LOCUS       NM_021930               2860 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAD50 interactor 1 (RINT1), transcript variant 1,
            mRNA.
ACCESSION   NM_021930
VERSION     NM_021930.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2860)
  AUTHORS   Arnold,F., Gout,J., Wiese,H., Weissinger,S.E., Roger,E.,
            Perkhofer,L., Walter,K., Scheible,J., Prelli Bozzo,C., Lechel,A.,
            Ettrich,T.J., Azoitei,N., Hao,L., Furstberger,A., Kaminska,E.K.,
            Sparrer,K.M.J., Rasche,V., Wiese,S., Kestler,H.A., Moller,P.,
            Seufferlein,T., Frappart,P.O. and Kleger,A.
  TITLE     RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve
            Cellular Homeostasis in Pancreatic Cancer
  JOURNAL   Cancer Res 81 (7), 1758-1774 (2021)
   PUBMED   33531371
  REMARK    GeneRIF: RINT1 Regulates SUMOylation and the DNA Damage Response to
            Preserve Cellular Homeostasis in Pancreatic Cancer.
REFERENCE   3  (bases 1 to 2860)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2860)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2860)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2860)
  AUTHORS   Arasaki,K., Taniguchi,M., Tani,K. and Tagaya,M.
  TITLE     RINT-1 regulates the localization and entry of ZW10 to the syntaxin
            18 complex
  JOURNAL   Mol Biol Cell 17 (6), 2780-2788 (2006)
   PUBMED   16571679
  REMARK    GeneRIF: RINT-1 coordinates the localization and function of ZW10
            by serving as a link between ZW10 and the SNARE complex comprising
            syntaxin 18.
REFERENCE   7  (bases 1 to 2860)
  AUTHORS   Kops,G.J., Kim,Y., Weaver,B.A., Mao,Y., McLeod,I., Yates,J.R. 3rd,
            Tagaya,M. and Cleveland,D.W.
  TITLE     ZW10 links mitotic checkpoint signaling to the structural
            kinetochore
  JOURNAL   J Cell Biol 169 (1), 49-60 (2005)
   PUBMED   15824131
REFERENCE   8  (bases 1 to 2860)
  AUTHORS   Nakajima,K., Hirose,H., Taniguchi,M., Kurashina,H., Arasaki,K.,
            Nagahama,M., Tani,K., Yamamoto,A. and Tagaya,M.
  TITLE     Involvement of BNIP1 in apoptosis and endoplasmic reticulum
            membrane fusion
  JOURNAL   EMBO J 23 (16), 3216-3226 (2004)
   PUBMED   15272311
REFERENCE   9  (bases 1 to 2860)
  AUTHORS   Hirose,H., Arasaki,K., Dohmae,N., Takio,K., Hatsuzawa,K.,
            Nagahama,M., Tani,K., Yamamoto,A., Tohyama,M. and Tagaya,M.
  TITLE     Implication of ZW10 in membrane trafficking between the endoplasmic
            reticulum and Golgi
  JOURNAL   EMBO J 23 (6), 1267-1278 (2004)
   PUBMED   15029241
REFERENCE   10 (bases 1 to 2860)
  AUTHORS   Xiao,J., Liu,C.C., Chen,P.L. and Lee,W.H.
  TITLE     RINT-1, a novel Rad50-interacting protein, participates in
            radiation-induced G(2)/M checkpoint control
  JOURNAL   J Biol Chem 276 (9), 6105-6111 (2001)
   PUBMED   11096100
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC068483.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021930.5.
            
            Summary: This gene encodes a protein first identified for its
            ability to interact with the RAD50 double strand break repair
            protein, with the resulting interaction implicated in the
            regulation of cell cycle progression and telomere length. The
            encoded protein may also play a role in trafficking of cellular
            cargo from the endosome to the trans-Golgi network. Mutations in
            this gene may be associated with breast cancer in human patients.
