LOCUS       NM_002931               1741 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ring finger protein 1 (RING1), mRNA.
ACCESSION   NM_002931
VERSION     NM_002931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Ryan,C.W., Regan,S.L., Mills,E.F., McGrath,B.T., Gong,E., Lai,Y.T.,
            Sheingold,J.B., Patel,K., Horowitz,T., Moccia,A., Tsan,Y.C.,
            Srivastava,A. and Bielas,S.L.
  TITLE     RING1 missense variants reveal sensitivity of DNA damage repair to
            H2A monoubiquitination dosage during neurogenesis
  JOURNAL   Nat Commun 15 (1), 7931 (2024)
   PUBMED   39256363
  REMARK    GeneRIF: RING1 missense variants reveal sensitivity of DNA damage
            repair to H2A monoubiquitination dosage during neurogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Szustka,A., Kozal,K. and Krzeslak,A.
  TITLE     RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting
            Autophagy in Endometrial Cancer Cells
  JOURNAL   Cell Physiol Biochem 58 (1), 1-13 (2024)
   PUBMED   38219048
  REMARK    GeneRIF: RING1 Inhibition Has a Cell-Specific Antitumoral Role by
            Promoting Autophagy in Endometrial Cancer Cells.
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Liu,D., Guo,Y., Du,Q., Zhu,Y. and Guo,Y.
  TITLE     RING induces cell cycle arrest and apoptosis in human breast cancer
            cells by regulating the HSF1/MT2A axis
  JOURNAL   Exp Cell Res 433 (1), 113795 (2023)
   PUBMED   37797799
  REMARK    GeneRIF: RING induces cell cycle arrest and apoptosis in human
            breast cancer cells by regulating the HSF1/MT2A axis.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Liang,Q., Wang,S., Zhou,X., Li,Y., Xing,S., Sha,Y., Yang,F.,
            Huang,W., Liu,N., Li,Z., Chen,Y., Xu,Y., Zhu,P., Lan,F. and Sun,N.
  TITLE     Essential role of MESP1-RING1A complex in cardiac differentiation
  JOURNAL   Dev Cell 57 (22), 2533-2549 (2022)
   PUBMED   36413948
  REMARK    GeneRIF: Essential role of MESP1-RING1A complex in cardiac
            differentiation.
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Satijn,D.P. and Otte,A.P.
  TITLE     RING1 interacts with multiple Polycomb-group proteins and displays
            tumorigenic activity
  JOURNAL   Mol Cell Biol 19 (1), 57-68 (1999)
   PUBMED   9858531
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Kikuti,Y.Y., Tamiya,G., Ando,A., Chen,L., Kimura,M., Ferreira,E.,
            Tsuji,K., Trowsdale,J. and Inoko,H.
  TITLE     Physical mapping 220 kb centromeric of the human MHC and DNA
            sequence analysis of the 43-kb segment including the RING1, HKE6,
            and HKE4 genes
  JOURNAL   Genomics 42 (3), 422-435 (1997)
   PUBMED   9205114
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Lovering,R., Hanson,I.M., Borden,K.L., Martin,S., O'Reilly,N.J.,
            Evan,G.I., Rahman,D., Pappin,D.J., Trowsdale,J. and Freemont,P.S.
  TITLE     Identification and preliminary characterization of a protein motif
            related to the zinc finger
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2112-2116 (1993)
   PUBMED   7681583
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Hanson,I.M., Poustka,A. and Trowsdale,J.
  TITLE     New genes in the class II region of the human major
            histocompatibility complex
  JOURNAL   Genomics 10 (2), 417-424 (1991)
   PUBMED   1906426
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645940.4, BI259576.1 and
            BC051866.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002931.3.
            
            Summary: This gene belongs to the RING finger family, members of
            which encode proteins characterized by a RING domain, a
            zinc-binding motif related to the zinc finger domain. The gene
            product can bind DNA and can act as a transcriptional repressor. It
            is associated with the multimeric polycomb group protein complex.
