LOCUS       NM_024832               3852 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Ras and Rab interactor 3 (RIN3), transcript variant 1,
            mRNA.
ACCESSION   NM_024832
VERSION     NM_024832.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Bhattacharyya,R., Teves,C.A.F., Long,A., Hofert,M. and Tanzi,R.E.
  TITLE     The neuronal-specific isoform of BIN1 regulates beta-secretase
            cleavage of APP and Abeta generation in a RIN3-dependent manner
  JOURNAL   Sci Rep 12 (1), 3486 (2022)
   PUBMED   35241726
  REMARK    GeneRIF: The neuronal-specific isoform of BIN1 regulates
            beta-secretase cleavage of APP and Abeta generation in a
            RIN3-dependent manner.
            Erratum:[Sci Rep. 2022 Apr 6;12(1):5739. doi:
            10.1038/s41598-022-09896-1.. PMID: 35388126]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Shen,R., Zhao,X., He,L., Ding,Y., Xu,W., Lin,S., Fang,S., Yang,W.,
            Sung,K., Spencer,B., Rissman,R.A., Lei,M., Ding,J. and Wu,C.
  TITLE     Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's
            disease
  JOURNAL   Transl Neurodegener 9 (1), 26 (2020)
   PUBMED   32552912
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   De Ridder,R., Boudin,E., Vandeweyer,G., Devogelaer,J.P.,
            Fransen,E., Mortier,G. and Van Hul,W.
  TITLE     Genetic Variation in RIN3 in the Belgian Population Supports Its
            Involvement in the Pathogenesis of Paget's Disease of Bone and
            Modifies the Age of Onset
  JOURNAL   Calcif Tissue Int 104 (6), 613-621 (2019)
   PUBMED   30726512
  REMARK    GeneRIF: Genetic Variation in RIN3 in the Belgian Population
            Supports Its Involvement in the Pathogenesis of Paget's Disease of
            Bone and Modifies the Age of Onset.
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Kunkle,B.W., Vardarajan,B.N., Naj,A.C., Whitehead,P.L., Rolati,S.,
            Slifer,S., Carney,R.M., Cuccaro,M.L., Vance,J.M., Gilbert,J.R.,
            Wang,L.S., Farrer,L.A., Reitz,C., Haines,J.L., Beecham,G.W.,
            Martin,E.R., Schellenberg,G.D., Mayeux,R.P. and Pericak-Vance,M.A.
  TITLE     Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in
            Endolysosomal Transport
  JOURNAL   JAMA Neurol 74 (9), 1113-1122 (2017)
   PUBMED   28738127
  REMARK    GeneRIF: RIN3 may be involved in endolysosomal transport-a process
            known to be important to development of early onset AD.
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Yoshikawa,M., Kajiho,H., Sakurai,K., Minoda,T., Nakagawa,S.,
            Kontani,K. and Katada,T.
  TITLE     Tyr-phosphorylation signals translocate RIN3, the small GTPase
            Rab5-GEF, to early endocytic vesicles
  JOURNAL   Biochem Biophys Res Commun 372 (1), 168-172 (2008)
   PUBMED   18486601
  REMARK    GeneRIF: Tyrosine-phosphorylation signals are involved in the RIN3
            activation and translocation to early endocytic vesicles.
REFERENCE   7  (bases 1 to 3852)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   8  (bases 1 to 3852)
  AUTHORS   Kajiho,H., Saito,K., Tsujita,K., Kontani,K., Araki,Y., Kurosu,H.
            and Katada,T.
  TITLE     RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in
            the early endocytic pathway
  JOURNAL   J Cell Sci 116 (Pt 20), 4159-4168 (2003)
   PUBMED   12972505
  REMARK    GeneRIF: RIN3 biochemically characterized as the stimulator and
            stabilizer for GTP-Rab5 plays an important role in the transport
            pathway from plasma membrane to early endosomes
REFERENCE   9  (bases 1 to 3852)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   10 (bases 1 to 3852)
  AUTHORS   Saito,K., Murai,J., Kajiho,H., Kontani,K., Kurosu,H. and Katada,T.
  TITLE     A novel binding protein composed of homophilic tetramer exhibits
            unique properties for the small GTPase Rab5
  JOURNAL   J Biol Chem 277 (5), 3412-3418 (2002)
   PUBMED   11733506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR003779.1, BX248258.1, BC025248.1, BC070062.1, AB081753.1 and
            AK026092.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024832.4.
