LOCUS       NM_153182               4854 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal oxygenase 2 (RIOX2), transcript variant 2,
            mRNA.
ACCESSION   NM_153182
VERSION     NM_153182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4854)
  AUTHORS   Geng,F., Yang,W., Song,D., Hou,H., Han,B., Chen,Y. and Zhao,H.
  TITLE     MDIG, a 2-oxoglutarate-dependent oxygenase, acts as an oncogene and
            predicts the prognosis of multiple types of cancer
  JOURNAL   Int J Oncol 61 (1) (2022)
   PUBMED   35583005
  REMARK    GeneRIF: MDIG, a 2oxoglutaratedependent oxygenase, acts as an
            oncogene and predicts the prognosis of multiple types of cancer.
REFERENCE   2  (bases 1 to 4854)
  AUTHORS   Wang,J., Zhu,X., Dang,L., Jiang,H., Xie,Y., Li,X., Guo,J., Wang,Y.,
            Peng,Z., Wang,M., Wang,J., Wang,S., Li,Q., Wang,Y., Wang,Q., Ye,L.,
            Zhang,L. and Liu,Z.
  TITLE     Epigenomic reprogramming via HRP2-MINA dictates response to
            proteasome inhibitors in multiple myeloma with t(4;14)
            translocation
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   35166240
  REMARK    GeneRIF: Epigenomic reprogramming via HRP2-MINA dictates response
            to proteasome inhibitors in multiple myeloma with t(4;14)
            translocation.
REFERENCE   3  (bases 1 to 4854)
  AUTHORS   Shirvaliloo,M.
  TITLE     The unfavorable clinical outcome of COVID-19 in smokers is mediated
            by H3K4me3, H3K9me3 and H3K27me3 histone marks
  JOURNAL   Epigenomics 14 (3), 153-162 (2022)
   PUBMED   35021853
  REMARK    GeneRIF: The unfavorable clinical outcome of COVID-19 in smokers is
            mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks.
            Review article
REFERENCE   4  (bases 1 to 4854)
  AUTHORS   Sun,B. and Zhao,H.
  TITLE     The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma
            and squamous cell carcinoma
  JOURNAL   PLoS One 16 (12), e0259447 (2021)
   PUBMED   34855761
  REMARK    GeneRIF: The bioinformatics analysis of RIOX2 gene in lung
            adenocarcinoma and squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4854)
  AUTHORS   Zhang,Q., Wadgaonkar,P., Xu,L., Thakur,C., Fu,Y., Bi,Z., Qiu,Y.,
            Almutairy,B., Zhang,W., Stemmer,P. and Chen,F.
  TITLE     Environmentally-induced mdig contributes to the severity of
            COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs
            and glycan metabolism
  JOURNAL   Theranostics 11 (16), 7970-7983 (2021)
   PUBMED   34335974
  REMARK    GeneRIF: Environmentally-induced mdig contributes to the severity
            of COVID-19 through fostering expression of SARS-CoV-2 receptor
            NRPs and glycan metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4854)
  AUTHORS   Eilbracht,J., Kneissel,S., Hofmann,A. and Schmidt-Zachmann,M.S.
  TITLE     Protein NO52--a constitutive nucleolar component sharing high
            sequence homologies to protein NO66
  JOURNAL   Eur J Cell Biol 84 (2-3), 279-294 (2005)
   PUBMED   15819408
  REMARK    GeneRIF: Data suggests NO52 protein (MYC induced nuclear antigen)
            is directly involved in ribosome biogenesis, most likely during the
            assembly process of preribosomal particles.
REFERENCE   7  (bases 1 to 4854)
  AUTHORS   Tsuneoka,M., Fujita,H., Arima,N., Teye,K., Okamura,T., Inutsuka,H.,
            Koda,Y., Shirouzu,K. and Kimura,H.
  TITLE     Mina53 as a potential prognostic factor for esophageal squamous
            cell carcinoma
  JOURNAL   Clin Cancer Res 10 (21), 7347-7356 (2004)
   PUBMED   15534111
  REMARK    GeneRIF: Mina53 may have a role in progression of esophageal
            squamous cell carcinoma
REFERENCE   8  (bases 1 to 4854)
  AUTHORS   Eilbracht,J., Reichenzeller,M., Hergt,M., Schnolzer,M., Heid,H.,
            Stohr,M., Franke,W.W. and Schmidt-Zachmann,M.S.