            [provided by RefSeq, Oct 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068483.1, SRR1660803.231427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257700.7/ ENSP00000257700.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2860              BC068483.1         118-2977
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2860
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /note="RAD50 interactor 1"
                     /db_xref="GeneID:60561"
                     /db_xref="HGNC:HGNC:21876"
                     /db_xref="MIM:610089"
     exon            1..157
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2494
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Rad50-interacting protein 1"
                     /codon_start=1
                     /product="RAD50-interacting protein 1 isoform 1"
                     /protein_id="NP_068749.3"
                     /db_xref="CCDS:CCDS34726.1"
                     /db_xref="GeneID:60561"
                     /db_xref="HGNC:HGNC:21876"
                     /db_xref="MIM:610089"
                     /translation="MLPAGEIGASPAAPCCSESGDERKNLEEKSDINVTVLIGSKQVS
                     EGTDNGDLPSYVSAFIEKEVGNDLKSLKKLDKLIEQRTVSKMQLEEQVLTISSEIPKR
                     IRSALKNAEESKQFLNQFLEQETHLFSAINSHLLTAQPWMDDLGTMISQIEEIERHLA
                     YLKWISQIEELSDNIQQYLMTNNVPEAASTLVSMAELDIKLQESSCTHLLGFMRATVK
                     FWHKILKDKLTSDFEEILAQLHWPFIAPPQSQTVGLSRPASAPEIYSYLETLFCQLLK
                     LQTSDELLTEPKQLPEKYSLPASPSVILPIQVMLTPLQKRFRYHFRGNRQTNVLSKPE
                     WYLAQVLMWIGNHTEFLDEKIQPILDKVGSLVNARLEFSRGLMMLVLEKLATDIPCLL
                     YDDNLFCHLVDEVLLFERELHSVHGYPGTFASCMHILSEETCFQRWLTVERKFALQKM
                     DSMLSSEAAWVSQYKDITDVDEMKVPDCAETFMTLLLVITDRYKNLPTASRKLQFLEL
                     QKDLVDDFRIRLTQVMKEETRASLGFRYCAILNAVNYISTVLADWADNVFFLQLQQAA
                     LEVFAENNTLSKLQLGQLASMESSVFDDMINLLERLKHDMLTRQVDHVFREVKDAAKL
                     YKKERWLSLPSQSEQAVMSLSSSACPLLLTLRDHLLQLEQQLCFSLFKIFWQMLVEKL
                     DVYIYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYCKRPENYFKHIKEACIVLNLN
                     VGSALLLKDVLQSASGQLPATAALNEVGIYKLAQQDVEILLNLRTNWPNTGK"
     exon            158..203
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..388
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..630
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..804
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..954
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1111
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1222
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1448
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1586
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1786
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2001
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2182
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2301
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2860
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2840..2845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /note="hexamer: AATAAA"
     polyA_site      2860
                     /gene="RINT1"
                     /gene_synonym="ILFS3; RINT-1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcactca gtcctacggc ctccgaggct gggtagtgag tgtgtcgctg gccttagcca
       61 gactccacag gccacgctgg ctgcgaatgg agccgaggac tcgcgcggag gcgagatgct
