LOCUS       NM_001354932            4131 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 1
            (RIPK1), transcript variant 5, mRNA.
ACCESSION   NM_001354932
VERSION     NM_001354932.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   Mannion,J., Gifford,V., Bellenie,B., Fernando,W., Ramos Garcia,L.,
            Wilson,R., John,S.W., Udainiya,S., Patin,E.C., Tiu,C., Smith,A.,
            Goicoechea,M., Craxton,A., Moraes de Vasconcelos,N., Guppy,N.,
            Cheung,K.J., Cundy,N.J., Pierrat,O., Brennan,A., Roumeliotis,T.I.,
            Benstead-Hume,G., Alexander,J., Muirhead,G., Layzell,S., Lyu,W.,
            Roulstone,V., Allen,M., Baldock,H., Legrand,A., Gabel,F.,
            Serrano-Aparicio,N., Starling,C., Guo,H., Upton,J., Gyrd-Hansen,M.,
            MacFarlane,M., Seddon,B., Raynaud,F., Roxanis,I., Harrington,K.,
            Haider,S., Choudhary,J.S., Hoelder,S., Tenev,T. and Meier,P.
  TITLE     A RIPK1-specific PROTAC degrader achieves potent antitumor activity
            by enhancing immunogenic cell death
  JOURNAL   Immunity 57 (7), 1514-1532 (2024)
   PUBMED   38788712
  REMARK    GeneRIF: A RIPK1-specific PROTAC degrader achieves potent antitumor
            activity by enhancing immunogenic cell death.
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Jin,X., Zhang,Y., Zhou,Y., Luo,Y., Han,X., Gao,Y., Yu,H., Duan,Y.,
            Shi,L., Wu,Y. and Li,Y.
  TITLE     Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial
            Necroptosis by Activation of RIPK1 Acetylation
  JOURNAL   Circ Arrhythm Electrophysiol 17 (7), e012452 (2024)
   PUBMED   39012929
  REMARK    GeneRIF: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing
            Atrial Necroptosis by Activation of RIPK1 Acetylation.
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Yang,M., Wei,Y., He,X. and Xia,C.
  TITLE     The deubiquitinating protein OTUD6B promotes lung adenocarcinoma
            progression by stabilizing RIPK1
  JOURNAL   Biol Direct 19 (1), 46 (2024)
   PUBMED   38880876
  REMARK    GeneRIF: The deubiquitinating protein OTUD6B promotes lung
            adenocarcinoma progression by stabilizing RIPK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Damhofer,H., Tatar,T., Southgate,B., Scarneo,S., Agger,K.,
            Shlyueva,D., Uhrbom,L., Morrison,G.M., Hughes,P.F., Haystead,T.,
            Pollard,S.M. and Helin,K.
  TITLE     TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers
  JOURNAL   Cell Death Dis 15 (4), 273 (2024)
   PUBMED   38632238
  REMARK    GeneRIF: TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Lee,Y.M. and Vucic,D.
  TITLE     The role of autophagy in RIP1 mediated cell death and intestinal
            inflammation
  JOURNAL   Adv Immunol 163, 1-20 (2024)
   PUBMED   39271257
  REMARK    GeneRIF: The role of autophagy in RIP1 mediated cell death and
            intestinal inflammation.
            Review article
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Silke,J., Rickard,J.A. and Gerlic,M.
  TITLE     The diverse role of RIP kinases in necroptosis and inflammation
  JOURNAL   Nat Immunol 16 (7), 689-697 (2015)
   PUBMED   26086143
  REMARK    GeneRIF: Studies indicate that RIP kinases RIPK1 and RIPK3 directly
            regulate inflammatory signaling.
            Review article
            Erratum:[Nat Immunol. 2015 Aug;16(8):889. doi:
            10.1038/ni0815-889b.. PMID: 26194288]
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   Takeuchi,M., Rothe,M. and Goeddel,D.V.
  TITLE     Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB
            activation and association with tumor necrosis factor signaling
            proteins
  JOURNAL   J Biol Chem 271 (33), 19935-19942 (1996)
   PUBMED   8702708
REFERENCE   8  (bases 1 to 4131)
  AUTHORS   Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
  TITLE     TNF-dependent recruitment of the protein kinase RIP to the TNF
            receptor-1 signaling complex
  JOURNAL   Immunity 4 (4), 387-396 (1996)
   PUBMED   8612133
REFERENCE   9  (bases 1 to 4131)
  AUTHORS   Hsu,H., Xiong,J. and Goeddel,D.V.
  TITLE     The TNF receptor 1-associated protein TRADD signals cell death and
            NF-kappa B activation
  JOURNAL   Cell 81 (4), 495-504 (1995)
   PUBMED   7758105
REFERENCE   10 (bases 1 to 4131)
  AUTHORS   Stanger,B.Z., Leder,P., Lee,T.H., Kim,E. and Seed,B.
  TITLE     RIP: a novel protein containing a death domain that interacts with
            Fas/APO-1 (CD95) in yeast and causes cell death
  JOURNAL   Cell 81 (4), 513-523 (1995)
   PUBMED   7538908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031963.40.
