LOCUS       NM_024644               2462 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ribosomal oxygenase 1 (RIOX1), mRNA.
ACCESSION   NM_024644
VERSION     NM_024644.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Xiao,Y., Li,J., Liao,X., He,Y., He,T., Yang,C., Jiang,L.,
            Jeon,S.M., Lee,J.H., Chen,Y., Liu,R. and Chen,Q.
  TITLE     RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA
            repair
  JOURNAL   Bone Res 10 (1), 19 (2022)
   PUBMED   35210392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Yu,W., Lutz,C., Kramer,A. and Schmidt-Zachmann,M.S.
  TITLE     The JmjC-domain protein NO66/RIOX-1 affects the balance between
            proliferation and maturation in acute myeloid leukemia
  JOURNAL   Exp Cell Res 402 (1), 112566 (2021)
   PUBMED   33745927
  REMARK    GeneRIF: The JmjC-domain protein NO66/RIOX-1 affects the balance
            between proliferation and maturation in acute myeloid leukemia.
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Zhang,L., Chen,Q., Chen,Z., Wang,Y., Gamboa,J.L., Ikizler,T.A.,
            Garibotto,G. and Mitch,W.E.
  TITLE     Mechanisms Regulating Muscle Protein Synthesis in CKD
  JOURNAL   J Am Soc Nephrol 31 (11), 2573-2587 (2020)
   PUBMED   32764136
  REMARK    GeneRIF: Mechanisms Regulating Muscle Protein Synthesis in CKD.
            Erratum:[J Am Soc Nephrol. 2021 Feb;32(2):521. doi:
            10.1681/ASN.2020111609.. PMID: 33514643]
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Deng,H., Yu,B., Yu,Y., Tian,G. and Yang,L.
  TITLE     NO66 overexpression rescues ethanol-induced cell apoptosis in human
            AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt
            signaling
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (10), 1093-1101 (2020)
   PUBMED   33085743
  REMARK    GeneRIF: NO66 overexpression rescues ethanol-induced cell apoptosis
            in human AC16 cardiomyocytes by suppressing PTEN and activating the
            PI3K/Akt signaling.
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Wang,Q., Liu,P.Y., Liu,T. and Lan,Q.
  TITLE     The Histone Demethylase NO66 Induces Glioma Cell Proliferation
  JOURNAL   Anticancer Res 39 (11), 6007-6014 (2019)
   PUBMED   31704826
  REMARK    GeneRIF: High NO66 expression is associated with Glioma.
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Ge,W., Wolf,A., Feng,T., Ho,C.H., Sekirnik,R., Zayer,A.,
            Granatino,N., Cockman,M.E., Loenarz,C., Loik,N.D., Hardy,A.P.,
            Claridge,T.D.W., Hamed,R.B., Chowdhury,R., Gong,L., Robinson,C.V.,
            Trudgian,D.C., Jiang,M., Mackeen,M.M., Mccullagh,J.S.,
            Gordiyenko,Y., Thalhammer,A., Yamamoto,A., Yang,M., Liu-Yi,P.,
            Zhang,Z., Schmidt-Zachmann,M., Kessler,B.M., Ratcliffe,P.J.,
            Preston,G.M., Coleman,M.L. and Schofield,C.J.
  TITLE     Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes
            and humans
  JOURNAL   Nat Chem Biol 8 (12), 960-962 (2012)
   PUBMED   23103944
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Zhou,X., Tao,Y., Wu,M., Zhang,D. and Zang,J.
  TITLE     Purification, crystallization and preliminary crystallographic
            analysis of histone lysine demethylase NO66 from Homo sapiens
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 7), 764-766
            (2012)
   PUBMED   22750859
  REMARK    GeneRIF: NO66 crystallized in space group P3(1) or P3(2), with
            unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha =
            beta = 90, gamma = 120 degrees , and the crystal is likely to
            contain four molecules in the asymmetric unit
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Sinha,K.M., Yasuda,H., Coombes,M.M., Dent,S.Y. and de
            Crombrugghe,B.
  TITLE     Regulation of the osteoblast-specific transcription factor Osterix
            by NO66, a Jumonji family histone demethylase
  JOURNAL   EMBO J 29 (1), 68-79 (2010)
   PUBMED   19927124
  REMARK    GeneRIF: interactions between NO66 and Osx regulate Osx-target
            genes in osteoblasts by modulating histone methylation states
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Suzuki,C., Takahashi,K., Hayama,S., Ishikawa,N., Kato,T., Ito,T.,
            Tsuchiya,E., Nakamura,Y. and Daigo,Y.
