LOCUS       NM_001354930            4092 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens receptor interacting serine/threonine kinase 1
            (RIPK1), transcript variant 3, mRNA.
ACCESSION   NM_001354930 XM_005249457
VERSION     NM_001354930.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4092)
  AUTHORS   Mannion,J., Gifford,V., Bellenie,B., Fernando,W., Ramos Garcia,L.,
            Wilson,R., John,S.W., Udainiya,S., Patin,E.C., Tiu,C., Smith,A.,
            Goicoechea,M., Craxton,A., Moraes de Vasconcelos,N., Guppy,N.,
            Cheung,K.J., Cundy,N.J., Pierrat,O., Brennan,A., Roumeliotis,T.I.,
            Benstead-Hume,G., Alexander,J., Muirhead,G., Layzell,S., Lyu,W.,
            Roulstone,V., Allen,M., Baldock,H., Legrand,A., Gabel,F.,
            Serrano-Aparicio,N., Starling,C., Guo,H., Upton,J., Gyrd-Hansen,M.,
            MacFarlane,M., Seddon,B., Raynaud,F., Roxanis,I., Harrington,K.,
            Haider,S., Choudhary,J.S., Hoelder,S., Tenev,T. and Meier,P.
  TITLE     A RIPK1-specific PROTAC degrader achieves potent antitumor activity
            by enhancing immunogenic cell death
  JOURNAL   Immunity 57 (7), 1514-1532 (2024)
   PUBMED   38788712
  REMARK    GeneRIF: A RIPK1-specific PROTAC degrader achieves potent antitumor
            activity by enhancing immunogenic cell death.
REFERENCE   2  (bases 1 to 4092)
  AUTHORS   Jin,X., Zhang,Y., Zhou,Y., Luo,Y., Han,X., Gao,Y., Yu,H., Duan,Y.,
            Shi,L., Wu,Y. and Li,Y.
  TITLE     Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial
            Necroptosis by Activation of RIPK1 Acetylation
  JOURNAL   Circ Arrhythm Electrophysiol 17 (7), e012452 (2024)
   PUBMED   39012929
  REMARK    GeneRIF: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing
            Atrial Necroptosis by Activation of RIPK1 Acetylation.
REFERENCE   3  (bases 1 to 4092)
  AUTHORS   Yang,M., Wei,Y., He,X. and Xia,C.
  TITLE     The deubiquitinating protein OTUD6B promotes lung adenocarcinoma
            progression by stabilizing RIPK1
  JOURNAL   Biol Direct 19 (1), 46 (2024)
   PUBMED   38880876
  REMARK    GeneRIF: The deubiquitinating protein OTUD6B promotes lung
            adenocarcinoma progression by stabilizing RIPK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4092)
  AUTHORS   Damhofer,H., Tatar,T., Southgate,B., Scarneo,S., Agger,K.,
            Shlyueva,D., Uhrbom,L., Morrison,G.M., Hughes,P.F., Haystead,T.,
            Pollard,S.M. and Helin,K.
  TITLE     TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers
  JOURNAL   Cell Death Dis 15 (4), 273 (2024)
   PUBMED   38632238
  REMARK    GeneRIF: TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4092)
  AUTHORS   Lee,Y.M. and Vucic,D.
  TITLE     The role of autophagy in RIP1 mediated cell death and intestinal
            inflammation
  JOURNAL   Adv Immunol 163, 1-20 (2024)
   PUBMED   39271257
  REMARK    GeneRIF: The role of autophagy in RIP1 mediated cell death and
            intestinal inflammation.
            Review article
REFERENCE   6  (bases 1 to 4092)
  AUTHORS   Silke,J., Rickard,J.A. and Gerlic,M.
  TITLE     The diverse role of RIP kinases in necroptosis and inflammation
  JOURNAL   Nat Immunol 16 (7), 689-697 (2015)
   PUBMED   26086143
  REMARK    GeneRIF: Studies indicate that RIP kinases RIPK1 and RIPK3 directly
            regulate inflammatory signaling.