  TITLE     NO66, a highly conserved dual location protein in the nucleolus and
            in a special type of synchronously replicating chromatin
  JOURNAL   Mol Biol Cell 15 (4), 1816-1832 (2004)
   PUBMED   14742713
REFERENCE   9  (bases 1 to 4854)
  AUTHORS   Teye,K., Tsuneoka,M., Arima,N., Koda,Y., Nakamura,Y., Ueta,Y.,
            Shirouzu,K. and Kimura,H.
  TITLE     Increased expression of a Myc target gene Mina53 in human colon
            cancer
  JOURNAL   Am J Pathol 164 (1), 205-216 (2004)
   PUBMED   14695334
  REMARK    GeneRIF: the elevated expression of Mina53 is a characteristic
            feature in colon cancer
REFERENCE   10 (bases 1 to 4854)
  AUTHORS   Tsuneoka,M., Koda,Y., Soejima,M., Teye,K. and Kimura,H.
  TITLE     A novel myc target gene, mina53, that is involved in cell
            proliferation
  JOURNAL   J Biol Chem 277 (38), 35450-35459 (2002)
   PUBMED   12091391
  REMARK    GeneRIF: role in cell division
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA310030.1, DQ453796.1 and AC110491.5.
            
            On Nov 23, 2018 this sequence version replaced NM_153182.3.
            
            Summary: MINA is a c-Myc (MYC; MIM 190080) target gene that may
            play a role in cell proliferation or regulation of cell growth.
            (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005
            [PubMed 15897898]).[supplied by OMIM, May 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1, and encodes isoform A.
            Variants 1 and 2 encode the same protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.23269.1,
                                           SRR11853563.23295.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394198.7/ ENSP00000377748.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA310030.1         27-42
            17-2321             DQ453796.1         1-2305
            2322-4854           AC110491.5         754-3286
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..4854
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="ribosomal oxygenase 2"
                     /db_xref="GeneID:84864"
                     /db_xref="HGNC:HGNC:19441"
                     /db_xref="MIM:612049"
     exon            1..51
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            52..522
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1488
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /EC_number="1.14.11.79"
                     /note="isoform a is encoded by transcript variant 2;
                     myc-induced nuclear antigen, 53 kDa; mineral dust induced
                     gene protein; nucleolar protein 52; MYC induced nuclear
                     antigen; ribosomal oxygenase MINA; histone lysine
                     demethylase MINA; 60S ribosomal protein L27a histidine
                     hydroxylase; bifunctional lysine-specific demethylase and
                     histidyl-hydroxylase MINA; MYC-induced nuclear antigen 53"
                     /codon_start=1
                     /product="ribosomal oxygenase 2 isoform a"
                     /protein_id="NP_694822.2"
                     /db_xref="CCDS:CCDS43114.1"
                     /db_xref="GeneID:84864"
                     /db_xref="HGNC:HGNC:19441"
                     /db_xref="MIM:612049"
                     /translation="MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFES
                     LISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNV
                     CRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGS
                     LVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIG
                     RPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLV
                     FDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDF
                     IMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVY
                     IYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKE
                     SLVLSLWTECLIQVV"
     exon            523..642
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            643..771
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            772..875
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            876..978
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1150
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1239
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1329
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..4854
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2400..2405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="hexamer: AATAAA"
     polyA_site      2430
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="major polyA site"
     regulatory      4651..4656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="hexamer: AATAAA"
     regulatory      4673..4678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="hexamer: ATTAAA"
     polyA_site      4673
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
     polyA_site      4702
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
     regulatory      4833..4838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
                     /note="hexamer: AATAAA"
     polyA_site      4854
                     /gene="RIOX2"
                     /gene_synonym="JMJD10; MDIG; MINA; MINA53; NO52; ROX"
ORIGIN      
        1 gctgcgccgc aacgcagtgg gctcgcggcc gcgagcaaca ggccgtgccg ggtttgcatt
       61 tccttactgc tttgtcttga agacagaacg atgccaaaga aagcaaagcc tacagggagt
      121 gggaaggaag aggggccggc tccctgtaag cagatgaagt tagaagcagc tggggggcct
      181 tcagctttaa actttgacag tcccagtagt ctctttgaaa gtttaatctc gcccatcaag
      241 acagagactt ttttcaagga attctgggag cagaagcccc ttctcattca gagagatgac
      301 cctgcactgg ccacatacta tgggtccctg ttcaagctaa cagatctgaa gagtctgtgc
      361 agccggggga tgtactatgg aagagatgtg aatgtctgcc ggtgtgtcaa tgggaagaag
      421 aaggttttaa ataaagatgg caaagcacac tttcttcagc tgagaaaaga ttttgatcag
      481 aaaagggcaa cgattcagtt tcaccaacct cagagattta aggatgagct ttggaggatc
      541 caggagaagc tggaatgtta ctttggctcc ttggttggct cgaatgtgta cataactccc
      601 gcaggatctc agggcctgcc gccccattat gatgatgtcg aggttttcat cctgcagctg
      661 gagggagaga aacactggcg cctctaccac cccactgtgc ccctggcacg agagtacagc
      721 gtggaggccg aggaaaggat cggcaggccg gtgcatgagt ttatgctgaa gccgggtgat
      781 ttgttgtact ttcccagagg aaccattcat caagcggaca ctcctgcggg gctggcccac
      841 tctactcacg tgaccatcag cacctaccag aacaattcat ggggagattt ccttttggat
      901 accatctcgg ggcttgtatt tgatactgca aaggaagacg tggagttacg gaccggcata
      961 ccccggcagc tgctcctgca ggtggaatcc acaactgttg ctacaagacg attaagtggc
     1021 ttcctgagga cacttgcaga ccggctggag ggcaccaaag aactgctttc ctcagacatg
     1081 aagaaggatt ttattatgca cagactcccc ccttactctg cgggagatgg ggcagagctg
     1141 tcaacaccag gtggaaagtt accgaggctg gacagtgtag tgagactgca gtttaaagac
     1201 cacattgtcc tcacagtact gccggatcaa gatcaatctg atgaagctca agaaaagatg
     1261 gtgtacatct atcattcctt aaagaatagt agagagacac acatgatggg aaatgaggag
     1321 gaaacagagt ttcatggact tcgcttccct ttgtcacatt tggatgcact gaagcaaatt
     1381 tggaatagtc cagctatttc tgtcaaggac ctgaaactta ctacagatga ggaaaaggaa
     1441 agcctggtat tatccctctg gacagaatgt ttaattcaag tagtctagtg cctttgcaga
     1501 atcaaatgcc tactatttta tatgcatata ttaaaagaaa agcaaagacc tgagccgagg
     1561 agaggatgaa ttcaagtttc cttacctgcg tatctactaa caaacatgag acctccctgt
     1621 tacaggtggt cagttggcca aatgtactaa cgggcacatg aaagaaagaa cagcaaatta
     1681 ccaagtgtct cagaaaatga caaaaccata ttttgacaag tttatttaat ccagtgtggt
     1741 agaaaaggca caattccaat gtatcattta gaattgaatg tcattaacct ggctttgttc