  TITLE     Identification of Myc-associated protein with JmjC domain as a
            novel therapeutic target oncogene for lung cancer
  JOURNAL   Mol Cancer Ther 6 (2), 542-551 (2007)
   PUBMED   17308053
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Eilbracht,J., Reichenzeller,M., Hergt,M., Schnolzer,M., Heid,H.,
            Stohr,M., Franke,W.W. and Schmidt-Zachmann,M.S.
  TITLE     NO66, a highly conserved dual location protein in the nucleolus and
            in a special type of synchronously replicating chromatin
  JOURNAL   Mol Biol Cell 15 (4), 1816-1832 (2004)
   PUBMED   14742713
  REMARK    GeneRIF: NO66 has functions in ribosome biogenesis and in the
            replication or remodeling of certain heterochromatic regions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005280.5, HY178771.1, DA872764.1, DA509240.1, BC071954.1,
            CN259773.1 and BX390965.1.
            
            On May 17, 2019 this sequence version replaced NM_024644.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC011350.1, AY390535.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304061.8/ ENSP00000477507.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC005280.5         8826-8826           c
            2-13                HY178771.1         2-13
            14-44               DA872764.1         12-42
            45-582              DA509240.1         24-561
            583-738             BC071954.1         529-684
            739-1068            CN259773.1         117-446
            1069-1741           BX390965.1         219-891
            1742-2083           BC071954.1         1688-2029
            2084-2462           BC071954.1         2031-2409
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2462
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /note="ribosomal oxygenase 1"
                     /db_xref="GeneID:79697"
                     /db_xref="HGNC:HGNC:20968"
                     /db_xref="MIM:611919"
     exon            1..2462
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2011
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /EC_number="1.14.11.27"
                     /EC_number="1.14.11.79"
                     /note="MYC-associated protein with JmjC domain;
                     lysine-specific demethylase NO66; nucleolar protein 66;
                     ribosomal oxygenase NO66; histone lysine demethylase NO66;
                     60S ribosomal protein L8 histidine hydroxylase;
                     bifunctional lysine-specific demethylase and
                     histidyl-hydroxylase NO66; up-regulated in lung cancer 2"
                     /codon_start=1
                     /product="ribosomal oxygenase 1"
                     /protein_id="NP_078920.2"
                     /db_xref="CCDS:CCDS73660.1"
                     /db_xref="GeneID:79697"
                     /db_xref="HGNC:HGNC:20968"
                     /db_xref="MIM:611919"
                     /translation="MDGLQASAGPLRRGRPKRRRKPQPHSGSVLALPLRSRKIRKQLR
                     SVVSRMAALRTQTLPSENSEESRVESTADDLGDALPGGAAVAAVPDAARREPYGHLGP
                     AELLEASPAARSLQTPSARLVPASAPPARLVEVPAAPVRVVETSALLCTAQHLAAVQS
                     SGAPATASGPQVDNTGGEPAWDSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHF
                     YRRLWEREAVLVRRQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLN
                     PPGRALPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTPPNS
                     QGFAPHYDDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDDLGEPVLQTVLE
                     PGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAILPLAVQAAMEENVEF
                     RRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHD
                     SLPPVLTDRERALSVYGLPIRWEAGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLF
                     LYYTVENSRVYHLEEPKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLAT
                     TLYDKGLLLTKMPLALN"
     regulatory      2442..2447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /note="hexamer: ATTAAA"
     polyA_site      2455
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /note="major polyA site"
     polyA_site      2462
                     /gene="RIOX1"
                     /gene_synonym="C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX;
                     URLC2"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcacc gcagccgctg cattcaggaa ccgctttagc ttcgcccccg gccggccggg
       61 cggggaagac tggtgtggtc tggccatgga tgggctccag gccagtgcag ggccgttgag
      121 gcgcgggcgg ccgaagcgcc ggcgcaagcc ccagccacac agcgggtcgg tcctggccct
      181 gcccttgagg tccaggaaga tacgaaagca gctgcgaagt gttgtatccc gcatggcagc
      241 gctgaggacg cagacgctgc ctagcgagaa ctcggaggaa tcgagggtgg agtcgacggc
      301 cgacgacctg ggggacgcgc tacccggtgg ggcggcggtg gcggccgtcc cggacgcagc
      361 ccggcgagag ccatacggcc acctggggcc cgcagagctg ctggaggcct cgcccgccgc
      421 gcgctccctg cagaccccgt cggcgcgcct ggtgcccgct tccgcgccgc ccgcgcgcct
      481 ggtggaggtg cccgccgcgc cggtccgggt ggtggagacc tcggccctgc tgtgcaccgc
      541 gcaacactta gcggccgtcc agtcgtccgg ggcccctgcg acggcgtcgg ggccgcaggt
      601 ggataacacg ggtggggagc cggcctggga ctccccgctg cggcgcgtct tggccgagct
      661 gaaccgcatc cccagcagcc ggcggcgagc ggcccgcctc tttgagtggc tcatcgcgcc
      721 catgccgcca gatcactttt accggcgcct atgggagcgc gaggcggtgc tggtgcggcg
      781 gcaggaccac acctactacc agggactttt ctctaccgct gacctggatt cgatgctgcg
      841 caacgaggag gtgcagttcg gccagcattt ggacgccgct cgctacatca acggacgacg
      901 cgagaccctg aacccacccg gccgcgcgct gcccgccgcc gcgtggtccc tgtaccaggc
      961 cggctgctcc ctgcgtctcc tctgtccgca ggctttctct actactgtgt ggcagttttt
     1021 ggctgtgctt caagagcagt ttggaagcat ggcaggctcc aacgtttacc tcacgccccc
     1081 taactcgcag ggctttgccc cccactacga cgacatcgag gccttcgtgc tgcagctgga
     1141 aggtaggaaa ctctggcgtg tataccgacc ccgagtccca accgaggaac tggctctgac
     1201 atccagcccc aacttcagtc aggacgacct cggtgagccg gtgctgcaga ccgtgctgga
     1261 acctggagat ttgctgtatt ttcctcgggg cttcattcac caagctgaat gccaggatgg
     1321 agtccactct ctgcacctca ccttgtccac gtaccagcgc aatacctggg gtgacttctt
     1381 agaggccata ctgcctctgg cagtgcaggc tgcaatggaa gaaaatgtgg agtttcggag
     1441 gggtctgccc cgagacttca tggattacat gggggcccag cattcagatt ctaaggatcc
     1501 gcgaagaacc gctttcatgg agaaggtgcg ggtcttggtt gcccgcctgg gacactttgc
     1561 tcctgttgat gctgtggccg accagcgagc caaagacttc attcacgatt ctctgccccc
     1621 tgttttgact gatagggaga gggcactaag tgtttacggg cttccaattc gctgggaggc
     1681 tggagaacct gtaaacgtgg gggcccagtt gacaacagaa acagaagtcc atatgcttca
     1741 ggatgggata gctcggctgg tgggtgaggg gggccatttg tttctctatt acacagtgga
     1801 aaactcccgt gtgtatcatc tggaagaacc caagtgcttg gaaatatacc cccagcaagc
     1861 tgatgccatg gaactgttgc ttggttctta tccagagttt gtgagagtgg gggacctgcc
     1921 ctgtgacagt gtggaggacc agctgtcctt ggcaaccacg ttgtatgata aggggctgct
     1981 gctcactaag atgcctctag ccctaaatta gtttcttgtt gattgctgga aacaaggcag
     2041 tagtgattct ccgctgccac tgctaccttt tttttttttt tttccttaaa ctcacgttct
     2101 taccttgata agcatcagtg tgctcacatt tacctttatc actgcttcag tgtcacaaac
     2161 ctcggaaggt cttctaggaa gaaccatctc atctaggtac aaaaggaaaa ggagaagttg
     2221 gaggtggaaa aaaaaccctt gatccgtgat catttcagag caccaacttc atcaccttca
     2281 ggcttcagtg tactgggtaa cactgaccat gtcgttctgc ttgagacaga tattagattt
     2341 tttttggaat ttggatcttt catctgagtt ctttttcatg ggcgggtcgg ggtcagtatc
     2401 ctgtttgtta ttgttaaatt tgtatgaacc ttagaaaagt tattaaagtg ccaaagaatg
     2461 tt
//