            Review article
            Erratum:[Nat Immunol. 2015 Aug;16(8):889. doi:
            10.1038/ni0815-889b.. PMID: 26194288]
REFERENCE   7  (bases 1 to 4092)
  AUTHORS   Takeuchi,M., Rothe,M. and Goeddel,D.V.
  TITLE     Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB
            activation and association with tumor necrosis factor signaling
            proteins
  JOURNAL   J Biol Chem 271 (33), 19935-19942 (1996)
   PUBMED   8702708
REFERENCE   8  (bases 1 to 4092)
  AUTHORS   Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
  TITLE     TNF-dependent recruitment of the protein kinase RIP to the TNF
            receptor-1 signaling complex
  JOURNAL   Immunity 4 (4), 387-396 (1996)
   PUBMED   8612133
REFERENCE   9  (bases 1 to 4092)
  AUTHORS   Hsu,H., Xiong,J. and Goeddel,D.V.
  TITLE     The TNF receptor 1-associated protein TRADD signals cell death and
            NF-kappa B activation
  JOURNAL   Cell 81 (4), 495-504 (1995)
   PUBMED   7758105
REFERENCE   10 (bases 1 to 4092)
  AUTHORS   Stanger,B.Z., Leder,P., Lee,T.H., Kim,E. and Seed,B.
  TITLE     RIP: a novel protein containing a death domain that interacts with
            Fas/APO-1 (CD95) in yeast and causes cell death
  JOURNAL   Cell 81 (4), 513-523 (1995)
   PUBMED   7538908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031963.40.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001354930.1.
            
            Summary: This gene encodes a member of the receptor-interacting
            protein (RIP) family of serine/threonine protein kinases. The
            encoded protein plays a role in inflammation and cell death in
            response to tissue damage, pathogen recognition, and as part of
            developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is
            referred to as necroptosis. Genetic disruption of this gene in mice
            results in death shortly after birth. [provided by RefSeq, Aug
            2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.265177.1,
                                           SRR1660803.229431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259808.9/ ENSP00000259808.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL031963.40        30888-31055
            169-392             AL031963.40        39158-39381
            393-549             AL031963.40        40173-40329
            550-687             AL031963.40        43373-43510
            688-916             AL031963.40        45479-45707
            917-1066            AL031963.40        47653-47802
            1067-1143           AL031963.40        51975-52051
            1144-1234           AL031963.40        66619-66709
            1235-1804           AL031963.40        67876-68445
            1805-1957           AL031963.40        73197-73349
            1958-4092           AL031963.40        75447-77581
FEATURES             Location/Qualifiers
     source          1..4092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..4092
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="receptor interacting serine/threonine kinase 1"
                     /db_xref="GeneID:8737"
                     /db_xref="HGNC:HGNC:10019"
                     /db_xref="MIM:603453"
     exon            1..168
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..392
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2244
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     receptor-interacting serine/threonine-protein kinase 1;
                     serine/threonine-protein kinase RIP; cell death protein
                     RIP; receptor-interacting protein 1; receptor
                     (TNFRSF)-interacting serine-threonine kinase 1;