            
            On May 31, 2019 this sequence version replaced NM_001354932.1.
            
            Summary: This gene encodes a member of the receptor-interacting
            protein (RIP) family of serine/threonine protein kinases. The
            encoded protein plays a role in inflammation and cell death in
            response to tissue damage, pathogen recognition, and as part of
            developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is
            referred to as necroptosis. Genetic disruption of this gene in mice
            results in death shortly after birth. [provided by RefSeq, Aug
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.58571.1,
                                           SRR1660805.76197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL031963.40        26361-26453
            94-317              AL031963.40        39158-39381
            318-474             AL031963.40        40173-40329
            475-612             AL031963.40        43373-43510
            613-726             AL031963.40        44941-45054
            727-955             AL031963.40        45479-45707
            956-1105            AL031963.40        47653-47802
            1106-1182           AL031963.40        51975-52051
            1183-1273           AL031963.40        66619-66709
            1274-1843           AL031963.40        67876-68445
            1844-1996           AL031963.40        73197-73349
            1997-4131           AL031963.40        75447-77581
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..4131
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="receptor interacting serine/threonine kinase 1"
                     /db_xref="GeneID:8737"
                     /db_xref="HGNC:HGNC:10019"
                     /db_xref="MIM:603453"
     exon            1..93
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..317
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..474
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..612
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..726
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..955
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..2283
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 5;
                     receptor-interacting serine/threonine-protein kinase 1;
                     serine/threonine-protein kinase RIP; cell death protein
                     RIP; receptor-interacting protein 1; receptor
                     (TNFRSF)-interacting serine-threonine kinase 1;
                     receptor-interacting protein kinase 1"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 1 isoform 2"
                     /protein_id="NP_001341861.1"
                     /db_xref="GeneID:8737"
                     /db_xref="HGNC:HGNC:10019"
                     /db_xref="MIM:603453"
                     /translation="MWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTE
                     KSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMK
                     LCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQL
                     DCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDE
                     ANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAY
                     SSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHM
                     PSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSS
                     LLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQID
                     EIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
                     "
     exon            956..1105
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1182
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1273
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1843
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1996
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..4131
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4112..4117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="hexamer: AATAAA"
     polyA_site      4131
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="major polyA site"
ORIGIN      
        1 gggagtccgc ggcgagcgca gcagcagggc ccggtcctgc gcctcgggag tcggcgtcca
       61 ggctcggagc gcgacacgga gactaggtgg cagggtacag ctctgccggg gggggaaaaa
      121 gtggtaccat tttgggcgtt cttgagcttc agaatgcaac cagacatgtc cttgaatgtc
      181 attaagatga aatccagtga cttcctggag agtgcagaac tggacagcgg aggctttggg
      241 aaggtgtctc tgtgtttcca cagaacccag ggactcatga tcatgaaaac agtgtacaag
      301 gggcccaact gcattgagca caacgaggcc ctcttggagg aggcgaagat gatgaacaga
      361 ctgagacaca gccgggtggt gaagctcctg ggcgtcatca tagaggaagg gaagtactcc
