
            1808-1872           BE676675.1         24-88               c
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1872
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /note="receptor interacting serine/threonine kinase 3"
                     /db_xref="GeneID:11035"
                     /db_xref="HGNC:HGNC:10021"
                     /db_xref="MIM:605817"
     exon            1..185
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1722
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /EC_number="2.7.11.1"
                     /note="receptor interacting protein 3; RIP-like protein
                     kinase 3; RIP-3"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 3"
                     /protein_id="NP_006862.2"
                     /db_xref="CCDS:CCDS9628.1"
                     /db_xref="GeneID:11035"
                     /db_xref="HGNC:HGNC:10021"
                     /db_xref="MIM:605817"
                     /translation="MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWG
                     YDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSL
                     SGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLAD
                     FGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGR
                     EVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSF
                     QECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTI
                     ENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSM
                     AQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLV
                     NIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSR
                     PQGWYNHSGK"
     exon            186..326
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..636
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..782
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..829
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..997
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1065
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1440
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1501
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1872
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="RIPK3"
                     /gene_synonym="RIP3"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaaaggg taacaacccg gaaagtagac tcaccgtctt ggtctagaga ctgacccctg
       61 cacagacaga ccccttcccc tctctgcgaa aggaccaagc cccagaagtc actccatctc
      121 ctacggctcg caatttccag aggccccctg gcaccttcca gcctgatgtc gtgcgtcaag
      181 ttatggccca gcggtgcccc cgcccccttg gtgtccatcg aggaactgga gaaccaggag
      241 ctcgtcggca aaggcgggtt cggcacagtg ttccgggcgc aacataggaa gtggggctac
      301 gatgtggcgg tcaagatcgt aaactcgaag gcgatatcca gggaggtcaa ggccatggca
      361 agtctggata acgaattcgt gctgcgccta gaaggggtta tcgagaaggt gaactgggac
      421 caagatccca agccggctct ggtgactaaa ttcatggaga acggctcctt gtcggggctg
      481 ctgcagtccc agtgccctcg gccctggccg ctcctttgcc gcctgctgaa agaagtggtg
      541 cttgggatgt tttacctgca cgaccagaac ccggtgctcc tgcaccggga cctcaagcca
      601 tccaacgtcc tgctggaccc agagctgcac gtcaagctgg cagattttgg cctgtccaca
      661 tttcagggag gctcacagtc agggacaggg tccggggagc cagggggcac cctgggctac
      721 ttggccccag aactgtttgt taacgtaaac cggaaggcct ccacagccag tgacgtctac
      781 agcttcggga tcctaatgtg ggcagtgctt gctggaagag aagttgagtt gccaaccgaa
      841 ccatcactcg tgtacgaagc agtgtgcaac aggcagaacc ggccttcatt ggctgagctg
      901 ccccaagccg ggcctgagac tcccggctta gaaggactga aggagctaat gcagctctgc
      961 tggagcagtg agcccaagga cagaccctcc ttccaggaat gcctaccaaa aactgatgaa
     1021 gtcttccaga tggtggagaa caatatgaat gctgctgtct ccacggtaaa ggatttcctg
     1081 tctcagctca ggagcagcaa taggagattt tctatcccag agtcaggcca aggagggaca
     1141 gaaatggatg gctttaggag aaccatagaa aaccagcact ctcgtaatga tgtcatggtt
     1201 tctgagtggc taaacaaact gaatctagag gagcctccca gctctgttcc taaaaaatgc
     1261 ccgagcctta ccaagaggag cagggcacaa gaggagcagg ttccacaagc ctggacagca
     1321 ggcacatctt cagattcgat ggcccaacct ccccagactc cagagacctc aactttcaga
     1381 aaccagatgc ccagccctac ctcaactgga acaccaagtc ctggaccccg agggaatcag
     1441 ggggctgaga gacaaggcat gaactggtcc tgcaggaccc cggagccaaa tccagtaaca
     1501 gggcgaccgc tcgttaacat atacaactgc tctggggtgc aagttggaga caacaactac
     1561 ttgactatgc aacagacaac tgccttgccc acatggggct tggcaccttc gggcaagggg
     1621 aggggcttgc agcacccccc accagtaggt tcgcaagaag gccctaaaga tcctgaagcc
     1681 tggagcaggc cacagggttg gtataatcat agcgggaaat aaagcacctt ccaagcttgc
     1741 ctccaagagt tacgagttaa ggaagagtgc caccccttga ggcccctgac ttccttctag
     1801 ggcagtctgg cctgcccaca aactgacttt gtgacctgtc ccccaggagt caataaacat
     1861 gatggaatgc ta
//
