LOCUS       NM_003831               3574 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RIO kinase 3 (RIOK3), transcript variant 1, mRNA.
ACCESSION   NM_003831
VERSION     NM_003831.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3574)
  AUTHORS   Bisom,T.C., Smelser,H., Lanchy,J.M. and Lodmell,J.S.
  TITLE     Alternative Splicing of RIOK3 Engages the Noncanonical NFkappaB
            Pathway during Rift Valley Fever Virus Infection
  JOURNAL   Viruses 15 (7), 1566 (2023)
   PUBMED   37515252
  REMARK    GeneRIF: Alternative Splicing of RIOK3 Engages the Noncanonical
            NFkappaB Pathway during Rift Valley Fever Virus Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3574)
  AUTHORS   Qin,H., Sun,R., Guo,X., Fang,L., Xu,M., Teng,Y., Zhen,N., Wang,A.
            and Liu,J.
  TITLE     RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated
            arginine uptake in pancreatic ductal adenocarcinoma
  JOURNAL   Aging (Albany NY) 15 (4), 1039-1051 (2023)
   PUBMED   36880835
  REMARK    GeneRIF: RIOK3 promotes mTORC1 activation by facilitating
            SLC7A2-mediated arginine uptake in pancreatic ductal
            adenocarcinoma.
REFERENCE   3  (bases 1 to 3574)
  AUTHORS   Havranek,K.E., White,L.A., Bisom,T.C., Lanchy,J.M. and Lodmell,J.S.
  TITLE     The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated
            by Alternative Splicing
  JOURNAL   Viruses 13 (3), 367 (2021)
   PUBMED   33652597
  REMARK    GeneRIF: The Atypical Kinase RIOK3 Limits RVFV Propagation and Is
            Regulated by Alternative Splicing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3574)
  AUTHORS   Zhang,T., Ji,D., Wang,P., Liang,D., Jin,L., Shi,H., Liu,X.,
            Meng,Q., Yu,R. and Gao,S.
  TITLE     The atypical protein kinase RIOK3 contributes to glioma cell
            proliferation/survival, migration/invasion and the AKT/mTOR
            signaling pathway
  JOURNAL   Cancer Lett 415, 151-163 (2018)
   PUBMED   29233656
  REMARK    GeneRIF: RIO kinase 3 (RIOK3) positively regulates the activity of
            the AKT/mTOR pathway in glioma cells.
REFERENCE   5  (bases 1 to 3574)
  AUTHORS   Takashima,K., Oshiumi,H., Takaki,H., Matsumoto,M. and Seya,T.
  TITLE     RIOK3-mediated phosphorylation of MDA5 interferes with its assembly
            and attenuates the innate immune response
  JOURNAL   Cell Rep 11 (2), 192-200 (2015)
   PUBMED   25865883
  REMARK    GeneRIF: the ectopic expression of RIOK3 or a phosphomimetic
            MDA5-S828D mutation attenuated MDA5-mediated signaling.
REFERENCE   6  (bases 1 to 3574)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3574)
  AUTHORS   Shan,J., Wang,P., Zhou,J., Wu,D., Shi,H. and Huo,K.
  TITLE     RIOK3 interacts with caspase-10 and negatively regulates the
            NF-kappaB signaling pathway
  JOURNAL   Mol Cell Biochem 332 (1-2), 113-120 (2009)
   PUBMED   19557502
REFERENCE   8  (bases 1 to 3574)
  AUTHORS   Kimmelman,A.C., Hezel,A.F., Aguirre,A.J., Zheng,H., Paik,J.H.,
            Ying,H., Chu,G.C., Zhang,J.X., Sahin,E., Yeo,G., Ponugoti,A.,
            Nabioullin,R., Deroo,S., Yang,S., Wang,X., McGrath,J.P.,
            Protopopova,M., Ivanova,E., Zhang,J., Feng,B., Tsao,M.S.,
            Redston,M., Protopopov,A., Xiao,Y., Futreal,P.A., Hahn,W.C.,
            Klimstra,D.S., Chin,L. and DePinho,R.A.
  TITLE     Genomic alterations link Rho family of GTPases to the highly
            invasive phenotype of pancreas cancer
  JOURNAL   Proc Natl Acad Sci U S A 105 (49), 19372-19377 (2008)
   PUBMED   19050074
  REMARK    GeneRIF: Like RIOK3, PAK4 promotes pancreas ductal cell motility
            and invasion in pancreatic cancer
REFERENCE   9  (bases 1 to 3574)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE   10 (bases 1 to 3574)
  AUTHORS   Anaya,P., Evans,S.C., Dai,C., Lozano,G. and May,G.S.