      421 ctggtgatgg agtacatgga gaagggcaac ctgatgcacg tgctgaaagc cgagatgagt
      481 actccgcttt ctgtaaaagg aaggataatt ttggaaatca ttgaaggaat gtgctactta
      541 catggaaaag gcgtgataca caaggacctg aagcctgaaa atatccttgt tgataatgac
      601 ttccacatta aggttcaggc tacagctcaa aacaagcaac actgcagtcc ttatcctcag
      661 tgtgtctttg ggatccttgg acacttgcat ccatgggcct ctggacgcca tttggggaaa
      721 tagaagatcg cagacctcgg ccttgcctcc tttaagatgt ggagcaaact gaataatgaa
      781 gagcacaatg agctgaggga agtggacggc accgctaaga agaatggcgg caccctctac
      841 tacatggcgc ccgagcacct gaatgacgtc aacgcaaagc ccacagagaa gtcggatgtg
      901 tacagctttg ctgtagtact ctgggcgata tttgcaaata aggagccata tgaaaatgct
      961 atctgtgagc agcagttgat aatgtgcata aaatctggga acaggccaga tgtggatgac
     1021 atcactgagt actgcccaag agaaattatc agtctcatga agctctgctg ggaagcgaat
     1081 ccggaagctc ggccgacatt tcctggcatt gaagaaaaat ttaggccttt ttatttaagt
     1141 caattagaag aaagtgtaga agaggacgtg aagagtttaa agaaagagta ttcaaacgaa
     1201 aatgcagttg tgaagagaat gcagtctctt caacttgatt gtgtggcagt accttcaagc
     1261 cggtcaaatt cagccacaga acagcctggt tcactgcaca gttcccaggg acttgggatg
     1321 ggtcctgtgg aggagtcctg gtttgctcct tccctggagc acccacaaga agagaatgag
     1381 cccagcctgc agagtaaact ccaagacgaa gccaactacc atctttatgg cagccgcatg
     1441 gacaggcaga cgaaacagca gcccagacag aatgtggctt acaacagaga ggaggaaagg
     1501 agacgcaggg tctcccatga cccttttgca cagcaaagac cttacgagaa ttttcagaat
     1561 acagagggaa aaggcactgc ttattccagt gcagccagtc atggtaatgc agtgcaccag
     1621 ccctcagggc tcaccagcca acctcaagta ctgtatcaga acaatggatt atatagctca
     1681 catggctttg gaacaagacc actggatcca ggaacagcag gtcccagagt ttggtacagg
     1741 ccaattccaa gtcatatgcc tagtctgcat aatatcccag tgcctgagac caactatcta
     1801 ggaaatacac ccaccatgcc attcagctcc ttgccaccaa cagatgaatc tataaaatat
     1861 accatataca atagtactgg cattcagatt ggagcctaca attatatgga gattggtggg
     1921 acgagttcat cactactaga cagcacaaat acgaacttca aagaagagcc agctgctaag
     1981 taccaagcta tctttgataa taccactagt ctgacggata aacacctgga cccaatcagg
     2041 gaaaatctgg gaaagcactg gaaaaactgt gcccgtaaac tgggcttcac acagtctcag
     2101 attgatgaaa ttgaccatga ctatgagcga gatggactga aagaaaaggt ttaccagatg
     2161 ctccaaaagt gggtgatgag ggaaggcata aagggagcca cggtggggaa gctggcccag
     2221 gcgctccacc agtgttccag gatcgacctt ctgagcagct tgatttacgt cagccagaac
     2281 taaccctgga tgggctacgg cagctgaagt ggacgcctca cttagtggat aaccccagaa
     2341 agttggctgc ctcagagcat tcagaattct gtcctcactg ataggggttc tgtgtctgca
     2401 gaaattttgt ttcctgtact tcatagctgg agaatgggga aagaaatctg cagcaaaggg
     2461 gtctcactct gttgccaggc tggtctcaaa cttctggact caagtgatcc tcccgcctcg
     2521 gccttccaaa gtgctgggat atcaggcact gagccactgc gcccagccaa caatccgctc
     2581 tgaggaaagc gtaagcagga agacctctta atggcatagc accaataaaa aaatgactcc
     2641 tagttgtgtt tggaaaggga gagaagagat gtctgaggaa ggtcatgttc tttcagctta
     2701 tggcatttcc tagagttttg ttgaagcaag aagaaaaact cagagaatat aaaatcaact
     2761 tttaaaattg tgtgctctct tcttcacgta ggctcctgtt aaaaacaaag tgcagtcaga
     2821 ttctaagccc tgttcagaga cttcgtggat cacagctgca gctcaccgcc acatcacagg
     2881 atccgttaac gttaataccc aatactctgt cagccactgt aggctctaag aaccacgtgc
     2941 agtcttcagc ccattaaatt atcgattatt ttttaatgaa ttgaatttat attgagtctt
     3001 caaattaact gaatggattt aaaggggtac caaggagggg ggaaacatca gaatttccca
     3061 ggcagttgtt gcaaggaatt ggtactaacc gtgactacaa caaaaattct tgattgactt
     3121 ttaaagttat ttcctggcat tctggtacct tcacccagcc tgagtgccct ggagagggaa
     3181 caggaaatgc tgatctctac ccctgggtga gaccagaacc tcagggctga tactgttgag
     3241 tggcttcctc ggtttactct gtgtactgtg aaagtatttt catatttttt ctgtgtgcca
     3301 gagtgaaaaa ggacagcttc tgagtgtggt aattgtgcct ctagcaccca gcctttcaaa
     3361 gcccacctga aacctggggg tggatgaaag aactagaata gaagactgaa gctgggtagg
     3421 ccgctcagtg tccactggca ttttgctaaa ccgacaagga aggctgtgtg cttagctctc
     3481 cccagaggga gggcgagaag ggtgtggtga tggtcaatct ggctgtcgga acagattctg
     3541 gtgtcttggg ctgataacag tgttgttgat tctgattgtg aatcccctca actctagcag
     3601 acacatacac acccctgaaa tggggctgca gagcaggctg tctcagcctt gccactgtcg
     3661 gcatctcggc ctgggtaatt ctgttgtggg gactgtcctg ttccttgtag gatgtttagt
     3721 agcatccctg cccccaccta ctagatgcca ggggcactgt tctccccagc cccccgcccc
     3781 agttgtgaca atagtctcta aacattgtca aatggtccaa ggaaagggga aaattgcccc
     3841 ggttgagaag agcactgctg taaagtaatg agcctcggct ctcctgtctg cacctgtccg
     3901 gttactactt ggccaccacg cagccttggc tcctacagcc caaaagggag aatggaggga
     3961 ggctccaggc tttgctggag gggcctgggt gagttctgtt tgctccttgt accaccatcc
     4021 aaatggtgtt atcaaatctc ttagattcca aagaggttga ataattaatg ttcaaaggca
     4081 agagggcaag gcatttttta acacttttta aaataaaaat ttataccaca a
//