      121 accagccggc gagatcggcg cctctcctgc agccccgtgc tgctctgaaa gtggtgacga
      181 aaggaagaac ctcgaggaga aaagtgacat aaatgttaca gttcttattg gaagtaaaca
      241 agtcagtgaa ggtacagata atggtgatct cccttcttat gtgtctgcat tcatagaaaa
      301 ggaagttgga aatgacctta aatctttaaa gaaacttgat aaactcatag aacagaggac
      361 agtaagtaaa atgcagttag aagaacaggt acttacaatt tcatcagaaa ttcctaaaag
      421 aattcgaagt gccttaaaaa atgcagaaga atcaaagcaa tttcttaatc agtttctgga
      481 gcaggaaact catctcttca gcgccattaa cagccatttg ctgactgcgc aaccttggat
      541 ggacgatctt ggaaccatga ttagccagat tgaagagatc gaacgtcatc ttgcttacct
      601 taaatggatt tcacaaattg aagaactaag tgataacatt cagcaatatc tgatgaccaa
      661 taatgtaccg gaggcagcct ccactctagt gtctatggca gaacttgaca ttaaacttca
      721 ggaatcatct tgtactcatc ttcttggttt catgagagcc acagttaaat tctggcataa
      781 aattctcaag gacaagctta caagtgattt tgaggaaatt ttagcacagc ttcattggcc
      841 attcatcgca ccccctcaat cacaaactgt tggcttaagt cgacctgcca gtgccccgga
      901 gatatacagt tacctggaga cactgttttg tcagcttttg aaactacaaa cctcagatga
      961 attacttact gagccaaagc aactcccaga aaaatactct cttcctgcct ccccttctgt
     1021 catcctgccc atccaggtta tgctgactcc tcttcagaag aggttcaggt atcacttcag
     1081 agggaaccgg cagactaatg tgttaagcaa gccagaatgg tacttggctc aagtacttat
     1141 gtggattgga aaccatactg aatttctgga tgagaagatt cagccaatat tagacaaagt
     1201 aggctctttg gtaaacgcaa ggcttgaatt ttctcggggc cttatgatgc tggttcttga
     1261 gaagttagcc actgatattc cttgtctgct atatgatgac aatctcttct gtcatttggt
     1321 ggatgaagta ctcttgtttg aaagggagct acacagtgtt catggctatc ctggcacttt
     1381 tgctagttgt atgcatattc tatcagagga aacctgtttt cagagatggt tgacggtgga
     1441 gagaaaattt gctcttcaaa aaatggactc aatgctttcc tcagaagctg cctgggtatc
     1501 gcaatataag gatatcactg acgtggatga aatgaaagtt ccagattgtg cagaaacttt
     1561 tatgactcta ctcttggtta taactgacag gtataaaaat cttcccacag cttcccgaaa
     1621 gcttcagttc ctggagttac agaaggactt agtagatgat tttaggatac gattaacaca
     1681 agtgatgaaa gaagagacta gagcttccct tggctttcga tactgtgcaa ttcttaatgc
     1741 tgtgaactac atctcaacag tactagcaga ttgggctgac aatgttttct ttctacaact
     1801 tcaacaggct gcactggagg tgtttgcaga gaataatact ctgagtaaat tgcagctagg
     1861 acagctagcc tctatggaga gctctgtctt tgatgacatg attaacctct tagaacgttt
     1921 aaagcatgat atgttgaccc gtcaagtaga ccacgttttt agagaagtta aagatgctgc
     1981 aaaattgtat aaaaaagaaa gatggttgtc cttgccatct cagtcagagc aggcagtgat
     2041 gtccctgtcc agttcggctt gcccgttgct gctgacgtta cgagaccatt tacttcagtt
     2101 ggagcagcag ctttgtttct ccttatttaa aattttctgg caaatgcttg tagagaagct
     2161 ggatgtatac atctaccaag aaataattct tgctaatcac ttcaatgaag gaggagcagc
     2221 ccagctgcag tttgatatga ctcggaatct tttccctttg ttttctcact attgcaagag
     2281 accagaaaat tattttaaac atataaaaga agcctgtatt gttttgaatt tgaacgtcgg
     2341 ttctgcacta ctgctgaaag atgtactgca gtcagcttca gggcagcttc ctgccacagc
     2401 agcattaaat gaagttggaa tttacaaact ggctcaacaa gatgttgaga ttctacttaa
     2461 tttgaggaca aattggccta atactggaaa ataatgtctt tcagaaaaag gtttctttgg
     2521 tttttgtttc taagaaagag gaagccaatt ggatttcaag ttatatgatg aaattctgaa
     2581 ttaatgaaac tggaaaactt tatagaatta cttattatct tggatttatg gtgttattaa
     2641 aatgctgacc atatttcctt catcctcttg ttcctaagga aacaaaaaca gaaaacgaaa
     2701 caatgaaaac tcaattctat ttacaagtat aaatgctgag tatgtctgtt gaagacgagc
     2761 agagatatta aattataacc aactttcaat ttcctgtgct aattaaggga aattctgttg
     2821 tggataatca aacatagcca ataaattttt ttaaaactcc
//