  TITLE     Isolation of the Aspergillus nidulans sudD gene and its human
            homologue
  JOURNAL   Gene 211 (2), 323-329 (1998)
   PUBMED   9602165
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057292.1 and AC026634.11.
            
            On Nov 22, 2018 this sequence version replaced NM_003831.4.
            
            Summary: This gene was first identified by the similarity of its
            product to the Aspergillus nidulans SUDD protein. This gene is now
            recognized as a member of the right open reading frame (RIO) kinase
            gene family. This gene encodes a serine/threonine kinase that
            localizes to the cytoplasm and plays a role in the processing of
            the pre-40 S ribosomal subunit. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.144728.1,
                                           SRR1660807.22823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339486.8/ ENSP00000341874.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1916              AK057292.1         465-2380
            1917-3574           AC026634.11        26209-27866         c
FEATURES             Location/Qualifiers
     source          1..3574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..3574
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /note="RIO kinase 3"
                     /db_xref="GeneID:8780"
                     /db_xref="HGNC:HGNC:11451"
                     /db_xref="MIM:603579"
     exon            1..216
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1713
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; sudD
                     (suppressor of bimD6, Aspergillus nidulans) homolog;
                     homolog of the Aspergillus nidulans sudD gene product;
                     sudD suppressor of Aspergillus nidulans bimD6 homolog;
                     serine/threonine-protein kinase RIO3; sudD homolog; sudD
                     suppressor of bimD6 homolog; testicular secretory protein
                     Li 47"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO3 isoform 1"
                     /protein_id="NP_003822.2"
                     /db_xref="CCDS:CCDS11877.1"
                     /db_xref="GeneID:8780"
                     /db_xref="HGNC:HGNC:11451"
                     /db_xref="MIM:603579"
                     /translation="MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLA
                     KELQLEEEAAVFPEVAVAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKK
                     FNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGK
                     DITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSA
                     RLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDE
                     KEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMH
                     NLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHL
                     MRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFF
                     QKGGVKEALSERELFNAVSGLNITADNEADFLAEIEALEKMNEDHVQKNGRKAASFLK
                     DDGDPPLLYDE"
     exon            217..332
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            333..478
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            479..586
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            587..696
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            697..840
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            841..968
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1166
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1326
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1407
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1497
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1605
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..3574
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3549..3554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /note="hexamer: ATTAAA"
     polyA_site      3574
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /note="major polyA site"
ORIGIN      
        1 agttccggac gcggccgccg ccgtcgccgc catctgtcac ctccactccg gcatcagcag
       61 ccagtcgccc gtgtcccgcc tgtctcctcg gcggagcctg ctgcccgtcc tgccacctct
      121 ctgctctgtt cttgtctctg ccttcattcc cgaatggatc tggtaggagt ggcatcgcct