            The gene product interacts with the polycomb group proteins BMI1,
            EDR1, and CBX4, and colocalizes with these proteins in large
            nuclear domains. It interacts with the CBX4 protein via its
            glycine-rich C-terminal domain. The gene maps to the HLA class II
            region, where it is contiguous with the RING finger genes FABGL and
            HKE4. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.6253.1,
                                           SRR3476690.734216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374656.5/ ENSP00000363787.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL645940.4         93537-93545
            10-16               BI259576.1         10-16
            17-1741             BC051866.2         1-1725
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1741
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /note="ring finger protein 1"
                     /db_xref="GeneID:6015"
                     /db_xref="HGNC:HGNC:10018"
                     /db_xref="MIM:602045"
     exon            1..145
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..281
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1424
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /EC_number="2.3.2.27"
                     /note="polycomb complex protein RING1; really interesting
                     new gene 1 protein; RING-type E3 ubiquitin transferase
                     RING1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RING1"
                     /protein_id="NP_002922.2"
                     /db_xref="CCDS:CCDS34424.1"
                     /db_xref="GeneID:6015"
                     /db_xref="HGNC:HGNC:10018"
                     /db_xref="MIM:602045"
                     /translation="MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHS
                     ELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPN
                     FDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPI
                     PGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGG
                     GTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKG
                     EYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGG
                     EGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVS
                     RPLELCYAPTKDPK"
     exon            282..442
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..658
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1048
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1322
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1741
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /note="hexamer: AACAAA"
     polyA_site      1741
                     /gene="RING1"
                     /gene_synonym="RING1A; RNF1"
                     /note="major polyA site"
ORIGIN      
        1 gtagggcccc agcgcccggg ccatggcggc ggcggtggcg ggagctgctg tctgagcagc
       61 ggttgcggac cgagcgaact tggcccagga gcccgggcct agggagaggc gcggcggcgg
      121 cgggagcgcg aacggctgga gctggccttc ttcgccttct cctcggctgt ggagccctgg
      181 tggggggtct gcgcccggtc accatgacga cgccggcgaa tgcccagaat gccagcaaaa
      241 cgtgggaact gagtctgtat gagctgcacc ggaccccgca ggaagccata atggatggca
      301 cagagattgc tgtttcccct cggtcactgc attcagaact catgtgccct atctgcctgg
      361 acatgctgaa gaatacgatg accaccaagg agtgcctcca cagattctgc tctgactgca
      421 ttgtcacagc cctacggagc gggaacaagg agtgtcctac ctgccgaaag aagctggtgt
      481 ccaagcgatc cctacggcca gaccccaact ttgatgccct gatctctaag atctatccta
      541 gccgggagga atacgaggcc catcaagacc gagtgcttat ccgcctgagc cgcctgcaca
      601 accagcaggc attgagctcc agcattgagg aggggctacg catgcaggcc atgcacaggg
      661 cccagcgtgt gaggcggccg ataccagggt cagatcagac cacaacgatg agtggggggg
      721 aaggagagcc cggggaggga gaaggggatg gagaagatgt gagctcagac tccgcccctg
      781 actctgcccc aggccctgct cccaagcgac cccgtggagg gggcgcaggg gggagcagtg
      841 tagggacagg gggaggcggc actggtgggg tgggtggggg tgccggttcg gaagactctg
      901 gtgaccgggg agggactctg ggagggggaa cgctgggccc cccaagccct cctggggccc
      961 ccagcccccc agagccaggt ggagaaattg agctcgtgtt ccggccccac cccctgctcg
     1021 tggagaaggg agaatactgc cagacgaggt atgtgaagac aactgggaat gccacagtgg
     1081 accacctctc caagtacttg gccctgcgca ttgccctcga gcggaggcaa cagcaggaag
     1141 caggggagcc aggagggcct ggagggggcg cctctgacac cggaggacct gatgggtgtg
     1201 gcggggaggg tgggggtgcc ggaggaggtg acggtcctga ggagcctgct ttgcccagcc
     1261 tggagggcgt cagtgaaaag cagtacacca tctacatcgc acctggaggc ggggcgttca
     1321 cgacgttgaa tggctcgctg accctggagc tggtgaatga gaaattctgg aaggtgtccc
     1381 ggccactgga gctgtgctat gctcccacca aggatccaaa gtgaccccac caggggacag
     1441 ccagaggaag gggaccatgg ggtatccctg tgtcctggtc tatcacccca gcttctttgt
     1501 cccccagtac ccccagccca gccagccaat aagaggacac aaatgaggac acgtggcttt
     1561 tatacaaagt atctatatga gattcttcta tattgtacag agtggggcaa aacacgcccc
     1621 catctgctgc cttttctatt gccctgcaac gtcccatcta tacgaggtgt tggagaaggt
     1681 gaagaaccct cccattcacg cccgcctacc aacaacaaac gtgctttttt cctctttgaa
     1741 a
//
