LOCUS       NM_001375360            2362 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 2
            (RIPK2), transcript variant 2, mRNA.
ACCESSION   NM_001375360 XM_005251092
VERSION     NM_001375360.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Goncharov,T., Komuves,L.G., Kist,M., Castellanos,E.R., Witt,A.,
            Fedorova,A.V., Izrael-Tomasevic,A., Yu,K., Keir,M., Matsumoto,M.L.
            and Vucic,D.
  TITLE     Simultaneous substrate and ubiquitin modification recognition by
            bispecific antibodies enables detection of ubiquitinated RIP1 and
            RIP2
  JOURNAL   Sci Signal 17 (819), eabn1101 (2024)
   PUBMED   38227684
  REMARK    GeneRIF: Simultaneous substrate and ubiquitin modification
            recognition by bispecific antibodies enables detection of
            ubiquitinated RIP1 and RIP2.
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Lee,J., Sim,K.M., Kang,M., Oh,H.J., Choi,H.J., Kim,Y.E., Pack,C.G.,
            Kim,K., Kim,K.M., Oh,S.H., Kim,I. and Chang,I.
  TITLE     Understanding the molecular mechanism of pathogenic variants of
            BIR2 domain in XIAP-deficient inflammatory bowel disease
  JOURNAL   Sci Rep 14 (1), 853 (2024)
   PUBMED   38191507
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Zheng,S., Li,Y., Song,X., Wu,M., Yu,L., Huang,G., Liu,T., Zhang,L.,
            Shang,M., Zhu,Q., Gao,C., Chen,L. and Liu,H.
  TITLE     OTUD1 ameliorates cerebral ischemic injury through inhibiting
            inflammation by disrupting K63-linked deubiquitination of RIP2
  JOURNAL   J Neuroinflammation 20 (1), 281 (2023)
   PUBMED   38012669
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Hezinger,L., Bauer,S., Ellwanger,K., Piotrowsky,A., Biber,F.,
            Venturelli,S. and Kufer,T.A.
  TITLE     NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2-
            and NF-kB-independent manner
  JOURNAL   FEBS J 290 (22), 5295-5312 (2023)
   PUBMED   37488967
  REMARK    GeneRIF: NOD1 cooperates with HAX-1 to promote cell migration in a
            RIPK2- and NF-kB-independent manner.
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   Cui,K., Wang,X., Han,C., Liu,S. and Hu,Y.
  TITLE     Mechanism of Human Cytomegalovirus-Induced Epithelial-Mesenchymal
            Transition in Glioma Cells via the Upregulation of RIP2 Expression
  JOURNAL   Biol Pharm Bull 46 (11), 1506-1511 (2023)
   PUBMED   37914353
  REMARK    GeneRIF: Mechanism of Human Cytomegalovirus-Induced
            Epithelial-Mesenchymal Transition in Glioma Cells via the
            Upregulation of RIP2 Expression.
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
            Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
  TITLE     Nod1, an Apaf-1-like activator of caspase-9 and nuclear
            factor-kappaB
  JOURNAL   J Biol Chem 274 (21), 14560-14567 (1999)
   PUBMED   10329646
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
            Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
            Glucksmann,M.A. and DiStefano,P.S.
  TITLE     Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
            member that activates NF-kappaB
  JOURNAL   J Biol Chem 274 (19), 12955-12958 (1999)
   PUBMED   10224040
REFERENCE   8  (bases 1 to 2362)
  AUTHORS   Thome,M., Hofmann,K., Burns,K., Martinon,F., Bodmer,J.L.,
            Mattmann,C. and Tschopp,J.
  TITLE     Identification of CARDIAK, a RIP-like kinase that associates with
            caspase-1
  JOURNAL   Curr Biol 8 (15), 885-888 (1998)
   PUBMED   9705938
REFERENCE   9  (bases 1 to 2362)
  AUTHORS   McCarthy,J.V., Ni,J. and Dixit,V.M.
  TITLE     RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
  JOURNAL   J Biol Chem 273 (27), 16968-16975 (1998)
   PUBMED   9642260
REFERENCE   10 (bases 1 to 2362)
  AUTHORS   Inohara,N., del Peso,L., Koseki,T., Chen,S. and Nunez,G.
  TITLE     RICK, a novel protein kinase containing a caspase recruitment
            domain, interacts with CLARP and regulates CD95-mediated apoptosis
  JOURNAL   J Biol Chem 273 (20), 12296-12300 (1998)
   PUBMED   9575181
  REMARK    Erratum:[J Biol Chem 1998 Jul 17;273(29):18675]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF117829.3.
            
            On Oct 25, 2019 this sequence version replaced XM_005251092.3.