                     receptor-interacting protein kinase 1"
                     /codon_start=1
                     /product="receptor-interacting serine/threonine-protein
                     kinase 1 isoform 1"
                     /protein_id="NP_001341859.1"
                     /db_xref="CCDS:CCDS4482.1"
                     /db_xref="GeneID:8737"
                     /db_xref="HGNC:HGNC:10019"
                     /db_xref="MIM:603453"
                     /translation="MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIM
                     KTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMH
                     VLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA
                     SFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVL
                     WAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARP
                     TFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSN
                     SATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMD
                     RQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVH
                     QPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPET
                     NYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKE
                     EPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGL
                     KEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN"
     exon            393..549
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..687
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..916
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1066
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1143
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1234
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1804
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1957
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..4092
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4073..4078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="hexamer: AATAAA"
     polyA_site      4092
                     /gene="RIPK1"
                     /gene_synonym="AIEFL; IMD57; RIP; RIP-1; RIP1"
                     /note="major polyA site"
ORIGIN      
        1 agtccacgcc ctccagccgg gcgcgctcga cgcggacggc gggccagctg ccggagcgcg
       61 gcgactccag gggacccaca gctggggcgc cagagcgcgg ccatccgggc ggggccgacg
      121 gagcgcggca ggacttggct ggacggcgcg gccacggaga agggcgcggg tacagctctg
      181 ccgggggggg aaaaagtggt accattttgg gcgttcttga gcttcagaat gcaaccagac
      241 atgtccttga atgtcattaa gatgaaatcc agtgacttcc tggagagtgc agaactggac
      301 agcggaggct ttgggaaggt gtctctgtgt ttccacagaa cccagggact catgatcatg
      361 aaaacagtgt acaaggggcc caactgcatt gagcacaacg aggccctctt ggaggaggcg
      421 aagatgatga acagactgag acacagccgg gtggtgaagc tcctgggcgt catcatagag
      481 gaagggaagt actccctggt gatggagtac atggagaagg gcaacctgat gcacgtgctg
      541 aaagccgaga tgagtactcc gctttctgta aaaggaagga taattttgga aatcattgaa
      601 ggaatgtgct acttacatgg aaaaggcgtg atacacaagg acctgaagcc tgaaaatatc
      661 cttgttgata atgacttcca cattaagatc gcagacctcg gccttgcctc ctttaagatg
      721 tggagcaaac tgaataatga agagcacaat gagctgaggg aagtggacgg caccgctaag
      781 aagaatggcg gcaccctcta ctacatggcg cccgagcacc tgaatgacgt caacgcaaag
      841 cccacagaga agtcggatgt gtacagcttt gctgtagtac tctgggcgat atttgcaaat
      901 aaggagccat atgaaaatgc tatctgtgag cagcagttga taatgtgcat aaaatctggg
      961 aacaggccag atgtggatga catcactgag tactgcccaa gagaaattat cagtctcatg
     1021 aagctctgct gggaagcgaa tccggaagct cggccgacat ttcctggcat tgaagaaaaa
     1081 tttaggcctt tttatttaag tcaattagaa gaaagtgtag aagaggacgt gaagagttta
