LOCUS       NM_003821               2516 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 2
            (RIPK2), transcript variant 1, mRNA.
ACCESSION   NM_003821
VERSION     NM_003821.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Goncharov,T., Komuves,L.G., Kist,M., Castellanos,E.R., Witt,A.,
            Fedorova,A.V., Izrael-Tomasevic,A., Yu,K., Keir,M., Matsumoto,M.L.
            and Vucic,D.
  TITLE     Simultaneous substrate and ubiquitin modification recognition by
            bispecific antibodies enables detection of ubiquitinated RIP1 and
            RIP2
  JOURNAL   Sci Signal 17 (819), eabn1101 (2024)
   PUBMED   38227684
  REMARK    GeneRIF: Simultaneous substrate and ubiquitin modification
            recognition by bispecific antibodies enables detection of
            ubiquitinated RIP1 and RIP2.
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Lee,J., Sim,K.M., Kang,M., Oh,H.J., Choi,H.J., Kim,Y.E., Pack,C.G.,
            Kim,K., Kim,K.M., Oh,S.H., Kim,I. and Chang,I.
  TITLE     Understanding the molecular mechanism of pathogenic variants of
            BIR2 domain in XIAP-deficient inflammatory bowel disease
  JOURNAL   Sci Rep 14 (1), 853 (2024)
   PUBMED   38191507
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2516)
  AUTHORS   Zheng,S., Li,Y., Song,X., Wu,M., Yu,L., Huang,G., Liu,T., Zhang,L.,
            Shang,M., Zhu,Q., Gao,C., Chen,L. and Liu,H.
  TITLE     OTUD1 ameliorates cerebral ischemic injury through inhibiting
            inflammation by disrupting K63-linked deubiquitination of RIP2
  JOURNAL   J Neuroinflammation 20 (1), 281 (2023)
   PUBMED   38012669
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2516)
  AUTHORS   Hezinger,L., Bauer,S., Ellwanger,K., Piotrowsky,A., Biber,F.,
            Venturelli,S. and Kufer,T.A.
  TITLE     NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2-
            and NF-kB-independent manner
  JOURNAL   FEBS J 290 (22), 5295-5312 (2023)
   PUBMED   37488967
  REMARK    GeneRIF: NOD1 cooperates with HAX-1 to promote cell migration in a
            RIPK2- and NF-kB-independent manner.
REFERENCE   5  (bases 1 to 2516)
  AUTHORS   Cui,K., Wang,X., Han,C., Liu,S. and Hu,Y.
  TITLE     Mechanism of Human Cytomegalovirus-Induced Epithelial-Mesenchymal
            Transition in Glioma Cells via the Upregulation of RIP2 Expression
  JOURNAL   Biol Pharm Bull 46 (11), 1506-1511 (2023)
   PUBMED   37914353
  REMARK    GeneRIF: Mechanism of Human Cytomegalovirus-Induced
            Epithelial-Mesenchymal Transition in Glioma Cells via the
            Upregulation of RIP2 Expression.
REFERENCE   6  (bases 1 to 2516)
  AUTHORS   Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
            Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
REFERENCE   7  (bases 1 to 2516)
  AUTHORS   Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
            Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
            Glucksmann,M.A. and DiStefano,P.S.
  TITLE     Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
            member that activates NF-kappaB
  JOURNAL   J Biol Chem 274 (19), 12955-12958 (1999)
   PUBMED   10224040
REFERENCE   8  (bases 1 to 2516)
  AUTHORS   Thome,M., Hofmann,K., Burns,K., Martinon,F., Bodmer,J.L.,
            Mattmann,C. and Tschopp,J.
  TITLE     Identification of CARDIAK, a RIP-like kinase that associates with
            caspase-1
  JOURNAL   Curr Biol 8 (15), 885-888 (1998)
   PUBMED   9705938
REFERENCE   9  (bases 1 to 2516)
  AUTHORS   McCarthy,J.V., Ni,J. and Dixit,V.M.
  TITLE     RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
  JOURNAL   J Biol Chem 273 (27), 16968-16975 (1998)
   PUBMED   9642260
REFERENCE   10 (bases 1 to 2516)
  AUTHORS   Inohara,N., del Peso,L., Koseki,T., Chen,S. and Nunez,G.
  TITLE     RICK, a novel protein kinase containing a caspase recruitment
            domain, interacts with CLARP and regulates CD95-mediated apoptosis
  JOURNAL   J Biol Chem 273 (20), 12296-12300 (1998)
   PUBMED   9575181
  REMARK    Erratum:[J Biol Chem 1998 Jul 17;273(29):18675]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358814.1 and AI824070.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003821.5.