            
            Summary: Summary: This protein encoded by this gene is a member of
            the RIN family of Ras interaction-interference proteins, which are
            binding partners to the RAB5 small GTPases. The protein functions
            as a guanine nucleotide exchange for RAB5B and RAB31. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081753.1, BX248258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216487.12/ ENSP00000216487.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DR003779.1         41-54
            15-1131             BX248258.1         1-1117
            1132-2375           BC025248.1         1-1244
            2376-3056           BC070062.1         2136-2816
            3057-3064           BC025248.1         1926-1933
            3065-3110           AB081753.1         2913-2958
            3111-3849           BC025248.1         1977-2715
            3850-3852           AK026092.1         2296-2298
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..3852
                     /gene="RIN3"
                     /note="Ras and Rab interactor 3"
                     /db_xref="GeneID:79890"
                     /db_xref="HGNC:HGNC:18751"
                     /db_xref="MIM:610223"
     exon            1..196
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..3110
                     /gene="RIN3"
                     /note="isoform 1 is encoded by transcript variant 1; RAB5
                     interacting protein 3; ras interaction/interference
                     protein 3"
                     /codon_start=1
                     /product="ras and Rab interactor 3 isoform 1"
                     /protein_id="NP_079108.3"
                     /db_xref="CCDS:CCDS32144.1"
                     /db_xref="GeneID:79890"
                     /db_xref="HGNC:HGNC:18751"
                     /db_xref="MIM:610223"
                     /translation="MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCL
                     PHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHF
                     PSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAI
                     LEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDAN
                     CACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWA
                     PRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPN
                     QPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVS
                     ERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELP
                     RTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQA
                     GTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPS
                     VKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYK
                     VYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESA
                     LYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMME
                     KILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARS
                     NLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDS
                     IHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFA
                     VERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGG
                     SPPCLVVREPNFL"
     exon            197..401
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            402..519
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            520..592
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..684
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..2178
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2487
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2619
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2783
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3852
                     /gene="RIN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3830..3835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIN3"
                     /note="hexamer: AATAAA"
     polyA_site      3852
                     /gene="RIN3"
                     /note="major polyA site"
ORIGIN      
        1 agaagggagc gagagcccca gagcgcggcg gcagcggcgg cctggccctt ccagagggcc
       61 agagccaggg acatgcgggc gcccgggact ccgcgttccg cgcggcccgg cgcctgagcg
      121 cctccgttcc ccgtcccgga gctgccggcg gcatgatccg acacgccggg gcgcccgcgc
      181 gcggggaccc cacgggtccg gttccagttg ttggcaaagg agaggaagag gaagaggaag
      241 atggcatgcg gctttgtctg ccagccaacc cgaaaaactg ccttcctcac cgccggggca
