LOCUS       NM_001195833            3058 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Ras and Rab interactor like (RINL), transcript variant
            1, mRNA.
ACCESSION   NM_001195833
VERSION     NM_001195833.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3058)
  AUTHORS   Kajiho,H., Fukushima,S., Kontani,K. and Katada,T.
  TITLE     RINL, guanine nucleotide exchange factor Rab5-subfamily, is
            involved in the EphA8-degradation pathway with odin
  JOURNAL   PLoS One 7 (1), e30575 (2012)
   PUBMED   22291991
  REMARK    GeneRIF: RINL, as a GEF for Rab5 subfamily, is implicated in the
            EphA8-degradation pathway via its interaction with odin.
REFERENCE   2  (bases 1 to 3058)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 3058)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298327.1 and AC011455.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001195833.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298327.1, SRR1163657.293540.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591812.2/ ENSP00000467107.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1906              AK298327.1         5-1910
            1907-3058           AC011455.6         20989-22140         c
FEATURES             Location/Qualifiers
     source          1..3058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3058
                     /gene="RINL"
                     /note="Ras and Rab interactor like"
                     /db_xref="GeneID:126432"
                     /db_xref="HGNC:HGNC:24795"
                     /db_xref="MIM:620678"
     exon            1..44
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            45..133
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1784
                     /gene="RINL"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     and Rab interactor-like protein"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein isoform 1"
                     /protein_id="NP_001182762.1"
                     /db_xref="CCDS:CCDS59386.1"
                     /db_xref="GeneID:126432"
                     /db_xref="HGNC:HGNC:24795"
                     /db_xref="MIM:620678"
                     /translation="MAQPEDKAPEVPTEGVRLVPPQVNKADRTPLGVLSTLEPLTRLQ
                     RTWGVWHVPELDTQDAEALVGLWPLGSFLVTGRDPSQALVLRSGPLPGEVNTYQIQKI
                     PRGVSLESSNLCMPDLPHLLAFLSASRDVLPRTLLLPPPTLGPRDEHTDPVQIGRVQQ
                     DTPGKVLSIVNQLYLETHRGWGREQTPQETEPEAAQRHDPAPRNPAPHGVSWVKGPLS
                     PEVDHPGPALASLLEEEEEDLEGKEEGREDDPEEEGPEDVLTIHVQSLVRARSSYVAR
                     QYRSLRVRIASDSGGPHGSGDPATELLQDVRHLLTDLQDHLAKDSYIRAVFGSRGPGL
                     PKKDEDPGPALETAVCQAVLAPLKPALWTRLRTLRAPELRRLRRRQTALRAGAGPPGA
                     QGPGPEGQSPAPALRSRIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPL
                     GADAFLPALTEELIWSPDIGDTQLDVEFLMELLDPDELRGEAGYYLTTWFGALHHIAH
                     YQPETDRAPRGLSSEARASLHQWHRRRTLHRKDHPRAQANLPFKEPWAEETVTGTSDN
                     "
     exon            134..293
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            294..396
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            397..469
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            470..534
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            535..684
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1107
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1425
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1557
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1721
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..3058
                     /gene="RINL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RINL"
                     /note="hexamer: ATTAAA"
     polyA_site      3058
                     /gene="RINL"
                     /note="major polyA site"