     1141 aagaaagagt attcaaacga aaatgcagtt gtgaagagaa tgcagtctct tcaacttgat
     1201 tgtgtggcag taccttcaag ccggtcaaat tcagccacag aacagcctgg ttcactgcac
     1261 agttcccagg gacttgggat gggtcctgtg gaggagtcct ggtttgctcc ttccctggag
     1321 cacccacaag aagagaatga gcccagcctg cagagtaaac tccaagacga agccaactac
     1381 catctttatg gcagccgcat ggacaggcag acgaaacagc agcccagaca gaatgtggct
     1441 tacaacagag aggaggaaag gagacgcagg gtctcccatg acccttttgc acagcaaaga
     1501 ccttacgaga attttcagaa tacagaggga aaaggcactg cttattccag tgcagccagt
     1561 catggtaatg cagtgcacca gccctcaggg ctcaccagcc aacctcaagt actgtatcag
     1621 aacaatggat tatatagctc acatggcttt ggaacaagac cactggatcc aggaacagca
     1681 ggtcccagag tttggtacag gccaattcca agtcatatgc ctagtctgca taatatccca
     1741 gtgcctgaga ccaactatct aggaaataca cccaccatgc cattcagctc cttgccacca
     1801 acagatgaat ctataaaata taccatatac aatagtactg gcattcagat tggagcctac
     1861 aattatatgg agattggtgg gacgagttca tcactactag acagcacaaa tacgaacttc
     1921 aaagaagagc cagctgctaa gtaccaagct atctttgata ataccactag tctgacggat
     1981 aaacacctgg acccaatcag ggaaaatctg ggaaagcact ggaaaaactg tgcccgtaaa
     2041 ctgggcttca cacagtctca gattgatgaa attgaccatg actatgagcg agatggactg
     2101 aaagaaaagg tttaccagat gctccaaaag tgggtgatga gggaaggcat aaagggagcc
     2161 acggtgggga agctggccca ggcgctccac cagtgttcca ggatcgacct tctgagcagc
     2221 ttgatttacg tcagccagaa ctaaccctgg atgggctacg gcagctgaag tggacgcctc
     2281 acttagtgga taaccccaga aagttggctg cctcagagca ttcagaattc tgtcctcact
     2341 gataggggtt ctgtgtctgc agaaattttg tttcctgtac ttcatagctg gagaatgggg
     2401 aaagaaatct gcagcaaagg ggtctcactc tgttgccagg ctggtctcaa acttctggac
     2461 tcaagtgatc ctcccgcctc ggccttccaa agtgctggga tatcaggcac tgagccactg
     2521 cgcccagcca acaatccgct ctgaggaaag cgtaagcagg aagacctctt aatggcatag
     2581 caccaataaa aaaatgactc ctagttgtgt ttggaaaggg agagaagaga tgtctgagga
     2641 aggtcatgtt ctttcagctt atggcatttc ctagagtttt gttgaagcaa gaagaaaaac
     2701 tcagagaata taaaatcaac ttttaaaatt gtgtgctctc ttcttcacgt aggctcctgt
     2761 taaaaacaaa gtgcagtcag attctaagcc ctgttcagag acttcgtgga tcacagctgc
     2821 agctcaccgc cacatcacag gatccgttaa cgttaatacc caatactctg tcagccactg
     2881 taggctctaa gaaccacgtg cagtcttcag cccattaaat tatcgattat tttttaatga
     2941 attgaattta tattgagtct tcaaattaac tgaatggatt taaaggggta ccaaggaggg
     3001 gggaaacatc agaatttccc aggcagttgt tgcaaggaat tggtactaac cgtgactaca
     3061 acaaaaattc ttgattgact tttaaagtta tttcctggca ttctggtacc ttcacccagc
     3121 ctgagtgccc tggagaggga acaggaaatg ctgatctcta cccctgggtg agaccagaac
     3181 ctcagggctg atactgttga gtggcttcct cggtttactc tgtgtactgt gaaagtattt
     3241 tcatattttt tctgtgtgcc agagtgaaaa aggacagctt ctgagtgtgg taattgtgcc
     3301 tctagcaccc agcctttcaa agcccacctg aaacctgggg gtggatgaaa gaactagaat
     3361 agaagactga agctgggtag gccgctcagt gtccactggc attttgctaa accgacaagg
     3421 aaggctgtgt gcttagctct ccccagaggg agggcgagaa gggtgtggtg atggtcaatc
     3481 tggctgtcgg aacagattct ggtgtcttgg gctgataaca gtgttgttga ttctgattgt
     3541 gaatcccctc aactctagca gacacataca cacccctgaa atggggctgc agagcaggct
     3601 gtctcagcct tgccactgtc ggcatctcgg cctgggtaat tctgttgtgg ggactgtcct
     3661 gttccttgta ggatgtttag tagcatccct gcccccacct actagatgcc aggggcactg
     3721 ttctccccag ccccccgccc cagttgtgac aatagtctct aaacattgtc aaatggtcca
     3781 aggaaagggg aaaattgccc cggttgagaa gagcactgct gtaaagtaat gagcctcggc
     3841 tctcctgtct gcacctgtcc ggttactact tggccaccac gcagccttgg ctcctacagc
     3901 ccaaaaggga gaatggaggg aggctccagg ctttgctgga ggggcctggg tgagttctgt
     3961 ttgctccttg taccaccatc caaatggtgt tatcaaatct cttagattcc aaagaggttg
     4021 aataattaat gttcaaaggc aagagggcaa ggcatttttt aacacttttt aaaataaaaa
     4081 tttataccac aa
//