      181 gagcccggga cggcagcggc ctggggaccc agcaagtgtc catgggctat tcctcaaaat
      241 acaatatctt gttctttggc tgatgtaatg agtgaacagc tggccaaaga attgcagtta
      301 gaagaagaag ctgccgtttt tcctgaagtt gctgttgctg aaggaccatt tattactgga
      361 gaaaacattg atacttccag tgaccttatg ctggctcaga tgctacagat ggaatatgac
      421 agagaatatg atgcacagct taggcgtgaa gaaaaaaaat tcaatggaga tagcaaagtt
      481 tccatttcct ttgaaaatta tcgaaaagtg catccttatg aagacagcga tagctctgaa
      541 gatgaggttg actggcagga tactcgtgat gatccctaca gaccagcaaa accggttccc
      601 actcctaaaa agggctttat tggaaaagga aaagatatca ccaccaaaca tgatgaagta
      661 gtatgtggga gaaagaacac agcaagaatg gaaaattttg cacctgagtt tcaggtagga
      721 gatggaattg gaatggattt aaaactatca aaccatgttt tcaatgcttt aaaacaacat
      781 gcctactcag aagaacgtcg aagtgcccgc ctacatgaga aaaaggagca ttctacagca
      841 gaaaaagcag ttgatcctaa gacacgttta cttatgtata aaatggtcaa ctctggaatg
      901 ttggagacaa tcactggctg tattagtaca ggaaaggagt ctgttgtctt tcatgcatat
      961 ggagggagca tggaggatga aaaggaagat agtaaagtta tacctacaga atgtgccatc
     1021 aaggtattta aaacaaccct taatgaattt aagaatcgtg acaaatatat taaagatgat
     1081 ttcaggttta aagatcgctt cagtaaacta aatccacgta agatcatccg catgtgggca
     1141 gaaaaagaaa tgcacaatct cgcaagaatg cagagagctg gaattccttg tccaacagtt
     1201 gtactactga agaaacacat tttagttatg tcttttattg gccatgatca agttccagcc
     1261 cctaaattaa aagaagtaaa gctcaatagt gaagaaatga aagaagccta ctatcaaact
     1321 cttcatttga tgcggcagtt atatcatgaa tgtacgcttg tccatgctga cctcagtgag
     1381 tataacatgc tgtggcatgc tggaaaggtc tggttgatcg atgtcagtca gtcagtagaa
     1441 cctacccacc ctcacggcct ggagttcttg ttccgggact gcaggaatgt ctcgcagttt
     1501 ttccagaaag gaggagtcaa ggaagccctt agtgaacgag aactcttcaa tgctgtttca
     1561 ggcttaaaca tcacagcaga taatgaagct gattttttag ctgagataga agctttggag
     1621 aaaatgaatg aagatcacgt tcagaagaat ggaaggaaag ctgcttcatt tttgaaagat
     1681 gatggagacc caccactact atatgatgaa tagcactaat acccactgct tcagtgttaa
     1741 cacagcagtg attgtcagct gccaatagca aatgaagtta tgggtgactt gaaataccaa
     1801 aacctgagga gtgggcaatg gtgcttctgt gcttttcccc cttgtaaccc atgtgccaga
     1861 tgtgtggaat ttttagctca gcattgagag aataaaatgt cactacctct catcttatga
     1921 acaggataat ataattcttt aacagctata ggttatctgg ctgaagtaga cctaatttta
     1981 tgtgacttgt ggtgtaaaat gtcttgatga taatttttaa aacttgggta acacttccaa
     2041 atatgggagg aaaggacaga tgtgtttaca agggaggatt ttacaacata cttgctttat
     2101 tcacctccct gttttgtgtt gcgtctttcc ttgaatattt tattggccca gagttagcct
     2161 ttctcaatta tgtttccaga ctgtggccgt gattctaaag gaaaatgtgt gctctttagt
     2221 gggtagaaca aatggaaatt tggtttcaga atggctgaca gaaatcgaca taagtcatgt
     2281 aatttttgtt gatatatcat gaaaatgaac agaattcttt ttccatactt atatctaaga
     2341 aaaggcatca taggtttctg aaagagataa ctatataaca gctttttaac tatccagtca
     2401 actttcagct tttctacatt taggtaaaat ggttaggata taactcatgg tgtggctaat
     2461 ctacatttat caataaaatg taaattatct gaaaggacag aatataagat ttaaccatgt
     2521 ttgacgtatt ttaatttagt taatgaagca aaattcagtt tatatttcac tagaactgtg
     2581 tacttgattg attttcagag aaatatcaca aattagaaat attaaatcta aggatgaaag
     2641 gtatatataa aacaatttgg gggccaggca cgatggctca aacctgtaat cccagcactt
     2701 tgggagacca aggcgggtgg atcacttgag gtcaggagtt caagaccagc ctgggcaaca
     2761 tggcgaaacc ctgtctctac taaaaataca aaaattagcc gggtgtggtg gcacttctct
     2821 gtaatctcag cttctcagga ggctgagaca ggagaatcgc ttgaacccgg gaggcagagg
     2881 ttgcagtgag ctgagatcat gccactgcac tccggcctag gtgacagagg gaaactccat
     2941 ctccaggaaa aaaaaaaaaa aacccaattt ggataccaaa ttaatcaact aatttgagct
     3001 atctggcctt actcttagta gtttttagta cgtgctggac accactttta aaaagcaatc
     3061 actgtgctag aaaagtatat tggctttgtt aggattaaag ttcattaact tcaatgtaat
     3121 catgcctcct attactgaag tcagattgga accactaaag atccaaactt tctgtctggt
     3181 aatagaaagt aaaaatctag acatcattta catttgagaa agctgttttt aacattattt
     3241 taaaatgcca aatatgttct ttctagaaaa atatttattt ttgtttttgt tggatagctt
     3301 ttaattacat ttcagagagg tgtaattttg ggtagatgct cattacattt ttgaaaggtt
     3361 tatgattcca aaataaagat ttatatgact ggtgatactg gctttacaga aatttcagag
     3421 aactaatttt taaaatcttt agcatttaaa actttttttg ttttgttttc tgacatattc
     3481 tgacaaagag cagcaaacca ctgctgtgtg gcattcttgg agtgtgctgt gaatgtgctt
     3541 tttaagaaat taaaaagaga tcattttaaa attg
//