ORIGIN      
        1 ctctctccac ttcctgctac tgcaggcctc tcctccgaga acagaggcca ggtcatgact
       61 cactggcttc ctgcaacctg acgatggccc agccagaaga caaggcacct gaagtcccca
      121 cagagggggt gaggctggtc ccaccacagg tgaacaaagc agacaggacc cctctagggg
      181 tcctcagcac cctagagcca cttactcgcc tgcagaggac atggggggtg tggcatgtgc
      241 cagagctgga tacccaggat gcggaggccc ttgtggggct gtggccacta gggagtttct
      301 tggtcacagg acgtgacccc agccaggccc tggtgttgag gtcaggacct ttaccaggag
      361 aagtcaatac ctaccagatc cagaagattc ccagaggtgt gtccctggaa tcctccaacc
      421 tctgcatgcc agacctgccc catctcctgg cctttctatc agccagcagg gatgttctgc
      481 ccagaaccct gctcttgccc cctcccactc tagggcccag agatgaacac acagatcctg
      541 tgcagatcgg cagggtccaa caggacaccc cagggaaggt gctttccatt gtgaaccagc
      601 tctacctgga gacccacaga ggctggggga gggagcagac ccctcaagaa acagagccag
      661 aggctgctca gagacatgat ccagccccca ggaaccctgc gcctcacggg gtctcctggg
      721 tgaaaggccc gctcagcccg gaagtggacc atcctgggcc ggctctcgcc agcctactgg
      781 aagaggagga ggaagacctt gaaggaaagg aggaaggaag ggaggacgac cctgaagagg
      841 aaggccctga ggacgtgctc accattcacg tccagtctct ggtcagggcc cggagcagct
      901 acgtggccag gcagtaccga agccttcggg tgcgcatcgc ctcagattct gggggtcccc
      961 acgggtctgg ggacccggcc acggagctgc ttcaggatgt gcggcacctc cttactgacc
     1021 tccaggatca cctggcaaag gactcctaca tcagggctgt ctttggaagc aggggtcctg
     1081 ggctccccaa gaaggacgag gatccaggcc ccgcgctgga gacggcggtg tgccaggcgg
     1141 tgctggcgcc cctgaagccg gccctgtgga cacgactccg cacactccga gcaccggagc
     1201 tgcggcggct gcggcggcga cagacagccc tgcgggcggg ggcggggcct ccgggggcac
     1261 aggggccggg accggaaggg cagagccccg cccccgcctt gcggagccgc atccacgagc
     1321 gccttgcgca cctccacgct gcctgcgccc cgcgccgcaa ggtggcgctc ctcttggagg
     1381 tgtgcagaga tgtctatgcg ggcctggctc gaggcgagaa ccaagatccc ctgggggccg
     1441 acgccttcct gccggcgctg accgaggaac tcatctggag cccggacatt ggggacacgc
     1501 agctggacgt agagtttctt atggagctct tagatccaga tgagctgcgg ggagaggctg
     1561 ggtactacct gaccacgtgg tttggggcgc tgcaccacat tgcccactac cagcccgaaa
     1621 cagaccgcgc tccccggggg ctcagctccg aggcccgcgc ctccctgcac cagtggcacc
     1681 gcaggcggac gctgcacaga aaggatcatc ccagagccca ggccaacctg ccctttaagg
     1741 agccatgggc agaagagact gtgacaggga ccagtgacaa ctaggggttt cacacccctc
     1801 cgttcatgcc tgtaatccca acattttggg aggccaaggt gggaggattg cttgagccca
     1861 ggagtttgag accagcctgg gcaaaacagt gggaccccca tctaccaaaa aaaaaaaaaa
     1921 acaaaaatta gccgggcgtg gtggcgtact cctgtggtac cagctactca ggaggctttg
     1981 cagttttaga caggcgtatc agagaaagcc tcactgaggt gacatctgca gaaaggcctg
     2041 aaggagggga ggggaaggga ggagcagagt gggtattagg aagagcattc cgagaagcag
     2101 gatgagccag tgcaaaggcc cagaggtagg ctgttccctt ttcctgggac ccctccctcc
     2161 tccttgctgc tcctaaacca cataggtcag gagtctggac tgacccaggt acgtctggca
     2221 tcttgcttga ggaacagggg gttttgtttt gttttgaaag aacgtctctg tctgttgccc
     2281 aggctggagt gtagtggcat gatctcggct cactgcagcc ttaacctcct ggctcaaaca
     2341 agccccctgc ctctgcctac caagtagctg agactacagg cacctaccac cgtgcctgtc
     2401 taatttttaa aattttttat aaagatgagg tctctctttg ttgcccaggc tggtctcaaa
     2461 ctcctaacct caagcaatct gcccacgtcg gcctcccaaa gtgctgagat tataggcgtg
     2521 agccaccgtg cccaattgtg atcgtttttc ccaaagaatg tatcacatgc taacaaacca
     2581 tatatttatg tatttcattg ttcatagtaa ctacaattta aaaaactaaa aagaaacaag
     2641 tgaggccggg tgcggttgct catgcctgta atcccagcac tttgggaggc caaggtgggc
     2701 agatcacctg aggtcgggag ttcaagacca gcctgacaaa catggagaaa cccgtctcta
     2761 ctaaaaatac aaacttagcc gggcatggtg gcgcatgcct gtaatcccag ctactccgga
     2821 ggctaaggca ggagaatggc ttgaacccgg gaggcgaaga ttgcggtgag cggagattgc
     2881 gccattgcac tccagcctgg gcaacaagag tgaaacacca tctcaaaaat aaataaataa
     2941 ataaaaagaa acaagtgaag ttaacgttaa taataatata tttgatttaa cacaatgtat
     3001 cccaaatatt atcacttcaa catgtatcca tattaaaaag ttactgacat atttaaaa
//