      301 tcagcatcct ggagaagctc atcaaaacat gcccggtgtg gctgcagctg agtctgggcc
      361 aggcagaggt ggccaggatc ctgcaccggg tggtggctgg gatgttcctg gttcgccggg
      421 acagcagctc gaagcagctg gtgctctgtg tccactttcc ttctctgaac gaaagctcgg
      481 ccgaggtgct cgaatacacc attaaggaag aaaagtcgat attgtacctg gaaggctcgg
      541 ctcttgtgtt tgaggacatc ttcagattga ttgcgttcta ctgtgtcagt agagacttac
      601 tgcccttcac actgcggcta ccccaggcca tccttgaggc cagcagcttc acggaccttg
      661 agaccatcgc caacctgggt ctgggtttct gggactcctc gctgaatcct ccacaagaaa
      721 gagggaagcc agcagagccc ccaagagacc gggcccccgg attcccccta gtctccagcc
      781 tcaggcccac agcccatgac gcaaactgtg cctgtgaaat cgagctgtcg gtaggaaatg
      841 accgcctgtg gtttgtgaat cctattttca tcgaggactg cagcagcgcc ctgcccaccg
      901 accagccacc tcttggaaat tgccctgcac gccctttgcc gcccacctct gatgccacct
      961 cacccacctc caggtgggcc ccacgccgcc caccaccccc tcccccagtg ctgcccctgc
     1021 agccctgcag cccagcccag ccccctgtgc tccctgctct tgcccccgcc cctgcctgtc
     1081 ctttgcccac ctctccccca gtgcctgccc cccacgtcac accccatgcc ccaggtcccc
     1141 cagaccatcc gaaccagccg cccatgatga cctgcgagag actcccatgc cccactgcag
     1201 gcctgggccc cctcagggag gaagcgatga agccaggggc agcctccagt cccttgcagc
     1261 aggtccccgc cccgccactg cctgcgaaga agaaccttcc cactgcccct cccagacgcc
     1321 gcgtttccga gagggtgtcc ttagaagacc aaagtccggg gatggcggca gagggggacc
     1381 agctcagcct gcctccccaa gggacctcag acggccctga ggacacgccc cgggagagca
     1441 cggagcaagg ccaggacaca gaggtgaaag ccagcgatcc tcacagcatg ccagagctgc
     1501 ccaggacagc caaacaaccc ccagtcccgc cccccaggaa aaaacggatc tctcgacaac
     1561 tggcctcgac cctcccagct cccttagaga acgctgagct ctgcacacag gcgatggcct
     1621 tggagacacc cacgccgggt ccacccagag agggccaaag ccctgcttct caggctggga
     1681 ctcagcaccc tcctgcccag gccactgccc attcccagag ctctccagag ttcaagggct
     1741 ccctggcctc cctctcagac agcttggggg tgtctgtcat ggccaccgac caggactcct
     1801 actccaccag cagcacggag gaggagctgg agcagttcag cagccccagc gtgaagaaga
     1861 agccctccat gatcctgggc aaggctcggc accggctgag ctttgccagt ttcagcagca
     1921 tgttccacgc tttcctctcc aacaaccgca agctgtacaa gaaggtggtg gagctggcgc
     1981 aggacaaggg ctcgtacttt ggcagcctgg tgcaggacta caaggtgtac agcctggaga
     2041 tgatggcgcg ccagacctcc agcacggaga tgctgcagga gattcgcacc atgatgaccc
     2101 agctcaagag ctacctgctg cagagcaccg agctcaaggc cctggtggac cccgccctgc
     2161 actccgagga ggagctcgaa gcaattgtag agtctgcctt gtacaaatgt gtcctgaagc
     2221 ccctgaagga agccatcaac tcatgcctgc atcagatcca cagcaaggat ggttcgctgc
     2281 agcagctcaa ggagaaccag ttagtgatcc tggccaccac caccactgac ctaggtgtga
     2341 ccaccagcgt gccggaggtg cccatgatgg agaagatcct gcagaagttc accagcatgc
     2401 acaaggccta ctcacctgag aagaagatct ccatcctgct caagacctgc aaactcatct
     2461 acgactccat ggccctcggc aacccaggga agccctatgg ggcggatgac ttcctgcctg
     2521 tgctcatgta tgtgctggcc cgcagcaacc tcacggagat gcttctcaat gtggagtaca
     2581 tgatggagct catggacccc gccctgcagc tgggggaggg ttcctactat ctgaccacca
     2641 cctacggggc cctggagcac atcaagagct acgacaagat cacggtgacc cggcagctga
     2701 gtgtggaggt gcaggactcc atccaccgct gggagcgccg gcgtactctc aacaaggccc
     2761 gggcctcccg ctcctccgta caggacttca tctgcgtgtc gtacctggag cccgagcagc
     2821 aggcgcggac gctggcgtcg cgggcggaca cccaggccca ggcgctgtgc gcgcagtgcg
     2881 cggagaagtt cgcggtggag cggccgcagg cgcaccggct gttcgtgctg gtggacgggc
     2941 gctgcttcca gctggcggac gacgcgctgc cgcactgcat caagggctac ctgctgcgca
     3001 gcgagcccaa gcgcgacttc cactttgtct accggcccct ggacggtggt ggcggcggcg
     3061 gcggcgggag cccgccctgc ctggtggtgc gggagcccaa cttcctgtga ggccctcccg
     3121 gggcgcctcc cctcaccccc aggcgcacgt ctggccccgc ctctggctgc gcactcccga
     3181 ccgcgacgtc cacgcagcag agggacatgg gccattccat gacgtgccca ggccaacgtc
     3241 gcaggacagt tgtgaaaata acatgacgct cgtccaaggc cacttcctga gggcaagtcc
     3301 taatagccct gagacaccga gacggcatgt tcttcattag acggaaaggg aaactgaggc
     3361 tcaggagaga ggcgctccag gccgctgcag ccaacaaacc ggcgccctct tcacacgtag
     3421 ctcctcaggc cattccccat gagtccccca cacccacccc atcctcggtc tttgcaaaga
     3481 agggcccgag cttagtttcc ccaggactgg cctaggaagg agcaccggcc acagctgctc
     3541 cccgtgccac tcagggtgga cccagcatct caggagcacc tcagggtgtc ggttaagaga
     3601 caggcctcca cccctgcacc agagcctgct cttagctccc ggtgccccca gaccccgcag
     3661 ctctgtgccc ggcaagaagc agctagacac acgccagggc gccaagcacg gccagctccg
     3721 cggacccatg gacaagccca gccccgcctc agggaaaaca gggcctttcc ctacaggaca
     3781 cgccccagag ctgtggcaga ttgcaggagc catcgtgtgg ggagaattta ataaaagccc
     3841 ttttgaaaat ga
//
