LOCUS       NP_003822                519 aa            linear   PRI 27-APR-2025
DEFINITION  serine/threonine-protein kinase RIO3 isoform 1 [Homo sapiens].
ACCESSION   NP_003822
VERSION     NP_003822.2
DBSOURCE    REFSEQ: accession NM_003831.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Bisom,T.C., Smelser,H., Lanchy,J.M. and Lodmell,J.S.
  TITLE     Alternative Splicing of RIOK3 Engages the Noncanonical NFkappaB
            Pathway during Rift Valley Fever Virus Infection
  JOURNAL   Viruses 15 (7), 1566 (2023)
   PUBMED   37515252
  REMARK    GeneRIF: Alternative Splicing of RIOK3 Engages the Noncanonical
            NFkappaB Pathway during Rift Valley Fever Virus Infection.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Qin,H., Sun,R., Guo,X., Fang,L., Xu,M., Teng,Y., Zhen,N., Wang,A.
            and Liu,J.
  TITLE     RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated
            arginine uptake in pancreatic ductal adenocarcinoma
  JOURNAL   Aging (Albany NY) 15 (4), 1039-1051 (2023)
   PUBMED   36880835
  REMARK    GeneRIF: RIOK3 promotes mTORC1 activation by facilitating
            SLC7A2-mediated arginine uptake in pancreatic ductal
            adenocarcinoma.
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Havranek,K.E., White,L.A., Bisom,T.C., Lanchy,J.M. and Lodmell,J.S.
  TITLE     The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated
            by Alternative Splicing
  JOURNAL   Viruses 13 (3), 367 (2021)
   PUBMED   33652597
  REMARK    GeneRIF: The Atypical Kinase RIOK3 Limits RVFV Propagation and Is
            Regulated by Alternative Splicing.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Zhang,T., Ji,D., Wang,P., Liang,D., Jin,L., Shi,H., Liu,X.,
            Meng,Q., Yu,R. and Gao,S.
  TITLE     The atypical protein kinase RIOK3 contributes to glioma cell
            proliferation/survival, migration/invasion and the AKT/mTOR
            signaling pathway
  JOURNAL   Cancer Lett 415, 151-163 (2018)
   PUBMED   29233656
  REMARK    GeneRIF: RIO kinase 3 (RIOK3) positively regulates the activity of
            the AKT/mTOR pathway in glioma cells.
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Takashima,K., Oshiumi,H., Takaki,H., Matsumoto,M. and Seya,T.
  TITLE     RIOK3-mediated phosphorylation of MDA5 interferes with its assembly
            and attenuates the innate immune response
  JOURNAL   Cell Rep 11 (2), 192-200 (2015)
   PUBMED   25865883
  REMARK    GeneRIF: the ectopic expression of RIOK3 or a phosphomimetic
            MDA5-S828D mutation attenuated MDA5-mediated signaling.
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Shan,J., Wang,P., Zhou,J., Wu,D., Shi,H. and Huo,K.
  TITLE     RIOK3 interacts with caspase-10 and negatively regulates the
            NF-kappaB signaling pathway
  JOURNAL   Mol Cell Biochem 332 (1-2), 113-120 (2009)
   PUBMED   19557502
REFERENCE   8  (residues 1 to 519)
  AUTHORS   Kimmelman,A.C., Hezel,A.F., Aguirre,A.J., Zheng,H., Paik,J.H.,
            Ying,H., Chu,G.C., Zhang,J.X., Sahin,E., Yeo,G., Ponugoti,A.,
            Nabioullin,R., Deroo,S., Yang,S., Wang,X., McGrath,J.P.,
            Protopopova,M., Ivanova,E., Zhang,J., Feng,B., Tsao,M.S.,
            Redston,M., Protopopov,A., Xiao,Y., Futreal,P.A., Hahn,W.C.,
            Klimstra,D.S., Chin,L. and DePinho,R.A.
  TITLE     Genomic alterations link Rho family of GTPases to the highly
            invasive phenotype of pancreas cancer
  JOURNAL   Proc Natl Acad Sci U S A 105 (49), 19372-19377 (2008)
   PUBMED   19050074
  REMARK    GeneRIF: Like RIOK3, PAK4 promotes pancreas ductal cell motility
            and invasion in pancreatic cancer
REFERENCE   9  (residues 1 to 519)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
REFERENCE   10 (residues 1 to 519)
  AUTHORS   Anaya,P., Evans,S.C., Dai,C., Lozano,G. and May,G.S.
  TITLE     Isolation of the Aspergillus nidulans sudD gene and its human
            homologue
  JOURNAL   Gene 211 (2), 323-329 (1998)
   PUBMED   9602165
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057292.1 and AC026634.11.
            
            On Aug 20, 2002 this sequence version replaced NP_003822.1.
            
            Summary: This gene was first identified by the similarity of its
            product to the Aspergillus nidulans SUDD protein. This gene is now
            recognized as a member of the right open reading frame (RIO) kinase
            gene family. This gene encodes a serine/threonine kinase that
            localizes to the cytoplasm and plays a role in the processing of
            the pre-40 S ribosomal subunit. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.144728.1,
                                           SRR1660807.22823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339486.8/ ENSP00000341874.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     Protein         1..519
                     /product="serine/threonine-protein kinase RIO3 isoform 1"
                     /EC_number="2.7.11.1"
                     /note="sudD (suppressor of bimD6, Aspergillus nidulans)
                     homolog; homolog of the Aspergillus nidulans sudD gene
                     product; sudD suppressor of Aspergillus nidulans bimD6
                     homolog; serine/threonine-protein kinase RIO3; sudD
                     homolog; sudD suppressor of bimD6 homolog; testicular
                     secretory protein Li 47"
                     /calculated_mol_wt=58962
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Site            112
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Region          121..159
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O14730.2)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Site            125
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DBU3; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Site            128
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O14730.2)"
     Region          253..453
                     /region_name="RIO3_euk"
                     /note="Catalytic domain of the atypical protein serine
                     kinase, RIO3 kinase; cd05146"
                     /db_xref="CDD:270697"
     Site            order(257,262..263,265,288,290,347,359..362,371,411,413,
                     422..423)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270697"
     CDS             1..519
                     /gene="RIOK3"
                     /gene_synonym="SUDD"
                     /coded_by="NM_003831.5:154..1713"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11877.1"
                     /db_xref="GeneID:8780"
                     /db_xref="HGNC:HGNC:11451"
                     /db_xref="MIM:603579"
ORIGIN      
        1 mdlvgvaspe pgtaaawgps kcpwaipqnt iscsladvms eqlakelqle eeaavfpeva
       61 vaegpfitge nidtssdlml aqmlqmeydr eydaqlrree kkfngdskvs isfenyrkvh
      121 pyedsdssed evdwqdtrdd pyrpakpvpt pkkgfigkgk dittkhdevv cgrkntarme
      181 nfapefqvgd gigmdlklsn hvfnalkqha yseerrsarl hekkehstae kavdpktrll
      241 mykmvnsgml etitgcistg kesvvfhayg gsmedekeds kviptecaik vfkttlnefk
      301 nrdkyikddf rfkdrfskln prkiirmwae kemhnlarmq ragipcptvv llkkhilvms
      361 fighdqvpap klkevklnse emkeayyqtl hlmrqlyhec tlvhadlsey nmlwhagkvw
      421 lidvsqsvep thphgleflf rdcrnvsqff qkggvkeals erelfnavsg lnitadnead
      481 flaeiealek mnedhvqkng rkaasflkdd gdppllyde
//