            
            Summary: This gene encodes a member of the receptor-interacting
            protein (RIP) family of serine/threonine protein kinases. The
            encoded protein contains a C-terminal caspase activation and
            recruitment domain (CARD), and is a component of signaling
            complexes in both the innate and adaptive immune pathways. It is a
            potent activator of NF-kappaB and inducer of apoptosis in response
            to various stimuli. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358813.1, AK301448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               AF117829.3         147159-147576
            419-574             AF117829.3         154684-154839
            575-732             AF117829.3         159115-159272
            733-782             AF117829.3         161084-161133
            783-944             AF117829.3         162010-162171
            945-1030            AF117829.3         169418-169503
            1031-1120           AF117829.3         173393-173482
            1121-1214           AF117829.3         175936-176029
            1215-1376           AF117829.3         178664-178825
            1377-2362           AF117829.3         179422-180407
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2362
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="receptor interacting serine/threonine kinase 2"
                     /db_xref="GeneID:8767"
                     /db_xref="HGNC:HGNC:10020"
                     /db_xref="MIM:603455"
     exon            1..418
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..574
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             503..1714
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     receptor-interacting protein (RIP)-like interacting
                     caspase-like apoptosis regulatory protein (CLARP) kinase;
                     CARD-containing interleukin-1 beta-converting enzyme
                     (ICE)-associated kinase; growth-inhibiting gene 30;
                     CARD-carrying kinase; receptor-interacting
                     serine/threonine-protein kinase 2; RIP-2;
                     receptor-interacting protein 2; CARD-containing IL-1 beta
                     ICE-kinase; tyrosine-protein kinase RIPK2"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 2 isoform 2"
                     /protein_id="NP_001362289.1"
                     /db_xref="GeneID:8767"
                     /db_xref="HGNC:HGNC:10020"
                     /db_xref="MIM:603455"
                     /translation="MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSS
                     KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIM
                     YSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF
                     EEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENS
                     GSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTP
                     CSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMK
                     EDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRS
                     PSLNLLQNKSM"
     exon            575..732
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..782
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..944
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1030
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1120
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1214
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1376
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2362
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AGTAAA"
     polyA_site      1907
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="major polyA site"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2282
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2362
                     /gene="RIPK2"
                     /gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgcggc gctacggcgt tggcaccagt ctctagaaaa gaagtcagct ctggttcgga
       61 gaagcagcgg ctggcgtggg ccatccgggg aatgggcgcc ctcgtgacct agtgttgcgg
      121 ggcaaaaagg gtcttgccgg cctcgctcgt gcaggggcgt atctgggcgc ctgagcgcgg
      181 cgtgggagcc ttgggagccg ccgcagcagg gggcacaccc ggaaccggcc tgagcgcccg
      241 ggaccatgaa cggggaggcc atctgcagcg ccctgcccac cattccctac cacaaactcg
      301 ccgacctgcg ctacctgagc cgcggcgcct ctggcactgt gtcgtccgcc cgccacgcag
      361 actggcgcgt ccaggtggcc gtgaagcacc tgcacatcca cactccgctg ctcgacagaa
      421 aactgaatat cctgatgttg cttggccatt gagatttcgc atcctgcatg aaattgccct
      481 tggtgtaaat tacctgcaca atatgactcc tcctttactt catcatgact tgaagactca
      541 gaatatctta ttggacaatg aatttcatgt taagattgca gattttggtt tatcaaagtg
      601 gcgcatgatg tccctctcac agtcacgaag tagcaaatct gcaccagaag gagggacaat
      661 tatctatatg ccacctgaaa actatgaacc tggacaaaaa tcaagggcca gtatcaagca
      721 cgatatatat agctatgcag ttatcacatg ggaagtgtta tccagaaaac agccttttga
      781 agatgtcacc aatcctttgc agataatgta tagtgtgtca caaggacatc gacctgttat
      841 taatgaagaa agtttgccat atgatatacc tcaccgagca cgtatgatct ctctaataga
      901 aagtggatgg gcacaaaatc cagatgaaag accatctttc ttaaaatgtt taatagaact
      961 tgaaccagtt ttgagaacat ttgaagagat aacttttctt gaagctgtta ttcagctaaa
     1021 gaaaacaaag ttacagagtg tttcaagtgc cattcaccta tgtgacaaga agaaaatgga
     1081 attatctctg aacatacctg taaatcatgg tccacaagag gaatcatgtg gatcctctca
     1141 gctccatgaa aatagtggtt ctcctgaaac ttcaaggtcc ctgccagctc ctcaagacaa
     1201 tgatttttta tctagaaaag ctcaagactg ttattttatg aagctgcatc actgtcctgg
     1261 aaatcacagt tgggatagca ccatttctgg atctcaaagg gctgcattct gtgatcacaa
     1321 gaccactcca tgctcttcag caataataaa tccactctca actgcaggaa actcagaacg
     1381 tctgcagcct ggtatagccc agcagtggat ccagagcaaa agggaagaca ttgtgaacca
     1441 aatgacagaa gcctgcctta accagtcgct agatgccctt ctgtccaggg acttgatcat
     1501 gaaagaggac tatgaacttg ttagtaccaa gcctacaagg acctcaaaag tcagacaatt
     1561 actagacact actgacatcc aaggagaaga atttgccaaa gttatagtac aaaaattgaa
     1621 agataacaaa caaatgggtc ttcagcctta cccggaaata cttgtggttt ctagatcacc
     1681 atctttaaat ttacttcaaa ataaaagcat gtaagtgact gtttttcaag aagaaatgtg
     1741 tttcataaaa ggatatttat atctctgttg ctttgacttt ttttatataa aatccgtgag
     1801 tattaaagct ttattgaagg ttctttgggt aaatattagt ctccctccat gacactgcag
     1861 tatttttttt aattaataca agtaaaaagt ttgaattttg ctacatagtt caatttttat
     1921 gtctcttttg ttaacagaaa ccacttttaa aggatagtaa ttattcttgt ttataacagt
     1981 gccttaaggt atgatgtatt tctgatggaa gccattttca cattcatgtt cttcatggat
     2041 tatttgttac ttgtctaaga tgcaatttga ttttatgaag tatataccct ttacccacca
     2101 gagacagtac agaatccctg ccctaaaatc ccaggcttaa ttgccctaca aagggttatt
     2161 aatttaaaac tccattatta ggattacatt ttaaagtttt atttatgaat tccctttaaa
     2221 aatgatattt caaaggtaaa acaatacaat ataaagaaaa aaataaatat attaataccg
     2281 gcttcctgtc cccattttta acctcagcct tccctactgt caccaacaac caagctaaat
     2341 aaagtcaaca gcctgatgtg ta
//