     1801 tttggaagaa acaacttctt taaagagctt ctttggctct agaaaaattt caaacaatta
     1861 aaataagaaa aaattttaaa ctggtttttt ataatgaaaa tatacatacc tttgtgtata
     1921 gacaagccca tgcccattaa aataaagtta tcctgtaaca taaattttat taaataatac
     1981 ttccccacag atgagaggca cgcaacacct atggacaaaa gggagttaca gaggctgctt
     2041 aaaagatgga gaaaagcctg agattgaagg aggaaaaaaa cccagtattt aaagtctata
     2101 aaaaatactc aaaatagtgg gtcttcgagt ttaaaatagt cattgttatt ttacattcta
     2161 aagtgcatgt aggttgatat tttttaaaat atcattggag aatttaatct ttctttataa
     2221 aaatagagca tttttctgct ttctggcaaa agttggggat aaaaggaaaa aaagttgtca
     2281 aaatgtaatt ttcagtccaa ttcaccagga aaacatgctt gtgaattgtg cagtaaaagg
     2341 tggtaatgac tactggaagc taagtcaaag gtgatttcct acctgatttt acttacttaa
     2401 ataaaagtta cttacaatgg gagtgaaaaa ctgaggtttc tgttatttag tagagaaatc
     2461 aactccacgt ttacttaaag agatggtaag gtcaaggttc aaatgctact gtgttttaat
     2521 ttggatattt gaaatttctc ttgaggcaaa aaaaaaaaaa aattgatgcc tctccttaaa
     2581 tctaggatga agtgtcaaca tggagacagg taaccactgt tatagagtct tgtcacctaa
     2641 agggatgtct tggttaacac gtaacagtgc aagtttggcc ataggttatt tatttgtact
     2701 tttttagttt gaaggactga ggaaacaata gctacagaaa atacttcttg tgccttattc
     2761 ctaacaaagc tgaggtccct gcctggggtt agttacaagt ataaatactt aacgaggtgc
     2821 gttcattata aaagcctcag tatagaaacc ttaaagttta tctaggaaag tttagtatat
     2881 tttcaggtgt tgctaaaaaa ttactcatct gtttgcaaaa gtatgacttg acctatagaa
     2941 atctgtttct ttatgctttg tactcataca agcatctagg taggatatta ataaataata
     3001 caggataata gcatcaccag tgtccaataa cgggccatca ggaacaggat tcacgtttgg
     3061 tggatatgag agaaaataaa cacttcagga aacttgctca ccacagctgg agatcaggaa
     3121 tagaaccttt ccaagatatc ataatatttt ctttatagga acactgagta atggcaagaa
     3181 tattttgagc ttttccatgg ttaagagcga tagtctcaga ggctggagaa aatgttcatt
     3241 ctgctcagtg atccaggagt gtgaggacag tagcttcctt tccacgtcca caagacaatg
     3301 acagatgtgt ttccttcttt gctctttcta gggatctttc tagggatgtt gattctctca
     3361 caatatttca atgtcccatt tctgtgtttc ttctccctcc aggggctgat ttacaattac
     3421 atgagtcttg tcacaataat ttcctcctaa aatagaaatt ccaaaagaaa agattatttg
     3481 ttcaggcagg tgcttagcaa tttcacaatt ttcacaagct tctgttcagc tcaccatttc
     3541 ggtggatgaa tgtgtcattt acaaagaagt ctgaaatggg aagctgagtt tgaacaggct
     3601 tagccattat tcacctcaaa ttggacctta ttatgactca aattgaaata ctaaaaggta
     3661 taatacatga ttgtataagt ggcgtgcctt aatgtgattc tttagaacaa agtgctcttg
     3721 agagaactct ggctgaatgt caggtactgt gtttttgttt ctacaccaac aaaactgtga
     3781 ctaacccaat taaagcaaca gccatgaata atattggccc tgaccttgct gaattcaaaa
     3841 acaaggttaa ttgataccta ccataaattc tacctgaggg tttttaagga ccatggcaat
     3901 tcctggcaaa aagctagaga tgtttctaag aaacagatga cattcatttc atggtttatg
     3961 gtgcttgaaa tttagaactg ttctgagttc acgtagcaaa tgaaagtttt acaactgtac
     4021 taatgaacaa aaaccctaag ctttgttgtt tggctttttc tgctaattgt tttgtttgta
     4081 aaactgccta tcttaatttt cttcaagcat aattttaaat gacttaacat ttctcttata
     4141 cataaggatg tcctttaccc aaaatgagga gatttggaac tgaaactaat atccagggac
     4201 acaacattgg gtatcatcaa aggcccacct ttaacatcaa ggacaagttg atcactgaga
     4261 taagagctga tagttccatt tttattcagt ctccacttct gcctgaattg cccatgttca
     4321 gtccatagag ctactttagc tccaggtgtg tcccggccac caatcacatc aagacatgta
     4381 tcactggcct aaaagggtta agaaatgatt aattggcagt agtatgtttg ctaaagtaag
     4441 ttgaattagg tcccttttat cttaggtaaa caagtcatag acatgaagtg tgtgtgtgtc
     4501 ttatctaaaa aaatactata tagtataatt tcagtaagcc ttttttaatg tcttctttac
     4561 ggctgtgggt aggagatggt acagaaataa accaactgaa atagaggtac ttgtttttaa
     4621 taggatgtct acatctgaca acagatgttc aataaagatt tggtgaattg gaattaaatg
     4681 ttaaatccct gtttgcttaa aacgtattat gttgagcttg gttttcttat gaaaacattg
     4741 catgatgggc taaagatatc cagacaataa ttacttttaa aagtttttca tttttgaagc
     4801 atgagaaaaa gtagataatc cattggtgat acaataaaac acagtttgaa tgtt
//