            
            Summary: This gene encodes a member of the receptor-interacting
            protein (RIP) family of serine/threonine protein kinases. The
            encoded protein contains a C-terminal caspase activation and
            recruitment domain (CARD), and is a component of signaling
            complexes in both the innate and adaptive immune pathways. It is a
            potent activator of NF-kappaB and inducer of apoptosis in response
            to various stimuli. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358814.1, SRR1660807.150538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220751.5/ ENSP00000220751.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1986              AY358814.1         7-1992
            1987-2516           AI824070.1         4-533               c
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2516
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="receptor interacting serine/threonine kinase 2"
                     /db_xref="GeneID:8767"
                     /db_xref="HGNC:HGNC:10020"
                     /db_xref="MIM:603455"
     exon            1..418
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1868
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     receptor-interacting protein (RIP)-like interacting
                     caspase-like apoptosis regulatory protein (CLARP) kinase;
                     CARD-containing interleukin-1 beta-converting enzyme
                     (ICE)-associated kinase; growth-inhibiting gene 30;
                     CARD-carrying kinase; receptor-interacting
                     serine/threonine-protein kinase 2; RIP-2;
                     receptor-interacting protein 2; CARD-containing IL-1 beta
                     ICE-kinase; tyrosine-protein kinase RIPK2"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 2 isoform 1"
                     /protein_id="NP_003812.1"
                     /db_xref="CCDS:CCDS6247.1"
                     /db_xref="GeneID:8767"
                     /db_xref="HGNC:HGNC:10020"
                     /db_xref="MIM:603455"
                     /translation="MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQV
                     AVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS
                     LNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHV
                     KIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI
                     TWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQN
                     PDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLN
                     IPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNH
                     SWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQ
                     MTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQK
                     LKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM"
     exon            419..572
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..728
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..886
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..936
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1098
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1184
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1274
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1368
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1530
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2516
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AGTAAA"
     polyA_site      2061
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="major polyA site"
     regulatory      2416..2421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2436
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2516
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgcggc gctacggcgt tggcaccagt ctctagaaaa gaagtcagct ctggttcgga
       61 gaagcagcgg ctggcgtggg ccatccgggg aatgggcgcc ctcgtgacct agtgttgcgg
      121 ggcaaaaagg gtcttgccgg cctcgctcgt gcaggggcgt atctgggcgc ctgagcgcgg
      181 cgtgggagcc ttgggagccg ccgcagcagg gggcacaccc ggaaccggcc tgagcgcccg
      241 ggaccatgaa cggggaggcc atctgcagcg ccctgcccac cattccctac cacaaactcg
      301 ccgacctgcg ctacctgagc cgcggcgcct ctggcactgt gtcgtccgcc cgccacgcag
      361 actggcgcgt ccaggtggcc gtgaagcacc tgcacatcca cactccgctg ctcgacagtg
      421 aaagaaagga tgtcttaaga gaagctgaaa ttttacacaa agctagattt agttacattc
      481 ttccaatttt gggaatttgc aatgagcctg aatttttggg aatagttact gaatacatgc
      541 caaatggatc attaaatgaa ctcctacata ggaaaactga atatcctgat gttgcttggc
      601 cattgagatt tcgcatcctg catgaaattg cccttggtgt aaattacctg cacaatatga
      661 ctcctccttt acttcatcat gacttgaaga ctcagaatat cttattggac aatgaatttc
      721 atgttaagat tgcagatttt ggtttatcaa agtggcgcat gatgtccctc tcacagtcac
      781 gaagtagcaa atctgcacca gaaggaggga caattatcta tatgccacct gaaaactatg
      841 aacctggaca aaaatcaagg gccagtatca agcacgatat atatagctat gcagttatca
      901 catgggaagt gttatccaga aaacagcctt ttgaagatgt caccaatcct ttgcagataa
      961 tgtatagtgt gtcacaagga catcgacctg ttattaatga agaaagtttg ccatatgata
     1021 tacctcaccg agcacgtatg atctctctaa tagaaagtgg atgggcacaa aatccagatg
     1081 aaagaccatc tttcttaaaa tgtttaatag aacttgaacc agttttgaga acatttgaag
     1141 agataacttt tcttgaagct gttattcagc taaagaaaac aaagttacag agtgtttcaa
     1201 gtgccattca cctatgtgac aagaagaaaa tggaattatc tctgaacata cctgtaaatc
     1261 atggtccaca agaggaatca tgtggatcct ctcagctcca tgaaaatagt ggttctcctg
     1321 aaacttcaag gtccctgcca gctcctcaag acaatgattt tttatctaga aaagctcaag
     1381 actgttattt tatgaagctg catcactgtc ctggaaatca cagttgggat agcaccattt
     1441 ctggatctca aagggctgca ttctgtgatc acaagaccac tccatgctct tcagcaataa
     1501 taaatccact ctcaactgca ggaaactcag aacgtctgca gcctggtata gcccagcagt
     1561 ggatccagag caaaagggaa gacattgtga accaaatgac agaagcctgc cttaaccagt
     1621 cgctagatgc ccttctgtcc agggacttga tcatgaaaga ggactatgaa cttgttagta
     1681 ccaagcctac aaggacctca aaagtcagac aattactaga cactactgac atccaaggag
     1741 aagaatttgc caaagttata gtacaaaaat tgaaagataa caaacaaatg ggtcttcagc
     1801 cttacccgga aatacttgtg gtttctagat caccatcttt aaatttactt caaaataaaa
     1861 gcatgtaagt gactgttttt caagaagaaa tgtgtttcat aaaaggatat ttatatctct
     1921 gttgctttga ctttttttat ataaaatccg tgagtattaa agctttattg aaggttcttt
     1981 gggtaaatat tagtctccct ccatgacact gcagtatttt ttttaattaa tacaagtaaa
     2041 aagtttgaat tttgctacat agttcaattt ttatgtctct tttgttaaca gaaaccactt
     2101 ttaaaggata gtaattattc ttgtttataa cagtgcctta aggtatgatg tatttctgat
     2161 ggaagccatt ttcacattca tgttcttcat ggattatttg ttacttgtct aagatgcaat
     2221 ttgattttat gaagtatata ccctttaccc accagagaca gtacagaatc cctgccctaa
     2281 aatcccaggc ttaattgccc tacaaagggt tattaattta aaactccatt attaggatta
     2341 cattttaaag ttttatttat gaattccctt taaaaatgat atttcaaagg taaaacaata
     2401 caatataaag aaaaaaataa atatattaat accggcttcc tgtccccatt tttaacctca
     2461 gccttcccta ctgtcaccaa caaccaagct aaataaagtc aacagcctga tgtgta
//
